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Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy
Open accessAbstract
Gut microbiota are linked to chronic inflammation and carcinogenesis. Chemotherapy failure is the major cause of recurrence and poor prognosis in colorectal cancer patients. Here, we investigated the contribution of gut microbiota to chemoresistance in patients with colorectal cancer. We found that Fusobacterium (F.) nucleatum was abundant in colorectal cancer tissues in patients with recurrence post chemotherapy, and was associated with patient clinicopathological characterisitcs. Furthermore, our bioinformatic and functional studies demonstrated that F. nucleatum promoted colorectal cancer resistance to chemotherapy. Mechanistically, F. nucleatum targeted TLR4 and MYD88 innate immune signaling and specific microRNAs to activate the autophagy pathway and alter colorectal cancer chemotherapeutic response. Thus, F. nucleatum orchestrates a molecular network of the Toll-like receptor, microRNAs, and autophagy to clinically, biologically, and mechanistically control colorectal cancer chemoresistance. Measuring and targeting F. nucleatum and its associated pathway will yield valuable insight into clinical management and may ameliorate colorectal cancer patient outcomes.
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“a higher abundance of F nucleatum (present in approximately 10%–15% of tumors) has been associated with advanced disease stage, higher risk of recurrence, and shorter patient survival times.23, 26, 28”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [28]
In the citing paper
“Bioinformatic and functional studies indicated that F nucleatum activates innate immune responses, via TLR4 and MYD88, resulting in loss of specific microRNAs. This resulted in activation of autophagy activation and promotion of chemoresistance in patients with CRC.28”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [28]
In the citing paper
“F nucleatum was promotes resistance of CRC cells to chemotherapy.28”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [28]
In the citing paper
“Patients with post-chemotherapy recurrence had a higher abundance of F nucleatum in tumor tissues.28, 193”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [28]
In the citing paper
“(iii) chemoresistance via direct microbial metabolism (cytidine deaminase degradation of gemcitabine) in pancreatic cancer or indirect amplification of cancer cell autophagy in colorectal cancer (14, 104)”
From The microbiome and human cancer (2021) · cites this paper as [104]
In the citing paper
“regulate chemoresistance via direct drug metabolism by microbes [415, 416]”
From Tumor microenvironment signaling and therapeutics in cancer progression (2023) · cites this paper as [416]
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Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192
GSVA: gene set variation analysis for microarray and RNA-Seq data
Hänzelmann, S., Castelo, R., & Guinney, J. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-7 · Cited by 15,440
Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668
Siegel, R., Naishadham, D., & Jemal, A. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21166 · Cited by 11,825
Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20006 · Cited by 9,709
The resurgence of platinum-based cancer chemotherapy
Kèlland, L. R. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2167 · Cited by 4,733
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Flagged first, then by citations
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Items 701–800 of 1,002
Shen, X., Li, J., Li, J., Zhang, Y., Li, X., Cui, Y., Gao, Q., Chen, X., Chen, Y., & Fang, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.661048 · Cited by 33
Self-citationFighting Cancer with Bacteria and Their Toxins
Trivanović, D., Pavelić, K., & Peršurić, Ž. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312980 · Cited by 34
Chen, H., Zhou, J., Chen, H., Liang, J., Xie, C., Gu, X., Wang, R., Mao, Z., Zhang, Y., Li, Q., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.574 · Cited by 34
Self-citationFusobacterium nucleatum : a novel immune modulator in breast cancer?
