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A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells
Open accessAbstract
Factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is inefficient, complicating mechanistic studies. Here, we examined defined intermediate cell populations poised to becoming iPSCs by genome-wide analyses. We show that induced pluripotency elicits two transcriptional waves, which are driven by c-Myc/Klf4 (first wave) and Oct4/Sox2/Klf4 (second wave). Cells that become refractory to reprogramming activate the first but fail to initiate the second transcriptional wave and can be rescued by elevated expression of all four factors. The establishment of bivalent domains occurs gradually after the first wave, whereas changes in DNA methylation take place after the second wave when cells acquire stable pluripotency. This integrative analysis allowed us to identify genes that act as roadblocks during reprogramming and surface markers that further enrich for cells prone to forming iPSCs. Collectively, our data offer new mechanistic insights into the nature and sequence of molecular events inherent to cellular reprogramming.
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“Taken together, these two attributes may act as the source of memory for initial cell identity during a time when the somatic transcriptional program is otherwise mostly repressed and somatic proteins such as CD13 are lost (Polo et al., 2012; David and Polo, 2014).”
From Multi-omic rejuvenation of human cells by maturation phase transient reprogramming (2022) · cites this paper as Polo et al., 2012
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Importantly, we must note that all of the transcriptional remodeling studies utilizing OSKM occupancy data are limited to the events that occur in the beginning (fibroblasts) or end points (pluripotent stem cells), with everything in between still up for interpretation 80,83,85 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [83]
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“The distinct mechanisms observed among combinations of OCT4 and SOX2 (without KLF4) versus OSK may explain the controversy regarding whether OSK mainly function as the pioneer factors or bind readily open chromatin in early reprogramming, or both 80,82,83,85 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [83]
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“Cellular reprogramming to pluripotency by forced expression of the Yamanaka factors (Oct4, Sox2, Klf4, and c-Myc [OSKM]) occurs through the global remodeling of epigenetic marks”
From In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. (2016) · cites this paper as Polo et al., 2012
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“Interestingly, cellular reprogramming to pluripotency occurs through a stepwise global epigenetic remodeling (Benayoun et al., 2015;Liu et al., 2013b;Polo et al., 2012).”
From In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. (2016) · cites this paper as Polo et al., 2012
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“First, MYC primarily facilitates early gene induction for proliferation, whereas OCT4 and SOX2 induce chromatin opening while also binding readily open chromatin enriched with KLF4 motifs, supporting the notion that KLF4 recruits OCT4 and SOX2 to somatic chromatin that later becomes closed 83 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [83]
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“Genes associated with cell proliferation, metabolism and cytoskeleton organization were activated first, with developmental genes temporarily downregulated.”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [83]
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“It was initially reported in MEFs that transcriptional remodeling occurs in two waves, the first driven by MYC and KLF4 in the first 3 days and the second by OSK (ref.83).”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [83]
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“Changes in DNA methylation were initially thought to happen in the late stages of reprogramming 83 , but a recent study revealed that loci near Oct4, Klf4 and Nanog are demethylated earlier and de novo DNA methylation occurs in late reprogramming 85 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [83]
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“OSKM induction triggers complex cellular changes1–3.”
