Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone
Open accessAbstract
AgRP neuron activity drives feeding and weight gain whereas that of nearby POMC neurons does the opposite. However, the role of excitatory glutamatergic input in controlling these neurons is unknown. To address this question, we generated mice lacking NMDA receptors (NMDARs) on either AgRP or POMC neurons. Deletion of NMDARs from AgRP neurons markedly reduced weight, body fat and food intake whereas deletion from POMC neurons had no effect. Activation of AgRP neurons by fasting, as assessed by c-Fos, Agrp and Npy mRNA expression, AMPA receptor-mediated EPSCs, depolarization and firing rates, required NMDARs. Furthermore, AgRP but not POMC neurons have dendritic spines and increased glutamatergic input onto AgRP neurons caused by fasting was paralleled by an increase in spines, suggesting fasting induced synaptogenesis and spinogenesis. Thus glutamatergic synaptic transmission and its modulation by NMDARs play key roles in controlling AgRP neurons and determining the cellular and behavioral response to fasting.
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Glutamatergic projections to the hypothalamus are involved in neuroplastic changes that follow fasting and facilitate feeding.
“glutamatergic projections to the hypothalamus are involved in the neuroplastic changes that follow fasting and that facilitate feeding (52).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [52]
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Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030 · see citing works
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729 · see citing works
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782 · cited 5× · see citing works
“…knockin mice (#012899) (Tong et al., 2008), Pomc-Cre BAC transgenic mice (#005965) (Balthasar et al., 2004), lox-flanked Grin1 mice (#005246) (Tsien et al., 1996a), Npy-hrGFP BAC transgenic mice (#006417) (van den Pol et al., 2009) and Pomc-hrGFP BAC transgenic mice (#006421) (Parton et al.,…”
BackgroundMethodResultInfluentialCowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679 · see citing works
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Engert, F., & Bonhoeffer, T. (1999) · Nature · doi:10.1038/19978 · Cited by 1,664 · see citing works
Anatomy and regulation of the central melanocortin system
Cone, R. D. (2005) · Nature Neuroscience · doi:10.1038/nn1455 · Cited by 1,583 · see citing works
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46229 · Cited by 1,578 · see citing works
Self-citationSubregion- and Cell Type–Restricted Gene Knockout in Mouse Brain
Tsien, J. Z., Chen, D. F., Gerber, D., Tom, C., Mercer, E. H., Anderson, D. J., Mayford, M., Kandel, E. R., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81826-7 · Cited by 1,280 · see citing works
Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons
Vong, L., Ye, C., Yang, Z., Choi, B. J., Chua, S. C., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,238 · see citing works
Self-citationRapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity
Maletić‐Savatić, M., Malinow, R., & Svoboda, K. (1999) · Science · doi:10.1126/science.283.5409.1923 · Cited by 1,189 · see citing works
Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons
Hahn, T. M., Breininger, J. F., Baskin, D. G., & Schwartz, M. W. (1998) · Nature Neuroscience · doi:10.1038/1082 · Cited by 1,164 · see citing works
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
Aponte, Y., Atasoy, D., & Sternson, S. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2739 · Cited by 1,157 · see citing works
NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates
Luquet, S. H., Perez, F. A., Hnasko, T. S., & Palmiter, R. D. (2005) · Science · doi:10.1126/science.1115524 · Cited by 1,127 · see citing works
Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure
Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J. H., Funahashi, H., Williams, T. B., Ferreira, M. A. R., Tang, V., McGovern, R. A., Kenny, C. D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.035 · Cited by 1,122 · see citing works
Self-citationObesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
Yaswen, L. R., Diehl, N. L., Brennan, M. B., & Hochgeschwender, U. (1999) · Nature Medicine · doi:10.1038/12506 · Cited by 1,010 · see citing works
Striatal Plasticity and Basal Ganglia Circuit Function
Kreitzer, A. C., & Malenka, R. C. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.005 · Cited by 1,009 · see citing works
