MYC on the Path to Cancer

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673

Identification of c- MYC as a Target of the APC Pathway

He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566

The landscape of somatic copy-number alteration across human cancers

Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Delmore, J. E., Issa, G. C., Lemieux, M. E., Rahl, P. B., Shi, J., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.017 · Cited by 2,888

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804

c-Myc-regulated microRNAs modulate E2F1 expression

O'Donnell, K. A., Wentzel, E. A., Zeller, K. I., Dang, C. V., & Mendell, J. T. (2005) · Nature · doi:10.1038/nature03677 · Cited by 2,347

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

Brodeur, G. M., Seeger, R. C., Schwab, M., VARMUS, H. E., & Bishop, J. M. (1984) · Science · doi:10.1126/science.6719137 · Cited by 2,261

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

Kelly, K., Cochran, B., Stiles, C. D., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90092-2 · Cited by 2,227

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 2×

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124

Recent Advances in Neuroblastoma

Maris, J. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0804577 · Cited by 2,025

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001

Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals

Xie, X., Lu, J., Kulbokas, E. J., Golub, T. R., Mootha, V., Lindblad-Toh, K., Lander, E. S., & Kellis, M. (2005) · Nature · doi:10.1038/nature03441 · Cited by 1,872

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

Adams, J. M., Harris, A. W., Pinkert, C. A., Corcoran, L. M., Alexander, W. S., Cory, S., Palmiter, R. D., & Brinster, R. L. (1985) · Nature · doi:10.1038/318533a0 · Cited by 1,779

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

Dalla‐Favera, R., Bregni, M., Erikson, J., Patterson, D., Gallo, R. C., & Croce, C. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7824 · Cited by 1,764

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

Blackwood, E. M., & Eisenman, R. N. (1991) · Science · doi:10.1126/science.2006410 · Cited by 1,681

Transcriptional paradigms in mammalian mitochondrial biogenesis and function

Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

Fantin, V. R., St-Pierre, J., & Leder, P. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.023 · Cited by 1,635

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

Dang, E. V., Barbi, J., Yang, H.-Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H.-R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.033 · Cited by 1,595

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

Le, A., Cooper, C. R., Gouw, A. M., Dinavahi, R., Maitra, A., Deck, L. M., Royer, R. E., Jagt, D. L. V., Semenza, G. L., & Dang, C. V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914433107 · Cited by 1,528

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

Kota, J., Chivukula, R. R., O'Donnell, K. A., Wentzel, E. A., Montgomery, C. L., Hwang, H.-W., Chang, T.-C., Vivekanandan, P., Torbenson, M., Clark, K. R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.04.021 · Cited by 1,452

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

Taub, R. A., Kirsch, I. R., Morton, C. C., Lenoir, G., Swan, D., Tronick, S. R., Aaronson, S. A., & Leder, P. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7837 · Cited by 1,421

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

Ma, L., Young, J. J., Prabhala, H. K., Pan, E., Mestdagh, P., Muth, D., Teruya‐Feldstein, J., Reinhardt, F., Önder, T. T., Valastyan, S., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2024 · Cited by 1,358

Widespread microRNA repression by Myc contributes to tumorigenesis

Chang, T.-C., Yu, D., Lee, Y., Wentzel, E. A., Arking, D. E., West, K. M., Dang, C. V., Thomas‐Tikhonenko, A., & Mendell, J. T. (2007) · Nature Genetics · doi:10.1038/ng.2007.30 · Cited by 1,346

c-Myc Regulates Transcriptional Pause Release

Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., Sharp, P. A., & Young, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.03.030 · Cited by 1,279

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J., & Roussel, M. F. (1998) · Genes & Development · doi:10.1101/gad.12.15.2424 · Cited by 1,245

The c-Myc target gene network

Dang, C. V., O’Donnell, K. A., Zeller, K. I., Nguyen, T., Osthus, R. C., & Li, F. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.014 · Cited by 1,188

Targeting MYC dependence in cancer by inhibiting BET bromodomains

Mertz, J. A., Conery, A. R., Bryant, B. M., Sandy, P., Balasubramanian, S., Mele, D. A., Bergeron, L., & Sims, R. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108190108 · Cited by 1,145

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD + Biosynthesis

Ramsey, K. M., Yoshino, J., Brace, C. S., Abrassart, D., Kobayashi, Y., Marcheva, B., Hong, H.-K., Chong, J. L., Buhr, E. D., Lee, C., et al. (2009) · Science · doi:10.1126/science.1171641 · Cited by 1,126