Little, A., Tangney, M., Tunney, M. M., & Buckley, N. E. (2023) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2023.9 · Cited by 33
Intratumour microbiome of pancreatic cancer
Guan, S.-W., Lin, Q., & Yu, H. (2023) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v15.i5.713 · Cited by 34
Li, X., Wang, J., Yu, H., Mei, H., He, P., Wang, M., Liu, Y., Fan, Q., Chen, Y., Li, Y., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.09.037 · Cited by 33
Self-citationAndrews, M. C., Reuben, A., Gopalakrishnan, V., & Wargo, J. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00946 · Cited by 33
Huang, X., Chen, C., Xie, W., Zhou, C., Tian, X. W., Zhang, Z., Wang, Q., Chang, H., Xiao, W., Zhang, R., et al. (2023) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2023.06.2515 · Cited by 32
Zhou, X., You, L., Xin, Z., Su, H., Zhou, J., & Ma, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04582-w · Cited by 32
Robinson, W., Stone, J. K., Schischlik, F., Gasmi, B., Kelly, M. C., Seibert, C., Dadkhah, K., Gertz, E. M., Lee, J. S., Zhu, K., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj7402 · Cited by 37
Rahal, Z., Liu, Y., Peng, F., Yang, S., Jamal, M. A., Sharma, M., Moreno, H., Damania, A. V., Wong, M. C., Ross, M. C., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-0469 · Cited by 34
Immunoregulation and male reproductive function: Impacts and mechanistic insights into inflammation
Ma, Y., Yu, X., Liu, Y. F., Song, B., Sun, Z., & Zhao, S. (2024) · Andrology · doi:10.1111/andr.13772 · Cited by 35
Wang, X., Zhang, X., Yuan, J., Wu, J., Deng, X., Peng, J., Wang, S., Yang, C., Ge, J., & Zou, Y. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.04.128 · Cited by 32
Shah, M. S., DeSantis, T. Z., Yamal, J., Weir, T. L., Ryan, E. P., Cope, J. L., & Hollister, E. B. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207002 · Cited by 33
Jiang, Y., Guo, Z., Fang, J., Wang, B., Lin, Z., Chen, Z., Chen, Y., Zhang, N., Yang, X., & Gao, W. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110224 · Cited by 32
Self-citationLncRNA TUG1 promotes the progression of colorectal cancer via the miR-138-5p/ZEB2 axis
Yan, Z., Bi, M., Zhang, Q., Song, Y., & Hong, S. (2020) · Bioscience Reports · doi:10.1042/bsr20201025 · Cited by 32
RetractedDoes the Gut Microbiota Modulate Host Physiology through Polymicrobial Biofilms?
Yang, J., Yang, Y., Ishii, M., Nagata, M., Aw, W., Obana, N., Tomita, M., Nomura, N., & Fukuda, S. (2020) · Microbes and Environments · doi:10.1264/jsme2.me20037 · Cited by 33
Deng, Y., Yao, H., Chen, W., Wei, H., Li, X., Zhang, F., Gao, S., Man, H., Chen, J., Tao, X., et al. (2020) · Journal of Cancer · doi:10.7150/jca.47631 · Cited by 32
Antibiotics modulate neoadjuvant therapy efficiency in patients with breast cancer: a pilot analysis
Zhang, X., Yu, L., Shi, J., Li, S., Yang, S., Gao, W., Yang, S., Cheng, M., Wang, H., Guo, Z., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-93428-w · Cited by 32
Casimiro‐Soriguer, C. S., Loucera, C., Peña-Chilet, M., & Dopazo, J. (2022) · Scientific Reports · doi:10.1038/s41598-021-04182-y · Cited by 38
Zhang, T., Deng, Y., Yang, S. L., Chua, S. L., Tang, B. Z., & Khoo, B. L. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.137579 · Cited by 31
Burcher, K. M., Burcher, J. T., Inscore, L., Bloomer, C. H., Furdui, C. M., & Porosnicu, M. (2022) · Cancers · doi:10.3390/cancers14174116 · Cited by 34
Queen, J., Shaikh, F. Y., & Sears, C. L. (2023) · Nature Cancer · doi:10.1038/s43018-023-00602-2 · Cited by 34
Retracted: CircRNA_103948 inhibits autophagy in colorectal cancer in a ceRNA manner
