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Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy
Open accessAbstract
Gut microbiota are linked to chronic inflammation and carcinogenesis. Chemotherapy failure is the major cause of recurrence and poor prognosis in colorectal cancer patients. Here, we investigated the contribution of gut microbiota to chemoresistance in patients with colorectal cancer. We found that Fusobacterium (F.) nucleatum was abundant in colorectal cancer tissues in patients with recurrence post chemotherapy, and was associated with patient clinicopathological characterisitcs. Furthermore, our bioinformatic and functional studies demonstrated that F. nucleatum promoted colorectal cancer resistance to chemotherapy. Mechanistically, F. nucleatum targeted TLR4 and MYD88 innate immune signaling and specific microRNAs to activate the autophagy pathway and alter colorectal cancer chemotherapeutic response. Thus, F. nucleatum orchestrates a molecular network of the Toll-like receptor, microRNAs, and autophagy to clinically, biologically, and mechanistically control colorectal cancer chemoresistance. Measuring and targeting F. nucleatum and its associated pathway will yield valuable insight into clinical management and may ameliorate colorectal cancer patient outcomes.
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“a higher abundance of F nucleatum (present in approximately 10%–15% of tumors) has been associated with advanced disease stage, higher risk of recurrence, and shorter patient survival times.23, 26, 28”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [28]
In the citing paper
“Bioinformatic and functional studies indicated that F nucleatum activates innate immune responses, via TLR4 and MYD88, resulting in loss of specific microRNAs. This resulted in activation of autophagy activation and promotion of chemoresistance in patients with CRC.28”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [28]
In the citing paper
“F nucleatum was promotes resistance of CRC cells to chemotherapy.28”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [28]
In the citing paper
“Patients with post-chemotherapy recurrence had a higher abundance of F nucleatum in tumor tissues.28, 193”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [28]
In the citing paper
“(iii) chemoresistance via direct microbial metabolism (cytidine deaminase degradation of gemcitabine) in pancreatic cancer or indirect amplification of cancer cell autophagy in colorectal cancer (14, 104)”
From The microbiome and human cancer (2021) · cites this paper as [104]
In the citing paper
“regulate chemoresistance via direct drug metabolism by microbes [415, 416]”
From Tumor microenvironment signaling and therapeutics in cancer progression (2023) · cites this paper as [416]
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Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192
GSVA: gene set variation analysis for microarray and RNA-Seq data
Hänzelmann, S., Castelo, R., & Guinney, J. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-7 · Cited by 15,440
Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668
Siegel, R., Naishadham, D., & Jemal, A. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21166 · Cited by 11,825
Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20006 · Cited by 9,709
The resurgence of platinum-based cancer chemotherapy
Kèlland, L. R. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2167 · Cited by 4,733
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
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Gaiani, F., Marchesi, F., Negri, F., Greco, L., Malesci, A., de’Angelis, G. L., & Laghi, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105246 · Cited by 24
Ying, H., Sun, F., Liao, Y., Cai, D., Yang, Y., & Cheng, X. (2021) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359211022886 · Cited by 23
Nanotechnological interventions of the microbiome as a next-generation antimicrobial therapy
