The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Hippo Pathway Activity Influences Liver Cell Fate
Open accessAbstract
The Hippo-signaling pathway is an important regulator of cellular proliferation and organ size. However, little is known about the role of this cascade in the control of cell fate. Employing a combination of lineage tracing, clonal analysis, and organoid culture approaches, we demonstrate that Hippo pathway activity is essential for the maintenance of the differentiated hepatocyte state. Remarkably, acute inactivation of Hippo pathway signaling in vivo is sufficient to dedifferentiate, at very high efficiencies, adult hepatocytes into cells bearing progenitor characteristics. These hepatocyte-derived progenitor cells demonstrate self-renewal and engraftment capacity at the single-cell level. We also identify the NOTCH-signaling pathway as a functional important effector downstream of the Hippo transducer YAP. Our findings uncover a potent role for Hippo/YAP signaling in controlling liver cell fate and reveal an unprecedented level of phenotypic plasticity in mature hepatocytes, which has implications for the understanding and manipulation of liver regeneration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Following diverse injuries, often involving cholestasis, YAP signalling also drives hepatocyte reprogramming via SOX9 induction.”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [59]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These reprogrammed zone 1 hepatocytes exhibited reduced metabolic function, upregulated tissue stem cell markers and increased proliferative capacity, contributing to regeneration.59,60,100,101”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [59]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Acute YAP overexpression results in hepatocyte reprogramming into BEC10.”
From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [10]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“YAP, the main transducer of the Hippo pathway, has been reported to be necessary and sufficient for hepatocyte reprogramming into ductal cells10,11.”
From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [10]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Furthermore, increased chromatin accessibility near YAP target genes suggested a pivotal role for YAP/TEAD signaling in the reprogramming process (Figure S1C), supporting previous data10.”
From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [10]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Under physiological conditions, activation of YAP is necessary and sufficient to not only reprogram hepatocytes but to precisely control developmental outcomes, organ size and tissue repair10,16,40,41.”
From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [10]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Lineage-tracing studies in animal models have confirmed that hepatocytes contribute to bile duct remodeling following cholangiocyte injury10,43–48”
From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [10]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In periportal injury, LPLCs are mainly generated in the region 1-5 layers away from injured bile ducts.[7][8][9]12,13”
From Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers (2023) · cites this paper as [12]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“However, YAP promotes SRY-box transcription factor 9 (SOX9) expression in hepatocytes59 and may confer the hybrid hepatocyte-biliary identity of periportal SOX9+ hepatocytes.60”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [59]
The cited source says what the claim attributes to it.
In the citing paper
“Hepatocytes display remarkable plasticity and under some conditions can transdifferentiate into BECs, epithelial cells of the bile ducts with completely different morphology, gene expression and function59,[97], [98], [99]”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [59]
The cited source says what the claim attributes to it.
In the citing paper
“Even at this later stage, reprogrammed hepatocytes maintained distinct chromatin accessibility compared to BECs (Figure 1H), despite resembling them morphologically and transcriptionally10 (Figure S1E).”
From HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury (2025) · cites this paper as [10]
The cited source says what the claim attributes to it.
In the citing paper
“only very recent studies using a mosaic YAP1 induction model have shown that nuclear YAP1 is able to induce hepatocyte dedifferentiation into clonogenic progenitors in vivo (Yimlamai et al., 2014).”
From Hippo Signaling Influences HNF4A and FOXA2 Enhancer Switching during Hepatocyte Differentiation (2014) · cites this paper as Yimlamai et al., 2014
In the citing paper
“Further experiments in mice have shown that hepatocytes can change into a biliary ductular phenotype21, 22 then later re-differentiate into hepatocytes23.”
