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Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat
Open accessAbstract
The primary task of white adipose tissue (WAT) is the storage of lipids. However, "beige" adipocytes also exist in WAT. Beige adipocytes burn fat and dissipate the energy as heat, but their abundance is diminished in obesity. Stimulating beige adipocyte development, or WAT browning, increases energy expenditure and holds potential for combating metabolic disease and obesity. Here, we report that insulin and leptin act together on hypothalamic neurons to promote WAT browning and weight loss. Deletion of the phosphatases PTP1B and TCPTP enhanced insulin and leptin signaling in proopiomelanocortin neurons and prevented diet-induced obesity by increasing WAT browning and energy expenditure. The coinfusion of insulin plus leptin into the CNS or the activation of proopiomelanocortin neurons also increased WAT browning and decreased adiposity. Our findings identify a homeostatic mechanism for coordinating the status of energy stores, as relayed by insulin and leptin, with the central control of WAT browning.
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“The actions of leptin and insulin in POMC neurons can also be triggered by a decrease in the hypothalamic levels of T‐cell protein tyrosine phosphatase (TCPTP), which is a negative regulator of insulin signaling, to further increase the browning of WAT and energy expenditure 108, 109.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [108]
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“Apart from its role in the regulation of food intake described above, leptin can increase energy expenditure by inducing BAT activation.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [108]
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Cites
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Identification and Importance of Brown Adipose Tissue in Adult Humans
Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399
Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,406
Functional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
Self-citationRole of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235
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Items 301–394 of 394
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Kim, J. W., Han, K. R., Kim, W., Jung, H. Y., Nam, S. M., Yoo, D. Y., Hwang, I. K., Seong, J. K., & Yoon, Y. S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00092 · Cited by 4
Effect of gastric bypass on BMI and lipid metabolism in type 2 diabetes mellitus
Zhang, C., Cai, W., Zhao, H., Zhu, M. J., Cui, J., & Sun, Z. (2020) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2020.1770263 · Cited by 5
A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunityPreprint
Liang, S., Tran, E., Du, X., Dong, J., Sudholz, H., Chen, H., Qu, Z., Huntington, N. D., Babon, J. J., Kershaw, N. J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.16.545220 · Cited by 5
Self-citationLoss of TC-PTP in keratinocytes leads to increased UVB-induced autophagy
Asare, O., Shim, L., Lee, C., Delgado, J., Quailes, N., Zavala, K., Park, J., Hafeez, B. B., Cho, Y., Chauhan, S. C., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02353-8 · Cited by 4
The potential role of hypothalamic POMCTRPM2 in interscapular BAT thermogenesis
Yang, J. H., Halanobis, A. B. B. I., Byeon, E.-H., Park, N. H., Park, S. W., Kim, H. J., Kang, D., Kim, D. R., Yang, J., Choe, E. S., et al. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01538-6 · Cited by 4
Central leptin pathways in metabolic homeostasis
Zhao, Y., Laule, C. F., & Rahmouni, K. (2025) · Clinical Science · doi:10.1042/cs20257748 · Cited by 5
Simka-Lampa, K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020754 · Cited by 4
Sadeghi, A., Nazarali, P., Alizadeh, R., Ceylan, H. İ., & Nobarı, H. (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01608-6 · Cited by 4
Seliem, E. M., Azab, M., Ismaila, R., & Nafeaa, A. (2022) · Benha Veterinary Medical Journal · doi:10.21608/bvmj.2021.98099.1473 · Cited by 4
Can Exercise-Mediated Adipose Browning Provide an Alternative Explanation for the Obesity Paradox?