Trivedi, R., Upadhyay, T. K., Kausar, M. A., Saeed, A., Sharangi, A. B., Almatroudi, A., Alabdallah, N. M., Saeed, M., & Aqil, F. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155085 · Cited by 24
Immunomodulation by Gut Microbiome on Gastrointestinal Cancers: Focusing on Colorectal Cancer
AL-Ishaq, R. K., Koklesová, L., Kubatka, P., & Büsselberg, D. (2022) · Cancers · doi:10.3390/cancers14092140 · Cited by 23
Gupta, I., Pedersen, S., Vranić, S., & Moustafa, A. A. (2022) · Cancers · doi:10.3390/cancers14122964 · Cited by 25
Yin, H., Zhang, J., Zhang, H., Li, Q., Qiu, H., Hong, K., Wang, W., Xiao, Y., & Yu, B. (2022) · FEBS Journal · doi:10.1111/febs.16619 · Cited by 27
Pharmacomicrobiomics in Anticancer Therapies: Why the Gut Microbiota Should Be Pointed Out
Conti, G., D’Amico, F., Fabbrini, M., Brigidi, P., Barone, M., & Turroni, S. (2022) · Genes · doi:10.3390/genes14010055 · Cited by 25
Wei, X., Mu, D., Li, Y., Zhao, J., & Zhou, S. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101796 · Cited by 23
Connecting the dots in the associations between diet, obesity, cancer, and microRNAs
Otsuka, K., Nishiyama, H., Kuriki, D., Kawada, N., & Ochiya, T. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.05.001 · Cited by 26
Feng, K., Ren, F., & Wang, X. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1327893 · Cited by 24
H19: An Oncogenic Long Non-coding RNA in Colorectal Cancer
Chowdhury, P. R., Salvamani, S., Gunasekaran, B., Hoh, B., & Ulaganathan, V. (2023) · The Yale Journal of Biology and Medicine · doi:10.59249/tdbj7410 · Cited by 26
Unveiling intratumoral microbiota: An emerging force for colorectal cancer diagnosis and therapy
Zhang, J., Wang, P., Wang, J., Wei, X., & Wang, M. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107185 · Cited by 25
Oral hygiene might prevent cancer
Cordero, O. J., & Varela‐Calviño, R. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00879 · Cited by 25
Yan, X., Chen, Q., An, J., Liu, D., Huang, Y., Yang, R., Li, W., Chen, L., & Gao, H. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb02370k · Cited by 24
Mihai, M. M., Ion, A., Giurcăneanu, C., Niţipir, C., Popa, A. M., Chifiriuc, M. C., Popa, M. I., Říčař, J., Popa, L. G., Sârbu, I., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153219 · Cited by 24
Wu, T., Jin, D., Wu, M., Xin, Y., Liu, H., Li, N., Ma, F., Yu, Y., Wang, B., Zhao, J., et al. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102288 · Cited by 22
Self-citationCell Death: Mechanisms and Potential Targets in Breast Cancer Therapy
Qian, J., Zhao, L., Xu, L., Zhao, J. X., Tang, Y., Yu, M., Lin, J., Ding, L., & Cui, Q. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179703 · Cited by 23
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Qi, H., Gao, H., Li, M., Sun, T., Gu, X., Wei, L., Zhi, M., Li, Z., Fu, D., Liu, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57530-1 · Cited by 25
Self-citationCancer microbiota: a focus on tumor-resident bacteria
Vella, G., & Rescigno, M. (2025) · EMBO Reports · doi:10.1038/s44319-025-00482-w · Cited by 25
Chen, Y. X., Qin, Y., Dai, M., Liu, L., Ni, Y., Sun, Q., Li, L., Zhou, Y., Qiu, C., & Jiang, Y. (2021) · Cancer Medicine · doi:10.1002/cam4.3959 · Cited by 22
Self-citationChen, Z., Liu, S., Xie, P., Zhang, B., Yu, M., Yan, J., Jin, L., Zhang, W., Zhou, B., Li, X., et al. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.03.075 · Cited by 22
Feng, R., Zhang, T., Kayani, M. U. R., Wang, Z., Shen, Y., Su, K. L., Bielike, K., & Chen, L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.881489 · Cited by 22
Kim, Y.-H., Cho, N., & Kang, G. H. (2022) · Journal of Pathology and Translational Medicine · doi:10.4132/jptm.2022.03.13 · Cited by 28
Han, Y., Zhang, X., Guan, M., Huo, C., Yu, C., Hu, B., & Cai, J. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17395 · Cited by 21
Shang, H., Niu, X., Cui, W., Sha, Z., Wang, C., Huang, T., Guo, P., Wang, X., Gao, P., Zhang, S., et al. (2022) · Food & Function · doi:10.1039/d1fo03908c · Cited by 22
