The microbiota-gut-brain axis: from motility to mood

Human gut microbiome viewed across age and geography

Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070 · see citing works

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works

Revised Estimates for the Number of Human and Bacteria Cells in the Body

Sender, R., Fuchs, S., & Milo, R. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002533 · Cited by 5,425 · see citing works

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works

The gut microbiota shapes intestinal immune responses during health and disease

Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572 · see citing works

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works

Ingestion of <i>Lactobacillus</i> strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works

Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis

Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614 · see citing works

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569 · see citing works

Normal gut microbiota modulates brain development and behavior

Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228 · see citing works

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

Agus, A., Planchais, J., & Sokol, H. (2018) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2018.05.003 · Cited by 3,180 · see citing works

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice

Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works

Current understanding of the human microbiome

Gilbert, J. A., Blaser, M. J., Caporaso, J. G., Jansson, J. K., Lynch, S. V., & Knight, R. (2018) · Nature Medicine · doi:10.1038/nm.4517 · Cited by 2,609 · see citing works

Succession of microbial consortia in the developing infant gut microbiome

Koenig, J. E., Spor, A., Scalfone, N., Fricker, A. D., Stombaugh, J., Knight, R., Angenent, L. T., & Ley, R. E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000081107 · Cited by 2,540 · see citing works

The gut microbiota influences blood-brain barrier permeability in mice

Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530 · see citing works

Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features, and Rome IV

Drossman, D. A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.032 · Cited by 2,444 · see citing works

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.44 · Cited by 2,023 · see citing works

Temporal development of the gut microbiome in early childhood from the TEDDY study

Stewart, C. J., Ajami, N. J., O’Brien, J. L., Hutchinson, D. S., Smith, D. P., Wong, M. C., Ross, M. C., Lloyd, R. E., Doddapaneni, H., Metcalf, G., et al. (2018) · Nature · doi:10.1038/s41586-018-0617-x · Cited by 1,996 · see citing works

The neuroactive potential of the human gut microbiota in quality of life and depression

Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0337-x · Cited by 1,963 · see citing works

Rome IV—Functional GI Disorders: Disorders of Gut-Brain Interaction

Drossman, D. A., & Hasler, W. L. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.035 · Cited by 1,928 · see citing works

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893 · see citing works

Gut feelings: the emerging biology of gut-brain communication

Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726 · see citing works

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683 · see citing works

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

Olszak, T., An, D., Zeissig, S., Vera, M. P., Richter, J., Franke, A., Glickman, J. N., Siebert, R., Baron, R. M., Kasper, D. L., et al. (2012) · Science · doi:10.1126/science.1219328 · Cited by 1,661 · see citing works

The interplay between the intestinal microbiota and the brain

Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · see citing works

The vagus nerve at the interface of the microbiota-gut-brain axis

Bonaz, B., Bazin, T., & Pellissier, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00049 · Cited by 1,397 · see citing works

Principles and clinical implications of the brain-gut-enteric microbiota axis

Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · see citing works

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

Reigstad, C. S., Salmonson, C. E., III, J. F. R., Szurszewski, J. H., Linden, D. R., Sonnenburg, J. L., Farrugia, G., & Kashyap, P. C. (2015) · The FASEB Journal · doi:10.1096/fj.14-259598 · Cited by 1,335 · see citing works

Assessment of psychotropic-like properties of a probiotic formulation ( <i>Lactobacillus helveticus</i> R0052 and <i>Bifidobacterium longum</i> R0175) in rats and human subjects

Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324 · see citing works

Consumption of fermented milk product with probiotic modulates brain activity

Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192 · see citing works

Serotonin signalling in the gut: functions, dysfunctions and therapeutic targets

Mawe, G. M., & Hoffman, J. M. (2013) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2013.105 · Cited by 1,165 · see citing works

Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring

Buffington, S. A., Di Prisco, G. V., Auchtung, T. A., Ajami, N. J., Petrosino, J. F., & Costa-Mattioli, M. (2016) · Cell · doi:10.1016/j.cell.2016.06.001 · Cited by 1,163 · see citing works

A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome

Perez-Muñoz, M. E., Arrieta, M.-C., Ramer-Tait, A. E., & Walter, J. (2017) · Microbiome · doi:10.1186/s40168-017-0268-4 · Cited by 1,096 · see citing works

The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication

Bercik, P., Park, A. J., Sinclair, D., Khoshdel, A., Lu, J., Huang, X., Deng, Y., Blennerhassett, P. A., Fahnestock, M., Moine, D., et al. (2011) · Neurogastroenterology &amp; Motility · doi:10.1111/j.1365-2982.2011.01796.x · Cited by 1,018 · see citing works

Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children

Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068322 · Cited by 976 · see citing works

Intestinal microbiota in functional bowel disorders: a Rome foundation report

Simrén, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J., & Zoetendal, E. G. (2013) · Gut · doi:10.1136/gutjnl-2012-302167 · Cited by 939 · see citing works

The epidemiology of irritable bowel syndrome

Card, T., Canavan, C., & West, J. (2014) · Clinical Epidemiology · doi:10.2147/clep.s40245 · Cited by 889 · see citing works

Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder

Sgritta, M., Dooling, S. W., Buffington, S. A., Momin, E. N., Francis, M. B., Britton, R. A., & Costa-Mattioli, M. (2019) · Neuron · doi:10.1016/j.neuron.2018.11.018 · Cited by 865 · see citing works

An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota

Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835 · see citing works

Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain–gut axis alterations

van de Wouw, M., Boehme, M., Lyte, J. M., Wiley, N., Strain, C., O'Sullivan, O., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2018) · The Journal of Physiology · doi:10.1113/jp276431 · Cited by 789 · see citing works

Shifting the balance: antibiotic effects on host–microbiota mutualism

Willing, B. P., Russell, S. L., & Finlay, B. B. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2536 · Cited by 747 · see citing works

A Neural Circuit for Gut-Induced Reward

Han, W., Téllez, L. A., Perkins, M. H., Pérez-Martínez, I. O., Qu, T., Ferreira, J. G. P., Ferreira, T. L., Quinn, D., Liu, Z.-W., Gao, X., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.049 · Cited by 739 · see citing works

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

Muller, P. A., Koscsó, B., Rajani, G. M., Stevanovic, K. D., Berres, M., Hashimoto, D., Mortha, A., Leboeuf, M., Li, X.-M., Mucida, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.050 · Cited by 727 · see citing works

Kynurenine pathway metabolism and the microbiota-gut-brain axis

Kennedy, P. J., Cryan, J. F., Dinan, T. G., & Clarke, G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.002 · Cited by 724 · see citing works

A weaning reaction to microbiota is required for resistance to immunopathologies in the adult

Al Nabhani, Z., Dulauroy, S., Marques, R., Cousu, C., Al Bounny, S., Déjardin, F., Sparwasser, T., Bérard, M., Cerf-Bensussan, N., & Eberl, G. (2019) · Immunity · doi:10.1016/j.immuni.2019.02.014 · Cited by 679 · see citing works

A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood

Steenbergen, L., Sellaro, R., van Hemert, S., Bosch, J. A., & Colzato, L. S. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.04.003 · Cited by 671 · see citing works

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

Gabanyi, I., Muller, P. A., Feighery, L. M., Oliveira, T. Y., Costa‐Pinto, F. A., & Mucida, D. (2016) · Cell · doi:10.1016/j.cell.2015.12.023 · Cited by 658 · see citing works

Identification of an Intestinal Microbiota Signature Associated With Severity of Irritable Bowel Syndrome

Tap, J., Derrien, M., Törnblom, H., Brazeilles, R., Cools-Portier, S., Doré, J., Störsrud, S., Le Nevé, B., Öhman, L., & Simrén, M. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.09.049 · Cited by 642 · see citing works

Regulation of prefrontal cortex myelination by the microbiota

Hoban, A. E., Stilling, R. M., Ryan, F. J., Shanahan, F., Dinan, T. G., Claesson, M. J., Clarke, G., & Cryan, J. F. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.42 · Cited by 635 · see citing works

Growing up in a bubble: using germ-free animals to assess the influence of the gut microbiota on brain and behavior

Luczynski, P., McVey Neufeld, K.-A., Oriach, C. S., Clarke, G., Dinan, T. G., & Cryan, J. F. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw020 · Cited by 632 · see citing works

Innate immune recognition of the microbiota promotes host-microbial symbiosis

Chu, H., & Mazmanian, S. K. (2013) · Nature Immunology · doi:10.1038/ni.2635 · Cited by 630 · see citing works

The bowel and beyond: The enteric nervous system in neurological disorders

Rao, M., & Gershon, M. D. (2016) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2016.107 · Cited by 629 · see citing works