From Hepatic progenitor cells of biliary origin with liver repopulation capacity (2015) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Model-Based Clustering, Discriminant Analysis, and Density Estimation
Fraley, C., & Raftery, A. E. (2002) · Journal of the American Statistical Association · doi:10.1198/016214502760047131 · Cited by 4,274
Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092
TEAD mediates YAP-dependent gene induction and growth control
Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498
Elucidation of a universal size-control mechanism in Drosophila and mammals
Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
Huch, M., Dorrell, C., Boj, S. F., van Es, J. H., Li, V. S. W., van de Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., et al. (2013) · Nature · doi:10.1038/nature11826 · Cited by 1,555
YAP1 increases organ size and expands undifferentiated progenitor cells
Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252
Self-citationZhou, D., Conrad, C. H., Xia, F., Park, J.-S., Payer, B., Yin, Y., Lauwers, G. Y., Thasler, W. E., Lee, J. T., Avruch, J., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.09.026 · Cited by 937
Furuyama, K., Kawaguchi, Y., Akiyama, H., Horiguchi, M., Kodama, S., Kuhara, T., Hosokawa, S., Elbahrawy, A., Soeda, T., Koizumi, M., et al. (2010) · Nature Genetics · doi:10.1038/ng.722 · Cited by 841
Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.015 · Cited by 804
Hamaratoǧlu, F., Willecke, M., Kango‐Singh, M., Nolo, R. M., Hyun, E., Tao, C., Jafar‐Nejad, H., & Halder, G. A. (2005) · Nature Cell Biology · doi:10.1038/ncb1339 · Cited by 765
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 846
YAP/TAZ Initiates Gastric Tumorigenesis via Upregulation of MYC
Choi, W., Kim, J., Park, J., Lee, D.-H., Hwang, D., Kim, J., Ashktorab, H., Smoot, D. T., Kim, S., Choi, C., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3487 · Cited by 144
Bipotent transitional liver progenitor cells contribute to liver regeneration
Pu, W., Zhu, H., Zhang, M., Pikiolek, M., Ercan, C., Li, J., Huang, X., Han, X., Zhang, Z., Lv, Z., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01335-9 · Cited by 138
The regulation and function of YAP transcription co-activator
Zhu, C., Li, L., & Zhao, B. (2014) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmu110 · Cited by 143
Machado, M. V., Michelotti, G. A., Pereira, T. A., Xie, G., Premont, R., Cortez-Pinto, H., & Diehl, A. M. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.05.031 · Cited by 135
Patient-derived organoid models help define personalized management of gastrointestinal cancer
Aberle, M. R., Burkhart, R. A., Tiriac, H., Damink, S. W. M. O., Dejong, C. H. C., Tuveson, D. A., & van Dam, R. M. (2018) · British journal of surgery · doi:10.1002/bjs.10726 · Cited by 141
Li, L., Cui, L., Lin, P., Liu, Z., Bao, S., Ma, X., Nan, H., Zhu, W., Cen, J., Mao, Y., et al. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.01.009 · Cited by 134
Singh, A., Ramesh, S., Cibi, D. M., Yun, L. S., Li, J., Li, L., Manderfield, L. J., Olson, E. N., Epstein, J. A., & Singh, M. K. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.027 · Cited by 131
Yap-Sox9 signaling determines hepatocyte plasticity and lineage-specific hepatocarcinogenesis
Liu, Y., Zhuo, S., Zhou, Y., Ma, L., Sun, Z., Wu, X., Wang, X. W., Gao, B., & Yang, Y. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.11.010 · Cited by 133
NUAK2 is a critical YAP target in liver cancer
Yuan, W.-C., Pepe-Mooney, B. J., Galli, G. G., Dill, M. T., Huang, H., Hao, M., Wang, Y., Liang, H., Calogero, R., & Camargo, F. D. (2018) · Nature Communications · doi:10.1038/s41467-018-07394-5 · Cited by 129
Self-citationLoforese, G., Malinka, T., Keogh, A., Baier, F. A., Simillion, C., Montani, M., Halazonetis, T. D., Candinas, D., & Stroka, D. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201506089 · Cited by 126
