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Cited by 865

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

Open access
Qiu, Yifu, Nguyen, Khoa D., Odegaard, Justin I., Cui, Xiaojin, Tian, Xiaoyu, Locksley, Richard M., Palmiter, Richard D., Chawla, Ajay·2014·Cell
DOI 10.1016/j.cell.2014.03.066
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Abstract

SUMMARY Beige fat, which expresses the thermogenic protein UCP1, provides a defense against cold and obesity. Although a cold environment is the physiologic stimulus for inducing beige fat in mice and humans, the events that lead from the sensing of cold to the development of beige fat remain poorly understood. Here, we identify the efferent beige fat thermogenic circuit, consisting of eosinophils, type 2 cytokines interleukin (IL)-4/13 and alternatively activated macrophages. Genetic loss of eosinophils or IL-4/13 signaling impairs cold-induced biogenesis of beige fat. Mechanistically, macrophages recruited to cold-stressed subcutaneous white adipose tissue (scWAT) undergo alternative activation to induce tyrosine hydroxylase expression and catecholamine production, factors required for browning of scWAT. Conversely, administration of IL-4 to thermoneutral mice increases beige fat mass and thermogenic capacity to ameliorate pre-established obesity. Together, our findings have uncovered the efferent circuit controlling biogenesis of beige fat and provide support for its targeting to treat obesity.

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Metadata

Authors
Qiu, Y., Nguyen, K. D., Odegaard, J. I., Cui, X., Tian, X., Locksley, R. M., Palmiter, R. D., & Chawla, A.
Venue
Cell
Publisher
Elsevier BV
Published
2014-06
Volume
157
Issue
6
Pages
1292-1308
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2014.03.066
OpenAlex
W2064899968
Cited by
865
References
54
FWCI
62.59
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat. https://app.cochat.ai/papers/10.1016/j.cell.2014.03.066
The paper
Qiu, Y., Nguyen, K. D., Odegaard, J. I., Cui, X., Tian, X., Locksley, R. M., Palmiter, R. D., & Chawla, A. (2014). Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat. Cell. https://doi.org/10.1016/j.cell.2014.03.066

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