The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1
Open accessAbstract
Summary Dendritic cells (DCs) play a critical role in the immune response to viral infection through the facilitation of cell intrinsic antiviral activity and the activation of adaptive immunity. HIV-1 infection of DCs triggers an IRF3-dependent innate immune response, which requires the activity of cyclic GAMP synthase (cGAS). We report the results of a targeted RNAi screen utilizing primary human monocyte-derived DCs (MDDCs) to identify immune regulators that directly interface with HIV-1-encoded features to initiate this innate response. Polyglutamine binding protein 1 (PQBP1) emerged as a strong candidate through this analysis. We found that PQBP1 directly binds to reverse-transcribed HIV-1 DNA and interacts with cGAS to initiate an IRF3-dependent innate response. MDDCs derived from Renpenning Syndrome patients, who harbor mutations in the PQBP1 locus, possess a severely attenuated innate immune response to HIV-1 challenge, underscoring the role of PQBP1 as a proximal innate sensor of a HIV-1 infection.
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Cites
Genome engineering using the CRISPR-Cas9 system
Ran, F. A., Hsu, P. D., Wright, J., Agarwala, V., Scott, D. A., & Zhang, F. (2013) · Nature Protocols · doi:10.1038/nprot.2013.143 · Cited by 11,133
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
Laguette, N., Sobhian, B., Casartelli, N., Ringeard, M., Chable-Bessia, C., Ségéral, E., Yatim, A., Emiliani, S., Schwartz, O., & Benkirane, M. (2011) · Nature · doi:10.1038/nature10117 · Cited by 1,511
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Hrecka, K., Hao, C., Gierszewska, M., Swanson, S. K., Kesik-Brodacka, M., Srivastava, S., Florens, L., Washburn, M. P., & Skowronski, J. (2011) · Nature · doi:10.1038/nature10195 · Cited by 1,200 · cited 2×
“The experimental models in this report have relied on the introduction of Vpx, which alleviates the block of early reverse transcription at the minus strand strong stop in highly restrictive cells, such as DCs (Hrecka et al., 2011; Laguette et al., 2011).”
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
Schoggins, J. W., MacDuff, D. A., Imanaka, N., Gainey, M. D., Shrestha, B., Eitson, J. L., Mar, K. B., Richardson, R. B., Ratushny, A. V., Litvak, V., et al. (2014) · Nature · doi:10.1038/nature12862 · Cited by 896
Self-citationA cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
Manel, N., Hogstad, B., Wang, Y., Levy, D. E., Unutmaz, D., & Littman, D. R. (2010) · Nature · doi:10.1038/nature09337 · Cited by 427
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IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
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Cited by
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333
Molecular mechanisms and cellular functions of cGAS–STING signalling
Hopfner, K.-P., & Hornung, V. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0244-x · Cited by 2,052
DNA sensing by the cGAS–STING pathway in health and disease
Motwani, M., Pesiridis, S., & Fitzgerald, K. A. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0151-1 · Cited by 1,467
STING: infection, inflammation and cancer.
Barber, G. N. (2015) · Nature Reviews Immunology · doi:10.1038/nri3921 · Cited by 1,313
Discriminating self from non-self in nucleic acid sensing
Schlee, M., & Hartmann, G. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.78 · Cited by 593
Metadata
- Authors
- Yoh, S. M., Schneider, M., Seifried, J., Soonthornvacharin, S., Akleh, R. E., Olivieri, K. C., De Jesus, P. D., Ruan, C., de Castro, E., Ruiz, P. A., Germanaud, D., des Portes, V., García-Sastre, A., König, R., & Chanda, S. K.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 161
- Issue
- 6
- Pages
- 1293-1305
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1504179404
- Cited by
- 202
- References
- 7
- FWCI
- 7.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yoh, S. M., Schneider, M., Seifried, J., Soonthornvacharin, S., Akleh, R. E., Olivieri, K. C., De Jesus, P. D., Ruan, C., de Castro, E., Ruiz, P. A., Germanaud, D., des Portes, V., García-Sastre, A., König, R., & Chanda, S. K. (2015). PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1. Cell. https://doi.org/10.1016/j.cell.2015.04.050
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