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

Le, A., Lane, A. N., Hamaker, M., Bose, S., Gouw, A., Barbi, J., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Zhang, H., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.009 · Cited by 1,095

Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs

Cawley, S., Bekiranov, S., Ng, H. H., Kapranov, P., Sekinger, E. A., Kampa, D., Piccolboni, A., Sementchenko, V., Cheng, J., Williams, A. J., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00127-8 · Cited by 1,095

c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth

Shim, H., Dolde, C., Lewis, B. C., Wu, C.-S., Dang, G., Jungmann, R. A., Dalla-Favera, R., & Dang, C. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6658 · Cited by 1,092

Genomic targets of the human c-Myc proteinPreprint

Fernandez, P. C., Frank, S. R., Wang, L., Schroeder, M., Liu, S., Greene, J. R., Cocito, A., & Amati, B. B. (2003) · Genes & Development · doi:10.1101/gad.1067003 · Cited by 963

MYC as a regulator of ribosome biogenesis and protein synthesis

van Riggelen, J., Yetil, A., & Felsher, D. W. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2819 · Cited by 956

Hypoxia-Inducible Factor 1 (HIF-1) Pathway

Semenza, G. L. (2007) · Science s STKE · doi:10.1126/stke.4072007cm8 · Cited by 942

Reversible tumorigenesis by MYC in hematopoietic lineages.

Felsher, D., & Bishop, J. (1999) · Molecules and Cells · doi:10.1016/s1097-2765(00)80367-6 · Cited by 917

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., & Semenza, G. L. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.04.001 · Cited by 885

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876

Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc

Osthus, R. C., Shim, H., Kim, S., Li, Q., Reddy, R., Mukherjee, M., Xu, Y., Wonsey, D. R., Lee, L. A., & Dang, C. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000023200 · Cited by 876

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

Shachaf, C. M., Kopelman, A. M., Arvanitis, C., Karlsson, Å., Beer, S., Mandl, S., Bachmann, M. H., Borowsky, A. D., Ruebner, B., Cardiff, R. D., et al. (2004) · Nature · doi:10.1038/nature03043 · Cited by 874

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphomaPreprint

Weng, A. P., Millholland, J. M., Yashiro–Ohtani, Y., Arcangeli, M.-L., Lau, A. N., Wai, C., Bianco, C. D., Rodríguez, C. G., Sai, H., Tobias, J. W., et al. (2006) · Genes & Development · doi:10.1101/gad.1450406 · Cited by 863

Modelling Myc inhibition as a cancer therapy

Soucek, L., Whitfield, J. R., Martins, C. P., Finch, A. J., Murphy, D. J., Sodir, N. M., Karnezis, A. N., Swigart, L. B., Nasi, S., & Evan, G. I. (2008) · Nature · doi:10.1038/nature07260 · Cited by 846

p53 represses c-Myc through induction of the tumor suppressor miR-145

Sachdeva, M., Zhu, S., Wu, F., Wu, H., Walia, V., Kumar, S. R., Elble, R. C., Watabe, K., & Mo, Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808042106 · Cited by 841

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

Wang, J.-B., Erickson, J. W., Fuji, R., Ramachandran, S., Gao, P., Dinavahi, R., Wilson, K. F., Ambrosio, A. L. B., Dias, S. M. G., Dang, C. V., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.08.009 · Cited by 821

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

Palomero, T., Lim, W. K., Odom, D. T., Sulis, M. L., Real, P. J., Margolin, A. A., Barnes, K., O’Neil, J., Neuberg, D. S., Weng, A. P., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606108103 · Cited by 821

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

Eischen, C. M., Weber, J. D., Roussel, M. F., Sherr, C. J., & Cleveland, J. L. (1999) · Genes & Development · doi:10.1101/gad.13.20.2658 · Cited by 819

Myc-driven murine prostate cancer shares molecular features with human prostate tumors

Ellwood‐Yen, K., Graeber, T. G., Wongvipat, J., Iruela‐Arispe, M. L., Zhang, J., Matusik, R. J., THOMAS, G. V., & Sawyers, C. L. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00197-1 · Cited by 816

HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity

Gordan, J. D., Bertout, J. A., Hu, C.-J., Diehl, J. A., & Simon, M. C. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.02.006 · Cited by 781

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells

Wong, D. J., Liu, H. W., Ridky, T. W., Cassarino, D. S., Segal, E., & Chang, H. Y. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.02.009 · Cited by 717

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells

Yuneva, M., Zamboni, N., Oefner, P., Sachidanandam, R., & Lazebnik, Y. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200703099 · Cited by 690 · cited 1×