Synaptic AMPA receptor plasticity and behavior
Kessels, H. W., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.015 · Cited by 993 · see citing works
Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin
Pinto, S., Roseberry, A. G., Liu, H., Diano, S., Shanabrough, M., Cai, X., Friedman, J. M., & Horvath, T. L. (2004) · Science · doi:10.1126/science.1089459 · Cited by 987 · see citing works
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935 · see citing works
Self-citationLong-term depression in the CNS
Collingridge, G. L., Peineau, S., Howland, J. G., & Wang, Y. T. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2867 · Cited by 926 · see citing works
Ghrelin controls hippocampal spine synapse density and memory performance
Diano, S., Farr, S. A., Benoit, S. C., McNay, E. C., da Silva, I., Horvath, B., Gaskin, F. S., Nonaka, N., Jaeger, L. B., Banks, W. A., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1656 · Cited by 828 · see citing works
Agouti-related peptide–expressing neurons are mandatory for feeding
Gropp, E., Shanabrough, M., Borók, E., Xu, A. W., Janoschek, R., Buch, T., Plum, L., Balthasar, N., Hampel, B., Waisman, A., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1548 · Cited by 800 · see citing works
Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791 · see citing works
Self-citationGlucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
Parton, L. E., Ye, C. P., Coppari, R., Enriori, P. J., Choi, B., Zhang, C.-Y., Xu, C., Vianna, C. R., Balthasar, N., Lee, C. E., et al. (2007) · Nature · doi:10.1038/nature06098 · Cited by 700 · see citing works
Self-citationSynaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
Tong, Q., Ye, C.-P., Jones, J. E., Elmquist, J. K., & Lowell, B. B. (2008) · Nature Neuroscience · doi:10.1038/nn.2167 · Cited by 689 · see citing works
Self-citationSilent synapses and the emergence of a postsynaptic mechanism for LTP
Kerchner, G. A., & Nicoll, R. A. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2501 · Cited by 602 · see citing works
Reassessment of the structural basis of the ascending arousal system
Fuller, P. M., Sherman, D. L., Pedersen, N. P., Saper, C. B., & Lu, J. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22559 · Cited by 507 · see citing works
Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop
Yang, Y., Atasoy, D., Su, H. H., & Sternson, S. M. (2011) · Cell · doi:10.1016/j.cell.2011.07.039 · Cited by 431 · see citing works
A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse
Schnütgen, F., Doerflinger, N., Calleja, C., Wendling, O., Chambon, P., & Ghyselinck, N. B. (2003) · Nature Biotechnology · doi:10.1038/nbt811 · Cited by 401 · see citing works
Glutamate induces de novo growth of functional spines in developing cortex
Kwon, H.-B., & Sabatini, B. L. (2011) · Nature · doi:10.1038/nature09986 · Cited by 368 · see citing works
Self-citationGhrelin in the regulation of body weight and metabolism
Castañeda, T. R., Tong, J., Datta, R., Culler, M. D., & Tschöp, M. H. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.008 · Cited by 350 · see citing works
5-HT2CRs Expressed by Pro-Opiomelanocortin Neurons Regulate Energy Homeostasis
Xu, Y., Jones, J. E., Kohno, D., Williams, K. W., Lee, C. E., Choi, M. J., Anderson, J. G., Heisler, L. K., Zigman, J. M., Lowell, B. B., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.033 · Cited by 339 · see citing works
Self-citationTakahashi, K. A., & Cone, R. D. (2005) · Endocrinology · doi:10.1210/en.2004-1397 · Cited by 308 · see citing works
Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting
Sternson, S. M., Shepherd, G. M., & Friedman, J. M. (2005) · Nature Neuroscience · doi:10.1038/nn1550 · Cited by 307 · see citing works
Mushroom bodies of the cockroach: Their participation in place memory
Mizunami, M., Weibrecht, J. M., & Strausfeld, N. J. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981228)402:4 · Cited by 284 · see citing works
Leptin at 14 y of age: an ongoing story
Friedman, J. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26788b · Cited by 272 · see citing works
Butler, A. A., & Kozak, L. P. (2010) · Diabetes · doi:10.2337/db09-1471 · Cited by 263 · see citing works
Hormone and glucose signalling in POMC and AgRP neurons
Belgardt, B., Okamura, T., & Brüning, J. C. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179192 · Cited by 245 · see citing works
Yuste, R. (2010) · doi:10.7551/mitpress/9780262013505.001.0001 · Cited by 241 · see citing works
