The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Oxytocin Modulates Female Sociosexual Behavior through a Specific Class of Prefrontal Cortical Interneurons
Open accessAbstract
Human imaging studies have revealed that intranasal administration of the "prosocial" hormone oxytocin (OT) activates the frontal cortex, and this action of OT correlates with enhanced brain function in autism. Here, we report the discovery of a population of somatostatin (Sst)-positive, regular spiking interneurons that express the oxytocin receptor (OxtrINs). Silencing of OxtrINs in the medial prefrontal cortex (mPFC) of female mice resulted in loss of social interest in male mice specifically during the sexually receptive phase of the estrous cycle. This sociosexual deficit was also present in mice in which the Oxtr gene was conditionally deleted from the mPFC and in control mice infused with an Oxtr antagonist. Our data demonstrate a gender-, cell type-, and state-specific role for OT/Oxtr signaling in the mPFC and identify a latent cortical circuit element that may modulate other complex social behaviors in response to OT.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Cortical oxytocin receptors are found primarily on parvalbumin-positive or somatostatin-positive inhibitory interneurons”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Nakajima et al. 2014
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“a small subpopulation of Sst neurons in prefrontal cortex express oxytocin receptors, and this expression is critical to the modulation of sociosexual behavior by this hormone (Nakajima et al., 2014).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Nakajima et al., 2014
In the citing paper
“For example, sex-specific differences in the effects of activating OXT receptor positive mPFC interneurons have been reported with activation inducing anxiety in males, but promoting social behavior in females [68,69].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [68]
In the citing paper
“Oxytocin is involved not only in homeostatic regulation of reflexes such as parturition and lactation, but it is crucial part of other aspects of motherhood such as care and protection of the offspring (Marlin et al., 2015; Nakajima et al., 2014; Sabihi et al., 2014).”
From Neuromodulation of maternal circuits by oxytocin (2019) · cites this paper as Nakajima et al., 2014
In the citing paper
“Oxytocin is involved not only in homeostatic regulation of reflexes such as parturition and lactation, but it is crucial part of other aspects of motherhood such as care and protection of the offspring (Marlin et al., 2015; Nakajima et al., 2014; Sabihi et al., 2014).”
From Neuromodulation of maternal circuits by oxytocin (2019) · cites this paper as Nakajima et al., 2014
In the citing paper
“OT regulates neuronal activities in multiple neural circuits, such as sensory cortices (Marlin et al., 2015), nucleus accumbens (Dölen et al., 2013), and prefrontal cortex (Nakajima et al., 2014).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Nakajima et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90076-5 · Cited by 9,150
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768
Neocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Self-citationZăgrean, L. (2014) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2014.529 · Cited by 1,922
A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsani, D., Fu, Y., Lu, J., Lin, Y., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.026 · Cited by 1,828
How Inhibition Shapes Cortical Activity
Isaacson, J. S., & Scanziani, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.027 · Cited by 1,678
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645
Cited by
Sorted by citations
Items 101–200 of 262
Neural circuit control of innate behaviors
