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Dynamic RNA Modifications in Gene Expression Regulation
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“N6-methyladenosine, the most common internal modification of eukaryotic mRNA, is associated with the maturation, translation, and eventual decay of protein-coding transcripts (Roundtree et al., 2017; Tuck, 1992).”
From YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs (2017) · cites this paper as Roundtree et al., 2017
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“N6-methyladenosine, the most common internal modification of eukaryotic mRNA, is associated with the maturation, translation, and eventual decay of protein-coding transcripts (Roundtree et al., 2017; Tuck, 1992).”
From YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs (2017) · cites this paper as Roundtree et al., 2017
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IDH1 and IDH2 Mutations in Gliomas
Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847
N6-methyladenosine-dependent regulation of messenger RNA stability
Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., et al. (2014) · Nature · doi:10.1038/nature12730 · Cited by 4,558
Self-citationComprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
Meyer, K. D., Saletore, Y., Zumbo, P., Elemento, O., Mason, C. E., & Jaffrey, S. R. (2012) · Cell · doi:10.1016/j.cell.2012.05.003 · Cited by 4,223
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.687 · Cited by 4,106
Self-citationALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.015 · Cited by 3,550
Self-citationComprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
The Cancer Genome Atlas Research Network (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1402121 · Cited by 3,148
Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing
Xiao, W., Adhikari, S., Dahal, U., Chen, Y.-S., Hao, Y.-J., Sun, B.-F., Sun, H.-Y., Li, A., Ping, X.-L., Lai, W.-Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.012 · Cited by 2,054
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
Shi, H., Wang, X., Lu, Z., Zhao, B. S., Ma, H., Hsu, P. J., Liu, C., & He, C. (2017) · Cell Research · doi:10.1038/cr.2017.15 · Cited by 1,815
Self-citationm6A RNA methylation promotes XIST-mediated transcriptional repression
Patil, D. P., Chen, C.-K., Pickering, B. F., Chow, A., Jackson, C., Guttman, M., & Jaffrey, S. R. (2016) · Nature · doi:10.1038/nature19342 · Cited by 1,747
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome
Linder, B., Grozhik, A. V., Olarerin-George, A. O., Meydan, C., Mason, C. E., & Jaffrey, S. R. (2015) · Nature Methods · doi:10.1038/nmeth.3453 · Cited by 1,569
HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
Alarcón, C. R., Goodarzi, H., Lee, H., Liu, X., Tavazoie, S., & Tavazoie, S. F. (2015) · Cell · doi:10.1016/j.cell.2015.08.011 · Cited by 1,514
Sloan, K. E., Warda, A. S., Sharma, S., Entian, K.-D., Lafontaine, D. L. J., & Bohnsack, M. T. (2017) · RNA Biology · doi:10.1080/15476286.2016.1259781 · Cited by 707
AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation
Ougland, R., Zhang, C.-M., Liiv, A., Johansen, R. F., Seeberg, E., Hou, Y.-M., Remme, J., & Falnes, P. Ø. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.09.002 · Cited by 205
Research works printed but not linked: 127
- Adams, 1975, Modified nucleosides and bizarre 5′-termini in mouse myeloma mRNA, Nature, 255, 28, 10.1038/255028a0 · DOI
- Agris, 2008, Bringing order to translation: the contributions of transfer RNA anticodon-domain modifications, EMBO Rep., 9, 629, 10.1038/embor.2008.104 · DOI
- Agris, 2015, The importance of being modified: an unrealized code to RNA structure and function, RNA, 21, 552, 10.1261/rna.050575.115 · DOI
- Agris, 2007, tRNA’s wobble decoding of the genome: 40 years of modification, J. Mol. Biol., 366, 1, 10.1016/j.jmb.2006.11.046 · DOI
