The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury
Open accessAbstract
SUMMARY Neural stem cells (NSCs) expressing GFP were embedded into fibrin matrices containing growth factor cocktails and grafted to sites of severe spinal cord injury. Grafted cells differentiated into multiple cellular phenotypes, including neurons, which extended large numbers of axons over remarkable distances. Extending axons formed abundant synapses with host cells. Axonal growth was partially dependent on mammalian target of rapamycin (mTOR) but not Nogo signaling. Grafted neurons supported formation of electrophysiological relays across sites of complete spinal transection, resulting in functional recovery. Two human stem cell lines (566RSC and HUES7) embedded in growth factor-containing fibrin exhibited similar growth, and 566RSC cells supported functional recovery. Thus, properties intrinsic to early stage neurons can overcome the inhibitory milieu of the injured adult spinal cord to mount remarkable axonal growth resulting in formation of novel relay circuits that significantly improve function. These therapeutic properties extend across stem cell sources and species.
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Citations
Cites
Chondroitinase ABC promotes functional recovery after spinal cord injury
Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357
Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., Xu, B., Connolly, L., Kramvis, I., Sahin, M., et al. (2008) · Science · doi:10.1126/science.1161566 · Cited by 1,686
Fitch, M. T., & Silver, J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.014 · Cited by 1,007 · cited 2×
“…(He and Koprivica, 2004; Buchli and Schwab, 2005), the deposition of inhibitory extracellular matrix molecules around injury sites (Fawcett, 2006; Fitch and Silver, 2008), and the lack of positive environmental stimuli such as 1264 Cell 150, 1264–1273, September 14, 2012 ª2012 Elsevier…”
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3
Sun, F., Park, K. K., Belin, S., Wang, D., Lu, T., Chen, G., Zhang, K., Yeung, C., Feng, G., Yankner, B. A., et al. (2011) · Nature · doi:10.1038/nature10594 · Cited by 754
Davies, S. J. A., Goucher, D. R., Doller, C., & Silver, J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05810.1999 · Cited by 606
Knott, G. W., Holtmaat, A., Trachtenberg, J. T., Svoboda, K., & Welker, E. (2009) · Nature Protocols · doi:10.1038/nprot.2009.114 · Cited by 76
Cited by
Spinal cord repair: advances in biology and technology
Courtine, G., & Sofroniew, M. V. (2019) · Nature Medicine · doi:10.1038/s41591-019-0475-6 · Cited by 508
Asboth, L., Friedli, L., Beauparlant, J., Martinez-Gonzalez, C., Anil, S., Rey, E., Baud, L., Pidpruzhnykova, G., Anderson, M. A., Shkorbatova, P., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0093-5 · Cited by 324
Regulation of axonal regeneration after mammalian spinal cord injury
Zheng, B., & Tuszynski, M. H. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00562-y · Cited by 328
Self-citationInjured adult neurons regress to an embryonic transcriptional growth state
Poplawski, G. H. D., Kawaguchi, R., Van Niekerk, E., Lu, P., Mehta, N., Canete, P., Lie, R., Dragatsis, I., Meves, J. M., Zheng, B., et al. (2020) · Nature · doi:10.1038/s41586-020-2200-5 · Cited by 247
Self-citationKobashi, S., Terashima, T., Katagi, M., Nakae, Y., Okano, J., Suzuki, Y., Urushitani, M., & Kojima, H. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2019.09.004 · Cited by 186
Metadata
- Authors
- Lu, P., Wang, Y., Graham, L., McHale, K., Gao, M., Wu, D., Brock, J., Blesch, A., Rosenzweig, E. S., Havton, L. A., Zheng, B., Conner, J. M., Marsala, M., & Tuszynski, M. H.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 150
- Issue
- 6
- Pages
- 1264-1273
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1974432822
- Cited by
- 896
- References
- 6
- FWCI
- 40.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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