Zhang, N., Zhang, X., Xu, W., Zhang, X., & Mu, Z. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14679 · Cited by 31
RetractedThe oral-gut-circulatory axis: from homeostasis to colon cancer
Tortora, S. C., Agurto, M. I. G., & Martello, L. A. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1289452 · Cited by 34
Bacterial infection and microbiota in carcinogenesis and tumor development
Li, Q. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1294082 · Cited by 32
Targeting the gut microbiota: a new strategy for colorectal cancer treatment
Hu, Y., Zhou, P., Deng, K., Zhou, Y., & Hu, K. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05671-0 · Cited by 32
Relationship between periodontitis and systemic health conditions: a narrative review
Kim, M.-Y., & Pang, E. (2025) · Ewha Medical Journal · doi:10.12771/emj.2025.00101 · Cited by 41
Intestinal dysbiosis and colorectal cancer
Kang, Z., Jiang, S., Fang, J., & Chen, H. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003617 · Cited by 36
Self-citationYu, H., Du, Y., He, Y., Sun, Y., Li, J., Jia, B., Chen, J., Peng, X., An, T., Li, J., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.06.013 · Cited by 34
Liao, K., Wen, J., Liu, Z., Zhang, B., Zhang, X., Fu, Y., Zhang, W., Hu, H., Ai, K., Zhu, W., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102820 · Cited by 34
Self-citationPersonalized colorectal cancer risk assessment through explainable AI and Gut microbiome profiling
Novielli, P., Baldi, S., Romano, D., Magarelli, M., Diacono, D., Bitonto, P. D., Nannini, G., Gloria, L. D., Bellotti, R., Amedei, A., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2543124 · Cited by 34
Programmed cell death network in cancer drug resistance: A framework for therapeutic intervention
Guo, D., Guo, Y., Zhu, C., Liao, Y., Lin, Z., Zhang, H., Zhang, W., & Zou, Z. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101387 · Cited by 36
Zhu, X.-H., Lang, H., Wang, X., Hui, S., Zhou, M., Kang, C., Yi, L., Mi, M., & Zhang, Y. (2019) · Food & Function · doi:10.1039/c8fo01756e · Cited by 30
The Role of Fusobacterium nucleatum in Colorectal Carcinogenesis
Datorre, J. G., de Carvalho, A. C., Guimarães, D. P., & Reis, R. M. (2020) · Pathobiology · doi:10.1159/000512175 · Cited by 32
Zhang, Y., Jiang, W., Xu, J., Wu, N., Wang, Y., Lin, T., Liu, Y., & Liu, Y. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.535940 · Cited by 32
Liu, S., Zeng, F., Fan, G., & Dong, Q. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.649752 · Cited by 30
Wang, Y., Zhang, Y., Wang, Z., Tang, J., Cao, D., Qian, Y., Xie, Y.-H., Chen, H.-Y., Chen, Y.-X., Chen, Z.-F., et al. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-8168 · Cited by 17
Self-citationLi, C., Liu, F., Xu, Y., Guo, B., Li, G., Yin, J., He, G., Yang, C., Xu, L., Li, S., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00884-y · Cited by 31
Borgognone, A., Serna, G., Noguera-Julián, M., Alonso, L., Parera, M., Català‐Moll, F., Sanchez, L. R., Fasani, R., Paredes, R., & Nuciforo, P. G. (2021) · Cancers · doi:10.3390/cancers13215421 · Cited by 34
Combination gut microbiota modulation and chemotherapy for orthotopic colorectal cancer therapy
Chen, Z., Li, J.-L., Pan, P., Bao, P., Zeng, X., & Zhang, X. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101329 · Cited by 31
Panebianco, C., Ciardiello, D., Villani, A., Maiorano, B. A., Latiano, T. P., Maiello, E., Perri, F., & Pazienza, V. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.11.007 · Cited by 33
Pan, Z., Wei, X., Li, S.-J., Guo, H., Li, Z., Zhang, K.-K., Lyu, Q., Liu, W., Yang, Q., & Cheng, D. (2022) · Oncogenesis · doi:10.1038/s41389-022-00390-x · Cited by 33