- Alexandrov, 2006, Rapid tRNA decay can result from lack of nonessential modifications, Mol. Cell, 21, 87, 10.1016/j.molcel.2005.10.036 · DOI
- Anadón, 2017, Epigenetic loss of the RNA decapping enzyme NUDT16 mediates C-MYC activation in T-cell acute lymphoblastic leukemia, Leukemia, 10.1038/leu.2017.99 · DOI
- Batista, 2014, m6A RNA modification controls cell fate transition in mammalian embryonic stem cells, Cell Stem Cell, 15, 707, 10.1016/j.stem.2014.09.019 · DOI · Paper page
- Bélanger, 2010, Characterization of hMTr1, a human Cap1 2′-O-ribose methyltransferase, J. Biol. Chem., 285, 33037, 10.1074/jbc.M110.155283 · DOI
- Blanco, 2014, Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders, EMBO J., 33, 2020, 10.15252/embj.201489282 · DOI
- Blanco, 2016, Stem cell function and stress response are controlled by protein synthesis, Nature, 534, 335, 10.1038/nature18282 · DOI
- Buchhaupt, 2014, Partial methylation at Am100 in 18S rRNA of baker’s yeast reveals ribosome heterogeneity on the level of eukaryotic rRNA modification, PLoS ONE, 9, e89640, 10.1371/journal.pone.0089640 · DOI
- Camper, 1984, Effect of undermethylation on mRNA cytoplasmic appearance and half-life, Mol. Cell. Biol., 4, 538, 10.1128/MCB.4.3.538 · DOI · Paper page
- Carlile, 2014, Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells, Nature, 515, 143, 10.1038/nature13802 · DOI · Paper page
- Cenik, 2017, A common class of transcripts with 5′-intron depletion, distinct early coding sequence features, and N1-methyladenosine modification, RNA, 23, 270, 10.1261/rna.059105.116 · DOI
- Chan, 2010, A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress, PLoS Genet., 6, e1001247, 10.1371/journal.pgen.1001247 · DOI
- Chan, 2012, Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins, Nat. Commun., 3, 937, 10.1038/ncomms1938 · DOI
- Charette, 2000, Pseudouridine in RNA: what, where, how, and why, IUBMB Life, 49, 341, 10.1080/152165400410182 · DOI
- Chen, 2015, High-resolution N6-methyladenosine (m6A) map using photo-crosslinking-assisted m6A sequencing, Angew. Chem. Int. Ed. Engl., 54, 1587, 10.1002/anie.201410647 · DOI
- Chou, 2011, The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia, Leukemia, 25, 246, 10.1038/leu.2010.267 · DOI
- Clark, 2016, tRNA base methylation identification and quantification via high-throughput sequencing, RNA, 22, 1771, 10.1261/rna.056531.116 · DOI
- Cohn, 1960, Pseudouridine, a carbon-carbon linked ribonucleoside in ribonucleic acids: isolation, structure, and chemical characteristics, J. Biol. Chem., 235, 1488, 10.1016/S0021-9258(18)69432-3 · DOI
- Cui, 2017, m6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells, Cell Rep., 18, 2622, 10.1016/j.celrep.2017.02.059 · DOI
- Decatur, 2002, rRNA modifications and ribosome function, Trends Biochem. Sci., 27, 344, 10.1016/S0968-0004(02)02109-6 · DOI
- Delatte, 2016, RNA biochemistry. Transcriptome-wide distribution and function of RNA hydroxymethylcytosine, Science, 351, 282, 10.1126/science.aac5253 · DOI · Paper page
- Desrosiers, 1974, Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells, Proc. Natl. Acad. Sci. USA, 71, 3971, 10.1073/pnas.71.10.3971 · DOI
- Dominissini, 2012, Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq, Nature, 485, 201, 10.1038/nature11112 · DOI · Paper page
- Dominissini, 2016, The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA, Nature, 530, 441, 10.1038/nature16998 · DOI · Paper page
- Dönmez, 2004, Modified nucleotides at the 5′ end of human U2 snRNA are required for spliceosomal E-complex formation, RNA, 10, 1925, 10.1261/rna.7186504 · DOI
- Du, 2016, YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex, Nat. Commun., 7, 12626, 10.1038/ncomms12626 · DOI
