Erk1/2 Activity Promotes Chromatin Features and RNAPII Phosphorylation at Developmental Promoters in Mouse ESCs
Open accessAbstract
Erk1/2 activation contributes to mouse ES cell pluripotency. We found a direct role of Erk1/2 in modulating chromatin features required for regulated developmental gene expression. Erk2 binds to specific DNA sequence motifs typically accessed by Jarid2 and PRC2. Negating Erk1/2 activation leads to increased nucleosome occupancy and decreased occupancy of PRC2 and poised RNAPII at Erk2-PRC2-targeted developmental genes. Surprisingly, Erk2-PRC2-targeted genes are specifically devoid of TFIIH, known to phosphorylate RNA polymerase II (RNAPII) at serine-5, giving rise to its initiated form. Erk2 interacts with and phosphorylates RNAPII at its serine 5 residue, which is consistent with the presence of poised RNAPII as a function of Erk1/2 activation. These findings underscore a key role for Erk1/2 activation in promoting the primed status of developmental genes in mouse ES cells and suggest that the transcription complex at developmental genes is different than the complexes formed at other genes, offering alternative pathways of regulation.
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In ES cells, reduced PRC2 activity accompanies lower MEK-ERK activation, while blocking MEK-ERK weakens PRC2 binding to its target genes.
“While the loss of PRC2 activity is associated with reduced MEK-ERK activation in ES cells47, the inhibition of MEK-ERK activity leads to attenuated PRC2 chromatin association on PRC2 target genes in these cells47.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [47]
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- Authors
- Tee, W.-W., Shen, S. S., Oksuz, O., Narendra, V., & Reinberg, D.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Reinberg, Danny
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 156
- Issue
- 4
- Pages
- 678-690
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4006806
- OpenAlex
- W2058890095
- Cited by
- 165
- References
- 85
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 10 · 2023: 15 · 2022: 11 · 2021: 13 · 2020: 12 · 2019: 13 · 2018: 8 · 2017: 20 · 2016: 21 · 2015: 21 · 2014: 8
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- New York Stem Cell Foundation
- National Institutes of Health
- National Cancer Institute (P30CA016087)
- National Institute of General Medical Sciences (T32GM007308, R01GM037120, R01GM064844)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- ERK signaling, mouse embryonic stem cells, pluripotency, chromatin, polycomb repressive complex 2, JARID2, nucleosome occupancy, TFIIH, developmental gene expression, transcriptional regulation
- MeSH terms
- Animals, Chromatin, Enzyme Activation, Nucleosomes, Phosphorylation, Promoter Regions, Genetic, RNA Polymerase II, Gene Expression Regulation, Developmental, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Mice, Transcription Factor TFIIH, Embryonic Stem Cells, Polycomb Repressive Complex 2
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