The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
lncRNA Directs Cooperative Epigenetic Regulation Downstream of Chemokine Signals
Open accessAbstract
Summary LncRNAs are known to regulate a number of different development and tumorigenic processes. Here we report a role for lncRNA BCAR4 in breast cancer metastasis that is mediated by chemokine-induced binding of BCAR4 to two transcription factors with extended regulatory consequences. BCAR4 binding of SNIP1 and PNUTS in response to CCL21 releases the SNIP1's inhibition of p300-dependent histone acetylation that in turn enables the BCAR4-recruited PNUTS to bind H3K18ac and relieve inhibition of RNA Pol II via activation of the PP1 phosphatase. This mechanism activates a noncanonical Hedgehog/GLI2 transcriptional program that promotes cell migration. BCAR4 expression correlates with advanced breast cancers and therapeutic delivery of Locked Nucleic Acids (LNAs) targeting BCAR4 strongly suppresses breast cancer metastasis in mouse models. The findings reveal a disease-relevant lncRNA mechanism consisting of both direct coordinated protein recruitment and indirect regulation of transcription factors.
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Cited by
The emerging role of lncRNAs in cancer
Huarte, M. (2015) · Nature Medicine · doi:10.1038/nm.3981 · Cited by 2,702
Linking Long Noncoding RNA Localization and Function
Chen, L.-L. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.07.003 · Cited by 1,052
Long Noncoding RNA in Cancer: Wiring Signaling Circuitry
Lin, C., & Yang, L. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.11.008 · Cited by 488
Self-citationLong noncoding RNAs in cancer: mechanisms of action and technological advancements
Bartonicek, N., Maag, J. L. V., & Dinger, M. E. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0530-6 · Cited by 459
A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression
Grelet, S., Link, L. A., Howley, B., Obellianne, C., Palanisamy, V., Gangaraju, V. K., Diehl, J. A., & Howe, P. H. (2017) · Nature Cell Biology · doi:10.1038/ncb3595 · Cited by 357
Metadata
- Authors
- Xing, Z., Lin, A., Li, C., Liang, K., Wang, S., Liu, Y., Park, P. K., Qin, L., Wei, Y., Hawke, D. H., Hung, M.-C., Lin, C., & Yang, L.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 159
- Issue
- 5
- Pages
- 1110-1125
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2000564844
- Cited by
- 447
- References
- 43
- FWCI
- 12.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xing, Z., Lin, A., Li, C., Liang, K., Wang, S., Liu, Y., Park, P. K., Qin, L., Wei, Y., Hawke, D. H., Hung, M.-C., Lin, C., & Yang, L. (2014). lncRNA Directs Cooperative Epigenetic Regulation Downstream of Chemokine Signals. Cell. https://doi.org/10.1016/j.cell.2014.10.013
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