- Dubin, 1975, The methylation state of poly A-containing messenger RNA from cultured hamster cells, Nucleic Acids Res., 2, 1653, 10.1093/nar/2.10.1653 · DOI
- Eckel-Passow, 2015, Glioma groups based on 1p/19q, IDH, and TERT promoter mutations in tumors, N. Engl. J. Med., 372, 2499, 10.1056/NEJMoa1407279 · DOI
- Esteller, 2017, The epitranscriptome of noncoding RNAs in cancer, Cancer Discov., 7, 359, 10.1158/2159-8290.CD-16-1292 · DOI
- Fernández, 2013, Unusual base pairing during the decoding of a stop codon by the ribosome, Nature, 500, 107, 10.1038/nature12302 · DOI
- Finkel, 1983, Methylations of adenosine residues (m6A) in pre-mRNA are important for formation of late simian virus 40 mRNAs, Virology, 131, 409, 10.1016/0042-6822(83)90508-1 · DOI
- Frayling, 2007, A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity, Science, 316, 889, 10.1126/science.1141634 · DOI · Paper page
- Fu, 2014, Tet-mediated formation of 5-hydroxymethylcytosine in RNA, J. Am. Chem. Soc., 136, 11582, 10.1021/ja505305z · DOI · Paper page
- Geula, 2015, Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation, Science, 347, 1002, 10.1126/science.1261417 · DOI · Paper page
- Harcourt, 2013, Identification of a selective polymerase enables detection of N6-methyladenosine in RNA, J. Am. Chem. Soc., 135, 19079, 10.1021/ja4105792 · DOI
- Hauenschild, 2015, The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent, Nucleic Acids Res., 43, 9950
- Haussmann, 2016, m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination, Nature, 540, 301, 10.1038/nature20577 · DOI
- He, 2010, Grand challenge commentary: RNA epigenetics?, Nat. Chem. Biol., 6, 863, 10.1038/nchembio.482 · DOI
- Helm, 2017, Detecting RNA modifications in the epitranscriptome: predict and validate, Nat. Rev. Genet., 18, 275, 10.1038/nrg.2016.169 · DOI
- Helm, 1999, A Watson-Crick base-pair-disrupting methyl group (m1A9) is sufficient for cloverleaf folding of human mitochondrial tRNALys, Biochemistry, 38, 13338, 10.1021/bi991061g · DOI
- Hoernes, 2016, Nucleotide modifications within bacterial messenger RNAs regulate their translation and are able to rewire the genetic code, Nucleic Acids Res., 44, 852, 10.1093/nar/gkv1182 · DOI
- Holley, 1965, Nucleotide sequences in the yeast alanine transfer ribonucleic acid, J Biol Chem., 240, 2122, 10.1016/S0021-9258(18)97435-1 · DOI
- Hussain, 2013, NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs, Cell Rep., 4, 255, 10.1016/j.celrep.2013.06.029 · DOI
- Kadaba, 2006, Nuclear RNA surveillance in Saccharomyces cerevisiae: Trf4p-dependent polyadenylation of nascent hypomethylated tRNA and an aberrant form of 5S rRNA, RNA, 12, 508, 10.1261/rna.2305406 · DOI
- Kaneko, 2003, Wobble modification differences and subcellular localization of tRNAs in Leishmania tarentolae: implication for tRNA sorting mechanism, EMBO J., 22, 657, 10.1093/emboj/cdg066 · DOI
- Karijolich, 2010, Spliceosomal snRNA modifications and their function, RNA Biol., 7, 192, 10.4161/rna.7.2.11207 · DOI
- Karijolich, 2011, Converting nonsense codons into sense codons by targeted pseudouridylation, Nature, 474, 395, 10.1038/nature10165 · DOI
- Khoddami, 2013, Identification of direct targets and modified bases of RNA cytosine methyltransferases, Nat. Biotechnol., 31, 458, 10.1038/nbt.2566 · DOI
- Kirchner, 2015, Emerging roles of tRNA in adaptive translation, signalling dynamics and disease, Nat. Rev. Genet., 16, 98, 10.1038/nrg3861 · DOI
- Kos, 2010, Yeast pre-rRNA processing and modification occur cotranscriptionally, Mol. Cell, 37, 809, 10.1016/j.molcel.2010.02.024 · DOI
- Krogh, 2016, Profiling of 2′-O-Me in human rRNA reveals a subset of fractionally modified positions and provides evidence for ribosome heterogeneity, Nucleic Acids Res., 44, 7884, 10.1093/nar/gkw482 · DOI