Jia, F., Yu, Q., Wang, R., Zhao, L., Yuan, F., Guo, H., Shen, Y., & He, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021469 · Cited by 32
Autophagy orchestrates resistance in hepatocellular carcinoma cells
Seydi, H., Nouri, K., Rezaei, N., Tamimi, A., Hassan, M., Mirzaei, H., & Vosough, M. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114487 · Cited by 33
Tumor-resident microbes: the new kids on the microenvironment block
Li, L., Chandra, V., & McAllister, F. (2024) · Trends in Cancer · doi:10.1016/j.trecan.2023.12.002 · Cited by 30
Hong, X., Yu, T., Huang, X., Wang, J., Sun, T., Yan, T., Zhou, C., Chen, H., Su, W., Du, W., et al. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-02044-6 · Cited by 30
Self-citationMicrobiota as the unifying factor behind the hallmarks of cancer
Benešová, I., Křížová, Ľ., & Kverka, M. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05244-6 · Cited by 34
Influence of Microbiota on Tumor Immunotherapy
Yu, X., Li, W., Li, Z., Wu, Q., & Sun, S. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.91771 · Cited by 33
Benej, M., Hoyd, R., Kreamer, M., Wheeler, C. E., Grencewicz, D. J., Choueiry, F., Chan, C. H. F., Zakharia, Y., Ma, Q., Dodd, R. D., et al. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0367 · Cited by 32
Reexamining the role of Fusobacterium nucleatum subspecies in clinical and experimental studies
Krieger, M., Guo, M., & Merritt, J. L. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2415490 · Cited by 33
Exploring the gut microbiome’s role in colorectal cancer: diagnostic and prognostic implications
Chen, G., Ren, Q., Zhong, Z., Li, Q., Huang, Z., Zhang, C., Yuan, H., Feng, Z., Chen, B., Wang, N., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1431747 · Cited by 34
Designing live bacterial therapeutics for cancer
Lee, J., McClure, S., Weichselbaum, R. R., & Mimee, M. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115579 · Cited by 31
Integrative systems biology approaches for analyzing microbiome dysbiosis and species interactions
Rehman, S. S. U., Nasar, M. I., Mesquita, C. S., Khodor, S. A., Notebaart, R. A., Ott, S., Mundra, S., Arasardanam, R. P., Muhammad, K., & Alam, M. T. (2025) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf323 · Cited by 35
Rastogi, Y. R., Saini, A. K., Thakur, V. K., & Saini, R. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093212 · Cited by 32
Dong, J., Gao, H.-L., Wang, W., Yu, X., & Liu, L. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188484 · Cited by 30
Bund, T., Nikitina, E., Chakraborty, D., Ernst, C., Gunst, K., Boneva, B., Tessmer, C., Volk, N., Brobeil, A., Weber, A., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2025830118 · Cited by 30
The intratumoural microbiota in cancer: new insights from inside
An, Y., Zhang, W., Liu, T., Wang, B., & Cao, H. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188626 · Cited by 29
Liu, L., Liu, T., Tao, W., Liao, N., Yan, Q., Li, L., Tan, J., Shen, W., Cheng, H., & Sun, D. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154007 · Cited by 30
Self-citationMassironi, S., Facciotti, F., Cavalcoli, F., Amoroso, C., Rausa, E., Centonze, G., Cribiù, F. M., Invernizzi, P., & Milione, M. (2022) · Cells · doi:10.3390/cells11040692 · Cited by 32
mbDenoise: microbiome data denoising using zero-inflated probabilistic principal components analysis
Zeng, Y., Li, J., Wei, C., Zhao, H., & Wang, T. (2022) · Genome biology · doi:10.1186/s13059-022-02657-3 · Cited by 29
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Intratumoral microbiota: new frontiers in tumor immunity
Zhang, Z., Liao, Y., & Tang, D. (2022) · Carcinogenesis · doi:10.1093/carcin/bgac063 · Cited by 30
