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Cited by 233Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Strength through Diversity

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Nelson, Sacha B., Turrigiano, Gina G.·2008·Neuron
DOI 10.1016/j.neuron.2008.10.020PMC PMC4919814
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Abstract

The remarkable versatility of the mammalian brain is made possible by a huge diversity of cellular plasticity mechanisms. These include long-term potentiation and depression at both excitatory and inhibitory synapses, as well as a variety of intrinsic and homeostatic plasticity mechanisms. A fundamental challenge for the field is to assemble our detailed knowledge of these specific mechanisms into a coherent picture of how plasticity within cortical circuits works to tune network properties.

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Crossref · 10.1016/j.neuron.2008.10.020

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  • Small changes in the balance between excitation and inhibition can have major effects on ongoing activity.

    “Central neurons are embedded in complex networks composed of many cell types, including both excitatory and inhibitory neurons, and small changes in the balance between excitation and inhibition can have major effects on ongoing activity (Nelson and Turrigiano 2008).”

    From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Nelson and Turrigiano 2008

    The Inhibitory Plasticity section discusses balancing excitation and inhibition, and the Homeostatic Plasticity section says changes in synaptic strength can alter neuronal activity. The copy does not establish the more specific claim that small shifts in excitation–inhibition balance have major effects on ongoing activity. Page numbers are unavailable in our copy. (LLM, conf=0.78)

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Authors
Nelson, S. B., & Turrigiano, G. G.
Affiliations
Brandeis University (US)
Corresponding author
  • Nelson, Sacha B.
  • Turrigiano, Gina G.
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2008-11
Volume
60
Issue
3
Pages
477-482
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2008.10.020
PMC
PMC4919814
OpenAlex
W1983158636
Cited by
233
References
7
Citations by year
2026: 7 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 9 · 2019: 8 · 2018: 8 · 2017: 17 · 2016: 16 · 2015: 15 · 2014: 16 · 2013: 17 · 2012: 16
FWCI
2.25
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R01MH066338)
  • National Institute of Neurological Disorders and Stroke (R01NS036853)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
synaptic plasticity, long-term potentiation, long-term depression, intrinsic plasticity, homeostatic plasticity, inhibitory synapses, excitatory synapses, cortical circuits, network characteristics, mammalian brain
MeSH terms
Animals, Behavior, Cerebral Cortex, Hippocampus, Homeostasis, Nerve Net, Synaptic Transmission, Neuronal Plasticity, Synapses, Long-Term Potentiation, Long-Term Synaptic Depression

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