Wei, X., Jiao, Z., Senol, E., Yao, J., Zhao, M., Zhao, Z., Chen, X., Cao, P., Fu, Y., Gao, Z., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-2043-2 · Cited by 40
Chen, D., Zhao, J.-H., Wang, H., An, N., Zhou, Y., Fan, J., Luo, J., Su, W., Liu, C., & Li, J. (2015) · Scientific Reports · doi:10.1038/srep11731 · Cited by 37
The Expanding Toolkit of Translating Ribosome Affinity Purification
Dougherty, J. D. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1929-17.2017 · Cited by 37
Finger, E. C., Berry, S. M., Cummings, J. L., Coleman, K. K. L., Hsiung, G. R., Feldman, H., & Boxer, A. L. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0427-2 · Cited by 38
Yang, Y., Zhang, Y., Luo, F., & Li, B. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.01.003 · Cited by 38
The Value in Science-Art Partnerships for Science Education and Science Communication
Zaelzer, C. A. (2020) · eNeuro · doi:10.1523/eneuro.0238-20.2020 · Cited by 45
Oxytocin reduces cocaine cued fos activation in a regionally specific manner
Leong, K.-C., Freeman, L. R., Berini, C., Ghee, S. M., See, R. E., & Reichel, C. M. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx058 · Cited by 37
Intranasal Neuropeptide Administration To Target the Human Brain in Health and Disease
Spetter, M. S., & Hallschmid, M. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00047 · Cited by 35
Yaseen, A., Shrivastava, K., Zuri, Z., Hatoum, O. A., & Maroun, M. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy070 · Cited by 35
Effects of oxytocin on methamphetamine-seeking exacerbated by predator odor pre-exposure in rats
Ferland‐Beckham, C., Reichel, C. M., & McGinty, J. F. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4184-7 · Cited by 34
Albin-Brooks, C., Nealer, C., Sabihi, S., Haim, A., & Leuner, B. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.12.015 · Cited by 36
Wang, X., Ding, R., Song, Y., Wang, J., Zhang, C., Han, S., Han, J., & Zhang, R. (2020) · Neural Plasticity · doi:10.1155/2020/8832694 · Cited by 34
Jurek, B., & Meyer, M. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00186 · Cited by 33
Huang, L., Duan, C., Xia, X., Wang, H., Wang, Y., Zhong, Z., Wang, B., Ding, W., & Yang, Y. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.12.001 · Cited by 32
Sexual Dimorphism of Parental Care: From Genes to Behavior
Zilkha, N., Scott, N., & Kimchi, T. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031447 · Cited by 33
Linden, J. R., Flores, C., Schmidt, E. F., Uzal, F. A., Michel, A. O., Valenzuela, M., Dobrow, S. S., & Vartanian, T. K. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008014 · Cited by 33
Lessons from the canine Oxtr gene: populations, variants and functional aspects
Bence, M., Marx, P., Szántai, E., Kubinyi, E., Rónai, Z., & Bánlaki, Z. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12356 · Cited by 32
Morphofunctional Alterations of the Hypothalamus and Social Behavior in Autism Spectrum Disorders
Carìa, A., Ciringione, L., & de Falco, S. (2020) · Brain Sciences · doi:10.3390/brainsci10070435 · Cited by 31
Oxytocin and Fear Memory Extinction: Possible Implications for the Therapy of Fear Disorders?
Baldi, E., Costa, A., Rani, B., Passani, M. B., Blandina, P., Romano, A., & Provensi, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810000 · Cited by 35
Kupferschmidt, D. A., Cummings, K. A., Joffe, M. E., MacAskill, A. F., Malik, R., Sánchez-Bellot, C., Tejeda, H. A., & Yarur, H. E. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1136-22.2022 · Cited by 28
Future Targets for Female Sexual Dysfunction
Farmer, M. A., Yoon, H., & Goldstein, I. (2016) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.05.016 · Cited by 28
Runyan, A. M., Lengel, D., Huh, J. W., Barson, J. R., & Raghupathi, R. (2021) · eNeuro · doi:10.1523/eneuro.0061-21.2021 · Cited by 27
The Role of Oxytocin in Early-Life-Stress-Related Neuropsychiatric Disorders
