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Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility
Open accessAbstract
SUMMARY Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial changes. It is tightly regulated by complex cellular interactions; however, our understanding of these controls is incomplete. A distinct population of macrophages is distributed in the intestinal muscularis externa. We demonstrate that in the steady state muscularis macrophages regulate peristaltic activity of the colon. They change the pattern of smooth muscle contractions by secreting bone morphogenetic protein 2 (BMP2), which activates BMP receptor (BMPR) expressed by enteric neurons. Enteric neurons, in turn, secrete colony stimulatory factor 1 (CSF1), a growth factor required for macrophage development. Finally, stimuli from microbial commensals regulate BMP2 expression by macrophages and CSF1 expression by enteric neurons. Our findings identify a plastic, microbiota-driven, crosstalk between muscularis macrophages and enteric neurons, which controls gastrointestinal motility.
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“demonstrated that antibiotics inhibit colony stimulating factor 1 (CSF1)-mediated gastrointestinal motility regulation by crosstalk between macrophages and intestinal neurons, while OAL prevents antibiotic-induced intestinal CSF1 downregulation and intestinal macrophage depletion (22).”
Background
Metadata
- Authors
- Muller, P. A., Koscsó, B., Rajani, G. M., Stevanovic, K., Berres, M.-L., Hashimoto, D., Mortha, A., Leboeuf, M., Li, X.-M., Mucida, D., Stanley, E. R., Dahan, S., Margolis, K. G., Gershon, M. D., Merad, M., & Bogunovic, M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 158
- Issue
- 2
- Pages
- 300-313
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2126263479
- Cited by
- 727
- References
- 9
- FWCI
- 39.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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