Lv, X., He, C., Huang, C., Wang, H., Hua, G., Wang, Z., Zhou, J. R., Chen, X., Ma, B., Timm, B. K., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900179rr · Cited by 126
Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts
Poncy, A., Antoniou, A., Cordi, S., Pierreux, C. E., Jacquemin, P., & Lemaigre, F. P. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.05.012 · Cited by 125
Li, W., Yang, L., He, Q., Hu, C., Zhu, L., Ma, X., Ma, X., Bao, S., Li, L., Chen, Y., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.06.008 · Cited by 124
YAP drives fate conversion and chemoresistance of small cell lung cancer
Wu, Q., Guo, J., Liu, Y., Zheng, Q., Li, X., Wu, C., Dong, F., Chen, X., Ma, L., Xu, P., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg1850 · Cited by 127
TEAD family transcription factors in development and disease
Currey, L., Thor, S., & Piper, M. (2021) · Development · doi:10.1242/dev.196675 · Cited by 120
Meng, Y., Zhao, Q., An, L., Jiao, S., Li, R., Sang, Y., Liao, J., Nie, P., Wen, F., Ju, J., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-3175 · Cited by 119
White, S. M., Avantaggiati, M. L., Nemazanyy, I., Poto, C. D., Yang, Y., Pende, M., Gibney, G. T., Ressom, H. W., Field, J., Atkins, M. B., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.04.014 · Cited by 121
The Roles of Notch Signaling in Liver Development and Disease
Adams, J., & Jafar‐Nejad, H. (2019) · Biomolecules · doi:10.3390/biom9100608 · Cited by 118
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
Cox, A. G., Tsomides, A., Yimlamai, D., Hwang, K. L., Miesfeld, J. B., Galli, G. G., Fowl, B. H., Fort, M. W., Kimberly, Y., Sullivan, M. R., et al. (2018) · The EMBO Journal · doi:10.15252/embj.2018100294 · Cited by 116
Self-citationNew Insights into Hippo/YAP Signaling in Fibrotic Diseases
Mia, M. M., & Singh, M. K. (2022) · Cells · doi:10.3390/cells11132065 · Cited by 120
Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers
Naugler, W. E., Tarlow, B., Fedorov, L. M., Taylor, M. J., Pelz, C., Li, B., Darnell, J. C., & Grompe, M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.043 · Cited by 120
MRTF potentiates TEAD‐YAP transcriptional activity causing metastasis
Kim, T., Hwang, D., Lee, D., Kim, J., Kim, S., & Lim, D. (2017) · The EMBO Journal · doi:10.15252/embj.201695137 · Cited by 114
Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases
Fabris, L., Fiorotto, R., Spirlì, C., Cadamuro, M., Mariotti, V., Perugorria, M. J., Bañales, J. M., & Strazzabosco, M. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0156-4 · Cited by 116
Drug resistance in cancer therapy: the Pandora's Box of cancer stem cells
Rezayatmand, H., Razmkhah, M., & Razeghian‐Jahromi, I. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02856-6 · Cited by 118
Hippo Signaling Influences HNF4A and FOXA2 Enhancer Switching during Hepatocyte Differentiation
Alder, O., Cullum, R., Lee, S., Kan, A. C., Wei, W., Yi, Y., Garside, V. C., Bilenky, M., Griffith, M., Morrissy, A. S., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.046 · Cited by 113
“Although the Hippo signaling cascade has previously been implicated in regulation of liver size and cancer development, only very recent studies using a mosaic YAP1 induction model have shown that nuclear YAP1 is able to induce hepatocyte dedifferentiation into clonogenic progenitors in vivo (Yimlamai et al., 2014).”
BackgroundLiver progenitor cell-driven liver regeneration
So, J., Kim, A. S., Lee, S., & Shin, D. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0483-0 · Cited by 117
Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration
Han, X., Wang, Y., Pu, W., Huang, X., Qiu, L., Li, Y., Yu, W., Zhao, H., Liu, X., He, L., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.01.010 · Cited by 113
Maladaptive regeneration - the reawakening of developmental pathways in NASH and fibrosis
Zhu, C., Tabas, I., Schwabe, R. F., & Pajvani, U. B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00365-6 · Cited by 112