Jin, Y., Song, D. F., Yan, Y., Quan, Z., & Qing, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310430 · Cited by 30
Oxytocin receptor behavioral effects and cell types in the bed nucleus of the stria terminalis
Luo, P. X., Zakharenkov, H. C., Torres, L. Y., Rios, R. A., Gegenhuber, B., Black, A. M., Xu, C. K., Minie, V. A., Tran, A. M., Tollkuhn, J., et al. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105203 · Cited by 27
Pan, G., Yang, J.-M., Hu, X.-Y., & Li, X.-M. (2016) · Scientific Reports · doi:10.1038/srep28137 · Cited by 30
Acute and Repeated Intranasal Oxytocin Differentially Modulate Brain-wide Functional Connectivity
Pagani, M., Felice, A. D., Montani, C., Galbusera, A., Papaleo, F., & Gozzi, A. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2019.12.036 · Cited by 27
Amygdala neural ensemble mediates mouse social investigation behaviors
Wei, J., Han, Q., Luo, Z., Liu, L., Cui, J., Tan, J., Chow, B., So, K., & Zhang, L. (2022) · National Science Review · doi:10.1093/nsr/nwac179 · Cited by 26
Karlsson, S. A., Studer, E., Kettunen, P., & Westberg, L. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00041 · Cited by 26
Mechanisms for the Approach/Avoidance Decision Applied to Autism
Pfaff, D., & Barbas, H. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.05.002 · Cited by 26
Hodges, T. E., Eltahir, A. M., Patel, S. D., Bredewold, R., Veenema, A. H., & McCormick, C. M. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.104579 · Cited by 28
Oxytocin modulates hemodynamic responses to monetary incentives in humans
Mickey, B. J., Heffernan, J., Heisel, C. J., Peciña, M., Hsu, D. T., Zubieta, J.-K., & Love, T. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4423-6 · Cited by 24
Río, R. T.-D., van den Burg, E. H., Stoop, R., & Hegoburu, C. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5030-5 · Cited by 26
Agarwalla, S., De, A., & Bandyopadhyay, S. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2353-22.2023 · Cited by 24
Sex-Specific Differences in Oxytocin Receptor Expression and Function for Parental Behavior
Mitre, M., Kranz, T. M., Marlin, B. J., Schiavo, J. K., Erdjument‐Bromage, H., Zhang, X., Minder, J. L., Neubert, T. A., Hackett, T. A., Chao, M. V., et al. (2017) · Gender and the Genome · doi:10.1089/gg.2017.0017 · Cited by 22
Crane, J. W., Holmes, N. M., Fam, J. P., Westbrook, R. F., & Delaney, A. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00571.2019 · Cited by 24
Shedding Light on Social Reward Circuitry: (Un)common Blueprints in Humans and Rodents
Grimm, C., Balsters, J. H., & Zerbi, V. (2020) · The Neuroscientist · doi:10.1177/1073858420923552 · Cited by 26
Small ubiquitin‐like modifier 2 (SUMO2) is critical for memory processes in mice
Yu, S., Galeffi, F., Rodriguiz, R. M., Wang, Z., Shen, Y., Lyu, J., Li, R., Bernstock, J. D., Johnson, K. R., Liu, S., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000850rr · Cited by 23
Tripp, J. A., Feng, N. Y., & Bass, A. H. (2018) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2017.2742 · Cited by 23
Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala
Francesconi, W., Berton, F., Olivera-Pasilio, V., & Dabrowska, J. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108601 · Cited by 22
The Microtubule Regulator NEK7 Coordinates the Wiring of Cortical Parvalbumin Interneurons
Hinojosa, A. J., Deogracias, R., & Rico, B. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.115 · Cited by 22
Brainwide input-output architecture of paraventricular oxytocin and vasopressin neuronsPreprint
Freda, S. N., Priest, M. F., Badong, D., Xiao, L., Liu, Y., & Kozorovitskiy, Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.17.476652 · Cited by 22
Candidate Biological Markers for Social Anxiety Disorder: A Systematic Review
Caldiroli, A., Capuzzi, E., Affaticati, L. M., Surace, T., Forti, C. L. D., Dakanalis, A., Clerici, M., & Buoli, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010835 · Cited by 27