Liu, J., Zhang, X., Ta, X., Luo, M., Chang, X., & Wang, H. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113925 · Cited by 24
Das, B. K. (2022) · Apmis · doi:10.1111/apm.13282 · Cited by 25
Intratumour Fusobacterium nucleatum and immune response to oesophageal cancer
Kosumi, K., Baba, Y., Yamamura, K., Nomoto, D., Okadome, K., Yagi, T., Toihata, T., Kiyozumi, Y., Harada, K., Eto, K., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-022-02112-x · Cited by 21
Welham, Z., Li, J., Engel, A. F., & Molloy, M. P. (2023) · Cancers · doi:10.3390/cancers15205045 · Cited by 23
From the Colon to the Liver: How Gut Microbiota May Influence Colorectal Cancer Metastatic Potential
Mignini, I., Piccirilli, G., Galasso, L., Termite, F., Esposto, G., Ainora, M. E., Gasbarrini, A., & Zocco, M. A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020420 · Cited by 25
Aiding and Abetting: How the Tumor Microenvironment Protects Cancer from Chemotherapy
Fiedler, E. C., & Hemann, M. T. (2018) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055524 · Cited by 22
Sanders, B. E., Umaña, A., Lemkul, J. A., & Slade, D. J. (2018) · mSphere · doi:10.1128/msphere.00228-18 · Cited by 22
Park, R., Umar, S., & Kasi, A. (2020) · Current Colorectal Cancer Reports · doi:10.1007/s11888-020-00456-1 · Cited by 21
Ma, L., Liu, H., Wang, X., Jiang, C., Yao, S., Guo, Y., Wang, H., & Cao, Z. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118923 · Cited by 23
The Role of Gut Microbiota in Modulating Cancer Therapy Efficacy
Madkour, M. A., Altaf, R. A., Sayed, Z. S., Yasen, N. S., Elbary, H. A., Elsayed, R. A., Mohamed, E. N., Toema, M., Wadan, A.-H. S., Nafady, M. H., et al. (2024) · Advanced Gut & Microbiome Research · doi:10.1155/2024/9919868 · Cited by 24
Interactions between the tumor microbiota and breast cancer
Guo, H. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1499203 · Cited by 22
Qin, W., Wang, S., Min, Y., Liu, X., Fang, J., Lang, J., & Chen, M. (2025) · BMC Women s Health · doi:10.1186/s12905-025-03599-1 · Cited by 23
Self-citationHarnessing the microbiome for cancer therapy
Hajjar, R., Mars, R. A. T., & Kashyap, P. (2026) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01268-6 · Cited by 29
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Ma, R., Li, X., Liu, H., Jiang, R., Yang, M., Zhang, M., Wang, Y., Zhao, Y., & Li, H. (2019) · Cancer Biology & Therapy · doi:10.1080/15384047.2019.1599665 · Cited by 22
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Yang, Z., & Ji, G. (2019) · Oncology Letters · doi:10.3892/ol.2019.10433 · Cited by 20
Composition of fecal microbiota in low-set rectal cancer patients treated with FOLFOX
Li, J., Li, J., Lyu, N., Ma, Y., Liu, F., Feng, Y., Li, Y., Hou, Z., Song, X., Zhao, H.-C., et al. (2020) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622320904293 · Cited by 23
Intervention on gut microbiota may change the strategy for management of colorectal cancer
Taghinezhad‐S, S., Mohseni, A. H., & Fu, X. (2020) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15369 · Cited by 22
Role of Microbial Infection-Induced Inflammation in the Development of Gastrointestinal Cancers
Kouzu, K., Tsujimoto, H., Kishi, Y., Ueno, H., & Shinomiya, N. (2021) · Medicines · doi:10.3390/medicines8080045 · Cited by 22
You, B., Zhang, P., Gu, M., Yin, H., Fan, Y., Yao, H., Pan, S. Y., Xie, H., Cheng, T., Liu, H., et al. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.01.019 · Cited by 21
Liang, Q., Zeng, Y., Kwok, G., Cheung, C. P., Suen, B. Y., Ching, J. Y., To, K. F., Yu, J., Chan, F. K. L., & Ng, S. C. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16799 · Cited by 20
Chang, S., Wu, J., Jin, J., Shi, H., Gao, R., Li, X., Jia, D., Sun, X., Ou, T., Yang, J., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2555476 · Cited by 23
Santacroce, L., Muzio, E. L., Bottalico, L., Spirito, F., Charitos, I. A., Passarelli, P. C., & Jirillo, E. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220629101357 · Cited by 22
The intestinal microbiota in colorectal cancer metastasis – Passive observer or key player?
