Cited by 398Adipose Tissue and MetabolismRegulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

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Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

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Dodd, Garron T., Decherf, Stephanie, Loh, Kim, Simonds, Stephanie E., Wiede, Florian, Balland, Eglantine, Merry, Troy L., Münzberg, Heike, Zhang, Zhong-Yin, Kahn, Barbara B., Neel, Benjamin G., Bence, Kendra K., Andrews, Zane B., Cowley, Michael A., Tiganis, Tony·2015·Cell

DOI 10.1016/j.cell.2014.12.022PMC PMC4453004

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Abstract

The primary task of white adipose tissue (WAT) is the storage of lipids. However, "beige" adipocytes also exist in WAT. Beige adipocytes burn fat and dissipate the energy as heat, but their abundance is diminished in obesity. Stimulating beige adipocyte development, or WAT browning, increases energy expenditure and holds potential for combating metabolic disease and obesity. Here, we report that insulin and leptin act together on hypothalamic neurons to promote WAT browning and weight loss. Deletion of the phosphatases PTP1B and TCPTP enhanced insulin and leptin signaling in proopiomelanocortin neurons and prevented diet-induced obesity by increasing WAT browning and energy expenditure. The coinfusion of insulin plus leptin into the CNS or the activation of proopiomelanocortin neurons also increased WAT browning and decreased adiposity. Our findings identify a homeostatic mechanism for coordinating the status of energy stores, as relayed by insulin and leptin, with the central control of WAT browning.

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Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Identification and Importance of Brown Adipose Tissue in Adult Humans
Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399
Cold-Activated Brown Adipose Tissue in Healthy Men
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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,406
Functional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058
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Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
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Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356
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Jiang, L., Su, H., Wu, X., Shen, H., Kim, M., Li, Y., Myers, M. G., Owyang, C., & Rui, L. (2020) · Nature Communications · doi:10.1038/s41467-020-15328-3 · Cited by 71
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Cheng, L., Zhang, S., Shang, F., Ning, Y., Huang, Z., He, R., Sun, J., & Dong, S. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.618037 · Cited by 68
Functional Relationship between Leptin and Nitric Oxide in Metabolism
Becerril, S., Rodrı́guez, A., Catalán, V., Ramírez, B., Unamuno, X., Portincasa, P., Gómez‐Ambrosi, J., & Frühbeck, G. (2019) · Nutrients · doi:10.3390/nu11092129 · Cited by 71
Age-Associated Weight Gain, Leptin, and SIRT1: A Possible Role for Hypothalamic SIRT1 in the Prevention of Weight Gain and Aging through Modulation of Leptin Sensitivity
Sasaki, T. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00109 · Cited by 66
Hypothalamic Regulation of Brown Adipose Tissue Thermogenesis and Energy Homeostasis
Zhang, W., & Bi, S. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00136 · Cited by 70
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Dodd, G. T., Andrews, Z. B., Simonds, S. E., Michael, N. J., DeVeer, M., Brüning, J. C., Spanswick, D., Cowley, M. A., & Tiganis, T. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.013 · Cited by 66
Self-citation
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Krishnan, N., Bonham, C. A., Rus, I. A., Shrestha, O. K., Gauss, C. M., Haque, A., Tocilj, A., Joshua‐Tor, L., & Tonks, N. K. (2018) · Nature Communications · doi:10.1038/s41467-017-02252-2 · Cited by 69
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Cai, R., Tang, G., Zhang, Q., Yong, W., Zhang, W., Xiao, J., Wei, C., He, C., Yang, G., & Pang, W. (2019) · Cells · doi:10.3390/cells8050477 · Cited by 65
Pathogenic hypothalamic extracellular matrix promotes metabolic disease
Beddows, C. A., Shi, F., Horton, A. L., Dalal, S., Zhang, P., Ling, C., Yong, V. W., Loh, K., Cho, H., Karagiannis, C., et al. (2024) · Nature · doi:10.1038/s41586-024-07922-y · Cited by 66
Self-citation
Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia
Tsunekawa, T., Banno, R., Mizoguchi, A., Sugiyama, M., Tominaga, T., Onoue, T., Hagiwara, D., Ito, Y., Iwama, S., Goto, M., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.01.007 · Cited by 63
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Xiong, Z., Xiao, W., Bao, L., Xiong, W., Xiao, H., Qü, Y., Yuan, C., Ruan, H., Cao, Q., Wang, K., et al. (2019) · Advanced Science · doi:10.1002/advs.201801862 · Cited by 62
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Dong, J., Miao, J., Miao, Y., Qu, Z., Zhang, S., Zhu, P., Wiede, F., Jassim, B. A., Bai, Y., Nguyen, Q. D., et al. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202303818 · Cited by 60
Self-citation
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Mulya, A., & Kirwan, J. P. (2016) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2016.04.010 · Cited by 68
The Role of the Melanocortin System in Metabolic Disease: New Developments and Advances
Hill, J. W., & Faulkner, L. D. (2016) · Neuroendocrinology · doi:10.1159/000450649 · Cited by 57
Incendiary Leptin
Seoane‐Collazo, P., Martínez‐Sánchez, N., Milbank, E., & Contreras, C. (2020) · Nutrients · doi:10.3390/nu12020472 · Cited by 61
Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues
Ayari, A., Rosa‐Calatrava, M., Lancel, S., Barthelemy, J., Pizzorno, A., Mayeuf-Louchart, A., Baron, M., Hot, D., Deruyter, L., Soulard, D., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-0965-6 · Cited by 62
Uroguanylin Action in the Brain Reduces Weight Gain in Obese Mice via Different Efferent Autonomic Pathways
Folgueira, C., Beiroa, D., Callon, A., Al–Massadi, O., Barja-Fernández, S., Senra, A., Fernø, J., López, M., Diéguez, C., Casanueva, F. F., et al. (2015) · Diabetes · doi:10.2337/db15-0889 · Cited by 56
Understanding tumor anabolism and patient catabolism in cancer-associated cachexia.
Schcolnik‐Cabrera, A., Chávez-Blanco, A. D., Domínguez-Gómez, G., & Dueñas‐González, A. (2017) · Europe PMC (PubMed Central) · Cited by 54
Neural Control of Energy Expenditure
Münzberg, H., Qualls‐Creekmore, E., Berthoud, H., Morrison, C. D., & Yu, S. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_33 · Cited by 53
Self-citation
Cordycepin promotes browning of white adipose tissue through an AMP-activated protein kinase (AMPK)-dependent pathway
Qi, G., Zhou, Y., Zhang, X., Yu, J., Li, X., Cao, X., Wu, C., & Guo, P. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.10.004 · Cited by 54
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis
Merlin, J., Evans, B. A., Dehvari, N., Sato, M., Bengtsson, T., & Hutchinson, D. S. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500251 · Cited by 56
Hypothalamic endoplasmic reticulum stress as a key mediator of obesity‐induced leptin resistance
Ye, Z., Liu, G., Guo, J., & Su, Z. (2018) · Obesity Reviews · doi:10.1111/obr.12673 · Cited by 54