5-Hydroxytryptamine (serotonin) in the gastrointestinal tract

Gershon, M. D. (2013) · Current Opinion in Endocrinology, Diabetes &amp; Obesity · doi:10.1097/med.0b013e32835bc703 · Cited by 617 · see citing works

Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents

Walter, J., Armet, A. M., Finlay, B. B., & Shanahan, F. (2020) · Cell · doi:10.1016/j.cell.2019.12.025 · Cited by 596 · see citing works

Gut Microbe to Brain Signaling: What Happens in Vagus…

Fülling, C., Dinan, T. G., & Cryan, J. F. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.008 · Cited by 590 · see citing works

Vagal pathways for microbiome-brain-gut axis communication

Forsythe, P., Bienenstock, J., & Kunze, W. A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_5 · Cited by 576 · see citing works

Beneficial psychological effects of a probiotic formulation ( <i>Lactobacillus helveticus</i> R0052 and <i>Bifidobacterium longum</i> R0175) in healthy human volunteers

Messaoudi, M., Violle, N., Bisson, J.-F., Desor, D., Javelot, H., & Rougeot, C. (2011) · Gut Microbes · doi:10.4161/gmic.2.4.16108 · Cited by 574 · see citing works

Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks

De Vadder, F., Grasset, E., Mannerås Holm, L., Karsenty, G., Macpherson, A. J., Olofsson, L. E., & Bäckhed, F. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720017115 · Cited by 566 · see citing works

The maternal microbiome modulates fetal neurodevelopment in mice

Vuong, H. E., Pronovost, G. N., Williams, D. W., Coley, E. J. L., Siegler, E. L., Qiu, A., Kazantsev, M., Wilson, C. J., Rendon, T., & Hsiao, E. Y. (2020) · Nature · doi:10.1038/s41586-020-2745-3 · Cited by 564 · see citing works

The Gut–Brain Axis and the Microbiome: Mechanisms and Clinical Implications

Osadchiy, V., Martin, C. R., & Mayer, E. A. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.10.002 · Cited by 555 · see citing works

Infant gut microbiome associated with cognitive development

Carlson, A. L., Xia, K., Azcarate-Peril, M. A., Goldman, B. D., Ahn, M., Styner, M. A., Thompson, A. L., Geng, X., Gilmore, J. H., & Knickmeyer, R. C. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.021 · Cited by 541 · see citing works

Feedback control of AHR signalling regulates intestinal immunity

Schiering, C., Wincent, E., Metidji, A., Iseppon, A., Li, Y., Potocnik, A. J., Omenetti, S., Henderson, C. J., Wolf, C. R., Nebert, D. W., et al. (2017) · Nature · doi:10.1038/nature21080 · Cited by 537 · see citing works

Effect of probiotics on depression: a systematic review and meta-analysis of randomized controlled trials

Huang, R., Wang, K., & Hu, J. (2016) · Nutrients · doi:10.3390/nu8080483 · Cited by 505 · see citing works

Commensal bacteria make GPCR ligands that mimic human signalling molecules

Cohen, L. J., Esterhazy, D., Kim, S.-H., Lemetre, C., Aguilar, R. R., Gordon, E. A., Pickard, A. J., Cross, J. R., Emiliano, A. B., Han, S. M., et al. (2017) · Nature · doi:10.1038/nature23874 · Cited by 500 · see citing works

Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study

El-Salhy, M., Hatlebakk, J. G., Gilja, O. H., Bråthen Kristoffersen, A., & Hausken, T. (2020) · Gut · doi:10.1136/gutjnl-2019-319630 · Cited by 498 · see citing works

Systematic review with meta‐analysis: the prevalence of anxiety and depression in patients with irritable bowel syndrome

Zamani, M., Alizadeh‐Tabari, S., & Zamani, V. (2019) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/apt.15325 · Cited by 496 · see citing works

Adult hippocampal neurogenesis is regulated by the microbiome

Ogbonnaya, E. S., Clarke, G., Shanahan, F., Dinan, T. G., Cryan, J. F., & O’Leary, O. F. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.023 · Cited by 491 · see citing works

Feeding the microbiota–gut–brain axis: Diet, microbiome, and neuropsychiatry

Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Translational Research · doi:10.1016/j.trsl.2016.10.002 · Cited by 491 · see citing works

Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice

Kimura, I., Miyamoto, J., Ohue‐Kitano, R., Watanabe, K., Yamada, T., Onuki, M., Aoki, R., Isobe, Y., Kashihara, D., Inoue, D., et al. (2020) · Science · doi:10.1126/science.aaw8429 · Cited by 488 · see citing works

Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells

Bohórquez, D. V., Shahid, R. A., Erdmann, A., Kreger, A. M., Wang, Y., Calakos, N., Wang, F., & Liddle, R. A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78361 · Cited by 484 · see citing works

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut

Fung, T. C., Vuong, H. E., Luna, C. G. G., Pronovost, G. N., Aleksandrova, A. A., Riley, N. G., Vavilina, A., McGinn, J., Rendon, T. K., Forrest, L. R., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0540-4 · Cited by 481 · see citing works

Role of TLR4 in the gut-brain axis in Parkinson's disease: A translational study from men to mice

Perez-Pardo, P., Dodiya, H. B., Engen, P. A., Forsyth, C. B., Huschens, A. M., Shaikh, M., Voigt, R. M., Naqib, A., Green, S. J., Kordower, J. H., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-316844 · Cited by 467 · see citing works

Nutritional psychiatry: Towards improving mental health by what you eat

Adan, R. A. H., van der Beek, E. M., Buitelaar, J. K., Cryan, J. F., Hebebrand, J., Higgs, S., Schellekens, H., & Dickson, S. L. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.10.011 · Cited by 454 · see citing works

Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice

Kashyap, P. C., Marcobal, A., Ursell, L. K., Larauche, M., Duboc, H., Earle, K. A., Sonnenburg, E. D., Ferreyra, J. A., Higginbottom, S. K., Million, M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.047 · Cited by 451 · see citing works

Microbiota modulate sympathetic neurons via a gut–brain circuit

Muller, P. A., Schneeberger, M., Matheis, F., Wang, P., Kerner, Z. J., Ilanges, A., Pellegrino, K., del Mármol, J. I., Castro, T. B. R., Furuichi, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2474-7 · Cited by 449 · see citing works

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

Bhattarai, Y., Williams, B. B., Battaglioli, E. J., Whitaker, W. R., Till, L., Grover, M., Linden, D. R., Akiba, Y., Kandimalla, K. K., Zachos, N. C., et al. (2018) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2018.05.004 · Cited by 436 · see citing works

Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial

Slykerman, R. F., Hood, F., Wickens, K., Thompson, J. M. D., Barthow, C., Murphy, R., Kang, J., Rowden, J., Stone, P., Crane, J., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.09.013 · Cited by 422 · see citing works

The microbiota regulate neuronal function and fear extinction learning

Chu, C., Murdock, M. H., Jing, D., Won, T. H., Chung, H., Kressel, A. M., Tsaava, T., Addorisio, M. E., Putzel, G. G., Zhou, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1644-y · Cited by 421 · see citing works

AGA Clinical Practice Guidelines on the Role of Probiotics in the Management of Gastrointestinal Disorders

Su, G. L., Ko, C. W., Bercik, P., Falck-Ytter, Y., Sultan, S., Weizman, A. V., & Morgan, R. L. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.059 · Cited by 421 · see citing works

Microbiota-Gut-Brain Axis: New Therapeutic Opportunities

Long-Smith, C., O'Riordan, K. J., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2020) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023628 · Cited by 419 · see citing works

Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury

Laranjeira, C., Sandgren, K., Kessaris, N., Richardson, W. D., Potocnik, A. J., Berghe, P. V., & Pachnis, V. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58200 · Cited by 418 · see citing works

Quantitative Meta-analysis Identifies Brain Regions Activated During Rectal Distension in Irritable Bowel Syndrome

Tillisch, K., Mayer, E. A., & Labus, J. S. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.07.053 · Cited by 412 · see citing works

Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons

Li, Z., Chalazonitis, A., Huang, Y.-Y., Mann, J. J., Margolis, K. G., Yang, Q. M., Kim, D. O., Cote, F., Mallet, J., & Gershon, M. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6684-10.2011 · Cited by 403 · see citing works

Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling

Anitha, M., Vijay–Kumar, M., Sitaraman, S. V., Gewirtz, A. T., & Srinivasan, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.034 · Cited by 397 · see citing works

Brain functional magnetic resonance imaging of rectal pain and activation of endogenous inhibitory mechanisms in irritable bowel syndrome patient subgroups and healthy controls

Wilder‐Smith, C. H., Schindler, D., Lövblad, K., Redmond, S. M., & Nirkko, A. (2004) · Gut · doi:10.1136/gut.2003.028514 · Cited by 386 · see citing works