Ketchesin, K. D., Huang, N. S., & Seasholtz, A. F. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00090 · Cited by 22
Clinical potential of oxytocin in autism spectrum disorder: current issues and future perspectives
Benner, S., & Yamasue, H. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000341 · Cited by 19
Gigliucci, V., Busnelli, M., Santini, F., Paolini, C., Bertoni, A., Schaller, F., Muscatelli, F., & Chini, B. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1026939 · Cited by 20
Chen, W., Man, X., Zhang, Y., Yao, G., & Chen, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-32351-8 · Cited by 19
Ebbesen, C. L., Bobrov, E., Rao, R. P., & Brecht, M. (2019) · Nature Communications · doi:10.1038/s41467-019-12511-z · Cited by 17
Inoue, Y., Miwa, H., Hori, K., Kaneko, R., Morimoto, Y., Koike, E., Asami, J., Kamijo, S., Yamada, M., Hoshino, M., et al. (2022) · eNeuro · doi:10.1523/eneuro.0423-21.2022 · Cited by 18
Hearing, touching, and multisensory integration during mate choice
Lenschow, C., Mendes, A. R. P., & Lima, S. Q. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.943888 · Cited by 17
Riad, M. H., Park, K., Ibáñez-Tallon, I., & Heintz, N. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2211454119 · Cited by 18
Self-citationDorofeikova, M., Borkar, C. D., Weissmuller, K., Smith-Osborne, L., Basavanhalli, S., Bean, E., Smith, A., Duong, A., Resendez, A., & Fadok, J. P. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281388 · Cited by 17
Froemke, R. C., & Carcea, I. (2017) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-12-803506-1.00037-1 · Cited by 20
Oxytocin-Sensitive Neurons in Prefrontal Cortex Gate Social Recognition Memory
Raam, T. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1348-19.2019 · Cited by 16
Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases
Cui, X., & Xiao, L. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01424-1 · Cited by 17
Prefrontal Cortical Control of Anxiety: Recent Advances
Mack, N. R., Deng, S., Yang, S.-S., Shu, Y., & Gao, W. (2022) · The Neuroscientist · doi:10.1177/10738584211069071 · Cited by 15
Light disrupts social memory via a retina‐to‐supraoptic nucleus circuit
Huang, Y., Liao, P., Yu, J., & Chen, S. (2023) · EMBO Reports · doi:10.15252/embr.202356839 · Cited by 14
Tasaka, G., Hagihara, M., Irie, S., Kobayashi, H., Inada, K., Kobayashi, K., Kato, S., Kobayashi, K., & Miyamichi, K. (2025) · Science Advances · doi:10.1126/sciadv.adr4620 · Cited by 14
Paletta, P., Bass, N., Kavaliers, M., & Choleris, E. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0058 · Cited by 15
Prefrontal cortical circuits in social behaviors: an overview
Cao, W., Li, H., & Luo, J. (2024) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2300743 · Cited by 14
Integrating reproductive states and social cues in the control of sociosexual behaviors
Wang, Y., Song, X., Chen, X., Zhou, Y., Ma, J., Zhang, F., Wei, L., Qi, G., Yadav, N., Miao, B., et al. (2025) · Cell · doi:10.1016/j.cell.2025.04.035 · Cited by 17
Self-citationGABA in the medial prefrontal cortex regulates anxiety-like behavior during the postpartum period
Sabihi, S., Goodpaster, C. M., Maurer, S., & Leuner, B. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112967 · Cited by 14
Oxytocin Regulates Synaptic Transmission in the Sensory Cortices in a Developmentally Dynamic Manner
Zhang, J., Li, S.-J., Miao, W., Zhang, X., Zheng, J.-J., Wang, C., & Yu, X. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.673439 · Cited by 12
Talpo, F., Spaiardi, P., Castagno, A. N., Maniezzi, C., Raffin, F., Terribile, G., Sancini, G., Pisani, A., & Biella, G. R. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1082010 · Cited by 15
Jung, T., Jang, M., & Noh, J. (2021) · Experimental Neurobiology · doi:10.5607/en20038 · Cited by 12