A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs

Kim, J., Woo, A. J., Chu, J., Snow, J. W., Fujiwara, Y., Kim, C. G., Cantor, A. B., & Orkin, S. H. (2010) · Cell · doi:10.1016/j.cell.2010.09.010 · Cited by 683

Non-transcriptional control of DNA replication by c-Myc

Dominguez-Sola, D., Ying, C. Y., Grandori, C., Ruggiero, L., Chen, B., Li, M., Galloway, D. A., Gu, W. J., Gautier, J., & Dalla‐Favera, R. (2007) · Nature · doi:10.1038/nature05953 · Cited by 671

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

Pomerantz, M. M., Ahmadiyeh, N., Jia, L., Herman, P., Verzi, M. P., Doddapaneni, H., Beckwith, C. A., Chan, J. A., Hills, A., Davis, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.403 · Cited by 663

Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC

Jain, M., Arvanitis, C., Chu, K., Dewey, W. C., Leonhardt, E. A., Trinh, M., Sundberg, C. D., Bishop, J. M., & Felsher, D. W. (2002) · Science · doi:10.1126/science.1071489 · Cited by 661

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

Grandori, C., Gomez-Roman, N., Felton-Edkins, Z. A., Ngouenet, C., Galloway, D. A., Eisenman, R. N., & White, R. J. (2005) · Nature Cell Biology · doi:10.1038/ncb1224 · Cited by 659

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

Kim, J.-W., Gao, P., Liu, Y.-C., Semenza, G. L., & Dang, C. V. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00440-07 · Cited by 658

L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

Nau, M. M., Brooks, B. J., Battey, J. F., Sausville, E. A., Gazdar, A. F., Kirsch, I. R., McBride, O. W., Bertness, V. L., Hollis, G. F., & Minna, J. D. (1985) · Nature · doi:10.1038/318069a0 · Cited by 649

Drosophila myc Regulates Cellular Growth during Development

Johnston, L. A., Prober, D. A., Edgar, B. A., Eisenman, R. N., & Gallant, P. (1999) · Cell · doi:10.1016/s0092-8674(00)81512-3 · Cited by 648

The interplay between MYC and HIF in cancer

Dang, C. V., Kim, J., Gao, P., & Yustein, J. T. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2274 · Cited by 621

Myc deletion rescues Apc deficiency in the small intestine

Sansom, O. J., Méniel, V. S., Muncan, V., Phesse, T. J., Wilkins, J. A., Reed, K. R., Vass, J. K., Athineos, D., Clevers, H. C., & Clarke, A. R. (2007) · Nature · doi:10.1038/nature05674 · Cited by 618

Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis

Li, F., Wang, Y., Zeller, K. I., Potter, J. J., Wonsey, D. R., O’Donnell, K. A., Kim, J., Yustein, J. T., Lee, L. A., & Dang, C. V. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.6225-6234.2005 · Cited by 615

Crosstalk between components of circadian and metabolic cycles in mammals

Asher, G., & Schibler, U. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.006 · Cited by 601

HuR recruits let-7/RISC to repress c-Myc expressionPreprint

Kim, H. H., Kuwano, Y., Srikantan, S., Lee, E. K., Martindale, J. L., & Gorospe, M. (2009) · Genes & Development · doi:10.1101/gad.1812509 · Cited by 570

Oncogenic activity of the c-Myc protein requires dimerization with Max

Amati, B. B., Brooks, M. W., Levy-Strumpf, N., Littlewood, T. D., Evan, G. I., & Land, H. (1993) · Cell · doi:10.1016/0092-8674(93)90663-b · Cited by 566

Functional role for c-myc in mitogenic response to platelet-derived growth factor

Armelin, H. A., Armelin, M. C. S., Kelly, K., Stewart, T. A., Leder, P., Cochran, B., & Stiles, C. D. (1984) · Nature · doi:10.1038/310655a0 · Cited by 565

X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA

Nair, S. K., & Burley, S. K. (2003) · Cell · doi:10.1016/s0092-8674(02)01284-9 · Cited by 551

c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progressionPreprint

Baudino, T. A., McKay, C., Pendeville, H., Nilsson, J. A., Maclean, K. H., White, E. L., Davis, A. C., Ihle, J. N., & Cleveland, J. L. (2002) · Genes & Development · doi:10.1101/gad.1024602 · Cited by 530

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

Li, Z., Calcar, S. V., Qu, C., Cavenee, W. K., Zhang, M. Q., & Ren, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332764100 · Cited by 528

Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1

Seltzer, M. J., Bennett, B. D., Joshi, A. D., Gao, P., Thomas, A. G., Ferraris, D. V., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Rabinowitz, J. D., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1666 · Cited by 528

HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo

Gao, P., Zhang, H., Dinavahi, R., Li, F., Xiang, Y., Raman, V., Bhujwalla, Z. M., Felsher, D. W., Cheng, L., Pevsner, J., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.004 · Cited by 523

Global mapping of c-Myc binding sites and target gene networks in human B cells

Zeller, K. I., Zhao, X., Lee, C. W. H., Chiu, K. P., Yao, F., Yustein, J. T., Ooi, H., Orlov, Y. L., Shahab, A., Yong, H. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604129103 · Cited by 521

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

Tuupanen, S., Turunen, M. M., Lehtonen, R., Hallikas, O. K., Vanharanta, S., Kivioja, T., Björklund, M., Wei, G., Yan, J., Niittymäki, I., et al. (2009) · Nature Genetics · doi:10.1038/ng.406 · Cited by 498

The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc

McMahon, S. B., Wood, M. A., & Cole, M. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.2.556-562.2000 · Cited by 494

HIF-α effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

Gordan, J. D., Lal, P., Dondeti, V. R., Letrero, R., Parekh, K. N., Oquendo, C. E., Greenberg, R. A., Flaherty, K. T., Rathmell, W. K., Keith, B., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.10.016 · Cited by 493

TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

Seoane, J., Pouponnot, C., Staller, P., Schader, M. B., Eilers, M., & Massagué, J. (2001) · Nature Cell Biology · doi:10.1038/35070086 · Cited by 489

Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization

Gregory, M. A., Qi, Y., & Hann, S. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m310722200 · Cited by 486

The ubiquitin-specific protease USP28 is required for MYC stability

Popov, N., Wanzel, M., Madiredjo, M., Zhang, D., Beijersbergen, R. L., Bernards, R., Moll, R., Elledge, S. J., & Eilers, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1601 · Cited by 484

Identification of CDK4 as a target of c-MYC

Hermeking, H., Rago, C., Schuhmacher, M., Li, Q., Barrett, J. F., Obaya, Á. J., O’Connell, B. C., Mateyak, M. K., Tam, W., Kohlhuber, F., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050586197 · Cited by 476

Reversible Activation of c-Myc in Skin

Pelengaris, S., Littlewood, T. D., Khan, M., Elia, G., & Evan, G. I. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80350-0 · Cited by 469

c-Myc Proteolysis by the Ubiquitin-Proteasome Pathway: Stabilization of c-Myc in Burkitt's Lymphoma Cells

Gregory, M. A., & Hann, S. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.7.2423-2435.2000 · Cited by 469

Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis

Gurel, B., Iwata, T., Koh, C. M., Jenkins, R., Lan, F., Dang, C., Hicks, J., Morgan, J. D., Cornish, T. C., Sutcliffe, S., et al. (2008) · Modern Pathology · doi:10.1038/modpathol.2008.111 · Cited by 459

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max

Amati, B. B., Dalton, S., Brooks, M. W., Littlewood, T. D., Evan, G. I., & Land, H. (1992) · Nature · doi:10.1038/359423a0 · Cited by 457

Distinct Thresholds Govern Myc's Biological Output In Vivo

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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

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Myc and Max proteins possess distinct transcriptional activities

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Direct activation of RNA polymerase III transcription by c-Myc

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Transient excess of MYC activity can elicit genomic instability and tumorigenesis

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Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development

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c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

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Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

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An Amino-Terminal c-Myc Domain Required for Neoplastic Transformation Activates Transcription

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The Ubiquitin Ligase HectH9 Regulates Transcriptional Activation by Myc and Is Essential for Tumor Cell Proliferation

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The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

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MYC stimulates EZH2 expression by repression of its negative regulator miR-26a

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AID-Dependent Activation of a MYC Transgene Induces Multiple Myeloma in a Conditional Mouse Model of Post-Germinal Center Malignancies

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MicroRNA regulation of a cancer network: Consequences of the feedback loops involving miR-17-92, E2F, and Myc

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Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor networkPreprint

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Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design

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Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

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The Akt–SREBP nexus: cell signaling meets lipid metabolism

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8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC

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Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma.