Enteric nervous system development: migration, differentiation, and disease

Lake, J. I., & Heuckeroth, R. O. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00452.2012 · Cited by 383 · see citing works

The early infant gut microbiome varies in association with a maternal high-fat diet

Chu, D. M., Antony, K. M., Ma, J., Prince, A., Showalter, L., Moller, M., & Aagaard, K. M. (2016) · Genome Medicine · doi:10.1186/s13073-016-0330-z · Cited by 377 · see citing works

Corticotropin-releasing factor receptors and stress-related alterations of gut motor function

Taché, Y., & Bonaz, B. L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30085 · Cited by 373 · see citing works

Microbiota alteration is associated with the development of stress-induced despair behavior

Marin, I. A., Goertz, J. E., Ren, T., Rich, S. S., Onengut-Gumuscu, S., Farber, E., Wu, M., Overall, C. C., Kipnis, J., & Gaultier, A. (2017) · Scientific Reports · doi:10.1038/srep43859 · Cited by 369 · see citing works

Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder

MacFabe, D. F., Cain, N. E., Boon, F., Ossenkopp, K.-P., & Cain, D. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.005 · Cited by 365 · see citing works

Microbiota controls the homeostasis of glial cells in the gut lamina propria

Kabouridis, P. S., Lasrado, R., McCallum, S., Chng, S. H., Snippert, H. J., Clevers, H., Pettersson, S., & Pachnis, V. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.037 · Cited by 358 · see citing works

A meta-analysis of the use of probiotics to alleviate depressive symptoms

Ng, Q. X., Peters, C., Ho, C. Y. X., Lim, D. Y., & Yeo, W.-S. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.063 · Cited by 357 · see citing works

Neuronal programming by microbiota regulates intestinal physiology

Obata, Y., Castaño, Á., Boeing, S., Bon‐Frauches, A. C., Fung, C., Fallesen, T. L., de Agüero, M. G., Yılmaz, B., Lopes, R., Huseynova, A., et al. (2020) · Nature · doi:10.1038/s41586-020-1975-8 · Cited by 356 · see citing works

Distal gut microbiota of adolescent children is different from that of adults: Gut microbiota of adolescents differs from that of adults

Agans, R., Rigsbee, L., Kenche, H., Michail, S., Khamis, H. J., & Paliy, O. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01120.x · Cited by 343 · see citing works

<i>Lactobacillus reuteri</i> enhances excitability of colonic AH neurons by inhibiting calcium‐dependent potassium channel opening

Kunze, W. A., Mao, Y., Wang, B., Huizinga, J. D., Ma, X., Forsythe, P., & Bienenstock, J. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00686.x · Cited by 328 · see citing works

Evidence that independent gut‐to‐brain and brain‐to‐gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1‐year population‐based prospective study

Koloski, N. A., Jones, M., & Talley, N. J. (2016) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/apt.13738 · Cited by 318 · see citing works

Effects of intestinal microbiota on anxiety-like behavior

Neufeld, K.-A. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Communicative &amp; Integrative Biology · doi:10.4161/cib.15702 · Cited by 311 · see citing works

Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior

Gacias, M., Gaspari, S., Santos, P.-M. G., Tamburini, S., Andrade, M., Zhang, F., Shen, N., Tolstikov, V., Kiebish, M. A., Dupree, J. L., et al. (2016) · eLife · doi:10.7554/elife.13442 · Cited by 308 · see citing works

Developmental changes in serotonin signaling: Implications for early brain function, behavior and adaptation

Brummelte, S., Mc Glanaghy, E., Bonnin, A., & Oberlander, T. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.037 · Cited by 306 · see citing works

Toll-Like Receptor 2 Regulates Intestinal Inflammation by Controlling Integrity of the Enteric Nervous System

Brun, P., Giron, M. C., Qesari, M., Porzionato, A., Caputi, V., Zoppellaro, C., Banzato, S., Grillo, A. R., Spagnol, L., De Caro, R., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.047 · Cited by 300 · see citing works

The microbiome is essential for normal gut intrinsic primary afferent neuron excitability in the mouse

McVey Neufeld, K. A., Mao, Y. K., Bienenstock, J., Foster, J. A., & Kunze, W. A. (2013) · Neurogastroenterology &amp; Motility · doi:10.1111/nmo.12049 · Cited by 299 · see citing works

Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders

Nankova, B. B., Agarwal, R., MacFabe, D. F., & La Gamma, E. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103740 · Cited by 294 · see citing works

Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome

Labus, J. S., Hollister, E. B., Jacobs, J., Kirbach, K., Oezguen, N., Gupta, A., Acosta, J., Luna, R. A., Aagaard, K., Versalovic, J., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0260-z · Cited by 284 · see citing works

Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood

Golubeva, A. V., Crampton, S., Desbonnet, L., Edge, D., O'Sullivan, O., Lomasney, K. W., Zhdanov, A. V., Crispie, F., Moloney, R. D., Borre, Y. E., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.06.002 · Cited by 283 · see citing works

The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior

Arentsen, T., Qian, Y., Gkotzis, S., Femenia, T., Wang, T., Udekwu, K., Forssberg, H., & Diaz Heijtz, R. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.182 · Cited by 280 · see citing works

The Effect of Microbiota and the Immune System on the Development and Organization of the Enteric Nervous System

Obata, Y., & Pachnis, V. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.07.044 · Cited by 278 · see citing works

Sex hormones in the modulation of irritable bowel syndrome

Mulak, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i10.2433 · Cited by 277 · see citing works

The Microgenderome Revealed: Sex Differences in Bidirectional Interactions between the Microbiota, Hormones, Immunity and Disease Susceptibility

Vemuri, R., Sylvia, K. E., Klein, S. L., Forster, S. C., Plebanski, M., Eri, R., & Flanagan, K. L. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-018-0716-7 · Cited by 265 · see citing works

Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner

Jašarević, E., Howard, C. D., Misic, A. M., Beiting, D. P., & Bale, T. L. (2017) · Scientific Reports · doi:10.1038/srep44182 · Cited by 262 · see citing works

Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut

Joseph, N. M., He, S., Quintana, E., Kim, Y.-G., Núñez, G., & Morrison, S. J. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58186 · Cited by 256 · see citing works

A randomized double‐blind placebo‐controlled trial of <i>Lactobacillus</i> GG for abdominal pain disorders in children

GAWROŃSKA, A., DZIECHCIARZ, P., HORVATH, A., & SZAJEWSKA, H. (2007) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/j.1365-2036.2006.03175.x · Cited by 251 · see citing works

Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis

Kulkarni, S., Micci, M., Leser, J., Shin, C., Tang, S.-C., Fu, Y.-Y., Liu, L.-S., Li, Q., Saha, M., Li, C.-P., et al. (2017) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1619406114 · Cited by 248 · see citing works

A Randomized Controlled Trial of <i>Lactobacillus</i> GG in Children With Functional Abdominal Pain

Francavilla, R., Miniello, V., Magistà, A. M., De Canio, A., Bucci, N., Gagliardi, F., Lionetti, E., Castellaneta, S., Polimeno, L., Peccarisi, L., et al. (2010) · Pediatrics · doi:10.1542/peds.2010-0467 · Cited by 242 · see citing works

Probiotics drive gut microbiome triggering emotional brain signatures

Bagga, D., Reichert, J. L., Koschutnig, K., Aigner, C. S., Holzer, P. D., Koskinen, K., Moissl‐Eichinger, C., & Schöpf, V. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1460015 · Cited by 230 · see citing works

Making Sense of … the Microbiome in Psychiatry

Bastiaanssen, T. F. S., Cowan, C. S. M., Claesson, M. J., Dinan, T. G., & Cryan, J. F. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy067 · Cited by 223 · see citing works

Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis

Gheorghe, C. E., Martin, J. A., Manriquez, F. V., Dinan, T. G., Cryan, J. F., & Clarke, G. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.08.004 · Cited by 212 · see citing works

Microbe-host interactions: influence of the gut microbiota on the enteric nervous system

Hyland, N. P., & Cryan, J. F. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.06.027 · Cited by 207 · see citing works

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

Jarret, A. P., Jackson, R. P., Duizer, C., Healy, M. E., Zhao, J., Rone, J. M., Bielecki, P., Sefik, E., Roulis, M., Rice, T., et al. (2020) · Cell · doi:10.1016/j.cell.2019.12.016 · Cited by 204 · see citing works

Meta-analysis: Lactobacillus rhamnosus GG for abdominal pain-related functional gastrointestinal disorders in childhood: Meta-analysis: Lactobacillus GG and abdominal pain-related functional disorders

