The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Neuronal Firing Rate Homeostasis Is Inhibited by Sleep and Promoted by Wake
Open accessAbstract
SUMMARY Homeostatic mechanisms stabilize neural circuit function by keeping firing rates within a set-point range, but whether this process is gated by brain state is unknown. Here, we monitored firing rate homeostasis in individual visual cortical neurons in freely behaving rats as they cycled between sleep and wake states. When neuronal firing rates were perturbed by visual deprivation, they gradually returned to a precise, cell-autonomous set-point during periods of active wake, with lengthening of the wake period enhancing firing rate rebound. Unexpectedly, this resetting of neuronal firing was suppressed during sleep. This raises the possibility that memory consolidation or other sleep-dependent processes are vulnerable to interference from homeostatic plasticity mechanisms.
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Cites
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Metadata
- Authors
- Hengen, K. B., Torrado Pacheco, A., McGregor, J. N., Van Hooser, S. D., & Turrigiano, G. G.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 165
- Issue
- 1
- Pages
- 180-191
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2301435817
- Cited by
- 306
- References
- 25
- FWCI
- 23.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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