Zhao, J., Li, X., Liang, C., & Yan, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051790 · Cited by 5
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Ramadan, B. K., Salama, A., & Meselhy, K. M. (2017) · Al-Azhar Medical Journal · doi:10.12816/0045174 · Cited by 4
Wang, L., Liu, Y., Hu, F., & Zhou, Z. (2022) · Nutrición Hospitalaria · doi:10.20960/nh.03852 · Cited by 5
Ma, H., He, C., Li, L., Gao, P., Lu, Z., Hu, Y., Wang, L., Zhao, Y., Cao, T., Cui, Y., et al. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01151-x · Cited by 6
HypothalamicHnscrregulates glucose balance by mediating central inflammation and insulin signal
Liu, Y., Guo, Y., Peng, H., Zhou, H., Su, T., Yang, M., Guo, Q., Ye, X., Huang, Y., & Jiang, T. (2022) · Cell Proliferation · doi:10.1111/cpr.13332 · Cited by 4
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González‐García, I., Milbank, E., Martínez-Ordóñez, A., Diéguez, C., López, M., & Contreras, C. (2019) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-019-00719-y · Cited by 5
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Gautron, L. (2015) · Endocrinology · doi:10.1210/en.2015-1735 · Cited by 4
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Bosque, A., Howard, J. N., Zaikos, T. D., Levinger, C., Rivera, E., McMahon, E. K., Sanz, M., Copertino, D. C., Wang, W., Soriano-Sarabia, N., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2869323/v1 · Cited by 4
Phan, C., & Wagner, E. J. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.11.038 · Cited by 3
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Diaz-Garrido, N., Zagmutt, S., Regaldiz, A., Cisternas, P., & Bastías-Pérez, M. (2026) · Nutrients · doi:10.3390/nu18030371 · Cited by 3
Ji, X., Zhang, X., Zhang, T., Yao, X., He, M., Li, C., Huang, Y. L., Wang, H., Ju, J., Cai, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61904-w · Cited by 4
Niu, X., Zhang, Y., Lai, Z., Huang, X., Gao, J., Lu, F., Chang, Q., & Yuan, Y. (2022) · Aesthetic Surgery Journal · doi:10.1093/asj/sjac105 · Cited by 3
CREB coactivator CRTC1 in melanocortin‐4 receptor‐expressing cells regulate dietary fat intake
Matsumura, S., Fujisawa, M., Fujiwara, M., Okayama, H., Marutani, M., Nousou, E., Sasaki, T., & Harada, N. (2024) · FASEB BioAdvances · doi:10.1096/fba.2024-00111 · Cited by 2
López-Sánchez, M., Mendoza-Mota, H., De‐la‐Cruz‐Martínez, L., Matadamas‐Martínez, F., Torres-Chacón, D. L., Martínez‐Arellano, R., Palacios‐Espinosa, J. F., Pérez‐Villanueva, J., González‐Andrade, M., Páez-Franco, J. C., et al. (2025) · ACS Bio & Med Chem Au · doi:10.1021/acsbiomedchemau.5c00164 · Cited by 2
Selective Vagotomy Worsens Glucose Control After Ileal Transposition
Chen, W., Xia, Z., Liu, W., He, X., & Zhang, W. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3192-1 · Cited by 2
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Saltiel, A. R. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.010 · Cited by 2
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Rønnekleiv, O. K., & Kelly, M. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813156-5.00015-7 · Cited by 2
Upregulation of hypothalamic POMC neurons after biliary diversion in GK rats
Zhou, S., Chen, W., Bai, X., Chen, J., Xu, Q., Dong, L., Chen, W., Qu, Q., & He, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.999928 · Cited by 2
Cardoso, E. L. D. S., Cahuê, F. L. C., Miranda, I. F., Sant’Anna, M. D. L., de Andrade, C. B. V., Barbosa, R. A. Q., Ortiga-Carvalho, T. M., Vaisman, M., & Salerno, V. P. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102099 · Cited by 2
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Ye, J. (2023) · Obesity Medicine · doi:10.1016/j.obmed.2023.100501 · Cited by 2
Tang, L., Lv, J., Zhang, X., Wang, C., & Wang, D. (2024) · Journal of Experimental Biology · doi:10.1242/jeb.249264 · Cited by 2
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Manni, A., & Quarde, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-49872-6_7 · Cited by 2
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Wang, F., Huynh, P. M., & An, Y. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230009 · Cited by 10
Plotkin, A. (2022) · Reinvention an International Journal of Undergraduate Research · doi:10.31273/reinvention.v15i1.707 · Cited by 2
Han, H., Li, Q., Wang, C., Liang, Z., Zhang, L., Zhang, S., Tian, M., Li, S., Liu, D., Yang, G., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.07.028 · Cited by 1
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Tang, Q., Pang, J., Zhang, J., Liu, Q., Li, J., Zhang, A., Xu, Y., Song, H., Zeng, H., Jing, X., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71575-w · Cited by 2
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Guo, J., Yu, P., 李陈康, 聂桂英, Xu, W., Chen, M., Li, L., Peng, T., & Xie, W. (2026) · Cell Biochemistry and Function · doi:10.1002/cbf.70229 · Cited by 1
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Vázquez‐Cuevas, F. G., Aguilar‐Roblero, R. A., Arellanes-Licea, E. D. C., Macotela, Y., Martínez, O. V., Villanueva, I., & Díaz‐Muñoz, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00006-7 · Cited by 1
Fitrianingrum, Y., Indarto, D., Kusumawati, R., & Suselo, Y. H. (2019) · IOP Conference Series Materials Science and Engineering · doi:10.1088/1757-899x/546/6/062007 · Cited by 1
Correlation of Leptin level with obesity.