Yue, Y., Zhang, Q., Wang, X., & Sun, Z. (2023) · Cancer Science · doi:10.1111/cas.15761 · Cited by 29
Intestinal bacteria detected in cancer and adjacent tissue from patients with colorectal cancer
Liu, C., Yuan-Lian, Z., Shang, Y., Wu, B., Yang, E., Luo, Y., & Li, X. (2018) · Oncology Letters · doi:10.3892/ol.2018.9714 · Cited by 30
The role of TFEB in tumor cell autophagy: Diagnostic and therapeutic opportunities
Bahrami, A., Bianconi, V., Pirro, M., Orafai, H. M., & Sahebkar, A. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117341 · Cited by 29
Yao, X., Lan, Z., Lai, Q., Li, A., Liu, S., & Wang, X. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29672 · Cited by 30
Wang, H., Liang, Y., Zhang, T., Yu, X., Song, X., Chen, Y., Mao, Q., Xia, W., Chen, B., Xu, L., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01222-0 · Cited by 28
Self-citationAhluwalia, P. K., Ballur, K., Leeman, T., Vashisht, A., Singh, H., Omar, N., Mondal, A. K., Vaibhav, K., Baban, B., & Kolhe, R. B. (2024) · Cancers · doi:10.3390/cancers16030480 · Cited by 31
The role of microbiomes in gastrointestinal cancers: new insights
Yarahmadi, A., & Afkhami, H. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2023.1344328 · Cited by 30
Rauth, S., Malafa, M. P., Ponnusamy, M. P., & Batra, S. K. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.05.005 · Cited by 29
Guo, X., & Shao, Y. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01166-w · Cited by 31
Gao, Y., Fu, S., Peng, Y., Zhou, Y., Zhu, J., Zhang, X., Cai, C., Han, Y., Shen, H., & Zeng, S. (2025) · Autophagy · doi:10.1080/15548627.2025.2477443 · Cited by 29
Fusobacterium nucleatum prevents apoptosis in colorectal cancer cells via the ANO1 pathway
Lu, P., Xu, M., Xiong, Z., Zhou, F., & Wang, L. (2019) · Cancer Management and Research · doi:10.2147/cmar.s185766 · Cited by 31
microRNAs Tune Oxidative Stress in Cancer Therapeutic Tolerance and Resistance
Zhang, W. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236094 · Cited by 29
Gut Microbiota and Cancer of the Host: Colliding Interests
Baffy, G. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-34025-4_5 · Cited by 30
Bugs as drugs: The role of microbiome in cancer focusing on immunotherapeutics
Araujo, D. V., Watson, G. A., Oliva, M., Heirali, A., Coburn, B., Spreafico, A., & Siu, L. L. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2020.102125 · Cited by 29
A Crosstalk between Diet, Microbiome and microRNA in Epigenetic Regulation of Colorectal Cancer
Guz, M., Jeleniewicz, W., Malm, A., & Korona‐Głowniak, I. (2021) · Nutrients · doi:10.3390/nu13072428 · Cited by 31
Impact of Fusobacterium nucleatum in the gastrointestinal tract on natural killer cells
Kim, Y. J., Kim, B. K., Park, S. J., & Kim, J. H. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i29.4879 · Cited by 31
Xing, J., Liao, Y., Zhang, H., Zhang, W., Zhang, Z., Zhang, J., Wang, D., & Tang, D. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.804689 · Cited by 29
Hu, L.-P., Huang, W., Wang, X., Xu, C., Qin, W., Li, D., Tian, G.-A., Li, Q., Zhou, Y.-Q., Chen, S.-Y., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.06.015 · Cited by 31
Molecular Regulators of Embryonic Diapause and Cancer Diapause-like State
Hussein, A. M., Balachandar, N., Mathieu, J., & Ruohola‐Baker, H. (2022) · Cells · doi:10.3390/cells11192929 · Cited by 29
Gut microbiome in tumorigenesis and therapy of colorectal cancer
Wang, L., Yu, K., Hou, Y., Guo, M., Yao, F., & Chen, Z. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30917 · Cited by 31
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Yu, I., Wu, R., Tokumaru, Y., Terracina, K. P., & Takabe, K. (2022) · Cancers · doi:10.3390/cancers14225685 · Cited by 30
