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Cited by 727

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

Open access
Muller, Paul Andrew, Koscsó, Balázs, Rajani, Gaurav Manohar, Stevanovic, Korey, Berres, Marie-Luise, Hashimoto, Daigo, Mortha, Arthur, Leboeuf, Marylene, Li, Xiu-Min, Mucida, Daniel, Stanley, E. Richard, Dahan, Stephanie, Margolis, Kara Gross, Gershon, Michael David, Merad, Miriam, Bogunovic, Milena·2014·Cell
DOI 10.1016/j.cell.2014.04.050
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Abstract

SUMMARY Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial changes. It is tightly regulated by complex cellular interactions; however, our understanding of these controls is incomplete. A distinct population of macrophages is distributed in the intestinal muscularis externa. We demonstrate that in the steady state muscularis macrophages regulate peristaltic activity of the colon. They change the pattern of smooth muscle contractions by secreting bone morphogenetic protein 2 (BMP2), which activates BMP receptor (BMPR) expressed by enteric neurons. Enteric neurons, in turn, secrete colony stimulatory factor 1 (CSF1), a growth factor required for macrophage development. Finally, stimuli from microbial commensals regulate BMP2 expression by macrophages and CSF1 expression by enteric neurons. Our findings identify a plastic, microbiota-driven, crosstalk between muscularis macrophages and enteric neurons, which controls gastrointestinal motility.

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Metadata

Authors
Muller, P. A., Koscsó, B., Rajani, G. M., Stevanovic, K., Berres, M.-L., Hashimoto, D., Mortha, A., Leboeuf, M., Li, X.-M., Mucida, D., Stanley, E. R., Dahan, S., Margolis, K. G., Gershon, M. D., Merad, M., & Bogunovic, M.
Venue
Cell
Publisher
Elsevier BV
Published
2014-07
Volume
158
Issue
2
Pages
300-313
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2014.04.050
OpenAlex
W2126263479
Cited by
727
References
9
FWCI
39.43
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility. https://app.cochat.ai/papers/10.1016/j.cell.2014.04.050
The paper
Muller, P. A., Koscsó, B., Rajani, G. M., Stevanovic, K., Berres, M.-L., Hashimoto, D., Mortha, A., Leboeuf, M., Li, X.-M., Mucida, D., Stanley, E. R., Dahan, S., Margolis, K. G., Gershon, M. D., Merad, M., & Bogunovic, M. (2014). Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility. Cell. https://doi.org/10.1016/j.cell.2014.04.050

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.