Horvath, A., Dziechciarz, P., & Szajewska, H. (2011) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/j.1365-2036.2011.04665.x · Cited by 201 · see citing works

Brain-gut-microbiota axis: challenges for translation in psychiatry

Kelly, J. R., Clarke, G. A., Cryan, J. F., & Dinan, T. G. (2016) · Annals of Epidemiology · doi:10.1016/j.annepidem.2016.02.008 · Cited by 200 · see citing works

You’ve got male: Sex and the microbiota-gut-brain axis across the lifespan

Jaggar, M., Rea, K., Spichak, S., Dinan, T. G., & Cryan, J. F. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100815 · Cited by 200 · see citing works

The microbiome regulates amygdala-dependent fear recall

Hoban, A. E., Stilling, R. M., Moloney, G., Shanahan, F., Dinan, T. G., Clarke, G., & Cryan, J. F. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.100 · Cited by 197 · see citing works

Microbiota-gut-brain axis and cognitive function

Gareau, M. G. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_16 · Cited by 189 · see citing works

Brain structure and response to emotional stimuli as related to gut microbial profiles in healthy women

Tillisch, K., Mayer, E. A., Gupta, A., Gill, Z., Brazeilles, R., Le Nevé, B., van Hylckama Vlieg, J. E. T., Guyonnet, D., Derrien, M., & Labus, J. S. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000493 · Cited by 185 · see citing works

Efficacy of Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis

Xu, D., Chen, V. L., Steiner, C. A., Berinstein, J. A., Eswaran, S. L., Waljee, A. K., Higgins, P., & Owyang, C. (2019) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000198 · Cited by 181 · see citing works

Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons

Mao, Y.-K., Kasper, D. L., Wang, B., Forsythe, P., Bienenstock, J., & Kunze, W. A. (2013) · Nature Communications · doi:10.1038/ncomms2478 · Cited by 178 · see citing works

Gut commensal microvesicles reproduce parent bacterial signals to host immune and enteric nervous systems

Al‐Nedawi, K., Mian, M. F., Hossain, N., Karimi, K., Mao, Y., Forsythe, P., Min, K. K., Stanisz, A. M., Kunze, W. A., & Bienenstock, J. (2015) · The FASEB Journal · doi:10.1096/fj.14-259721 · Cited by 177 · see citing works

Annual Research Review: Critical windows – the microbiota-gut-brain axis in neurocognitive development

Cowan, C. S. M., Dinan, T. G., & Cryan, J. F. (2020) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13156 · Cited by 176 · see citing works

Mapping Interactions of Microbial Metabolites with Human G-Protein-Coupled Receptors

Colosimo, D. A., Kohn, J. A., Luo, P. M., Piscotta, F. J., Han, S. M., Pickard, A. J., Rao, A., Cross, J. R., Cohen, L. J., & Brady, S. F. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.07.002 · Cited by 173 · see citing works

Psychotropics and the Microbiome: a Chamber of Secrets…

Cussotto, S., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2019) · Psychopharmacology · doi:10.1007/s00213-019-5185-8 · Cited by 169 · see citing works

Neuronal Serotonin Regulates Growth of the Intestinal Mucosa in Mice

Gross, E. R., Gershon, M. D., Margolis, K. G., Gertsberg, Z. V., & Cowles, R. A. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.05.007 · Cited by 167 · see citing works

Epidemiology of Irritable Bowel Syndrome

Choung, R. S., & Saito, Y. A. (2014) · Wiley eBooks · doi:10.1002/9781118727072.ch20 · Cited by 163 · see citing works

Psychopathology in Irritable Bowel Syndrome: Support for a Psychophysiological Model

Sykes, M. A., Blanchard, E. B., Lackner, J., Keefer, L., & Krasner, S. S. (2003) · Journal of Behavioral Medicine · doi:10.1023/a:1024209111909 · Cited by 159 · see citing works

The enteric nervous system promotes intestinal health by constraining microbiota composition

Rolig, A. S., Mittge, E. K., Ganz, J., Troll, J. V., Melancon, E., Wiles, T. J., Alligood, K., Stephens, W. Z., Eisen, J. S., & Guillemin, K. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2000689 · Cited by 152 · see citing works

New trends and perspectives in the evolution of neurotransmitters in microbial, plant, and animal cells

Roshchina, V. V. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-20215-0_2 · Cited by 143 · see citing works

Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function

Margolis, K. G., Li, Z., Stevanovic, K., Saurman, V., Israelyan, N., Anderson, G. M., Snyder, I., Veenstra-VanderWeele, J., Blakely, R. D., & Gershon, M. D. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84877 · Cited by 139 · see citing works

Role of brain imaging in disorders of brain–gut interaction: a Rome Working Team Report

Mayer, E. A., Labus, J., Aziz, Q., Tracey, I., Kilpatrick, L., Elsenbruch, S., Schweinhardt, P., Van Oudenhove, L., & Borsook, D. (2019) · Gut · doi:10.1136/gutjnl-2019-318308 · Cited by 138 · see citing works

AGA Technical Review on the Role of Probiotics in the Management of Gastrointestinal Disorders

Preidis, G. A., Weizman, A. V., Kashyap, P., & Morgan, R. L. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.060 · Cited by 135 · see citing works

Microbial–host molecular exchange and its functional consequences in early mammalian life

Ganal-Vonarburg, S. C., Hornef, M. W., & Macpherson, A. J. (2020) · Science · doi:10.1126/science.aba0478 · Cited by 134 · see citing works

Antibiotic-Induced Depletion of Murine Microbiota Induces Mild Inflammation and Changes in Toll-Like Receptor Patterns and Intestinal Motility

Grasa, L., Abecia, L., Forcén, R., Castro, M., de Jalón, J. A. G., Latorre, E., Alcalde, A. I., & Murillo, M. D. (2015) · Microbial Ecology · doi:10.1007/s00248-015-0613-8 · Cited by 128 · see citing works

Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense

Farache, J., Zigmond, E., Shakhar, G., & Jung, S. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2012.79 · Cited by 128 · see citing works

Development of colonic motility in the neonatal mouse-studies using spatiotemporal maps

Roberts, R. R., Murphy, J. F., Young, H. M., & Bornstein, J. C. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00444.2006 · Cited by 128 · see citing works

New treatments and therapeutic targets for IBS and other functional bowel disorders

Simrén, M., & Tack, J. (2018) · Nature reviews: Gastroenterology & hepatology · doi:10.1038/s41575-018-0034-5 · Cited by 127 · see citing works

Gut microbiome and brain functional connectivity in infants-a preliminary study focusing on the amygdala

Gao, W., Salzwedel, A., Carlson, A. L., Xia, K., Azcárate-Peril, M. A., Styner, M. A., Thompson, A. L., Geng, X., Goldman, B. D., Gilmore, J. H., et al. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5161-8 · Cited by 127 · see citing works

Probiotics and Subclinical Psychological Symptoms in Healthy Participants: A Systematic Review and Meta-Analysis

McKean, J., Naug, H., Nikbakht, E., Amiet, B., & Colson, N. (2017) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2016.0023 · Cited by 125 · see citing works

Microbiome Composition in Pediatric Populations from Birth to Adolescence: Impact of Diet and Prebiotic and Probiotic Interventions

Davis, E. C., Dinsmoor, A. M., Wang, M., & Donovan, S. M. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06092-x · Cited by 121 · see citing works

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

Muller, P. A., Koscsó, B., Rajani, G. M., Stevanovic, K. D., Berres, M., Hashimoto, D., Mortha, A., Leboeuf, M., Li, X.-M., Mucida, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.002 · Cited by 113 · see citing works

The Dietary Management of Patients with Irritable Bowel Syndrome: A Narrative Review of the Existing and Emerging Evidence

Algera, J. P., Colomier, E., & Simrén, M. (2019) · Nutrients · doi:10.3390/nu11092162 · Cited by 109 · see citing works

5-HT3 Receptor Antagonists in Neurologic and Neuropsychiatric Disorders: The Iceberg Still Lies beneath the Surface

Fakhfouri, G., Rahimian, R., Dyhrfjeld‐Johnsen, J., Zirak, M. R., & Beaulieu, J. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015487 · Cited by 103 · see citing works

Beneficial actions of microbiota‐derived tryptophan metabolites

Galligan, J. J. (2018) · Neurogastroenterology &amp; Motility · doi:10.1111/nmo.13283 · Cited by 99 · see citing works

Fecal Clostridiales distribution and short‐chain fatty acids reflect bowel habits in irritable bowel syndrome

Gargari, G., Taverniti, V., Gardana, C., Cremon, C., Canducci, F., Pagano, I., Barbaro, M. R., Bellacosa, L., Castellazzi, A. M., Valsecchi, C., et al. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.14271 · Cited by 98 · see citing works

