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Cited by 363

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection

Open access
Yockey, Laura J., Varela, Luis, Rakib, Tasfia, Khoury-Hanold, William, Fink, Susan L., Stutz, Bernardo, Szigeti-Buck, Klara, Van den Pol, Anthony, Lindenbach, Brett D., Horvath, Tamas L., Iwasaki, Akiko·2016·Cell
DOI 10.1016/j.cell.2016.08.004
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Abstract

SUMMARY Zika virus (ZIKV) can be transmitted sexually between humans. However, it is unknown whether ZIKV replicates in the vagina and impacts the unborn fetus. Here, we establish a mouse model of vaginal ZIKV infection and demonstrate that, unlike other routes, ZIKV replicates within the genital mucosa even in wild-type (WT) mice. Mice lacking RNA sensors or transcription factors IRF3 and IRF7 resulted in higher levels of local viral replication. Furthermore, mice lacking the type I interferon (IFN) receptor became viremic and died of infection after a high-dose vaginal ZIKV challenge. Notably, vaginal infection of pregnant dams during early pregnancy led to fetal growth restriction and infection of the fetal brain in WT mice. This was exacerbated in mice deficient in IFN pathways, leading to abortion. Our study highlights the vaginal tract as a highly susceptible site of ZIKV replication and illustrates the dire disease consequences during pregnancy.

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Metadata

Authors
Yockey, L. J., Varela, L., Rakib, T., Khoury-Hanold, W., Fink, S. L., Stutz, B., Szigeti-Buck, K., Van den Pol, A., Lindenbach, B. D., Horvath, T. L., & Iwasaki, A.
Venue
Cell
Publisher
Elsevier BV
Published
2016-08
Volume
166
Issue
5
Pages
1247-1256.e4
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2016.08.004
OpenAlex
W2517229912
Cited by
363
References
53
FWCI
67.41
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection. https://app.cochat.ai/papers/10.1016/j.cell.2016.08.004
The paper
Yockey, L. J., Varela, L., Rakib, T., Khoury-Hanold, W., Fink, S. L., Stutz, B., Szigeti-Buck, K., Van den Pol, A., Lindenbach, B. D., Horvath, T. L., & Iwasaki, A. (2016). Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection. Cell. https://doi.org/10.1016/j.cell.2016.08.004

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.