Messina, B., Sardo, F. L., Scalera, S., Memeo, L., Colarossi, C., Mare, M., Blandino, G., Ciliberto, G., Maugeri‐Saccà, M., & Bon, G. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05568-8 · Cited by 113
Kras and Tp53 Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma
Hill, M. A., Alexander, W. B., Guo, B., Kato, Y., Patra, K. C., O’Dell, M. R., McCall, M. N., Whitney‐Miller, C. L., Bardeesy, N. M., & Hezel, A. F. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-1123 · Cited by 112
HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis
Hernandez, C., Huebener, P., Pradere, J.-P., Antoine, D. J., Friedman, R. A., & Schwabe, R. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci91786 · Cited by 110
Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus
Park, R., Moon, U. Y., Park, J. Y., Hughes, L. J., Johnson, R. L., Cho, S., & Kim, S. (2016) · Nature Communications · doi:10.1038/ncomms10329 · Cited by 110
Liver stem cells: experimental findings and implications for human liver disease
Michalopoulos, G. K., & Khan, Z. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.004 · Cited by 109
Functional and Structural Features of Cholangiocytes in Health and Disease
Maroni, L., Haibo, B., Ray, D., Zhou, T., Wan, Y., Meng, F., Marzioni, M., & Alpini, G. D. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.05.005 · Cited by 116
Yap and Taz regulate retinal pigment epithelial cell fate
Miesfeld, J. B., Gestri, G., Clark, B. S., Flinn, M. A., Poole, R. J., Bader, J. R., Besharse, J. C., Wilson, S. W., & Link, B. A. (2015) · Development · doi:10.1242/dev.119008 · Cited by 143
Cellular Pliancy and the Multistep Process of Tumorigenesis
Puisieux, A., Pommier, R. M., Morel, A., & Lavial, F. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.01.007 · Cited by 114
SOX9: An emerging driving factor from cancer progression to drug resistance
Panda, M., Tripathi, S. K., & Biswal, B. K. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188517 · Cited by 109
The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis
Shen, H., Huang, X., Zhao, Y., Wu, D., Xue, K., Yao, J., Wang, Y., Tang, N., & Qiu, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-33800-0 · Cited by 118
The mammalian Hippo pathway: regulation and function of YAP1 and TAZ
Kodaka, M., & Hata, Y. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1742-9 · Cited by 115
Wnt signaling regulates hepatobiliary repair following cholestatic liver injury in mice
Okabe, H., Yang, J., Sylakowski, K., Yovchev, M. I., Miyagawa, Y., Nagarajan, S., Chikina, M. D., Thompson, M. D., Oertel, M., Baba, H., et al. (2016) · Hepatology · doi:10.1002/hep.28774 · Cited by 108
The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation
Aylon, Y., Gershoni, A., Rotkopf, R., Biton, I. E., Porat, Z., Koh, A. P., Sun, X., Lee, Y., Fiel, M.-I., Hoshida, Y., et al. (2016) · European Journal of Cancer · doi:10.1016/s0959-8049(16)61580-0 · Cited by 105
Yi, J., Lu, L., Yanger, K., Wang, W., Sohn, B. H., Stanger, B. Z., Zhang, M., Martin, J. F., Ajani, J. A., Chen, J., et al. (2016) · Hepatology · doi:10.1002/hep.28768 · Cited by 105
Self-citationZhao, S., Jiang, J., Jing, Y., Liu, W., Yang, X. F., Hou, X., Gao, L., & Wei, L. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2264-z · Cited by 105
CK19-positive Hepatocellular Carcinoma is a Characteristic Subtype
Zhuo, J., Lu, D., Tan, W., Zheng, S., Shen, Y., & Xu, X. (2020) · Journal of Cancer · doi:10.7150/jca.44697 · Cited by 105
Small-molecule-mediated reprogramming: a silver lining for regenerative medicine
Kim, Y., Jeong, J., & Choi, D. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0383-3 · Cited by 113
Liver Injury and Regeneration: Current Understanding, New Approaches, and Future Perspectives
Hora, S., & Wüestefeld, T. (2023) · Cells · doi:10.3390/cells12172129 · Cited by 109
Jiang, Y., Feng, D., Ma, X., Fan, S., Gao, Y., Fu, K., Wang, Y., Sun, J., Yao, X., Liu, C., et al. (2019) · Hepatology · doi:10.1002/hep.30131 · Cited by 103