New-generation 5-HT4receptor agonists: potential for treatment of gastrointestinal motility disorders

Manabe, N., Wong, B. S., & Camilleri, M. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.482927 · Cited by 97 · see citing works

Maternal microbiota in pregnancy and early life

McDonald, B., & McCoy, K. D. (2019) · Science · doi:10.1126/science.aay0618 · Cited by 97 · see citing works

Feeding melancholic microbes: MyNewGut recommendations on diet and mood

Dinan, T. G., Stanton, C., Long-Smith, C., Kennedy, P., Cryan, J. F., Cowan, C. S. M., Cenit, M. C., van der Kamp, J.-W., & Sanz, Y. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.11.010 · Cited by 95 · see citing works

Understanding Neurogastroenterology From Neuroimaging Perspective: A Comprehensive Review of Functional and Structural Brain Imaging in Functional Gastrointestinal Disorders

Kano, M., Dupont, P. J., Aziz, Q., & Fukudo, S. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18072 · Cited by 94 · see citing works

The gut-brain axis rewired: adding a functional vagal nicotinic “sensory synapse”

Perez‐Burgos, A., Mao, Y., Bienenstock, J., & Kunze, W. A. (2014) · The FASEB Journal · doi:10.1096/fj.13-245282 · Cited by 91 · see citing works

Microbiota-gut-brain axis and toll-like receptors in Alzheimer’s disease

Lin, C., Zhao, S., Zhu, Y., Fan, Z., Wang, J., Zhang, B., & Chen, Y. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.09.008 · Cited by 91 · see citing works

Metabolic Endotoxemia: A Potential Underlying Mechanism of the Relationship between Dietary Fat Intake and Risk for Cognitive Impairments in Humans?

André, P., Laugerette, F., & Féart, C. (2019) · Nutrients · doi:10.3390/nu11081887 · Cited by 87 · see citing works

Cellular Organization of Neuroimmune Interactions in the Gastrointestinal Tract

Margolis, K. G., Gershon, M. D., & Bogunovic, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.05.003 · Cited by 86 · see citing works

Intestinal aganglionosis is associated with early and sustained disruption of the colonic microbiome

Ward, N. L., Pieretti, A. C., Dowd, S. E., Cox, S. B., & Goldstein, A. M. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01937.x · Cited by 85 · see citing works

Alterations in serotonin metabolism in the irritable bowel syndrome

Thijssen, A. Y., Mujagic, Z., Jonkers, D. M. A. E., Ludidi, S., Keszthelyi, D., Hesselink, M., Clemens, C. H. M., Conchillo, J. M., Kruimel, J. W., & Masclee, A. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13459 · Cited by 84 · see citing works

Toll-Like Receptor 4 Regulates Chronic Stress-Induced Visceral Pain in Mice

Tramullas, M., Finger, B. C., Moloney, R. D., Golubeva, A. V., Moloney, G., Dinan, T. G., & Cryan, J. F. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.004 · Cited by 81 · see citing works

Stress-induced disturbances along the gut microbiota-immune-brain axis and implications for mental health: Does sex matter?

Audet, M. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100772 · Cited by 79 · see citing works

Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjects

Osadchiy, V., Labus, J. S., Gupta, A., Jacobs, J. P., Ashe-McNalley, C., Hsiao, E. Y., & Mayer, E. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201772 · Cited by 76 · see citing works

Effects of the probiotic yeast Saccharomyces boulardii on the neurochemistry of myenteric neurones in pig jejunum

Kamm, K., Hoppe, S., Breves, G., Schröder, B., & Schemann, M. (2004) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2003.00458.x · Cited by 70 · see citing works

Alterations of Expression of the Serotonin 5-HT4 Receptor in Brain Disorders

Rebholz, H., Friedman, E., & Castelló, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113581 · Cited by 70 · see citing works

The chemical code of porcine enteric neurons and the number of enteric glial cells are altered by dietary probiotics

Giancamillo, A. D., Vitari, F., Bosi, G., Savoini, G., & Domeneghini, C. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01529.x · Cited by 67 · see citing works

Novel aspects of enteric serotonergic signaling in health and brain-gut disease

Colle, A. D., Israelyan, N., & Margolis, K. G. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00173.2019 · Cited by 65 · see citing works

The enteric nervous system undergoes significant chemical and synaptic maturation during adolescence in mice

Parathan, P., Wang, Y., Leembruggen, A. J. L., Bornstein, J. C., & Foong, J. P. P. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.10.011 · Cited by 64 · see citing works

Central control of gastrointestinal motility

Browning, K. N., & Travagli, R. A. (2018) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000449 · Cited by 59 · see citing works

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

Jarret, A. P., Jackson, R. P., Duizer, C., Healy, M. E., Zhao, J., Rone, J. M., Bielecki, P., Sefik, E., Roulis, M., Rice, T., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.004 · Cited by 57 · see citing works

Characterization of macrophage-like cells in the external layers of human small and large intestine

Mikkelsen, H. B., & Rumessen, J. J. (1992) · Cell and Tissue Research · doi:10.1007/bf00328013 · Cited by 55 · see citing works

Gut Microbiome and Modulation of <scp>CNS</scp> Function

Osadchiy, V., Martin, C. R., & Mayer, E. A. (2019) · Comprehensive Physiology · doi:10.1002/cphy.c180031 · Cited by 53 · see citing works

A case–control study of childhood trauma in the development of irritable bowel syndrome

Halland, M., Almazar, A. E., Lee, R., Atkinson, E. J., Larson, J. J., Talley, N. J., & Saito, Y. A. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12353 · Cited by 50 · see citing works

Epidemiology of irritable bowel syndrome.

Endo, Y., Shoji, T., & Fukudo, S. (2015) · PubMed Central · Cited by 38 · see citing works

Gastrointestinal hormones and the gut connectome

Ye, L., & Liddle, R. A. (2016) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000299 · Cited by 37 · see citing works

Bifidobacterium longum NCC 3001 inhibits AH neuron excitability

Khoshdel, A., Verdu, E. F., Kunze, W., McLean, P. G., Bergonzelli, G. E., & Huizinga, J. D. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12147 · Cited by 34 · see citing works

Neurophysiology of the brain stem in Parkinson’s disease

Bove, C., & Travagli, R. A. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00056.2019 · Cited by 31 · see citing works

Race, the microbiome and colorectal cancer

Royston, K. J., Adedokun, B., & Olopade, O. I. (2019) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v11.i10.773 · Cited by 30 · see citing works

Without a bug’s life: Germ-free rodents to interrogate microbiota-gut-neuroimmune interactions

Spichak, S., Guzzetta, K. E., O’Leary, O. F., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2018) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2019.08.002 · Cited by 28 · see citing works

The influence of the gastrointestinal microbiome on infant colic

Chaib, A. O., Levy, E. I., Chaib, M. O., & Vandenplas, Y. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1791702 · Cited by 23 · see citing works

Bioconversion of Tyrosine and Tryptophan Derived Biogenic Amines by Neuropathogenic Bacteria

Taj, A., & Jamil, N. (2018) · Biomolecules · doi:10.3390/biom8010010 · Cited by 22 · see citing works

A role for the serotonin reuptake transporter in the brain and intestinal features of autism spectrum disorders and developmental antidepressant exposure

Margolis, K. G. (2017) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.02.001 · Cited by 16 · see citing works

Targeting Serotonin Synthesis to Treat Irritable Bowel Syndrome

Tack, J. F., Janssen, P., Wouters, M. M., & Boeckxstaens, G. E. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.024 · Cited by 14 · see citing works

Diagnosis and management of renal dysfunction in patients with cirrhosis

Carrion, A. F., Radhakrishnan, R., & Martin, P. B. (2019) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1708190 · Cited by 11 · see citing works

Primum non nocere : is faecal microbiota transplantation doing harm to patients with IBS?