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p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC

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Identification of the Human c- myc Protein Nuclear Translocation Signal

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CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation

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N-myc can functionally replace c-myc in murine development, cellular growth, and differentiationPreprint

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c-Myc promotes differentiation of human epidermal stem cells

Gandarillas, A., & Watt, F. M. (1997) · Genes & Development · doi:10.1101/gad.11.21.2869 · Cited by 326

RTCGD: retroviral tagged cancer gene database

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The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma

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Isolation and characterization of c-myc, a cellular homolog of the oncogene (v-myc) of avian myelocytomatosis virus strain 29

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Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity

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Targeting MYC Expression through G-Quadruplexes

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A unique glucose-dependent apoptotic pathway induced by c-Myc

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The Cell Cycle and Myc Intersect with Mechanisms that Regulate Pluripotency and Reprogramming

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Max: functional domains and interaction with c-Myc.Preprint

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The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

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DNA and RNA from Uninfected Vertebrate Cells Contain Nucleotide Sequences Related to the Putative Transforming Gene of Avian Myelocytomatosis Virus

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The Myc–miR-17∼92 Axis Blunts TGFβ Signaling and Production of Multiple TGFβ-Dependent Antiangiogenic Factors

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Notch1 Contributes to Mouse T-Cell Leukemia by Directly Inducing the Expression of c-myc

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A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia

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Upregulation of c- MYC in cis through a Large Chromatin Loop Linked to a Cancer Risk-Associated Single-Nucleotide Polymorphism in Colorectal Cancer Cells

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Activated Expression of the N- myc Gene in Human Neuroblastomas and Related Tumors

Kohl, N. E., Gee, C. E., & Alt, F. W. (1984) · Science · doi:10.1126/science.6505694 · Cited by 245

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state

den Hollander, J., Rimpi, S., Doherty, J. R., Rudelius, M., Buck, A. K., Höllein, A., Kremer, M., Graf, N., Scheerer, M. F., Hall, M. A., et al. (2010) · Blood · doi:10.1182/blood-2009-11-251074 · Cited by 245

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

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Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

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Long-range enhancers on 8q24 regulate c-Myc

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Myc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell Differentiation

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Regulation of reactive oxygen species, DNA damage and c-Myc function by peroxiredoxin 1

Egler, R. A., Fernandes, E. R., Rothermund, K. D., Sereika, S. M., de Souza-Pinto, N. C., Jaruga, P., Dizdaroğlu, M., & Prochownik, E. V. (2005) · Oncogene · doi:10.1038/sj.onc.1208821 · Cited by 234

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

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Identification of the human c-myc protein nuclear translocation signal.

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C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells

Zhuang, D., Mannava, S., Grachtchouk, V., Tang, W. H., Patil, S. B., Wawrzyniak, J. A., Berman, A. E., Giordano, T. J., Prochownik, E. V., Soengas, M. S., et al. (2008) · Oncogene · doi:10.1038/onc.2008.258 · Cited by 219

PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis

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The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation

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The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1βPreprint

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An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancerPreprint

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Myc Enforces Overexpression ofEZH2in Early Prostatic Neoplasia via Transcriptional and Post-transcriptional Mechanisms

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Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

Frye, M., Gardner, C., Li, E. R., Arnold, I., & Watt, F. M. (2003) · Development · doi:10.1242/dev.00462 · Cited by 187

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

Kim, S., Li, Q., Dang, C. V., & Lee, L. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200372597 · Cited by 187

Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16 INK4a

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Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

Follis, A. V., Hammoudeh, D. I., Wang, H., Prochownik, E. V., & Metallo, S. J. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.09.011 · Cited by 183

A role for c-Myc in the regulation of ribosomal RNA processing

Schlosser, I. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg794 · Cited by 183

Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation

Boxer, R. B., Jang, J. W.-U., Sintasath, L., & Chodosh, L. A. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.10.013 · Cited by 180

Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase

Yang, D., Liu, H., Goga, A., Kim, S., Yuneva, M. O., & Bishop, J. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008366107 · Cited by 179

Endogenous Myc maintains the tumor microenvironmentPreprint

Sodir, N. M., Swigart, L. B., Karnezis, A. N., Hanahan, D., Evan, G. I., & Soucek, L. (2011) · Genes & Development · doi:10.1101/gad.2038411 · Cited by 177

c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle

Wang, H., Mannava, S., Grachtchouk, V., Zhuang, D., Soengas, M. S., Gudkov, A. V., Prochownik, E. V., & Nikiforov, M. A. (2007) · Oncogene · doi:10.1038/sj.onc.1210823 · Cited by 176

Demonstration that Drug-targeted Down-regulation of MYC in Non-Hodgkins Lymphoma Is Directly Mediated through the Promoter G-quadruplex