From In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche (2021) · cites this paper as [3]
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“It is worth noting, however, that full reprogramming is relatively inefficient, with ~3% of cells reaching full reprogramming in the first round 83 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [83]
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“whereas OCT4 and SOX2 induce chromatin opening while also binding readily open chromatin enriched with KLF4 motifs, supporting the notion that KLF4 recruits OCT4 and SOX2 to somatic chromatin that later becomes closed 83 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [83]
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Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Functions of DNA methylation: islands, start sites, gene bodies and beyond
Jones, P. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3230 · Cited by 6,061
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
Summaries of Affymetrix GeneChip probe level data
Irizarry, R. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng015 · Cited by 4,837
More powerful procedures for multiple significance testing
Hochberg, Y., & Benjamini, Y. (1990) · Statistics in Medicine · doi:10.1002/sim.4780090710 · Cited by 2,715
Maherali, N., Sridharan, R., Xie, W., Utikal, J., Eminli, S., Arnold, K., Stadtfeld, M., Yachechko, R., Tchieu, J., Jaenisch, R., et al. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.05.014 · Cited by 1,725
Self-citationDissecting direct reprogramming through integrative genomic analysis
Mikkelsen, T. S., Hanna, J. H., Zhang, X., Ku, M., Wernig, M., Schorderet, P., Bernstein, B., Jaenisch, R., Lander, E. S., & Meissner, A. (2008) · Nature · doi:10.1038/nature07056 · Cited by 1,515
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
Marson, A., Levine, S. S., Cole, M. F., Frampton, G. M., Brambrink, T., Johnstone, S. E., Guenther, M. G., Johnston, W. K., Wernig, M., Newman, J. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.020 · Cited by 1,405
An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells
Kim, J., Chu, J., Shen, X., Wang, J., & Orkin, S. H. (2008) · Cell · doi:10.1016/j.cell.2008.02.039 · Cited by 1,361
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2 of the 38 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Chang, C., Ding, Z., Hung, Y.S., and Fung, P.C. (2008). Fast network component analysis (FastNCA) for gene regulatory network reconstruction from microarray data. Bioinformatics 24, 1349–1358. · DOI
- Sridharan, R., Tchieu, J., Mason, M.J., Yachechko, R., Kuoy, E., Horvath, S., Zhou, Q., and Plath, K. (2009). Role of the murine reprogramming factors in the induction of pluripotency. Cell 136, 364–377. · DOI
- Stadtfeld, M., Maherali, N., Breault, D.T., and Hochedlinger, K. (2008). Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2, 230–240. · DOI · Paper page
- Stadtfeld, M., Maherali, N., Borkent, M., and Hochedlinger, K. (2010). A reprogrammable mouse strain from gene-targeted embryonic stem cells. Nat. Methods 7, 53–55. · DOI
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Augustyniak, E., Kulcenty, K. I., Lach, M., Piotrowski, I., & Suchorska, W. M. (2016) · Diagnostyka Laboratoryjna · doi:10.5604/01.3001.0009.3643
Herrera, E., & Morenilla‐Palao, C. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732811227.793559766
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Faculty Opinions recommendation of Influence of donor age on induced pluripotent stem cells.
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Lasry, R., Maoz, N., Cheng, A. W., Yom-Tov, N., Kulenkampff, E., Azagury, M., Yang, H., Ople, C., Markoulaki, S., Faddah, D. A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.18.492474
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de Lima, J. G. R. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2022.tde-03102022-084228
Fu, X., Zhuang, Q., Babarinde, I. A., Shi, L., Ma, G., Hu, H., Li, Y., Chen, J., Xiao, Z., Deng, B., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.01.518778
Chen, T. (2022) · Digital Repository Service (Northeastern University) · doi:10.17760/d20474742
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Tobias, I. C., Kao, M.-M. C., Parmentier, T., Hunter, H., LaMarre, J., & Betts, D. H. (2020) · Figshare · doi:10.6084/m9.figshare.13357239
Meshrkey, F., Scheulin, K. M., Littlejohn, C. M., Stabach, J., Saikia, B. B., Thorat, V., Huang, Y., LaFramboise, T., Lesnefsky, E. J., Rao, R. R., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24522583
