The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis
Open accessAbstract
SUMMARY Type 2 innate lymphoid cells (ILC2s), an innate source of the type 2 cytokines interleukin (IL)-5 and -13, participate in the maintenance of tissue homeostasis. Although type 2 immunity is critically important for mediating metabolic adaptations to environmental cold, the functions of ILC2s in beige or brown fat development are poorly defined. We report here that activation of ILC2s by IL-33 is sufficient to promote the growth of functional beige fat in thermoneutral mice. Mechanistically, ILC2 activation results in the proliferation of bipotential adipocyte precursors (APs) and their subsequent commitment to the beige fat lineage. Loss- and gain-of-function studies reveal that ILC2-and eosinophil-derived type 2 cytokines stimulate signaling via the IL-4Rα in PDGFRα+ APs to promote beige fat biogenesis. Together, our results highlight a critical role for ILC2s and type 2 cytokines in the regulation of adipocyte precursor numbers and fate, and as a consequence, adipose tissue homeostasis.
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Cites
What we talk about when we talk about fat
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PRDM16 controls a brown fat/skeletal muscle switch
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Adipocytes as regulators of energy balance and glucose homeostasis
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“White adipose tissue (WAT) is a highly dynamic organ that responds to nutrient and environmental stress (Berry et al., 2014; Rosen and Spiegelman, 2006; Rosen and Spiegelman, 2014; Zeve et al., 2009).”
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Self-citationAdaptive thermogenesis in adipocytes: Is beige the new brown?
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“Browning of WAT has principally been studied in adult rodents after prolonged exposure to cold (Nedergaard and Cannon, 2014; Wu et al., 2013).”
Nonshivering thermogenesis and its adequate measurement in metabolic studies
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Cited by
Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529
Adipogenesis and metabolic health
Ghaben, A. L., & Scherer, P. E. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0093-z · Cited by 1,395
Adapting to obesity with adipose tissue inflammation
Reilly, S. M., & Saltiel, A. R. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.90 · Cited by 1,204
Type 2 immunity in tissue repair and fibrosis
Gieseck, R. L., Wilson, M. S., & Wynn, T. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.90 · Cited by 1,055
Metabolic Inflammation and Insulin Resistance in Obesity
Wu, H., & Ballantyne, C. M. (2020) · Circulation Research · doi:10.1161/circresaha.119.315896 · Cited by 1,059
Metadata
- Authors
- Lee, M.-W., Odegaard, J. I., Mukundan, L., Qiu, Y., Molofsky, A. B., Nussbaum, J. C., Yun, K., Locksley, R. M., & Chawla, A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 160
- Issue
- 1-2
- Pages
- 74-87
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2013739762
- Cited by
- 677
- References
- 9
- FWCI
- 28.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, M.-W., Odegaard, J. I., Mukundan, L., Qiu, Y., Molofsky, A. B., Nussbaum, J. C., Yun, K., Locksley, R. M., & Chawla, A. (2015). Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis. Cell. https://doi.org/10.1016/j.cell.2014.12.011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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