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Daddy Issues: Paternal Effects on Phenotype
Open accessAbstract
The once popular and then heretical idea that ancestral environment can affect the phenotype of future generations is coming back into vogue due to advances in the field of epigenetic inheritance. How paternal environmental conditions influence the phenotype of progeny is now a tractable question, and researchers are exploring potential mechanisms underlying such effects.
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“Because of a phenomenon called imprinting, maternal and paternal genomes are differentially marked and re-programmed, and a small number of regions from the DNA of the parent of origin may remain with DNA methylation intact 173,189,191”
From Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms (2018) · cites this paper as [173]
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Metadata
- Authors
- Rando, O. J.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Rando, Oliver J.
- ORCID
- Rando, Oliver J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 151
- Issue
- 4
- Pages
- 702-708
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3564497
- OpenAlex
- W2161536630
- Cited by
- 292
- References
- 51
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 21 · 2023: 20 · 2022: 17 · 2021: 27 · 2020: 27 · 2019: 22 · 2018: 29 · 2017: 22 · 2016: 17 · 2015: 33 · 2014: 25 · 2013: 11
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01DA033664)
- National Institute of General Medical Sciences (R01GM088618)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Keywords
- paternal effects, epigenetic inheritance, transgenerational epigenetic inheritance, ancestral environment, phenotypes, epigenetic mechanisms
- MeSH terms
- Animals, Female, Gene Expression Regulation, Humans, Male, Phenotype, Plants, Epigenesis, Genetic, Gene-Environment Interaction
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