The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis
Open accessAbstract
Summary PGC1α is a key transcriptional coregulator of oxidative metabolism and thermogenesis. Through a high throughput chemical screen, we found that molecules antagonizing the TRPVs (Transient Receptor Potential Vanilloid), a family of ion channels, induced PGC1α expression in adipocytes. In particular, TRPV4 negatively regulated the expression of PGC1α, UCP1 and cellular respiration. Additionally, it potently controlled the expression of multiple proinflammatory genes involved in the development of insulin resistance. Mice with a null mutation for TRPV4 or wild-type mice treated with a TRPV4 antagonist showed elevated thermogenesis in adipose tissues and were protected from diet-induced obesity, adipose inflammation and insulin resistance. This role of TRPV4 as a cell-autonomous mediator for both the thermogenic and proinflammatory programs in adipocytes could offer a new target for treating obesity and related metabolic diseases.
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Cites
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Cited by
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Metadata
- Authors
- Ye, L., Kleiner, S., Wu, J., Sah, R., Gupta, R. K., Banks, A. S., Cohen, P., Khandekar, M. J., Boström, P., Mepani, R. J., Laznik, D., Kamenecka, T. M., Song, X., Liedtke, W., Mootha, V. K., Puigserver, P., Griffin, P. R., Clapham, D. E., & Spiegelman, B. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 151
- Issue
- 1
- Pages
- 96-110
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2007885739
- Cited by
- 343
- References
- 16
- FWCI
- 17.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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