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Oxytocin Modulates Female Sociosexual Behavior through a Specific Class of Prefrontal Cortical Interneurons
Open accessAbstract
Human imaging studies have revealed that intranasal administration of the "prosocial" hormone oxytocin (OT) activates the frontal cortex, and this action of OT correlates with enhanced brain function in autism. Here, we report the discovery of a population of somatostatin (Sst)-positive, regular spiking interneurons that express the oxytocin receptor (OxtrINs). Silencing of OxtrINs in the medial prefrontal cortex (mPFC) of female mice resulted in loss of social interest in male mice specifically during the sexually receptive phase of the estrous cycle. This sociosexual deficit was also present in mice in which the Oxtr gene was conditionally deleted from the mPFC and in control mice infused with an Oxtr antagonist. Our data demonstrate a gender-, cell type-, and state-specific role for OT/Oxtr signaling in the mPFC and identify a latent cortical circuit element that may modulate other complex social behaviors in response to OT.
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In the citing paper
“Cortical oxytocin receptors are found primarily on parvalbumin-positive or somatostatin-positive inhibitory interneurons”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Nakajima et al. 2014
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In the citing paper
“a small subpopulation of Sst neurons in prefrontal cortex express oxytocin receptors, and this expression is critical to the modulation of sociosexual behavior by this hormone (Nakajima et al., 2014).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Nakajima et al., 2014
In the citing paper
“For example, sex-specific differences in the effects of activating OXT receptor positive mPFC interneurons have been reported with activation inducing anxiety in males, but promoting social behavior in females [68,69].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [68]
In the citing paper
“Oxytocin is involved not only in homeostatic regulation of reflexes such as parturition and lactation, but it is crucial part of other aspects of motherhood such as care and protection of the offspring (Marlin et al., 2015; Nakajima et al., 2014; Sabihi et al., 2014).”
From Neuromodulation of maternal circuits by oxytocin (2019) · cites this paper as Nakajima et al., 2014
In the citing paper
“Oxytocin is involved not only in homeostatic regulation of reflexes such as parturition and lactation, but it is crucial part of other aspects of motherhood such as care and protection of the offspring (Marlin et al., 2015; Nakajima et al., 2014; Sabihi et al., 2014).”
From Neuromodulation of maternal circuits by oxytocin (2019) · cites this paper as Nakajima et al., 2014
In the citing paper
“OT regulates neuronal activities in multiple neural circuits, such as sensory cortices (Marlin et al., 2015), nucleus accumbens (Dölen et al., 2013), and prefrontal cortex (Nakajima et al., 2014).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Nakajima et al., 2014
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Metadata
- Authors
- Nakajima, M., Görlich, A., & Heintz, N.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Heintz, Nathaniel
- ORCID
- Heintz, Nathaniel
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 159
- Issue
- 2
- Pages
- 295-305
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4206218
- OpenAlex
- W2162459454
- Cited by
- 262
- References
- 80
- Citations by year
- 2026: 16 · 2025: 18 · 2024: 17 · 2023: 16 · 2022: 23 · 2021: 21 · 2020: 24 · 2019: 20 · 2018: 40 · 2017: 25 · 2016: 26 · 2015: 14 · 2014: 2
- FWCI
- 33.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of Mental Health (P50MH090963, MH090963)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, oxytocin receptor, medial prefrontal cortex, somatostatin interneurons, sociosexual behavior, female sexual behavior, estrous cycle, social behavior, conditional gene deletion, autism spectrum disorder
- MeSH terms
- Animals, Female, Interneurons, Male, Oxytocin, Sexual Behavior, Animal, Sex Characteristics, Social Behavior, Prefrontal Cortex, Receptors, Oxytocin, Estrous Cycle, Mice
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