NOTCH-YAP1/TEAD-DNMT1 Axis Drives Hepatocyte Reprogramming Into Intrahepatic Cholangiocarcinoma
Hu, S., Molina, L. M., Tao, J., Liu, S., Hassan, M., Singh, S., Poddar, M., Bell, A. W., Sia, D., Oertel, M., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2022.05.007 · Cited by 105
Inflammatory and fibrotic mechanisms in NAFLD—Implications for new treatment strategies
Lee, Y. A., & Friedman, S. L. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13380 · Cited by 104
Role of the Hippo pathway and mechanisms for controlling cellular localization of YAP/TAZ
Kwon, H., Kim, J.-Y., & Jho, E. (2021) · FEBS Journal · doi:10.1111/febs.16091 · Cited by 105
Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest
Manderfield, L. J., Aghajanian, H. K., Engleka, K. A., Lim, L. Y., Lui, F., Jain, R., Li, L., Olson, E. N., & Epstein, J. A. (2015) · Development · doi:10.1242/dev.125807 · Cited by 100
Zhang, X., Cai, D., Zhou, F., Yu, J., Wu, X., Yu, D., Zou, Y., Hong, Y., Yuan, C., Chen, Y., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119724 · Cited by 101
Loss of liver function in chronic liver disease: An identity crisis
Berasain, C., Arechederra, M., Argemí, J., Fernández-Barrena, M. G., & Avila, M. A. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2022.09.001 · Cited by 99
Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapies
Kim, M. H., & Kim, J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2412-x · Cited by 102
Morvaridi, S., Dhall, D., Greene, M. I., Pandol, S. J., & Wang, Q. (2015) · Scientific Reports · doi:10.1038/srep16759 · Cited by 98
Bell, D. E., Ranganathan, S., Tao, J., & Monga, S. P. (2016) · Gene Expression · doi:10.3727/105221616x693639 · Cited by 97
Regulation of cancer stem cells in triple negative breast cancer
Fultang, N., Chakraborty, M., & Peethambaran, B. (2021) · Cancer Drug Resistance · doi:10.20517/cdr.2020.106 · Cited by 101
Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie
Sun, X., Ding, Y., Zhan, M., Li, Y., Gao, D., Wang, G., Gao, Y., Li, Y., Wu, S., Lu, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08334-7 · Cited by 94
Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation
Grampa, V., Delous, M., Zaidan, M., Odye, G., Thomas, S., Elkhartoufi, N., Filhol-Blin, E., Niel, O., Silbermann, F., Lebreton, C., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005894 · Cited by 94
YAP and TAZ Take Center Stage in Cancer
Zhang, K., Qi, H.-X., Hu, Z., Chang, Y., Shi, Z., Han, X., Han, Y., Zhang, R., Zhang, Z., Chen, T., et al. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b01014 · Cited by 94
Transforming Growth Factor-β Promotes Liver Tumorigenesis in Mice via Up-regulation of Snail
Moon, H., Ju, H.-L., Chung, S. I., Cho, K. J., Eun, J. W., Nam, S. W., Han, K., Calvisi, D. F., & Ro, S. W. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.07.014 · Cited by 93
The two sides of Hippo pathway in cancer
Li, F., & Guan, K. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.07.006 · Cited by 94
Mehra, R., Vats, P., Cieslik, M. P., Cao, X., Su, F., Shukla, S. K., Udager, A. M., Wang, R., Pan, J., Kasaian, K., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0267 · Cited by 91
Lin, B., Coleman, J. H., Peterson, J. N., Zunitch, M. J., Jang, W., Herrick, D. B., & Schwob, J. E. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.09.008 · Cited by 90
Kietzmann, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092347 · Cited by 90
Wu, B.-K., Mei, S.-C., Chen, E. H., Zheng, Y., & Pan, D. (2022) · Nature Genetics · doi:10.1038/s41588-022-01119-7 · Cited by 91
de Lima, J. E., Bonnin, M.-A., Birchmeier, C., & Duprez, D. (2016) · eLife · doi:10.7554/elife.15593 · Cited by 89
McCarron, S., Bathon, B., Conlon, D. M., Abbey, D., Rader, D. J., Gawronski, K., Brown, C. D., Olthoff, K. M., Shaked, A., & Raabe, T. D. (2021) · Hepatology · doi:10.1002/hep.31857 · Cited by 89
Mokhtari, R. B., Ashayeri, N., Baghaie, L., Sambi, M., Satari, K., Baluch, N., Bosykh, D. A., Szewczuk, M. R., & Chakraborty, S. (2023) · Cancers · doi:10.3390/cancers15133468 · Cited by 92