Patel, M., McAllister, M. J., Nagaraju, R. T., Al-Badran, S. S. F., Edwards, J., McBain, A. J., Barriuso, J., & Aziz, O. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103856 · Cited by 21
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Xiong, H., Wang, J., Chang, Z., Hu, H., Yuan, Z., Zhu, Y., Hu, Z., Wang, C., Liu, Y., Wang, Y., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1036946 · Cited by 23
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Mei, S., Deng, Z., Chen, Y., Ning, D.-M., Guo, Y., Fan, X., Wang, R., Meng, Y., Zhou, Q., & Tian, X. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1040991 · Cited by 22
Self-citationImpact of microbiota on breast cancer hormone therapy
Terrisse, S. A., Zitvogel, L., & Kroemer, G. (2023) · Cell Stress · doi:10.15698/cst2023.03.277 · Cited by 22
Qing, Y., Guo, Y., Zhao, Q.-W., Hu, P., Li, H., Yu, X., Zhu, M., Wang, H., Wang, Z., Xu, J., et al. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1229 · Cited by 21
Yang, M., Dong, P., Cen, L., Shi, W., He, X., & Li, J. (2023) · The ISME Journal · doi:10.1038/s41396-023-01398-w · Cited by 22
Zhao, R., Xia, D., Chen, Y., Kai, Z., Ruan, F., Xia, C., Gong, J., Wu, J., & Wang, X. (2023) · Cancer Medicine · doi:10.1002/cam4.6067 · Cited by 22
Self-citationHerbal medicine and its impact on the gut microbiota in colorectal cancer
Bu, F., Tu, Y., Wan, Z., & Tu, S. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1096008 · Cited by 23
Karan, S., Cho, M. Y., Lee, H.-S., Kim, H. M., Park, H. S., Han, E. H., Sessler, J. L., & Hong, K. S. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01274 · Cited by 21
Li, S., Wang, T., Ren, Y., Liu, Z., Gao, J., & Guo, Z. (2024) · Systematic Reviews · doi:10.1186/s13643-023-02419-7 · Cited by 23
Unraveling the complexities of colorectal cancer and its promising therapies – An updated review
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Kumar, S., Sharma, V., & Yadav, S. (2024) · Current Protein and Peptide Science · doi:10.2174/0113892037324425241018061548 · Cited by 21
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Jobin, C. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.10.030 · Cited by 21
VINOGRADOV, E. V., Michael, F. S., & Cox, A. D. (2018) · Carbohydrate Research · doi:10.1016/j.carres.2018.08.011 · Cited by 21
Guenther, M., Haas, M., Heinemann, V., Krüger, S., Westphalen, C. B., von Bergwelt‐Baildon, M., Mayerle, J. V., Werner, J., Kirchner, T., Boeck, S. H., et al. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01029-7 · Cited by 22
Wei, P., Hung, C.-S., Kao, Y., Lin, Y., Lee, C., Chang, T., Shia, B., & Lin, J.-C. (2020) · Genes · doi:10.3390/genes11111374 · Cited by 21
Gao, Z., Li, Z., Liu, Y., & Liu, Z. (2019) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.554 · Cited by 21
Liu, L., Liang, L., Luo, Y., Han, J., Lu, D., Cai, R., Sethi, G., & Mai, S. (2024) · Research · doi:10.34133/research.0529 · Cited by 22
Self-citationIntratumor microbiome-derived butyrate promotes chemo-resistance in colorectal cancer
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Wu, W., Guo, F., Wang, C., Qu, X., Wang, Q., Yang, Y. P., Yang, Y., & Ma, Y. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100092 · Cited by 22
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Theis, B. F., Park, J. S., Kim, J. S., Zeydabadinejad, S., Vijay–Kumar, M., Yeoh, B. S., & Saha, P. (2025) · Biomedicines · doi:10.3390/biomedicines13061357 · Cited by 24
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Zhang, H., Lan, M., Cui, G., & Zhu, W. (2020) · Marine Drugs · doi:10.3390/md18050277 · Cited by 20
Chen, X., Luo, Q., Ding, J., Yang, M., Zhang, R., & Chen, F. (2020) · Infectious Agents and Cancer · doi:10.1186/s13027-020-00315-6 · Cited by 20
The Dynamic Changes of Gut Microbiota during the Perinatal Period in Sows
Lan, S., Zhang, Y., Chen, W., Lan, T., Wang, Y., Wu, Y., Liao, X., & Mi, J. (2020) · Animals · doi:10.3390/ani10122254 · Cited by 20
Huang, Q., Yao, F., Zhou, C., Huang, X., Wang, Q., Long, H., & Wu, Q. (2020) · World Journal of Clinical Cases · doi:10.12998/wjcc.v8.i24.6213 · Cited by 21
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Rho, J. H., Kim, H. J., Joo, J., Lee, J. Y., Lee, J. H., & Park, H. R. (2021) · Journal of Dental Research · doi:10.1177/00220345211008811 · Cited by 20
Wang, Z., Hopson, L. M., Singleton, S. S., Yang, X., Jogunoori, W. S., Mazumder, R., Obias, V., Lin, P., Nguyen, B.-N. H., Yao, M. D., et al. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166179 · Cited by 20
Wang, Y., Li, J., Ma, C., Jiang, S., Li, C., Zhang, L., & Zhang, J. (2021) · Food & Function · doi:10.1039/d1fo01388b · Cited by 22