Brown, R. V., Danford, F. L., Gokhale, V. M., Hurley, L. H., & Brooks, T. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274720 · Cited by 174

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

Cannell, I. G., Kong, Y. W., Johnston, S. J., Chen, M. L., Collins, H. M., Dobbyn, H. C., Elia, A., Kress, T. R., Dickens, M., Clemens, M. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910015107 · Cited by 172

Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland

Wang, X., Cunningham, M., Zhang, X., Tokarz, S. A., Laraway, B. J., Troxell, M. L., & Sears, R. C. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1032 · Cited by 171

Transcription-independent functions of MYC: regulation of translation and DNA replication

Cole, M. D., & Cowling, V. H. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2467 · Cited by 170

Control of the Initiation of DNA Synthesis in 3T3 Cells: Low-Molecular-Weight Nutrients

Holley, R. W., & Kiernan, J. A. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.8.2942 · Cited by 169

Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation

Ji, H., Wu, G. Y., Zhan, X., Nolan, A., Koh, C. M., Marzo, A. D., Doan, H. M., Fan, J., Cheadle, C., Fallahi, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026057 · Cited by 169

Visualization of Myc/Max/Mad Family Dimers and the Competition for Dimerization in Living Cells

Grinberg, A. V., Hu, C., & Kerppola, T. K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4294-4308.2004 · Cited by 169

miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression

Pickering, M., Stadler, B., & Kowalik, T. F. (2008) · Oncogene · doi:10.1038/onc.2008.372 · Cited by 166

A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer

Muellner, M. K., Uras, I. Z., Gapp, B. V., Kerzendorfer, C., Šmída, M., Lechtermann, H., Craig-Mueller, N., Colinge, J., Duernberger, G., & Nijman, S. M. B. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.695 · Cited by 165

c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus

Louis, S. F., Vermolen, B. J., Garini, Y., Young, I. T., Guffei, A., Lichtensztejn, Z., Kuttler, F., Chuang, T., Moshir, S., Mougey, V., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407512102 · Cited by 159

MYC in mammalian epidermis: how can an oncogene stimulate differentiation?

Watt, F. M., Frye, M., & Benitah, S. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2328 · Cited by 157

Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1α

Qing, G., Skuli, N., Mayes, P. A., Pawel, B., Martinez, D., Maris, J. M., & Simon, M. C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0740 · Cited by 157

An Amino-Terminal c-Myc Domain Required for Neoplastic Transformation Activates Transcription

Kato, G. J., Barrett, J., Villa‐Garcia, M., et al. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.11.5914-5920.1990 · Cited by 157

c-Myc Transformation Domain Recruits the Human STAGA Complex and Requires TRRAP and GCN5 Acetylase Activity for Transcription Activation

Liu, X., Tesfai, J., Evrard, Y. A., Dent, S., & Martinez, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211795200 · Cited by 155

The Myc Transactivation Domain Promotes Global Phosphorylation of the RNA Polymerase II Carboxy-Terminal Domain Independently of Direct DNA Binding

Cowling, V. H., & Cole, M. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01828-06 · Cited by 155

Therapeutic Targeting of Myc

Prochownik, E. V., & Vogt, P. K. (2010) · Genes & Cancer · doi:10.1177/1947601910377494 · Cited by 154

Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression

Karlsson, A. E., Deb-Basu, D., Cherry, A. M., Turner, S., Ford, J. M., & Felsher, D. W. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1732638100 · Cited by 153

Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch

Giuriato, S., Ryeom, S. W., Fan, A. C., Bachireddy, P., Lynch, R. C., Rioth, M. J., van Riggelen, J., Kopelman, A. M., Passegue, E. A., Tang, F. L. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608017103 · Cited by 152

Ubiquitylation of the amino terminus of Myc by SCFβ-TrCP antagonizes SCFFbw7-mediated turnover

Popov, N., Schülein‐Völk, C., Jaenicke, L. A., & Eilers, M. (2010) · Nature Cell Biology · doi:10.1038/ncb2104 · Cited by 151

Loss of FBP function arrests cellular proliferation and extinguishes c‐myc expression

He, L., Liu, J., Collins, I. J., Sanford, S., O'Connell, B. C., Benham, C. J., & Levens, D. (2000) · The EMBO Journal · doi:10.1093/emboj/19.5.1034 · Cited by 150

Conditional transgenic models define how MYC initiates and maintains tumorigenesis

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The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis

Kress, T. R., Cannell, I. G., Brenkman, A. B., Samans, B., Gaestel, M., Roepman, P., Burgering, B. M. T., Bushell, M., Rosenwald, A., & Eilers, M. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.01.023 · Cited by 148

