Liver stem cells: experimental findings and implications for human liver disease
Open accessAbstract
Evidence from human histopathology and experimental studies with rodents and zebrafish has shown that hepatocytes and cholangiocytes may function as facultative stem cells for each other in conditions of impaired regeneration. The interpretation of the findings derived from these studies has generated considerable discussion and some controversies. This review examines the evidence obtained from the different experimental models and considers implications that these studies may have for human liver disease.
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In chronic liver diseases, HHs with expression of progenitor-associated markers were documented in regenerative nodules.
“Notably, in chronic liver diseases, HHs with expression of progenitor-associated markers were also documented in regenerative nodules (Michalopoulos and Khan, 2015; Yoon et al., 2011”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Michalopoulos and Khan, 2015
The ‘Possible Origins of LPC’ section reports hepatocyte nodules in patients with micronodular cirrhosis, supporting the chronic-disease and nodule context. It does not say that hepatocytes in those nodules expressed progenitor-associated markers; its discussion of progenitor cells in regenerative clusters concerns fulminant hepatic failure instead. Page numbers were not provided in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measuredCell plasticity plays an important role in liver regeneration.
“Cell plasticity has lately been recognized to play an important role in liver regeneration (Kopp et al., 2016; Li et al., 2016; Michalopoulos and Khan, 2015”
From In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity (2018) · cites this paper as Michalopoulos and Khan, 2015
The Conclusions describe plasticity between liver cell types, and “Possible Origins of LPC” reports that cell-type conversion can contribute to repair under severe injury or when hepatocyte replication is blocked. But that section also says that during normal liver regeneration, hepatocytes and cholangiocytes generally proliferate while retaining their identities. The unqualified claim overstates plasticity’s role across liver regeneration. (LLM, conf=0.86)
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- Authors
- Michalopoulos, G. K., & Khan, Z.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 149
- Issue
- 4
- Pages
- 876-882
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC4584191
- OpenAlex
- W2112926558
- Cited by
- 109
- References
- 78
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 6 · 2023: 13 · 2022: 10 · 2021: 11 · 2020: 11 · 2019: 10 · 2018: 18 · 2017: 8 · 2016: 10 · 2015: 3
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (2r01ca103958-06a1)
- National Cancer Institute (R01CA035373, R01-CA103958)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK096990)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD071834, K12HD052892)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver stem cells, cholangiocytes, hepatocytes, liver regeneration, liver disease, zebrafish model, rodent models
- MeSH terms
- Animals, Bile Ducts, Intrahepatic, Cell Differentiation, Gene Expression Regulation, Humans, Liver, Liver Diseases, Liver Regeneration, Stem Cells, Signal Transduction, Cell Lineage, Hepatocytes, Cell Proliferation
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