Enck, P. (2018) · Gut · doi:10.1136/gutjnl-2018-317277 · Cited by 2 · see citing works

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works

The gut-brain axis

Mayer, E. A., Nance, K., & Chen, S. (2022) · Annual Review of Medicine · doi:10.1146/annurev-med-042320-014032 · Cited by 813 · see citing works

Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis

Wang, J., Zhu, N., Su, L., Gao, Y., & Yang, R. (2023) · Cells · doi:10.3390/cells12050793 · Cited by 624 · see citing works

A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders

Sorboni, S. G., Moghaddam, H. S., Jafarzadeh-Esfehani, R., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 562 · see citing works

Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review

Zhao, M., Chu, J., Feng, S., Guo, C., Xue, B., He, K., & Li, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114985 · Cited by 466 · see citing works

The enteric nervous system

Sharkey, K. A., & Mawe, G. M. (2022) · Physiological Reviews · doi:10.1152/physrev.00018.2022 · Cited by 423 · see citing works

Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications

Facchin, S., Bertin, L., Bonazzi, E., Lorenzon, G., Barba, C. D., Barberio, B., Zingone, F., Maniero, D., Scarpa, M., Ruffolo, C., et al. (2024) · Life · doi:10.3390/life14050559 · Cited by 422 · see citing works

Brain–gut–microbiota axis in depression: A historical overview and future directions

Chang, L., Wei, Y., & Hashimoto, K. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.02.004 · Cited by 395 · see citing works

The microbiota–gut–brain axis and neurodevelopmental disorders

Wang, Q., Yang, Q., & Liu, X. (2023) · Protein & Cell · doi:10.1093/procel/pwad026 · Cited by 407 · see citing works

The enteric nervous system relays psychological stress to intestinal inflammation

Schneider, K. M., Blank, N., Alvarez, Y., Thum, K., Lundgren, P., Litichevskiy, L., Sleeman, M., Bahnsen, K., Kim, J., Kardo, S., et al. (2023) · Cell · doi:10.1016/j.cell.2023.05.001 · Cited by 344 · see citing works

The neurobiology of irritable bowel syndrome

Mayer, E. A., Ryu, H. J., & Bhatt, R. R. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01972-w · Cited by 285 · see citing works

Irritable bowel syndrome and mental health comorbidity — approach to multidisciplinary management

Staudacher, H. M., Black, C. J., Teasdale, S. B., Mikocka‐Walus, A. A., & Keefer, L. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00794-z · Cited by 279 · see citing works

Rifaximin-mediated gut microbiota regulation modulates the function of microglia and protects against CUMS-induced depression-like behaviors in adolescent rat

Li, H., Xiang, Y., Zhu, Z., Wang, W., Jiang, Z., Zhao, M., Cheng, S., Pan, F., Liu, D., Ho, R., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02303-y · Cited by 255 · see citing works

The microbiota–gut–brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice

Chakrabarti, A., Geurts, L., Hoyles, L., Iozzo, P., Kraneveld, A. D., Fata, G. L., Miani, M., Patterson, E., Pot, B., Shortt, C., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04060-w · Cited by 252 · see citing works

The Potential Role of Gut Microbiota in Alzheimer’s Disease: From Diagnosis to Treatment

Varesi, A., Pierella, E., Romeo, M., Piccini, G. B., Alfano, C., Bjørklund, G., Oppong, A., Ricevuti, G., Esposito, C., Chirumbolo, S., et al. (2022) · Nutrients · doi:10.3390/nu14030668 · Cited by 225 · see citing works

Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome

Honarpisheh, P., Bryan, R. M., & McCullough, L. D. (2022) · Circulation Research · doi:10.1161/circresaha.122.319983 · Cited by 172 · see citing works

Fecal microbiota transplantation in Parkinson's disease—A randomized repeat-dose, placebo-controlled clinical pilot study

DuPont, H. L., Suescun, J., Jiang, Z.-D., Brown, E. L., Essigmann, H. T., Alexander, A. S., DuPont, A. W., Iqbal, T., Utay, N. S., Newmark, M., et al. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1104759 · Cited by 162 · see citing works

Sepsis‐Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment

Pan, S., Lv, Z., Wang, R., Shu, H., Yuan, S., Yu, Y., & Shang, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1328729 · Cited by 160 · see citing works

Obesity and its comorbidities, current treatment options and future perspectives: Challenging bariatric surgery?

Kloock, S., Ziegler, C. G., & Dischinger, U. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108549 · Cited by 157 · see citing works

Microalgae‐Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression

Zhong, D., Jin, K., Wang, R., Chen, B., Zhang, J., Ren, C., Chen, X. S., Lu, J., & Zhou, M. (2024) · Advanced Materials · doi:10.1002/adma.202312275 · Cited by 148 · see citing works

Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome

Hillestad, E. M. R., van der Meeren, A., Nagaraja, B. H., Bjørsvik, B. R., Haleem, N., Benítez‐Páez, A., Sanz, Y., Hausken, T., Lied, G. A., Lundervold, A., et al. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i4.412 · Cited by 145 · see citing works

Interaction of the Vagus Nerve and Serotonin in the Gut–Brain Axis

Hwang, Y. K., & Oh, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031160 · Cited by 136 · see citing works

Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons

Fan, Z., Zhu, P., Wu, J., Wu, J., 朱潇潇, Zhu, X., Wang, Y., Xiong, Z., Fan, D., Guo, H., et al. (2022) · Cell Research · doi:10.1038/s41422-022-00645-7 · Cited by 134 · see citing works

Brain-spleen axis in health and diseases: A review and future perspective

Wei, Y., Wang, T., Liao, L., Fan, X., Chang, L., & Hashimoto, K. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.02.008 · Cited by 134 · see citing works

Aging microglia

Antignano, I., Liu, Y., Offermann, N., & Capasso, M. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04775-y · Cited by 117 · see citing works

Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications

Ortega, M. A., Álvarez-Mon, M. Á., Montero, C. G., Fraile‐Μartinez, O., Guijarro, L. G., Lahera, G., Monserrat, J., Valls, P., Mora, F., Rodríguez–Jiménez, R., et al. (2022) · Metabolites · doi:10.3390/metabo12010050 · Cited by 125 · see citing works

Blood–Brain Barrier Dysfunction in the Pathogenesis of Major Depressive Disorder

Wu, S., Yin, Y., & Du, L. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01153-9 · Cited by 126 · see citing works

Effects of ultra-processed foods on the microbiota-gut-brain axis: The bread-and-butter issue

Song, Z., Song, R., Liu, Y., Wu, Z., & Zhang, X. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112730 · Cited by 132 · see citing works

Gut microbiota dysbiosis in functional gastrointestinal disorders: Underpinning the symptoms and pathophysiology

Wei, L., Singh, R., Ro, S., & Ghoshal, U. C. (2021) · JGH Open · doi:10.1002/jgh3.12528 · Cited by 127 · see citing works

Th17 cells and inflammation in neurological disorders: Possible mechanisms of action

Shi, Y., Wei, B., Li, L., Wang, B., & Sun, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.932152 · Cited by 108 · see citing works

High-cholesterol diet promotes depression- and anxiety-like behaviors in mice by impact gut microbe and neuroinflammation

Zou, L., Tian, Y., Wang, Y., Chen, D., Lu, X., Zeng, Z., Chen, Z., Lin, C., & Liang, Y. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.01.122 · Cited by 107 · see citing works

Effect of prebiotics, probiotics, synbiotics on depression: results from a meta-analysis

Zhang, Q., Chen, B., Zhang, J., Dong, J., Ma, J., Zhang, Y., Jin, K., & Lü, J. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04963-x · Cited by 114 · see citing works

Role of short‐chain fatty acids in host physiology

Liu, M., Lu, Y., Xue, G., Han, L., Jia, H., Wang, Z., Zhang, J., Liu, P., Yang, C., & Zhou, Y. (2024) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12464 · Cited by 112 · see citing works

The Human Gut Microbiome as a Potential Factor in Autism Spectrum Disorder

Alharthi, A., Alhazmi, S., Alburae, N. A., & Bahieldin, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031363 · Cited by 121 · see citing works

Microbiota–gut–brain axis in neurodegenerative diseases: molecular mechanisms and therapeutic targets

Chen, C., Wang, G., Li, D., & Zhang, F. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00307-1 · Cited by 119 · see citing works

The Gut–Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology

Guo, Y., Chen, X., Gong, P., Li, G., Yao, W., & Yang, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044089 · Cited by 102 · see citing works

Impact of the Gut Microbiota Balance on the Health–Disease Relationship: The Importance of Consuming Probiotics and Prebiotics

Olvera-Rosales, L. B., Cruz-Guerrero, A. E., Ramírez‐Moreno, E., Lira, A. Q., Contreras‐López, E., Ordaz, J. J., Ovando, A. C., Añorve‐Morga, J., Calderón‐Ramos, Z. G., Arias‐Rico, J., et al. (2021) · Foods · doi:10.3390/foods10061261 · Cited by 101 · see citing works

Gut Microbiota, an Additional Hallmark of Human Aging and Neurodegeneration

Molinero, N., Antón‐Fernández, A., Hernández, F., Ávila, J., Bartolomé, B., & Moreno-Arribas, M. V. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.02.014 · Cited by 96 · see citing works

Interactions between the microbiota and enteric nervous system during gut-brain disorders

Fried, S. G., Wemelle, E., Cani, P. D., & Knauf, C. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108721 · Cited by 90 · see citing works

Role of gut microbiota-derived signals in the regulation of gastrointestinal motility

Zheng, Z., Tang, J., Hu, Y., & Zhang, W. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.961703 · Cited by 91 · see citing works