Frankfurt, M., Gould, E., Woolley, C. S., & McEwen, B. S. (2008) · Neuroendocrinology · doi:10.1159/000125387 · Cited by 239 · see citing works
Postembryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype
Bewick, G. A., Gardiner, J., Dhillo, W. S., Kent, A. S., White, N. E., Webster, Z., Ghatei, M. A., & Bloom, S. R. (2005) · The FASEB Journal · doi:10.1096/fj.04-3434fje · Cited by 235 · see citing works
van den Pol, A. N., Yao, Y., Fu, L., Foo, K. S., Huang, H., Coppari, R., Lowell, B. B., & Broberger, C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3249-08.2009 · Cited by 221 · see citing works
Self-citationCalcium Signaling in Dendrites and Spines: Practical and Functional Considerations
Higley, M. J., & Sabatini, B. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.020 · Cited by 217 · see citing works
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Xu, A. W., Kaelin, C. B., Morton, G. J., Ogimoto, K., Stanhope, K. L., Graham, J. L., Baskin, D. G., Havel, P. J., Schwartz, M. W., & Barsh, G. S. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030415 · Cited by 211 · see citing works
Kong, D., Vong, L., Parton, L. E., Ye, C., Tong, Q., Hu, X., Choi, B. J., Brüning, J. C., & Lowell, B. B. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.013 · Cited by 198 · see citing works
Self-citationBuchanan, K. A., Petrovic, M. M., Chamberlain, S. E. L., Marrion, N. V., & Mellor, J. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.018 · Cited by 184 · see citing works
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Kaiyala, K. J., & Schwartz, M. W. (2010) · Diabetes · doi:10.2337/db10-0909 · Cited by 156 · see citing works
Giessel, A. J., & Sabatini, B. L. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.004 · Cited by 156 · see citing works
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Smart, J. L. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25243 · Cited by 99 · see citing works
Transcriptional Regulation of Agouti-Related Protein (Agrp) in Transgenic Mice
Kaelin, C. B., Xu, A. W., Lu, X., & Barsh, G. S. (2004) · Endocrinology · doi:10.1210/en.2004-0956 · Cited by 45 · see citing works
Fluctuation of synapse density in the arcuate nucleus during the estrous cycle
Csakvari, E., Hoyk, Z., Gyenes, A., García‐Ovejero, D., García‐Segura, L. M., & Párducz, Á. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.008 · Cited by 35 · see citing works
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Bito, H. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.408 · Cited by 17 · see citing works
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Self-citation
- Authors
- Liu, T., Kong, D., Shah, B. P., Ye, C., Koda, S., Saunders, A., Ding, J. B., Yang, Z., Sabatini, B. L., & Lowell, B. B.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Lowell, Bradford B.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 73
- Issue
- 3
- Pages
- 511-522
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3278709
- OpenAlex
- W2076262535
- Cited by
- 296
- References
- 54
- Citations by year
- 2026: 7 · 2025: 22 · 2024: 24 · 2023: 20 · 2022: 19 · 2021: 16 · 2020: 24 · 2019: 20 · 2018: 19 · 2017: 25 · 2016: 29 · 2015: 25 · 2014: 10 · 2013: 16 · 2012: 19
- FWCI
- 9.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 532 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Diabetes Association
- Parkinson's Disease Foundation
- Boston Area Diabetes Endocrinology Research Center (Core-P30 DK057521, F31 NS074842, K99 NS075136, NS046579, P30 DK057521)
- National Institutes of Health (DK046200, R01 DK071051, R01 DK075632, R01 DK089044, R37 DK053477)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- AgRP neurons, POMC neurons, NMDA receptor, fasting, spinogenesis, dendritic spines, glutamatergic neurotransmission, AMPA receptors, dietary intake, body weight, fat mass, appetite regulation, synaptogenesis
- MeSH terms
- Age Factors, Animals, Body Composition, Brain, Carrier Proteins, Eating, Energy Metabolism, Fasting, Female, Gene Expression Regulation, Male, Membrane Potentials, Mice, Transgenic, Nerve Tissue Proteins, Neurons, Neuropeptide Y, Picrotoxin, Pro-Opiomelanocortin, RNA, Messenger, Time Factors, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Proto-Oncogene Proteins c-fos, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, 6-Cyano-7-nitroquinoxaline-2,3-dione, GABA Antagonists, Excitatory Postsynaptic Potentials, Dendritic Spines, Green Fluorescent Proteins, Mice, Agouti-Related Protein, In Vitro Techniques
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