Developmental Context Determines Latency of MYC-Induced Tumorigenesis

Beer, S., Zetterberg, A., Ihrie, R. A., McTaggart, R., Yang, Q., Bradon, N., Arvanitis, C., Attardi, L. D., Feng, S., Ruebner, B. H., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020332 · Cited by 142

TRRAP-Dependent and TRRAP-Independent Transcriptional Activation by Myc Family Oncoproteins

Nikiforov, M. A., Chandriani, S. J., Park, J. H., Kotenko, I., Matheos, D. P., Johnsson, A., McMahon, S. B., & Cole, M. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5054-5063.2002 · Cited by 137

MYCN-regulated microRNAs repress estrogen receptor-α ( ESR1 ) expression and neuronal differentiation in human neuroblastoma

Lovén, J., Zinin, N., Wahlström, T., Müller, I., Brodin, P., Fredlund, E., Ribacke, U., Pivarcsi, A., Påhlman, S., & Arsenian‐Henriksson, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913517107 · Cited by 135

Oncogene addiction

Jonkers, J., & Berns, A. J. M. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.12.002 · Cited by 133

Alterations in Nucleolar Structure and Gene Expression Programs in Prostatic Neoplasia Are Driven by the MYC Oncogene

Koh, C. M., Gürel, B., Sutcliffe, S. S., Aryee, M. J., Schultz, D., Iwata, T., Uemura, M., Zeller, K. I., Anele, U. A., Zheng, Q., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.12.040 · Cited by 133

Identification of Downstream-Initiated c-Myc Proteins Which Are Dominant-Negative Inhibitors of Transactivation by Full-Length c-Myc Proteins

Spotts, G. D., Patel, S. V., Xiao, Q., & Hann, S. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1459 · Cited by 133

Proteolytic Control of the Oncoprotein Transcription Factor Myc

Thomas, L. R., & Tansey, W. P. (2011) · Advances in cancer research · doi:10.1016/b978-0-12-386469-7.00004-9 · Cited by 132

The Interplay Between MYC and HIF in the Warburg Effect

Dang, C. V. (2008) · Ernst Schering Research Foundation workshop/Ernst Schering Foundation Symposium proceedings · doi:10.1007/2789_2008_088 · Cited by 131

TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription

Kenneth, N. S., Ramsbottom, B. A., Gomez-Roman, N., Marshall, L., Cole, P. A., & White, R. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702909104 · Cited by 130

c-Myc Overexpression Uncouples DNA Replication from Mitosis

Li, Q., & Dang, C. V. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5339 · Cited by 129

Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation

Li, Z., Boone, D. N., & Hann, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806879105 · Cited by 128

MYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent Mechanisms

Felsher, D. W. (2010) · Genes & Cancer · doi:10.1177/1947601910377798 · Cited by 128

Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis

Greasley, P. J. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.2.446 · Cited by 126

18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers

Palaskas, N. J., Larson, S. M., Schultz, N. D., Komisopoulou, E., Wong, J., Rohle, D., Campos, C., Yannuzzi, N. A., Osborne, J. R., Linkov, I., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4633 · Cited by 126

The cancerous translation apparatus

Stumpf, C. R., & Ruggero, D. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.03.007 · Cited by 122

c-Myc Interacts with Hypoxia to Induce Angiogenesis In vivo by a Vascular Endothelial Growth Factor-Dependent Mechanism

Knies, U. E., Fox, S. B., Poulsom, R., Evan, G. I., & Harris, A. L. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3176 · Cited by 121

Drug Targeting of the c-MYC Promoter to Repress Gene Expression via a G-Quadruplex Silencer Element

Hurley, L. H., VonHoff, D. D., Siddiqui-Jain, A., & Yang, D. (2006) · Seminars in Oncology · doi:10.1053/j.seminoncol.2006.04.012 · Cited by 121

Ribosomal Protein L11 Recruits miR-24/miRISC To Repress c-Myc Expression in Response to Ribosomal Stress

Challagundla, K. B., Sun, X., Zhang, X., DeVine, T., Zhang, Q., Sears, R. C., & Dai, M. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05810-11 · Cited by 120

Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosisPreprint

Xiao, Q., Claassen, G. F., Shi, J., Adachi, S., Sedivy, J. M., & Hann, S. (1998) · Genes & Development · doi:10.1101/gad.12.24.3803 · Cited by 119