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Sekita, Y., Sugiura, Y., Matsumoto, A., Kawasaki, Y., Akasaka, K., Konno, R., Shimizu, M., Ito, T., Sugiyama, E., Yamazaki, T., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16681513
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Bialic, M. (2016) · theses.fr (ABES) · doi:10.70675/85996e74zbfe4z46aez9c39ze6cf738079b8
Creyssels, S. (2015) · theses.fr (ABES) · doi:10.70675/21fc6e23z5e64z4f05zb62ez3e9f56c90c92
Laaref, A. M. (2017) · theses.fr (ABES) · doi:10.70675/c2cfd784z5dd2z47cez9ddcz4ee6e8af424e
Daya, H. A. (2020) · theses.fr (ABES) · doi:10.70675/940ea21dz0f9cz491ez968cz64a92ef468a5
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Benhassoun, R. (2024) · theses.fr (ABES) · doi:10.70675/0b1d39b2za3d7z4b26zb4b0zaafa77d5068a
Silva-Almeida, C. C., Diaz, M. E., Ali, W., Ho, S., Pickup, M. E., Webb, S., Rajesh, D., & Mee, J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.30.721919
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Emelyanov, A., & Bulavin, D. V. (2026) · Clinical Science · doi:10.1042/cs20260240
Kelm, R. C. (2026) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.71076
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Nakatsukasa, Y., Hirano, M., Yamada, Y., Ohta, S., Sankoda, N., Nakasuka, F., Nakayama, Y., Sakurai, S., Yamamoto, T., & Yamada, Y. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.154488
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Khatib, A., Sabag, O., Buganim, Y., & Cedar, H. (2026) · Trends Open · doi:10.1016/j.treopn.2026.08.013
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Fort, V., Khelifi, G., He, R., Watters, V., Pye, M., Yamanaka, N., Gertsenstein, M., Lelong, E. I. J., Loehr, J., Micha, V., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-78011-z
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Yücel, A. D., Molière, A., & Gladyshev, V. N. (2026) · Nature · doi:10.1038/s41586-026-10955-0 · Cited by 1
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Zhi-jing, Z., Xu, J., Wu, Y., Qu, Y., Hu, X., Sun, Y., Wu, Y., Liu, Z. H., Wang, J., & Lei, L. (2026) · Advanced Science · doi:10.1002/advs.78131
Kumar, M., & Liu, J. (2026) · Nature Chemical Biology · doi:10.1038/s41589-026-02337-4
Epigenomic heterogeneity and spatial organization during human reprogrammingPreprint
Li, T. W., Langerman, J., Liu, C., Sun, Y., Baig, M. S., Kim, G., Fu, J., Ghoor, R. I., Zhang, Y., Behren, Z. V., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.15.757424
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Yang, C. (2014) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/m22p5j
Metadata
- Authors
- Polo, J. M., Anderssen, E., Walsh, R. M., Schwarz, B. A., Nefzger, C. M., Lim, S. M., Borkent, M., Apostolou, E., Alaei, S., Cloutier, J., Bar-Nur, O., Cheloufi, S., Stadtfeld, M., Figueroa, M. E., Robinton, D., Natesan, S., Melnick, A., Zhu, J., Ramaswamy, S., & Hochedlinger, K.
- Affiliations
- Harvard University (US)
- Broad Institute (US)
- Monash University (AU)
- Weill Cornell Medicine (US)
- National Institutes of Health (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Ramaswamy, Sridhar
- Hochedlinger, Konrad
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 151
- Issue
- 7
- Pages
- 1617-1632
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3608203
- OpenAlex
- W2060613703
- Cited by
- 861
- References
- 38
- Citations by year
- 2026: 30 · 2025: 20 · 2024: 37 · 2023: 51 · 2022: 48 · 2021: 47 · 2020: 61 · 2019: 69 · 2018: 63 · 2017: 79 · 2016: 90 · 2015: 83 · 2014: 105 · 2013: 76 · 2012: 1
- FWCI
- 34.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 385 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (1dp2od003266-01)
- National Cancer Institute (T32CA009216)
- National Institute of General Medical Sciences (P01GM099117)
- National Institute of Allergy and Infectious Diseases (ZIAAI001169)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD058013)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- induced pluripotent stem cells, cellular reprogramming, c-Myc, KLF4, Oct4, SOX2, bivalent domains, DNA methylation, cell surface markers, pluripotency
- MeSH terms
- Kruppel-Like Factor 4, Animals, Cytological Techniques, Humans, Transcription Factors, Mice, Genome-Wide Association Study, Induced Pluripotent Stem Cells, Cellular Reprogramming
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