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Grochowska, M., Perlejewski, K., Laskus, T., & Radkowski, M. (2022) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-021-00641-6 · Cited by 20
Guo, S., Zhang, H., Chu, Y., Jiang, Q., & Ma, Y. (2022) · iMeta · doi:10.1002/imt2.20 · Cited by 19
Song, Z., Liao, C., Yao, L., Xu, X., Shen, X., Tian, S., Wang, S., & Xing, F. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-022-00574-y · Cited by 20
Pan, L., Peng, H., Lee, B., Zhao, J., Shen, X., Yan, X., Hua, Y., Kim, J., Kim, D., Lin, M., et al. (2023) · Advanced Materials · doi:10.1002/adma.202305394 · Cited by 21
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Meng, Y., Fan, Z., Zhou, B., & Zhan, H. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.189014 · Cited by 20
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Yakar, N., Ünlü, Ö., Cen, L., Hastürk, H., Chen, T., Shi, W., He, X., & Kantarcı, A. (2024) · Journal of Oral Microbiology · doi:10.1080/20002297.2024.2388900 · Cited by 20
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Changes in intestinal microbiota affect metabolism of ginsenoside Re
Zhang, L., Li, F., Qin, W., Fu, C., & Zhang, X. (2018) · Biomedical Chromatography · doi:10.1002/bmc.4284 · Cited by 20
Chu, Y., Wang, Y., Li, K., Liu, M., Zhang, Y., Li, Y., Hu, X., Liu, C., Zhou, H., Zuo, J., et al. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109549 · Cited by 19
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Sang, J., Ji, Z., Li, H., Wang, H., Quan, H., Yu, Y. W., Yan, J., Mao, Z., Wang, Y., Li, L., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.108827 · Cited by 19
Self-citationProgress of tumor-resident intracellular bacteria for cancer therapy
Bao, P., & Zhang, X. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115458 · Cited by 19
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Zhang, R., Zhang, X., Lau, H. C.-H., & Yu, J. Q. (2024) · Science China Life Sciences · doi:10.1007/s11427-024-2831-x · Cited by 19
Han, Q., Li, J., Li, Z. Y., Aishajiang, R., & Yu, D. N. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101601 · Cited by 23
Tissue-resident microbiota impacts colorectal cancer progression and prognosis
Shi, Z., Ren, H., Lin, C., Li, F., Wu, M., Yang, F., Luo, T., Nunes, L., Isaksson, A., Hammarström, K., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67047-2 · Cited by 24
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Lin, R., Han, C., Ding, Z., Shi, H., He, R., Liu, J., Qian, W., Zhang, Q., Fu, X., Deng, X., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.08.032 · Cited by 19
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Han, T., Hu, X., Li, K., Zhang, D., Zhang, Y., & Li, J. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.761113 · Cited by 19
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Metadata
- Authors
- Yu, T., Guo, F., Yu, Y., Sun, T., Ma, D., Han, J., Qian, Y., Kryczek, I., Sun, D., Nagarsheth, N., Chen, Y., Chen, H., Hong, J., Zou, W., & Fang, J.-Y.
- Affiliations
- Shanghai Jiao Tong University (CN)
- University of Michigan (US)
- Corresponding author
- Chen, Yingxuan
- Chen, Haoyan
- Hong, Jie
- Zou, Weiping
- Fang, Jing-Yuan
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 170
- Issue
- 3
- Pages
- 548-563.e16
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC5767127
- OpenAlex
- W2742147437
- Cited by
- 2,198
- References
- 50
- Citations by year
- 2026: 265 · 2025: 291 · 2024: 300 · 2023: 323 · 2022: 287 · 2021: 268 · 2020: 214 · 2019: 124 · 2018: 105 · 2017: 17
- FWCI
- 51.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Natural Science Foundation of China (81421001, 81320108024, 81530072, 81522008 31371273, 31371420, 81572303, 81001070)
- National Key Technology R&D Program (2014BAI09B05)
- Program for Professor of Special Appointment (Eastern Scholar No. 201268, 2015 Youth Eastern Scholar NO.QD2015003)
- Shanghai Institutions of Higher Learning, the Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant (20152512, 20161309)
- National Cancer Institute (CA211016)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- Fusobacterium nucleatum, colorectal cancer, chemoresistance, autophagy, gut microbiota, TLR4, MyD88, microRNA, innate immune signaling, chronic inflammation
- MeSH terms
- Gastrointestinal Microbiome, Capecitabine, Animals, Antineoplastic Agents, Autophagy, Neoplasm Transplantation, Recurrence, Colorectal Neoplasms, Fusobacterium nucleatum, Platinum Compounds, Drug Resistance, Neoplasm, MicroRNAs, Toll-Like Receptors, Mice, Tumor Microenvironment, Heterografts
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