- Langberg, 1981, Post-transcriptional modifications of mRNA. Purification and characterization of cap I and cap II RNA (nucleoside-2′-)-methyltransferases from HeLa cells, J. Biol. Chem., 256, 10054, 10.1016/S0021-9258(19)68740-5 · DOI
- Lavi, 1977, Content of N-6 methyl adenylic acid in heterogeneous nuclear and messenger RNA of HeLa cells, Nucleic Acids Res., 4, 63, 10.1093/nar/4.1.63 · DOI
- Lence, 2016, m6A modulates neuronal functions and sex determination in Drosophila, Nature, 540, 242, 10.1038/nature20568 · DOI
- Li, 2017, Cytoplasmic m6A reader YTHDF3 promotes mRNA translation, Cell Res., 27, 444, 10.1038/cr.2017.10 · DOI
- Li, 2014, Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition, Cell Res., 24, 1490, 10.1038/cr.2014.153 · DOI
- Li, 2013, The maternal to zygotic transition in mammals, Mol. Aspects Med., 34, 919, 10.1016/j.mam.2013.01.003 · DOI
- Li, 2015, Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome, Nat. Chem. Biol., 11, 592, 10.1038/nchembio.1836 · DOI
- Li, 2016, Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome, Nat. Chem. Biol., 12, 311, 10.1038/nchembio.2040 · DOI
- Li, 2017, FTO plays an oncogenic role in acute myeloid leukemia as a N6-methyladenosine RNA demethylase, Cancer Cell, 31, 127, 10.1016/j.ccell.2016.11.017 · DOI
- Lichinchi, 2016, Dynamics of human and viral RNA methylation during Zika virus infection, Cell Host Microbe, 20, 666, 10.1016/j.chom.2016.10.002 · DOI
- Lin, 2008, X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines, Biochemistry, 47, 5503, 10.1021/bi7022392 · DOI
- Lin, 2016, The m6A methyltransferase METTL3 promotes translation in human cancer cells, Mol. Cell, 62, 335, 10.1016/j.molcel.2016.03.021 · DOI · Paper page
- Liu, 2016, ALKBH1-mediated tRNA demethylation regulates translation, Cell, 167, 816, 10.1016/j.cell.2016.09.038 · DOI
- Liu, 2014, A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation, Nat. Chem. Biol., 10, 93, 10.1038/nchembio.1432 · DOI · Paper page
- Liu, 2013, Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA, RNA, 19, 1848, 10.1261/rna.041178.113 · DOI
- Liu, 2015, N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions, Nature, 518, 560, 10.1038/nature14234 · DOI · Paper page
- Liu, 2017, N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein, Nucleic Acids Res.
- Ma, 2017, Evolution of transcript modification by N6-methyladenosine in primates, Genome Res., 27, 385, 10.1101/gr.212563.116 · DOI
- Machnicka, 2013, MODOMICS: a database of RNA modification pathways--2013 update, Nucleic Acids Res., 41, D262, 10.1093/nar/gks1007 · DOI
- Marchand, 2016, Illumina-based RiboMethSeq approach for mapping of 2′-O-Me residues in RNA, Nucleic Acids Res., 44, e135, 10.1093/nar/gkw547 · DOI
- Massenet, 1999, A limited number of pseudouridine residues in the human atac spliceosomal UsnRNAs as compared to human major spliceosomal UsnRNAs, RNA, 5, 1495, 10.1017/S1355838299991537 · DOI
- Mauer, 2017, Reversible methylation of m6Am in the 5′ cap controls mRNA stability, Nature, 541, 371, 10.1038/nature21022 · DOI
- Meier, 2016, RNA modification in Cajal bodies, RNA Biol., 0, 1
- Meyer, 2015, 5′ UTR m6A promotes cap-independent translation, Cell, 163, 999, 10.1016/j.cell.2015.10.012 · DOI
- Molinie, 2016, m6A-LAIC-seq reveals the census and complexity of the m6A epitranscriptome, Nat. Methods, 13, 692, 10.1038/nmeth.3898 · DOI
- Noeske, 2015, High-resolution structure of the Escherichia coli ribosome, Nat. Struct. Mol. Biol., 22, 336, 10.1038/nsmb.2994 · DOI
- Ozanick, 2005, The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans, RNA, 11, 1281, 10.1261/rna.5040605 · DOI
- Patel, 2012, Prognostic relevance of integrated genetic profiling in acute myeloid leukemia, N. Engl. J. Med., 366, 1079, 10.1056/NEJMoa1112304 · DOI
- Pendleton, 2017, The U6 snRNA m6A methyltransferase METTL16 regulates SAM synthetase intron retention, Cell, 169, 824, 10.1016/j.cell.2017.05.003 · DOI · Paper page