Oxytocin modulation in the medial prefrontal cortex of pair-exposed rats during fear conditioning
Jang, M., Jung, T., Jeong, Y., Byun, Y., & Noh, J. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105752 · Cited by 13
Li, H., Li, Y., Wang, T., Li, S., Liu, H., Ning, S., Shen, W., Zhao, Z., & Wu, H. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01296-x · Cited by 12
Oxytocin signaling regulates maternally directed behavior during early life
Zelmanoff, D. D., Bornstein, R., Kaufman, M., Dine, J., Wietek, J., Litvin, A., Abraham, S., Cohen, S., Atzmon, A., Porat, I., et al. (2025) · Science · doi:10.1126/science.ado5609 · Cited by 13
Liu, X., Cui, D., Li, D., Jiao, R., Wang, X., Jia, S., Hou, D., Li, T., Liu, H., Wang, P., et al. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00327 · Cited by 12
Raymond, J. S., Rehn, S., James, M. H., Everett, N. A., & Bowen, M. T. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00612-4 · Cited by 14
Cheong, R. Y., Tonetto, S., von Hörsten, S., & Petersén, Å. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104773 · Cited by 11
Oxytocin via oxytocin receptor excites neurons in the endopiriform nucleus of juvenile mice
Biggs, L. M., & Hammock, E. A. D. (2022) · Scientific Reports · doi:10.1038/s41598-022-15390-5 · Cited by 11
Dumais, K. M., & Veenema, A. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802114-9.00011-1 · Cited by 11
Tapias-Espinosa, C., Cañete, T., Sampedro-Viana, D., Brudek, T., Kaihøj, A., Oliveras, I., Tobeña, A., Aznar, S., & Fernández‐Teruel, A. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113547 · Cited by 10
Zebhauser, P. T., Macchia, A., Gold, E., Salcedo, S., Burum, B., Alonso‐Alonso, M., Gilbert, D. T., Pascual‐Leone, Á., & Brem, A. (2022) · Biomedicines · doi:10.3390/biomedicines10123230 · Cited by 9
Schimmer, S., Kania, A., Lefèvre, A., Afordakos, K., Wang, K.-Y., Lebedeva, J., Rozov, A. V., Raftogianni, A., Tiwari, R., Netser, S., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-68347-x · Cited by 11
Cupid’s quiver: Integrating sensory cues in rodent mating systems
Hoglen, N. E. G., & Manoli, D. S. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.944895 · Cited by 8
Sun, L., Chen, R., Bai, Y., Li, J., Wu, Q., Shen, Q., & Wang, X. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy265 · Cited by 8
Neuronal identity and cognitive control dynamics in the PFC
Nakajima, M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.08.014 · Cited by 8
Self-citationSocio-sexual processing in cortical circuits
Brecht, M., Lenschow, C., & Rao, R. P. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.04.003 · Cited by 8
Neuropeptides in control of left–right neural circuits
Kolber, B. J., Neugebauer, V., Thorn, C. A., Froemke, R. C., & Bakalkin, G. Y. (2026) · Trends in Neurosciences · doi:10.1016/j.tins.2025.12.003 · Cited by 9
Exogenous oxytocin increases gaze to humans in male cats
Hattori, M., Kinoshita, K., Saito, A., & Yamamoto, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-59161-w · Cited by 7
Potential role of oxytocin in the regulation of memories and treatment of memory disorders
Walia, V., Wal, P., Mishra, S., Agrawal, A., Kosey, S., & Patil, A. D. (2024) · Peptides · doi:10.1016/j.peptides.2024.171222 · Cited by 9
Kim, K., Hong, J. P., Cho, M. J., D, M. F. M., Mischoulon, D., Lee, D. W., Heo, J.-Y., & Jeon, H. J. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.11.050 · Cited by 7
Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons
George, K., Hoang, H., Tibbs, T., Nagaraja, R. Y., Li, G., Troyano‐Rodriguez, E., & Ahmad, M. (2024) · iScience · doi:10.1016/j.isci.2024.110047 · Cited by 7
Ito, W., Huang, H., Brayman, V. L., & Morozov, A. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12513 · Cited by 7