Direct Regulation of RNA Polymerase III Transcription by RB, p53 and c-Myc

Felton-Edkins, Z. A., Kenneth, N. S., Brown, T. R. P., Daly, N. L., Gomez-Roman, N., Grandori, C., Eisenman, R. N., & White, R. J. (2003) · Cell Cycle · doi:10.4161/cc.2.3.375 · Cited by 119

In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization

Clausen, D. M., Guo, J., Parise, R. A., Beumer, J. H., Egorin, M. J., Lazo, J. S., Prochownik, E. V., & Eiseman, J. L. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.170555 · Cited by 117

Myc stimulates B lymphocyte differentiation and amplifies calcium signaling

Habib, T., Park, H., Tsang, M., de Alborán, I. M., Nicks, A., Wilson, L., Knoepfler, P. S., Andrews, S. F., Rawlings, D. J., Eisenman, R. N., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704173 · Cited by 115

A ribosomal protein L23-nucleophosmin circuit coordinates Miz1 function with cell growth

Wanzel, M., Russ, A. C., Kleine‐Kohlbrecher, D., Colombo, E., Pelicci, P. G., & Eilers, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1764 · Cited by 114

Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts

Perna, D., Fagà, G., Verrecchia, A., Gorski, M. M., Barozzi, I., Narang, V., Khng, J., Lim, K., Sung, W.-K., Sanges, R., et al. (2011) · Oncogene · doi:10.1038/onc.2011.359 · Cited by 113

The interaction between Myc and Miz1 is required to antagonize TGFβ-dependent autocrine signaling during lymphoma formation and maintenancePreprint

van Riggelen, J., Müller, J., Otto, T., Beuger, V., Yetil, A., Choi, P. S., Kosan, C., Möröy, T., Felsher, D. W., & Eilers, M. (2010) · Genes & Development · doi:10.1101/gad.585710 · Cited by 113

Functional Interaction of the c-Myc Transactivation Domain with the TATA Binding Protein: Evidence for an Induced Fit Model of Transactivation Domain Folding

McEwan, I. J., Dahlman‐Wright, K., Ford, J., & Wright, A. P. H. (1996) · Biochemistry · doi:10.1021/bi960793v · Cited by 110

Novel c‐MYC target genes mediate differential effects on cell proliferation and migration

Cappellen, D., Schlange, T., Bauer, M., Maurer, F., & Hynes, N. E. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400849 · Cited by 110

Avian acute leukemia viruses MC29 and MH2 share specific RNA sequences: Evidence for a second class of transforming genes

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Translational activation of the non-AUG-initiated c-myc 1 protein at high cell densities due to methionine deprivation.Preprint

Hann, S., Sloan‐Brown, K., & Spotts, G. D. (1992) · Genes & Development · doi:10.1101/gad.6.7.1229 · Cited by 107

The PI3K Pathway in Human Disease

Fruman, D. A., Chiu, H., Hopkins, B. D., Bagrodia, S., Cantley, L. C., & Abraham, R. T. (2017) · Cell · doi:10.1016/j.cell.2017.07.029 · Cited by 2,749

Regulation and Function of the PD-L1 Checkpoint

Sun, C., Mezzadra, R., & Schumacher, T. N. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.014 · Cited by 2,248

Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways

Wee, P., & Wang, Z. (2017) · Cancers · doi:10.3390/cancers9050052 · Cited by 2,027

The multifaceted roles of fatty acid synthesis in cancer

Röhrig, F., & Schulze, A. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.89 · Cited by 1,651

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Lin, C. Y., Lovén, J., Rahl, P. B., Paranal, R. M., Burge, C. B., Bradner, J. E., Lee, T. I., & Young, R. A. (2012) · Cell · doi:10.1016/j.cell.2012.08.026 · Cited by 1,543

MAX-ing Out MYC: A Novel Small Molecule Inhibitor Against MYC-Dependent Tumors

Chio, I. I. C., Yordanov, G., & Tuveson, D. A. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju365 · Cited by 8

The MYC Oncogene as a Cancer Drug Target

Hermeking, H. (2003) · Current Cancer Drug Targets · doi:10.2174/1568009033481949 · Cited by 133

MYC, Metabolism, and Cancer

Stine, Z. E., Walton, Z. E., Altman, B. J., Hsieh, A. L., & Dang, C. V. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0507 · Cited by 1,435

The Myc oncoprotein as a therapeutic target for human cancer

Vita, M. F., & Arsenian‐Henriksson, M. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.015 · Cited by 575

MYC the oncogene from hell: Novel opportunities for cancer therapy

Papadimitropoulou, A., Makri, M., & Zoidis, G. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116194 · Cited by 40