Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer

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Additive reductions in zebrafish PRPS1 activity result in a spectrum of deficiencies modeling several human PRPS1-associated diseases

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Transcription Factor AP4 Mediates Cell Fate Decisions: To Divide, Age, or Die

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Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC–Driven Cancer Progression

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Myricetin is a novel inhibitor of human inosine 5′-monophosphate dehydrogenase with anti-leukemia activity

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PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression

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Filamentation modulates allosteric regulation of PRPS

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CDK12 controls transcription at damaged genes and prevents MYC-induced transcription-replication conflicts

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Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer

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Fine-tuned amplification in cells

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PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells

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Profiling of subcellular EGFR interactome reveals hnRNP A3 modulates nuclear EGFR localization

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Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation

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Spz/Toll-6 signal guides organotropic metastasis in Drosophila

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Non-Hodgkin Lymphoma Metabolism

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Systematically profiling the expression of eIF3 subunits in glioma reveals the expression of eIF3i has prognostic value in IDH-mutant lower grade glioma

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Is there a CDKN2A-centric network in pancreatic ductal adenocarcinoma?

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Antihyperuricemic Effect of Urolithin A in Cultured Hepatocytes and Model Mice

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ATIC facilitates cell growth and migration by upregulating Myc expression in lung adenocarcinoma

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c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis

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FOXK2 affects cancer cell response to chemotherapy by promoting nucleotide de novo synthesis

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MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer

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Phosphoribosyl pyrophosphate synthetases 2 knockdown inhibits prostate cancer progression by suppressing cell cycle and inducing cell apoptosis

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The “Superoncogene” Myc at the Crossroad between Metabolism and Gene Expression in Glioblastoma Multiforme

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On-demand utilization of phosphoribosyl pyrophosphate by downstream anabolic pathways

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Cell Fate Control by Translation: mRNA Translation Initiation as a Therapeutic Target for Cancer Development and Stem Cell Fate Control

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RNA expression differences in prostate tumors and tumor-adjacent stroma between Black and White Americans

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PRPS2 Enhances Resistance to Cisplatin via Facilitating Exosomes-mediated Macrophage M2 Polarization in Non-small Cell Lung Cancer

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Chromosomal instability causes sensitivity to protein folding stress and ATP depletion

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Integration of rare earth element stimulation, activated carbon adsorption and cell immobilization in ABE fermentation for promoting biobutanol production

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(TORC)ing up purine biosynthesis

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The role of gene duplication and paralog specialisation in the evolution of the mammalian PRPS complex

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NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma

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Low protein diet protects the liver from Salmonella Typhimurium-mediated injury by modulating the mTOR/autophagy axis in macrophages

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Metabolic control of cancer progression as novel targets for therapy

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Phosphoribosyl Pyrophosphate Amido Transferase: A New Prognostic Biomarker for Hepatocellular Carcinoma

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Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia

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Adapting Drosophila melanogaster Cell Lines to Serum-Free Culture Conditions

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PRPS-Associated Disorders and the Drosophila Model of Arts Syndrome

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The Myc trilogy: lord of RNA polymerases

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