- Perry, 1975, The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5′ terminus, Cell, 4, 387, 10.1016/0092-8674(75)90159-2 · DOI
- Ping, 2014, Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase, Cell Res., 24, 177, 10.1038/cr.2014.3 · DOI · Paper page
- Rezgui, 2013, tRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding, Proc. Natl. Acad. Sci. USA, 110, 12289, 10.1073/pnas.1300781110 · DOI
- Roost, 2015, Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification, J. Am. Chem. Soc., 137, 2107, 10.1021/ja513080v · DOI
- Rubio, 2017, Editing and methylation at a single site by functionally interdependent activities, Nature, 542, 494, 10.1038/nature21396 · DOI
- Schaefer, 2009, RNA cytosine methylation analysis by bisulfite sequencing, Nucleic Acids Res., 37, e12, 10.1093/nar/gkn954 · DOI
- Schibler, 1977, The 5′-termini of heterogeneous nuclear RNA: a comparison among molecules of different sizes and ages, Nucleic Acids Res., 4, 4133, 10.1093/nar/4.12.4133 · DOI
- Schwartz, 2014, Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA, Cell, 159, 148, 10.1016/j.cell.2014.08.028 · DOI
- Schwartz, 2014, Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5′ sites, Cell Rep., 8, 284, 10.1016/j.celrep.2014.05.048 · DOI
- Sharma, 2015, ‘View from a bridge’: a new perspective on eukaryotic rRNA base modification, Trends Biochem. Sci., 40, 560, 10.1016/j.tibs.2015.07.008 · DOI
- Śledź, 2016, Structural insights into the molecular mechanism of the m6A writer complex, eLife, 5, e18434, 10.7554/eLife.18434 · DOI
- Slobodin, 2017, Transcription impacts the efficiency of mRNA translation via co-transcriptional N6-adenosine methylation, Cell, 169, 326, 10.1016/j.cell.2017.03.031 · DOI · Paper page
- Spitale, 2015, Structural imprints in vivo decode RNA regulatory mechanisms, Nature, 519, 486, 10.1038/nature14263 · DOI
- Squires, 2012, Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA, Nucleic Acids Res., 40, 5023, 10.1093/nar/gks144 · DOI
- Stuart, 2003, Naturally-occurring modification restricts the anticodon domain conformational space of tRNA(Phe), J. Mol. Biol., 334, 901, 10.1016/j.jmb.2003.09.058 · DOI
- Takuma, 2015, Substrate tRNA recognition mechanism of eubacterial tRNA (m1A58) methyltransferase (TrmI), J. Biol. Chem., 290, 5912, 10.1074/jbc.M114.606038 · DOI
- Taoka, 2016, The complete chemical structure of Saccharomyces cerevisiae rRNA: partial pseudouridylation of U2345 in 25S rRNA by snoRNA snR9, Nucleic Acids Res., 44, 8951, 10.1093/nar/gkw564 · DOI
- Torres, 2014, Role of tRNA modifications in human diseases, Trends Mol. Med., 20, 306, 10.1016/j.molmed.2014.01.008 · DOI
- Turowski, 2015, Cotranscriptional events in eukaryotic ribosome synthesis, Wiley Interdiscip. Rev. RNA, 6, 129, 10.1002/wrna.1263 · DOI
- Ueda, 2017, AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells, Sci. Rep., 7, 42271, 10.1038/srep42271 · DOI
- Waas, 2007, Role of a tRNA base modification and its precursors in frameshifting in eukaryotes, J. Biol. Chem., 282, 26026, 10.1074/jbc.M703391200 · DOI
- Wang, 2016, Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases, Mol. Cell, 63, 306, 10.1016/j.molcel.2016.05.041 · DOI
- Wang, 2015, N6-methyladenosine modulates messenger RNA translation efficiency, Cell, 161, 1388, 10.1016/j.cell.2015.05.014 · DOI · Paper page
- Wang, 2016, Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex, Nature, 534, 575, 10.1038/nature18298 · DOI
- Wang, 2014, N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells, Nat. Cell Biol., 16, 191, 10.1038/ncb2902 · DOI
- Watkins, 2012, The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA, Wiley Interdiscip. Rev. RNA, 3, 397, 10.1002/wrna.117 · DOI
- Wei, 1977, Nucleotide sequences at the N6-methyladenosine sites of HeLa cell messenger ribonucleic acid, Biochemistry, 16, 1672, 10.1021/bi00627a023 · DOI
