The DOI matches its Crossref record; 187 of the 188 references it cites were found in a registry or an index.
Epigenetic Mechanisms of Longevity and Aging
Open accessAbstract
Aging is an inevitable outcome of life, characterized by progressive decline in tissue and organ function and increased risk of mortality. Accumulating evidence links aging to genetic and epigenetic alterations. Given the reversible nature of epigenetic mechanisms, these pathways provide promising avenues for therapeutics against age-related decline and disease. In this review, we provide a comprehensive overview of epigenetic studies from invertebrate organisms, vertebrate models, tissues, and in vitro systems. We establish links between common operative aging pathways and hallmark chromatin signatures that can be used to identify "druggable" targets to counter human aging and age-related disease.
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Metadata
- Authors
- Sen, P., Shah, P. P., Nativio, R., & Berger, S. L.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Berger, Shelley L.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 166
- Issue
- 4
- Pages
- 822-839
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC5821249
- OpenAlex
- W2517275410
- Cited by
- 956
- References
- 188
- Citations by year
- 2026: 76 · 2025: 96 · 2024: 111 · 2023: 116 · 2022: 97 · 2021: 128 · 2020: 113 · 2019: 87 · 2018: 76 · 2017: 51 · 2016: 5
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association
- National Institutes of Health (4r01ns078283-05)
- National Institute on Aging (P01AG031862)
- National Institute of Neurological Disorders and Stroke (R01-NS078283)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- aging, longevity, epigenetic mechanisms, chromatin signatures, age-related diseases, anti-aging therapeutics, druggable targets, invertebrate models, vertebrate models, tissue aging
- MeSH terms
- Aging, Animals, Histones, Humans, Longevity, DNA Methylation, Chromatin Assembly and Disassembly, Epigenesis, Genetic
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