Cited by 2,198Gut microbiota and healthOral microbiology and periodontitis researchCancer Immunotherapy and Biomarkers

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy

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Abstract

Gut microbiota are linked to chronic inflammation and carcinogenesis. Chemotherapy failure is the major cause of recurrence and poor prognosis in colorectal cancer patients. Here, we investigated the contribution of gut microbiota to chemoresistance in patients with colorectal cancer. We found that Fusobacterium (F.) nucleatum was abundant in colorectal cancer tissues in patients with recurrence post chemotherapy, and was associated with patient clinicopathological characterisitcs. Furthermore, our bioinformatic and functional studies demonstrated that F. nucleatum promoted colorectal cancer resistance to chemotherapy. Mechanistically, F. nucleatum targeted TLR4 and MYD88 innate immune signaling and specific microRNAs to activate the autophagy pathway and alter colorectal cancer chemotherapeutic response. Thus, F. nucleatum orchestrates a molecular network of the Toll-like receptor, microRNAs, and autophagy to clinically, biologically, and mechanistically control colorectal cancer chemoresistance. Measuring and targeting F. nucleatum and its associated pathway will yield valuable insight into clinical management and may ameliorate colorectal cancer patient outcomes.

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Crossref · 10.1016/j.cell.2017.07.008

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Metadata

Authors
Yu, T., Guo, F., Yu, Y., Sun, T., Ma, D., Han, J., Qian, Y., Kryczek, I., Sun, D., Nagarsheth, N., Chen, Y., Chen, H., Hong, J., Zou, W., & Fang, J.-Y.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • University of Michigan (US)
Corresponding author
  • Chen, Yingxuan
  • Chen, Haoyan
  • Hong, Jie
  • Zou, Weiping
  • Fang, Jing-Yuan
Venue
Cell
Publisher
Elsevier BV
Published
2017-07
Volume
170
Issue
3
Pages
548-563.e16
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2742147437
Cited by
2,198
References
50
Citations by year
2026: 265 · 2025: 291 · 2024: 300 · 2023: 323 · 2022: 287 · 2021: 268 · 2020: 214 · 2019: 124 · 2018: 105 · 2017: 17
FWCI
51.47
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Natural Science Foundation of China (81421001, 81320108024, 81530072, 81522008 31371273, 31371420, 81572303, 81001070)
  • National Key Technology R&D Program (2014BAI09B05)
  • Program for Professor of Special Appointment (Eastern Scholar No. 201268, 2015 Youth Eastern Scholar NO.QD2015003)
  • Shanghai Institutions of Higher Learning, the Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant (20152512, 20161309)
  • National Cancer Institute (CA211016)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
Fusobacterium nucleatum, colorectal cancer, chemoresistance, autophagy, gut microbiota, TLR4, MyD88, microRNA, innate immune signaling, chronic inflammation
MeSH terms
Gastrointestinal Microbiome, Capecitabine, Animals, Antineoplastic Agents, Autophagy, Neoplasm Transplantation, Recurrence, Colorectal Neoplasms, Fusobacterium nucleatum, Platinum Compounds, Drug Resistance, Neoplasm, MicroRNAs, Toll-Like Receptors, Mice, Tumor Microenvironment, Heterografts

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