Probiotic Clostridium butyricum ameliorates cognitive impairment in obesity via the microbiota-gut-brain axis

Zheng, M., Ye, H., Yang, X., Shen, L., Dang, X., Liu, X., Gong, Y., Wu, Q., Wang, L., Ge, X., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.11.016 · Cited by 89 · see citing works

Dermal injury drives a skin to gut axis that disrupts the intestinal microbiome and intestinal immune homeostasis in mice

Dokoshi, T., Chen, Y., Cavagnero, K. J., Rahman, G., Hakim, D., Brinton, S. L., Schwarz, H., Brown, E. A. R., O’Neill, A., Nakamura, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47072-3 · Cited by 83 · see citing works

The Power of Psychobiotics in Depression: A Modern Approach through the Microbiota–Gut–Brain Axis: A Literature Review

Dziedzic, A., Maciak, K., Bliźniewska-Kowalska, K. M., Gałecka, M., Kobierecka, W., & Saluk, J. (2024) · Nutrients · doi:10.3390/nu16071054 · Cited by 89 · see citing works

Vagus nerve stimulation and gut microbiota interactions: A novel therapeutic avenue for neuropsychiatric disorders

Faraji, N., Payami, B., Ebadpour, N., & Gorji, A. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105990 · Cited by 86 · see citing works

Applications of human organoids in the personalized treatment for digestive diseases

Wang, Q., Guo, F., Jin, Y., & Ma, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01194-6 · Cited by 81 · see citing works

Humid heat environment causes anxiety-like disorder via impairing gut microbiota and bile acid metabolism in mice

Weng, H., Deng, L., Wang, T., Xu, H., Wu, J., Zhou, Q., Yu, L., Chen, B., Huang, L., Qu, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49972-w · Cited by 79 · see citing works

Enteric Microbiota-Mediated Serotonergic Signaling in Pathogenesis of Irritable Bowel Syndrome

Mishima, Y., & Ishihara, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910235 · Cited by 77 · see citing works

Microbiome Gut-Brain-Axis: Impact on Brain Development and Mental Health

Ramadan, Y. N., Alqifari, S. F., Alshehri, K., Alhowiti, A., Mirghani, H. O., Alrasheed, T., Aljohani, F., Alghamdi, A. M., & Hetta, ‏. F. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04846-0 · Cited by 90 · see citing works

Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines

Fu, X., Wang, Y., Zhao, F., Cui, R., Xie, W., Liu, Q., & Yang, W. (2023) · Aging · doi:10.18632/aging.204847 · Cited by 76 · see citing works

Lactobacillus rhamnosus GG colonization in early life regulates gut-brain axis and relieves anxiety-like behavior in adulthood

Zhou, B., Jin, G., Pang, X., Mo, Q., Bao, J., Liu, T., Wu, J., Xie, R., Liu, X., Liu, J., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106090 · Cited by 77 · see citing works

Lactobacillus plantarum CCFM405 against Rotenone-Induced Parkinson’s Disease Mice via Regulating Gut Microbiota and Branched-Chain Amino Acids Biosynthesis

Chu, C., Yu, L., Li, Y. H., Guo, H., Zhai, Q., Chen, W., & Tian, F. (2023) · Nutrients · doi:10.3390/nu15071737 · Cited by 71 · see citing works

Sleep Deprivation and Gut Microbiota Dysbiosis: Current Understandings and Implications

Sun, J., Fang, D., Wang, Z., & Liu, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119603 · Cited by 79 · see citing works

Low FODMAP diet reduces gastrointestinal symptoms in irritable bowel syndrome and clinical response could be predicted by symptom severity: A randomized crossover trial

Algera, J. P., Demir, D., Törnblom, H., Nybacka, S., Simrén, M., & Störsrud, S. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.11.001 · Cited by 70 · see citing works

Gastrointestinal Microbiome and Neurologic Injury

Panther, E. J., Dodd, W., Clark, A., & Lucke-Wold, B. P. (2022) · Biomedicines · doi:10.3390/biomedicines10020500 · Cited by 71 · see citing works

Prebiotics modulate the microbiota-gut-brain axis and ameliorate anxiety and depression-like behavior in HFD-fed mice.

de Paiva, I. H. R., Maciel, L. M., da Silva, R. S., Mendonça, I. P., de Souza, J. D., & Peixoto, C. A. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114153 · Cited by 70 · see citing works

Stress and the gut-brain axis: an inflammatory perspective

Morys, J., Małecki, A., & Nowacka-Chmielewska, M. M. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1415567 · Cited by 77 · see citing works

Where Sex Meets Gender: How Sex and Gender Come Together to Cause Sex Differences in Mental Illness

Christiansen, D. M., McCarthy, M. M., & Seeman, M. V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.856436 · Cited by 65 · see citing works

Arginine-mediated gut microbiome remodeling promotes host pulmonary immune defense against nontuberculous mycobacterial infection

Kim, Y. J., Lee, J., Lee, J. J., Jeon, S. M., Silwal, P., Kim, I. S., Kim, H. J., Park, C. R., Chung, C., Han, J. E., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2073132 · Cited by 64 · see citing works

The Role of Short Chain Fatty Acids in Irritable Bowel Syndrome

Jiang, W., Wu, J., Zhu, S., Xin, L., Yu, C., & Shen, Z. (2022) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm22093 · Cited by 66 · see citing works

Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites

Zhang, W., Dong, X. Y., & Huang, R. (2022) · Translational Stroke Research · doi:10.1007/s12975-022-01096-3 · Cited by 66 · see citing works

Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease

Bello-Corral, L., Gomes, L., Fernández-Fernández, J. A., Fernández-García, D., Verdejo, I. C., & Sánchez-Valdeón, L. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122132 · Cited by 69 · see citing works

Alterations of the Composition and Neurometabolic Profile of Human Gut Microbiota in Major Depressive Disorder

Kovtun, A. S., Averina, O. V., Angelova, I. Y., Yunes, R. А., Zorkina, Y., Morozova, A. Y., Pavlichenko, A. V., Syunyakov, T., Karpenko, O., Kostyuk, G. P., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10092162 · Cited by 67 · see citing works

Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis

Layunta, E., Buey, B., Mesonero, J. E., & Latorre, E. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.748254 · Cited by 67 · see citing works

Enterochromaffin Cells–Gut Microbiota Crosstalk: Underpinning the Symptoms, Pathogenesis, and Pharmacotherapy in Disorders of Gut-Brain Interaction

Wei, L., Singh, R., & Ghoshal, U. C. (2022) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm22008 · Cited by 65 · see citing works

Redefining Roles: A Paradigm Shift in Tryptophan–Kynurenine Metabolism for Innovative Clinical Applications

Tanaka, M., Szabó, Á., & Vécsei, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312767 · Cited by 62 · see citing works

From bugs to brain: unravelling the GABA signalling networks in the brain–gut–microbiome axis

Belelli, D., Lambert, J. J., Wan, M. L. Y., Monteiro, A. R., Nutt, D., & Swinny, J. D. (2024) · Brain · doi:10.1093/brain/awae413 · Cited by 67 · see citing works

The Oral–Gut Microbiome–Brain Axis in Cognition

Adil, N. A., Omo-erigbe, C., Yadav, H., & Jain, S. (2025) · Microorganisms · doi:10.3390/microorganisms13040814 · Cited by 60 · see citing works

Disorders of Gut–Brain Interaction and the Rome V Process

Drossman, D. A., Chang, L., & Tack, J. F. (2026) · Gastroenterology · doi:10.1053/j.gastro.2026.02.014 · Cited by 69 · see citing works

Exploring the Potential of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 as Promising Psychobiotics Using SHIME

de Oliveira, F. L., Salgaço, M. K., de Oliveira, M. T., Mesa, V., Sartoratto, A., da Silva, A. M. P., Ramos, W. S., & Sivieri, K. (2023) · Nutrients · doi:10.3390/nu15061521 · Cited by 57 · see citing works

Podophyllotoxin-mediated neurotoxicity via the microbiota-gut-brain axis in SD rats based on the toxicological evidence chain (TEC) concept

Duan, J., Sun, J., Jiang, T., Ma, X., Li, X., Wang, Y., Zhang, F., & Liu, C. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.168106 · Cited by 57 · see citing works

The microbiota-gut-brain-immune interface in the pathogenesis of neuroinflammatory diseases: a narrative review of the emerging literature

Warren, A., Nyavor, Y., Zarabian, N., Mahoney, A., & Frame, L. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1365673 · Cited by 62 · see citing works

Interactions Between Antidepressants and Intestinal Microbiota

Xu, F., Xie, Q., Kuang, W., & Dong, Z. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01362-8 · Cited by 58 · see citing works