Andleeb, J., Javaid, S., & Karim, R. A. (2020) · The Professional Medical Journal · doi:10.29309/tpmj/2020.27.06.3692 · Cited by 1
Dong, J., Miao, J., Miao, Y., Qu, Z., Zhang, S., Zhu, P., Wiede, F., Jassim, B. A., Bai, Y., Nguyen, Q. D., et al. (2023) · Angewandte Chemie · doi:10.1002/ange.202303818 · Cited by 1
Self-citationObesity: A Multi Perspective of Physiology and Neurobiology Energy Regulation
Meiliana, A., Dewi, N. M., & Wijaya, A. (2024) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v16i1.2840 · Cited by 1
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Aziz, N., Tripathi, T., Rawat, A., Panigrahy, U. P., Darshan, J. C., Sharma, M. C., & Wal, P. (2025) · Current Cardiology Reviews · doi:10.2174/011573403x337113250212093810 · Cited by 2
Habek, N., Ratko, M., Sedmak, D., Banovac, I., Crljen, V., Kordić, M., Radmilović, M. D., Škokić, S., Tkalčić, M., Mažuranić, A., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1569163 · Cited by 1
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Londoño-Lemos, M. E. (2017) · Revista Colombiana de Ciencias Químico Farmacéuticas · doi:10.15446/rcciquifa.v46n1.67293 · Cited by 1
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Singhal, S., & Hill, J. W. (2018) · Springer eBooks · doi:10.1007/978-3-319-89506-2_11 · Cited by 1
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Mangieri, L. R. (2018) · Digital Commons-TMC (Texas Medical Center) · Cited by 1
Yeger, H. (2015) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-015-0285-7
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Galoiu, S. A. (2015) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2015.262
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Tonks, N. K. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3649-6_1
Cadagan, D. (2016) · Journal of Diabetes Metabolic Disorders & Control · doi:10.15406/jdmdc.2016.03.00082
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Ledda, A. (2016) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
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Mulya, A., & Kirwan, J. P. (2016)
Gao, Y.-X., Li, J., Zhang, Z., Zhang, R., Pollock, A., & Sun, T. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/366419
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Henry, B. A., & Clarke, I. J. (2018) · Wiley eBooks · doi:10.1002/9781119391128.ch15
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Begdache, L. (2018) · Global Journal of Endocrinological Metabolism · doi:10.31031/gjem.2018.01.000521
Bolin, A. P. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2018.tde-13062018-151546
Genetic features of hormonal regulation of energy metabolism (literature review)
Sazonova, T., Khrystenko, O., & Fedota, O. (2019) · Actual problems of modern medicine · doi:10.26565/2617-409x-2019-4-02
Brown Adipose Tissue in Obesity and Diabetes
Alcalá, M., Herrero, L., Serra, D., & Viana, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-53370-0_4
Non-coding RNAs Related to Obesity
Holvoet, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-68844-8_2
Silke, J. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733218432.793575596
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Ding, J., Li, Y., & Shan, C. (2022) · Highlights in Science Engineering and Technology · doi:10.54097/hset.v8i.1113
Kartinah, N. T., Anggraini, S., Fadilah, F., & Rickie, R. (2022) · doi:10.22541/au.166981377.72943628/v1
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Guerrero, H. T., Carreto, R. J. R., Rodríguez-Cortés, Y. M., & Chavarría, A. (2023) · Medicina e Investigación Universidad Autónoma del Estado de México · doi:10.36677/medicinainvestigacion.v11i1.19791
