Epigenetic Mechanisms of Longevity and Aging

Multiplex Genome Engineering Using CRISPR/Cas Systems

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DNA methylation age of human tissues and cell types

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TOR signaling in growth and metabolism

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Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

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Resveratrol improves health and survival of mice on a high-calorie diet

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Genome-wide methylation profiles reveal quantitative views of human aging rates

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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A C. elegans mutant that lives twice as long as wild type

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Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

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The genetics of ageing

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The role of senescent cells in ageing

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

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The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

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Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

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Cellular and molecular mechanisms of metformin: an overview

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

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Induction of autophagy by spermidine promotes longevity

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A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

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Extrachromosomal rDNA circles—a cause of aging in yeast

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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Metformin improves healthspan and lifespan in mice

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Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

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Lamin a truncation in Hutchinson-Gilford progeria

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The plasticity of aging: insights from long-lived mutants

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

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NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice

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The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Lamin A-dependent nuclear defects in human aging

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Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome

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Cellular Senescence in Aging Primates

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The role of mitochondria in aging

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The sirtuin SIRT6 regulates lifespan in male mice

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Lamin B1 loss is a senescence-associated biomarker

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Calorie restriction, SIRT1 and metabolism: understanding longevity

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Mitonuclear protein imbalance as a conserved longevity mechanism

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A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

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Extension of Chronological Life Span in Yeast by Decreased TOR Pathway Signaling

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Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

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Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

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Regulation of Longevity and Stress Resistance by Sch9 in Yeast

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

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Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

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A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)

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An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

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Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

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Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

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Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence

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Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

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Phenotype and Course of Hutchinson–Gilford Progeria Syndrome

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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

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DNA Methylation on N6-Adenine in C. elegans

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Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

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Histone H4 lysine 16 acetylation regulates cellular lifespan

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N6-Methyladenine DNA Modification in Drosophila

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Autophagy mediates degradation of nuclear lamina

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Sirtuins in aging and age-related disease

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Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

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Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

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Epigenetic regulation of ageing: linking environmental inputs to genomic stability

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Human longevity at the cost of reproductive success

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Increased cell-to-cell variation in gene expression in ageing mouse heart

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Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase–deficient mice

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Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

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Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

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The role of nuclear lamin B1 in cell proliferation and senescence

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Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

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Nuclear Trapping of the Forkhead Transcription Factor FoxO1 via Sirt-dependent Deacetylation Promotes Expression of Glucogenetic Genes

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Lysosome-mediated processing of chromatin in senescence

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A systematic RNAi screen for longevity genes in C. elegansPreprint

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The Aging Epigenome

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Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

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Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect

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Yeast Rtt109 Promotes Genome Stability by Acetylating Histone H3 on Lysine 56

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Elevated histone expression promotes life span extension

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Rtt109 Acetylates Histone H3 Lysine 56 and Functions in DNA Replication

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Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

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Molecular dissection of formation of senescence-associated heterochromatin foci

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