Verboven, E., Moya, I. M., Sansores-Garcia, L., Xie, J., Hillen, H., Kowalczyk, W., Vella, G., Verhulst, S., Castaldo, S. A., Algueró-Nadal, A., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.10.035 · Cited by 87
Regulation of Cellular Identity in Cancer
Roy, N., & Hebrok, M. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.12.001 · Cited by 97
The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae
Rausch, V., Bostrom, J. R., Park, J., Bravo, I. R., Feng, Y., Hay, D. C., Link, B. A., & Hansen, C. G. (2018) · Current Biology · doi:10.1016/j.cub.2018.11.066 · Cited by 90
dNTP metabolism links mechanical cues and YAP/TAZ to cell growth and oncogene‐induced senescence
Santinon, G., Brian, I., Pocaterra, A., Romani, P., Franzolin, E., Rampazzo, C., Bicciato, S., & Dupont, S. (2018) · The EMBO Journal · doi:10.15252/embj.201797780 · Cited by 93
Cozzolino, A. M., Noce, V., Battistelli, C., Marchetti, A., Grassi, G., Cicchini, C., Tripodi, M., & Amicone, L. (2016) · Stem Cells International · doi:10.1155/2016/5481493 · Cited by 86
The Hippo signaling pathway provides novel anti-cancer drug targets
Bae, J. S., Kim, S. M., & Lee, H. (2016) · Oncotarget · doi:10.18632/oncotarget.14306 · Cited by 88
Genetic lineage tracing analysis of the cell of origin of hepatotoxin‐induced liver tumors in mice
Shin, S., Wangensteen, K. J., Teta‐Bissett, M., Wang, Y. J., Mosleh‐Shirazi, E., Buza, E. L., Greenbaum, L. E., & Kaestner, K. H. (2016) · Hepatology · doi:10.1002/hep.28602 · Cited by 86
Transcriptional integration of mitogenic and mechanical signals by Myc and YAPPreprint
Croci, O., Fazio, S., Biagioni, F., Donato, E., Cagánová, M., Curti, L., Doni, M., Sberna, S., Aldeghi, D., Biancotto, C., et al. (2017) · Genes & Development · doi:10.1101/gad.301184.117 · Cited by 90
Generation of human adult hepatocyte organoids with metabolic functions
Igarashi, R., Oda, M., Okada, R., Yano, T., Takahashi, S., Pastuhov, S., Matano, M., Masuda, N., Togasaki, K., Ohta, Y., et al. (2025) · Nature · doi:10.1038/s41586-025-08861-y · Cited by 85
Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration
Bangru, S., Arif, W., Seimetz, J., Bhate, A., Chen, J., Rashan, E. H., Carstens, R. P., Anakk, S., & Kalsotra, A. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0129-2 · Cited by 85
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation
Sun, T., Annunziato, S., Bergling, S., Sheng, C., Orsini, V., Forcella, P., Pikiolek, M., Kancherla, V., Holwerda, S., Imanci, D., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.05.013 · Cited by 84
F-actin dynamics regulates mammalian organ growth and cell fate maintenance
Pocaterra, A., Santinon, G., Romani, P., Brian, I., Dimitracopoulos, A., Ghisleni, A., Carnicer-Lombarte, A., Forcato, M., Braghetta, P., Montagner, M., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.02.022 · Cited by 84
Murakami, S., Nemazanyy, I., White, S. M., Chen, H., Nguyen, C. D. K., Graham, G. T., Saur, D., Pende, M., & Yi, C. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.07.022 · Cited by 83
Bou Saleh, M., Louvet, A., Ntandja-Wandji, L. C., Boleslawski, E., Gnemmi, V., Lassailly, G., Truant, S., Maggiotto, F., Ningarhari, M., Artru, F., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.05.041 · Cited by 83
Wang, T., Qin, Z., Wen, L., Guo, Y., Liu, Q., Lei, Z., Pan, W. X., Liu, K., Wang, X., Lai, S., et al. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0095-6 · Cited by 82
CellOracle: Dissecting cell identity via network inference and in silico gene perturbation
Kamimoto, K., Hoffmann, C. M., & Morris, S. A. (2020) · doi:10.1101/2020.02.17.947416 · Cited by 81
Switching roles: the functional plasticity of adult tissue stem cells
Wabik, A., & Jones, P. H. (2015) · The EMBO Journal · doi:10.15252/embj.201490386 · Cited by 84
Zhang, X., Liu, X., Luo, J., Xiao, W. L., Ye, X., Chen, M., Li, Y., & Zhang, G.-J. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.67 · Cited by 84