Authors: Dodd, G. T., Decherf, S., Loh, K., Simonds, S. E., Wiede, F., Balland, E., Merry, T. L., Münzberg, H., Zhang, Z.-Y., Kahn, B. B., Neel, B. G., Bence, K. K., Andrews, Z. B., Cowley, M. A., & Tiganis, T.
Affiliations: Monash University (AU)
Pennington Biomedical Research Center (US)
Indiana University Indianapolis (US)
Beth Israel Deaconess Medical Center (US)
University of Toronto (CA)
University of Pennsylvania (US)
Corresponding author: Tiganis, Tony
ORCID: Dodd, Garron T.
Loh, Kim
Simonds, Stephanie E.
Wiede, Florian
Merry, Troy L.
Münzberg, Heike
Zhang, Zhong-Yin
Kahn, Barbara B.
Neel, Benjamin G.
Bence, Kendra K.
Andrews, Zane B.
Cowley, Michael A.
Tiganis, Tony
Venue: Cell
Publisher: Elsevier BV
Published: 2015-01
Volume: 160
Issue: 1-2
Pages: 88-104
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2014.12.022
PMC: PMC4453004
OpenAlex: W2078409165
Cited by: 398
References: 59
Citations by year: 2026: 15 · 2025: 30 · 2024: 33 · 2023: 28 · 2022: 29 · 2021: 46 · 2020: 35 · 2019: 37 · 2018: 38 · 2017: 34 · 2016: 42 · 2015: 31
FWCI: 35.25
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 379 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R37CA049152, R01CA126937, R01CA069202)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK082417, P01DK056116, R01DK098002)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: leptin, insulin, white adipose tissue browning, beige adipocytes, POMC neurons, hypothalamus, PTP1B, TCPTP, diet-induced obesity, energy expenditure, weight loss
MeSH terms: Animals, Body Temperature Regulation, Adipose Tissue, Brown, Insulin, Mice, Inbred C57BL, Neurons, Obesity, Pro-Opiomelanocortin, Mice, Knockout, Leptin, Adiposity, Adipose Tissue, White, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Protein Tyrosine Phosphatase, Non-Receptor Type 2

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Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

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