The Regulatory effect of chlorogenic acid on gut-brain function and its mechanism: A systematic review

Zeng, L., Xiang, R., Fu, C.-Y., Qu, Z., & Liu, C. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112831 · Cited by 54 · see citing works

Efficacy of Bifidobacterium animalis subsp. lactis BL-99 in the treatment of functional dyspepsia: a randomized placebo-controlled clinical trial

Zhang, Q., Li, G., Zhao, W., Zhou, L., Zhang, X., He, J., Zhang, X., Liu, Y., Zhang, C., Zhang, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44292-x · Cited by 54 · see citing works

Fecal microbiota transplantation improves VPA-induced ASD mice by modulating the serotonergic and glutamatergic synapse signaling pathways

Wang, J., Cao, Y., Hou, W., Bi, D., Yin, F., Gao, Y., Huang, D., Li, Y., Cao, Z., Yan, Y., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02307-7 · Cited by 53 · see citing works

Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review

Alamoudi, M. U. A., Hosie, S., Shindler, A. E., Wood, J. L., Franks, A. E., & Hill‐Yardin, E. L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.905841 · Cited by 52 · see citing works

Emerging therapeutic role of gut microbial extracellular vesicles in neurological disorders

Sun, B., Sawant, H., Borthakur, A., & Bihl, J. C. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1241418 · Cited by 52 · see citing works

A gut sense for a microbial pattern regulates feeding

Liu, W. W., Reicher, N., Alway, E., Rupprecht, L. E., Weng, P., Schaefgen, C., Klein, M. E., Villalobos, J. A., Puerto-Hernández, C., Altún, Y. G. K., et al. (2025) · Nature · doi:10.1038/s41586-025-09301-7 · Cited by 52 · see citing works

Organ cross-talk: molecular mechanisms, biological functions, and therapeutic interventions for diseases

Che, H., Gao, Y., Xu, Y., Xu, H., Eils, R., & Tian, M. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02329-1 · Cited by 55 · see citing works

Functional constipation and the effect of prebiotics on the gut microbiota: a review

Erhardt, R., Harnett, J., Steels, E., & Steadman, K. J. (2022) · British Journal Of Nutrition · doi:10.1017/s0007114522003853 · Cited by 51 · see citing works

Corylin ameliorates chronic ulcerative colitis via regulating the gut–brain axis and promoting 5-hydroxytryptophan production in the colon

Wang, Z.-J., Chen, L., Xu, J. B., Xu, Q., Xu, W., & Yang, X. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154651 · Cited by 51 · see citing works

Inflammatory Bowel Disease and Neurodegenerative Diseases

Kim, J. S., Chen, M., Wang, H. E., Lu, C., Wang, Y., & Zhang, B. (2023) · Gut and Liver · doi:10.5009/gnl220523 · Cited by 53 · see citing works

The Impact of Smoking on Microbiota: A Narrative Review

Cicchinelli, S., Rosa, F., Manca, F., Zanza, C., Ojetti, V., Covino, M., Candelli, M., Gasbarrini, A., Franceschi, F., & Piccioni, A. (2023) · Biomedicines · doi:10.3390/biomedicines11041144 · Cited by 51 · see citing works

Beyond the Microbiota: Understanding the Role of the Enteric Nervous System in Parkinson’s Disease from Mice to Human

Montanari, M., Imbriani, P., Bonsi, P., Martella, G., & Peppe, A. (2023) · Biomedicines · doi:10.3390/biomedicines11061560 · Cited by 49 · see citing works

Th17 Cells and IL-17A in Ischemic Stroke

Wang, J., Gao, Y., Yuan, Y., Wang, H., Wang, Z., & Zhang, X. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03723-y · Cited by 53 · see citing works

Microbiota Implications in Endocrine-Related Diseases: From Development to Novel Therapeutic Approaches

Clemente‐Suárez, V. J., Redondo-Flórez, L., Rubio-Zarapuz, A., Martín-Rodríguez, A., & Tornero-Aguilera, J. F. (2024) · Biomedicines · doi:10.3390/biomedicines12010221 · Cited by 57 · see citing works

Microbiota from healthy mice alleviates cognitive decline via reshaping the gut-brain metabolic axis in diabetic mice

Zhao, Q., Chen, J., Wu, M., Yin, X., Jiang, Q., Gao, H., & Zheng, H. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110638 · Cited by 49 · see citing works

Gastrointestinal symptoms in COVID-19: the long and the short of it

Freedberg, D. E., & Chang, L. (2022) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000876 · Cited by 51 · see citing works

BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis.

Matin, S., & Dadkhah, M. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.110882 · Cited by 44 · see citing works

Zuojin pill improves chronic unpredictable stress-induced depression-like behavior and gastrointestinal dysfunction in mice via the theTPH2/5-HT pathway

Wang, Y., Huang, Y., Zhao, M., Yang, L., Su, K., Wu, H., Wang, Y., Chang, Q., & Liu, W. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155067 · Cited by 48 · see citing works

Effect of fecal microbiota transplantation on patients with sporadic amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled trial

Feng, R., Zhu, Q., Wang, A., Wang, H., Wang, J., Chen, P., Zhang, R., Liang, D., Teng, J., Ma, M., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03781-6 · Cited by 49 · see citing works

The Molecular Gut-Brain Axis in Early Brain Development

Muhammad, F., Fan, B., Wang, R., Ren, J., Jia, S., Wang, L., Chen, Z., & Liu, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315389 · Cited by 47 · see citing works

Decoding the neurocircuitry of gut feelings: Region-specific microbiome-mediated brain alterations

Sharvin, B. L., Aburto, M. R., & Cryan, J. F. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106033 · Cited by 49 · see citing works

Clinical Effects of Faecal Microbiota Transplantation as Adjunctive Therapy in Dogs with Chronic Enteropathies—A Retrospective Case Series of 41 Dogs

Toresson, L., Spillmann, T., Pilla, R., Ludvigsson, U., Hellgren, J., Ölmedal, G., & Suchodolski, J. S. (2023) · Veterinary Sciences · doi:10.3390/vetsci10040271 · Cited by 47 · see citing works

Neurotransmitter signaling: a new frontier in colorectal cancer biology and treatment

Battaglin, F., Jayachandran, P., Strelez, C., Lenz, A. M., Algaze, S. D., Soni, S., Lo, J. H., Yang, Y., Millstein, J., Zhang, W., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02479-4 · Cited by 46 · see citing works

Dietary Polysaccharides Exert Anti-Fatigue Functions via the Gut-Muscle Axis: Advances and Prospectives

Zhou, Y., Chu, Z., Luo, Y., Yang, F., Cao, F., Luo, F., & Lin, Q. (2023) · Foods · doi:10.3390/foods12163083 · Cited by 46 · see citing works

Small molecules in the big picture of gut microbiome-host cross-talk

Ma, Y., Liu, X., & Wang, J. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104085 · Cited by 46 · see citing works

Periodontitis salivary microbiota exacerbates colitis-induced anxiety-like behavior via gut microbiota

Qian, J., Lu, J., Cheng, S., Zou, X., Tao, Q., Wang, M., Wang, N., Zheng, L., Liao, W., Li, Y., et al. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00462-9 · Cited by 45 · see citing works

Neuro-Nutrition and Exercise Synergy: Exploring the Bioengineering of Cognitive Enhancement and Mental Health Optimization

Clemente‐Suárez, V. J., Martín-Rodríguez, A., Curiel-Regueros, A., Rubio-Zarapuz, A., & Tornero-Aguilera, J. F. (2025) · Bioengineering · doi:10.3390/bioengineering12020208 · Cited by 47 · see citing works

Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis

Layunta, E., Buey, B., Mesonero, J. E., & Latorre, E. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.748254 · Cited by 67 · see citing works

Brain-gut-microbe communication in health and disease

Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952 · see citing works

The role of gut-brain axis in mood disorder

Sallem, C. C., Filho, L. B. D. A., da Costa, R. I., Lima, M. P. P., Pimentel, I. D. S., de Figueirêdo, L. R. B., Lima, N. M. P., Galvão, S. L., de Lima, G. M. D. S., Gomes, G. F., et al. (2022) · Journal of Neurology & Stroke · doi:10.15406/jnsk.2022.12.00516 · Cited by 4 · see citing works

Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis

Baj, A., Moro, E., Bistoletti, M., Orlandi, V. T., Crema, F., & Giaroni, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061482 · Cited by 330 · see citing works

Microbiota intestinal y eje intestino-cerebro: una revisión de su interacción con el sistema nervioso central

Cardenas, V. M., & Miranda, V. R. M. (2025) · Nutrición clínica y dietética hospitalaria/Nutrición clínica, dietética hospitalaria · doi:10.12873/1087martinez