- Wei, 1976, 5′-Terminal and internal methylated nucleotide sequences in HeLa cell mRNA, Biochemistry, 15, 397, 10.1021/bi00647a024 · DOI
- Wu, 2011, U2 snRNA is inducibly pseudouridylated at novel sites by Pus7p and snR81 RNP, EMBO J., 30, 79, 10.1038/emboj.2010.316 · DOI
- Wu, 2017, AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosine, Sci. Rep., 7, 41606, 10.1038/srep41606 · DOI
- Xiang, 2017, RNA m6A methylation regulates the ultraviolet-induced DNA damage response, Nature, 543, 573, 10.1038/nature21671 · DOI
- Xu, 2014, Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain, Nat. Chem. Biol., 10, 927, 10.1038/nchembio.1654 · DOI
- Xu, 2015, Structural basis for the discriminative recognition of N6-methyladenosine RNA by the human YT521-B homology domain family of proteins, J. Biol. Chem., 290, 24902, 10.1074/jbc.M115.680389 · DOI
- Yang, 2017, 5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader, Cell Res., 27, 606, 10.1038/cr.2017.55 · DOI · Paper page
- Yildirim, 2014, Interplay of LNA and 2′-O-methyl RNA in the structure and thermodynamics of RNA hybrid systems: a molecular dynamics study using the revised AMBER force field and comparison with experimental results, J. Phys. Chem. B, 118, 14177, 10.1021/jp506703g · DOI
- Zhang, 2016, Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA, Proc. Natl. Acad. Sci. USA, 113, E2047, 10.1073/pnas.1602883113 · DOI
- Zhang, 2016, Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells, Oncotarget, 7, 64527, 10.18632/oncotarget.11743 · DOI
- Zhang, 2015, The demethylase activity of FTO (fat mass and obesity associated protein) is required for preadipocyte differentiation, PLoS ONE, 10, e0133788, 10.1371/journal.pone.0133788 · DOI
- Zhang, 2017, m6A demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program, Cancer Cell, 31, 591, 10.1016/j.ccell.2017.02.013 · DOI
- Zhao, 2017, m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition, Nature, 542, 475, 10.1038/nature21355 · DOI
- Zhao, 2014, FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis, Cell Res., 24, 1403, 10.1038/cr.2014.151 · DOI
- Zhou, 2015, Dynamic m6A mRNA methylation directs translational control of heat shock response, Nature, 526, 591, 10.1038/nature15377 · DOI
- Zhou, 2016, N6-methyladenosine modification in a long noncoding RNA hairpin predisposes its conformation to protein binding, J. Mol. Biol., 428, 822, 10.1016/j.jmb.2015.08.021 · DOI
- Zhu, 2014, Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine, Cell Res., 24, 1493, 10.1038/cr.2014.152 · DOI
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Fang, E., Liu, X., Li, M., Zhang, Z., Song, L., Zhu, B., Wu, X., Liu, J., Zhao, D., & Li, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00950-y · Cited by 601
The roles of DNA, RNA and histone methylation in ageing and cancer
Michalak, E. M., Burr, M. L., Bannister, A. J., & Dawson, M. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0143-1 · Cited by 549
m6A facilitates hippocampus-dependent learning and memory through YTHDF1
Shi, H., Zhang, X., Weng, Y.-L., Lu, Z., Liu, Y., Lu, Z., Li, J., Hao, P., Zhang, Y., Zhang, F., et al. (2018) · Nature · doi:10.1038/s41586-018-0666-1 · Cited by 546
Self-citation
Metadata
- Authors
- Roundtree, I. A., Evans, M. E., Pan, T., & He, C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 169
- Issue
- 7
- Pages
- 1187-1200
- ISSN
- 0092-8674
- PMC
- PMC5657247
- Cited by
- 3,399
- References
- 13
- Language
- en
- Licence
- Funders
- NIH Medical Scientist National Research Service Award (T32 GM007281)
- NIH (F30 GM117646, NHGRI HG008935)
- NIH Chemistry and Biology Training Grant (T32 GM008720)
- NSF pre-doctoral fellowship (DGE-1144082)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.