Löwenmark, T., Löfgren‐Burström, A., Zingmark, C., Ljuslinder, I., Dahlberg, M. L., Edin, S., & Palmqvist, R. (2022) · Cancers · doi:10.3390/cancers14235937 · Cited by 30
Guevarra, L. A., Afable, A. C. F., Belza, P. J. O., Dy, K. J. S., Lee, S. J. Q., Sy-Ortin, T., & Albano, P. M. (2018) · Infectious Agents and Cancer · doi:10.1186/s13027-018-0184-7 · Cited by 29
Zhang, X., Li, Q., Du, A., Li, Y., Shi, Q., Chen, Y., Zhao, Y., Wang, B., & Pan, F. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.748730 · Cited by 28
Self-citationMicrobiome in Cancer Development and Treatment
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Singh, G., Chaudhry, Z., Boyadzhyan, A., Sasaninia, K., & Rai, V. (2025) · Exploration of Targeted Anti-tumor Therapy · doi:10.37349/etat.2025.1002329 · Cited by 32
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Huangfu, S., Zhang, W.-B., Zhang, H., Yang, L., Zhang, Y., Nie, J.-L., Chu, X., Chen, C.-S., Jiang, H., & Pan, J. (2021) · Journal of Cancer · doi:10.7150/jca.50111 · Cited by 29
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Li, Q., Lai, Q., He, C., Zhang, H., Pan, X., Li, H., Yan, Q., Fang, Y., Liu, S., & Li, A. (2021) · Journal of Cancer · doi:10.7150/jca.51338 · Cited by 30
You, L., Zhou, J., Xin, Z., Hauck, J. S., Na, F., Tang, J., Zhou, X., Lei, Z., & Ying, B. (2022) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbac005 · Cited by 30
Merali, N., Chouari, T. A. M., Kayani, K., Rayner, C. J., Jiménez, J. I., Krell, J., Giovannetti, E., Bagwan, I., Relph, K., Rockall, T., et al. (2022) · Cancers · doi:10.3390/cancers14041020 · Cited by 29
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Qi, X., Liu, Y., Hussein, S., Choi, G., Kimchi, E. T., Staveley-O’Carroll, K. F., & Li, G. (2022) · Cells · doi:10.3390/cells11223684 · Cited by 29
Metadata
- Authors
- Yu, T., Guo, F., Yu, Y., Sun, T., Ma, D., Han, J., Qian, Y., Kryczek, I., Sun, D., Nagarsheth, N., Chen, Y., Chen, H., Hong, J., Zou, W., & Fang, J.-Y.
- Affiliations
- Shanghai Jiao Tong University (CN)
- University of Michigan (US)
- Corresponding author
- Chen, Yingxuan
- Chen, Haoyan
- Hong, Jie
- Zou, Weiping
- Fang, Jing-Yuan
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 170
- Issue
- 3
- Pages
- 548-563.e16
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC5767127
- OpenAlex
- W2742147437
- Cited by
- 2,198
- References
- 50
- Citations by year
- 2026: 265 · 2025: 291 · 2024: 300 · 2023: 323 · 2022: 287 · 2021: 268 · 2020: 214 · 2019: 124 · 2018: 105 · 2017: 17
- FWCI
- 51.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Natural Science Foundation of China (81421001, 81320108024, 81530072, 81522008 31371273, 31371420, 81572303, 81001070)
- National Key Technology R&D Program (2014BAI09B05)
- Program for Professor of Special Appointment (Eastern Scholar No. 201268, 2015 Youth Eastern Scholar NO.QD2015003)
- Shanghai Institutions of Higher Learning, the Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant (20152512, 20161309)
- National Cancer Institute (CA211016)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- Fusobacterium nucleatum, colorectal cancer, chemoresistance, autophagy, gut microbiota, TLR4, MyD88, microRNA, innate immune signaling, chronic inflammation
- MeSH terms
- Gastrointestinal Microbiome, Capecitabine, Animals, Antineoplastic Agents, Autophagy, Neoplasm Transplantation, Recurrence, Colorectal Neoplasms, Fusobacterium nucleatum, Platinum Compounds, Drug Resistance, Neoplasm, MicroRNAs, Toll-Like Receptors, Mice, Tumor Microenvironment, Heterografts
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