Kartinah, N. T., Anggraini, S., Fadilah, F., & Rickie, R. (2023) · Current Computer - Aided Drug Design · doi:10.2174/1573409920666230822115144
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Akuffo Quarde, M. D. (2023) · Wiley eBooks · doi:10.1002/9781119863564.ch7
Hosseini, R., Emadian, S., Dogani, M., Ghazanfari, T., & Askari, N. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4812827
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Goldsmith, C. C., & Dodd, G. T. (2024) · Life Metabolism · doi:10.1093/lifemeta/loae019
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Wang, T., Han, S., Wang, Y., Li, Y., Zhang, S., Zhu, F., Chen, Z., Xing, Z., Li, Y. Z., Wang, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.11.642601
Caiazzo, S., Watt, M. J., Dodd, G. T., Bayliss, J. A., Thomas, H., Smith, L. K., Mitchell, C. B., & Phillips, W. A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0322544
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Barthelemy, J. (2022) · theses.fr (ABES) · doi:10.70675/6439a82ez7179z48e3zbb8ez93846ae0ac14
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Bouillon‐Minois, J. (2022) · theses.fr (ABES) · doi:10.70675/9293ae03ze761z4582zb5f5z9ecb1a766db9
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Lee, H. Y. T. (2025) · theses.fr (ABES) · doi:10.70675/8c37a24dzb8cez483ez8eabz2173315e4530
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Lu, Y., Xin, Y., Li, H., Fang, X., Lin, Y., & Zhang, C. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116880
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Deng, X., Shen, Y., Sun, Y. H., Lu, L., & Sun, C. (2026) · MedComm · doi:10.1002/mco2.70976
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Majeur, D., Manceau, R., Boisjoly, F., Depaauw-Holt, L. R., Fourn, M.-F., Robb, J. L., Rodaros, D., Bouyakdan, K., Fulton, S., Murphy‐Royal, C., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.16.752127
Raffaelli, F., Oelkrug, R., Iwen, K. A., & Mittag, J. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.18885903
Metadata
- Authors
- Dodd, G. T., Decherf, S., Loh, K., Simonds, S. E., Wiede, F., Balland, E., Merry, T. L., Münzberg, H., Zhang, Z.-Y., Kahn, B. B., Neel, B. G., Bence, K. K., Andrews, Z. B., Cowley, M. A., & Tiganis, T.
- Affiliations
- Monash University (AU)
- Pennington Biomedical Research Center (US)
- Indiana University Indianapolis (US)
- Beth Israel Deaconess Medical Center (US)
- University of Toronto (CA)
- University of Pennsylvania (US)
- Corresponding author
- Tiganis, Tony
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 160
- Issue
- 1-2
- Pages
- 88-104
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4453004
- OpenAlex
- W2078409165
- Cited by
- 398
- References
- 59
- Citations by year
- 2026: 15 · 2025: 30 · 2024: 33 · 2023: 28 · 2022: 29 · 2021: 46 · 2020: 35 · 2019: 37 · 2018: 38 · 2017: 34 · 2016: 42 · 2015: 31
- FWCI
- 35.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R37CA049152, R01CA126937, R01CA069202)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK082417, P01DK056116, R01DK098002)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- leptin, insulin, white adipose tissue browning, beige adipocytes, POMC neurons, hypothalamus, PTP1B, TCPTP, diet-induced obesity, energy expenditure, weight loss
- MeSH terms
- Animals, Body Temperature Regulation, Adipose Tissue, Brown, Insulin, Mice, Inbred C57BL, Neurons, Obesity, Pro-Opiomelanocortin, Mice, Knockout, Leptin, Adiposity, Adipose Tissue, White, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Protein Tyrosine Phosphatase, Non-Receptor Type 2
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