Leung, C. O. N., Mak, W.-N., Kai, A. K., Chan, K. K., Lee, T. K., Ng, I. O., & Lo, R. C. (2016) · Oncotarget · doi:10.18632/oncotarget.8835 · Cited by 82
Cell of origin in biliary tract cancers and clinical implications
Moeini, A., Haber, P. K., & Sia, D. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100226 · Cited by 85
Kong, F.-E., Li, G., Tang, Y.-Q., Xi, S., Loong, J. H. C., Li, M., Li, H., Cheng, W., Zhu, W., Mo, J.-Q., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb6282 · Cited by 80
Watanabe, Y., Miyasaka, K. Y., Kubo, A., Kida, Y. S., Nakagawa, O., Hirate, Y., Sasaki, H., & Ogura, T. (2017) · Scientific Reports · doi:10.1038/srep46135 · Cited by 80
Chen, T., Oh, S., Gregory, S., Shen, X., & Diehl, A. M. (2020) · JCI Insight · doi:10.1172/jci.insight.141024 · Cited by 79
Xu, J., Li, P.-X., Wu, J., Gao, Y., Yin, M.-X., Lin, Y., Yang, M., Chen, D., Sun, H., Liu, Z.-B., et al. (2015) · Clinical Science · doi:10.1042/cs20150385 · Cited by 79
Hippo Signaling in the Liver – A Long and Ever-Expanding Story
Manmadhan, S., & Ehmer, U. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00033 · Cited by 80
Cooperation Between MYC and β‐Catenin in Liver Tumorigenesis Requires Yap/Taz
Bisso, A., Filipuzzi, M., Figueroa, G. P. G., Brumana, G., Biagioni, F., Doni, M., Ceccotti, G., Tanasković, N., Morelli, M. J., Pendino, V., et al. (2020) · Hepatology · doi:10.1002/hep.31120 · Cited by 77
A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs
Shue, Y. T., Drainas, A. P., Li, N. Y., Pearsall, S. M., Morgan, D., Sinnott-Armstrong, N., Hipkins, S. Q., Coles, G. L., Lim, J. S., Oro, A. E., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30416-2 · Cited by 77
Lu, J., Yang, X., He, C., Chen, Y., Li, C., Li, C., Chen, Y., Wu, Y., Xiang, Z., Kang, J., et al. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.02.018 · Cited by 77
Jiang, Z., Chen, X., Chen, K., Sun, L., Gao, L., Zhou, C., Meng, L., Duan, W., Wang, Z., Ma, Q., et al. (2016) · Nutrients · doi:10.3390/nu8100546 · Cited by 77
The history and regulatory mechanism of the Hippo pathway
Kim, W., & Jho, E. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.3.022 · Cited by 81
Hyun, J., Sun, Z., Ahmadi, A. R., Bangru, S., Chembazhi, U. V., Du, K., Chen, T., Tsukamoto, H., Rusyn, I., Kalsotra, A., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci132691 · Cited by 76
Metadata
- Authors
- Yimlamai, D., Christodoulou, C., Galli, G. G., Yanger, K., Pepe-Mooney, B., Gurung, B., Shrestha, K., Cahan, P., Stanger, B. Z., & Camargo, F. D.
- Affiliations
- Boston Children's Hospital (US)
- University of Pennsylvania (US)
- Corresponding author
- Camargo, Fernando D.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 157
- Issue
- 6
- Pages
- 1324-1338
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4136468
- OpenAlex
- W2028593002
- Cited by
- 857
- References
- 48
- Citations by year
- 2026: 34 · 2025: 52 · 2024: 62 · 2023: 64 · 2022: 94 · 2021: 82 · 2020: 91 · 2019: 80 · 2018: 79 · 2017: 58 · 2016: 82 · 2015: 57 · 2014: 20
- FWCI
- 36.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AR064036, DK083355, DK099559)
- American-Italian Cancer Foundation
- National Institute of Diabetes and Digestive and Kidney Diseases (5T32 DK007477-27)
- National Science Foundation (DGE1144152)
- U.S. Department of Defense (W81XWH-9)
- Harvard Stem Cell Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- Hippo signaling pathway, YAP, hepatocyte dedifferentiation, hepatic progenitor cells, Notch signaling, phenotypic plasticity, liver regeneration, hepatocyte differentiation
- MeSH terms
- Hippo Signaling Pathway, YAP-Signaling Proteins, Animals, Liver, Phosphoproteins, Stem Cells, Signal Transduction, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Hepatocytes, Adaptor Proteins, Signal Transducing, Mice, Receptors, Notch, Cell Dedifferentiation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
