The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment
Open accessAbstract
Summary Autophagy, a cellular waste disposal process, has well-established tumor suppressive properties. New studies indicate that in addition to its cell autonomous anti-tumorigenic functions, autophagy inhibits cancer development by orchestrating inflammation and immunity. While attenuating tumor-promoting inflammation, autophagy enhances the processing and presentation of tumor antigens and thereby stimulates anti-tumor immunity. Although cancer cells can escape immunosurveillance by tuning down autophagy, certain chemotherapeutic agents with immunogenic properties may enhance anti-tumor immunity by inducing autophagic cell death. Understanding the intricate and complex relationships within this troika and how they are affected by autophagy enhancing drugs should improve the efficacy of cancer immunotherapy.
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Cites
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Cited by
Biological Functions of Autophagy Genes: A Disease Perspective
Levine, B., & Kroemer, G. (2019) · Cell · doi:10.1016/j.cell.2018.09.048 · Cited by 2,832
NF-κB, inflammation, immunity and cancer: coming of age
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Self-citationThe immune contexture in cancer prognosis and treatment
Fridman, W. H., Zitvogel, L., Sautès–Fridman, C., & Kroemer, G. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.101 · Cited by 2,263
Molecular definitions of autophagy and related processes
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Autophagy in major human diseases
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Metadata
- Authors
- Zhong, Z., Sanchez-Lopez, E., & Karin, M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 166
- Issue
- 2
- Pages
- 288-298
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2471277546
- Cited by
- 576
- References
- 34
- FWCI
- 66.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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