Borie, A. M., Dromard, Y., Chakraborty, P., Fontanaud, P., André, E. M., François, A., Colson, P. H., Muscatelli, F., Guillon, G., Desarménien, M. G., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101781 · Cited by 6
Neural control of sex differences in affiliative and prosocial behaviors
Mikulovic, S., & Lenschow, C. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106039 · Cited by 5
Evidence for the involvement of a fronto-striatal pathway in the processing of social reward
Lin, K., & Coutellier, L. D. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102834 · Cited by 6
Oxytocin lipidation expanding therapeutics for long-term reversal of autistic behaviors in rats
Li, H., Chen, Y., & Qiu, Y. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125299 · Cited by 5
The Relationship Between Oxytocin and Alcohol Dependence
Schimmer, J., Patwell, R., Küppers, S., & Grinevich, V. (2023) · Current topics in behavioral neurosciences · doi:10.1007/7854_2023_444 · Cited by 5
The yin and yang of cortical oxytocin
Liu, R. C. (2015) · Nature · doi:10.1038/nature14386 · Cited by 5
Faykoo-Martinez, M., Mooney, S. J., & Holmes, M. M. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00272 · Cited by 6
Complementary networks of cortical somatostatin interneurons enforce layer specific controlPreprint
Naka, A., Veit, J., Shababo, B., Chance, R. K., Risso, D., Stafford, D. A., Snyder, B. J., Egladyous, A., Chu, D., Sridharan, S., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/456574 · Cited by 6
Eyring, K. W., Liu, J., König, G. M., Hidema, S., Nishimori, K., Kostenis, E., & Tsien, R. W. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.07.082727 · Cited by 5
Yashima, J., & Sakamoto, T. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114706 · Cited by 4
Lateralized local circuit tuning in female mouse auditory cortex
Song, S. C., & Froemke, R. C. (2025) · Neuroscience Research · doi:10.1016/j.neures.2025.03.009 · Cited by 4
Mitsi, V., Ruiz, A., Polizu, C., Farzinpour, Z., Ramakrishnan, A., Serafini, R. A., Parise, E. M., Floodstrand, M., Sial, O. K., Gaspari, S., et al. (2024) · Molecular Pharmacology · doi:10.1124/molpharm.123.000753 · Cited by 5
Smith, C. J. W., Kingsbury, M. A., Dziabis, J. E., Hanamsagar, R. M., Malacon, K. E., Tran, J. N., Norris, H. A., Gulino, M., & Bilbo, S. D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.30.068924 · Cited by 4
Ensemble encoding of conditioned fear by prefrontal somatostatin interneuronsPreprint
Cummings, K. A., Bayshtok, S., Kenny, P. J., & Clem, R. L. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.18.452791 · Cited by 4
Tabaka, O., Lawal, S. A., Triana, R. D. R., Hou, M., Fraser, A., Gallagher, A., Ruiz, K. S. A., Marmarcz, M., Dickinson, M., Oliveira, M. M., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-09193-3 · Cited by 3
Metadata
- Authors
- Nakajima, M., Görlich, A., & Heintz, N.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Heintz, Nathaniel
- ORCID
- Heintz, Nathaniel
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 159
- Issue
- 2
- Pages
- 295-305
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4206218
- OpenAlex
- W2162459454
- Cited by
- 262
- References
- 80
- Citations by year
- 2026: 16 · 2025: 18 · 2024: 17 · 2023: 16 · 2022: 23 · 2021: 21 · 2020: 24 · 2019: 20 · 2018: 40 · 2017: 25 · 2016: 26 · 2015: 14 · 2014: 2
- FWCI
- 33.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of Mental Health (P50MH090963, MH090963)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, oxytocin receptor, medial prefrontal cortex, somatostatin interneurons, sociosexual behavior, female sexual behavior, estrous cycle, social behavior, conditional gene deletion, autism spectrum disorder
- MeSH terms
- Animals, Female, Interneurons, Male, Oxytocin, Sexual Behavior, Animal, Sex Characteristics, Social Behavior, Prefrontal Cortex, Receptors, Oxytocin, Estrous Cycle, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
