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Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer
Open accessAbstract
We conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on chromosome-arm-level aneuploidy, DNA hypermethylation, mRNA, and miRNA expression levels and reverse-phase protein arrays, of which all, except for aneuploidy, revealed clustering primarily organized by histology, tissue type, or anatomic origin. The influence of cell type was evident in DNA-methylation-based clustering, even after excluding sites with known preexisting tissue-type-specific methylation. Integrative clustering further emphasized the dominant role of cell-of-origin patterns. Molecular similarities among histologically or anatomically related cancer types provide a basis for focused pan-cancer analyses, such as pan-gastrointestinal, pan-gynecological, pan-kidney, and pan-squamous cancers, and those related by stemness features, which in turn may inform strategies for future therapeutic development.
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“The nature of these mutations differs for each cancer [90] and in each individual [90,91,92].”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [92]
Experimental — accuracy not yet measuredIn the citing paper
“First, although tumors are readily recognized through gene expression signatures, they retain transcriptomic features of the parental tissue so that tumors arising in the same organ are more similar to each other than tumors arising in different organs.”
From Metabolic reprogramming and cancer progression (2020) · cites this paper as [3]
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“A study that classified thousands of human tumors found that tissue of origin was a major factor defining DNA methylation and gene expression patterns (3).”
From Metabolic reprogramming and cancer progression (2020) · cites this paper as [3]
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USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity
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Cancer catecholamine conundrum
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Wenta, T., Schmidt, A., Zhang, Q., Devarajan, R., Singh, P., Yang, X., Ahtikoski, A. M., Vaarala, M. H., Wei, G., & Manninen, A. (2022) · Oncogene · doi:10.1038/s41388-022-02389-5 · Cited by 38
Larkin, K. T. M., Nicolet, D., Kelly, B., Mrózek, K., LaHaye, S., Miller, K. E., Wijeratne, S., Wheeler, G. L., Kohlschmidt, J., Blachly, J. S., et al. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022007544 · Cited by 36
“8 Disease-free at 5 y, % (95% CI) 24% (10-42) 42% (34-49) n = 42§ n = 212§ OS <.”
Self-citationCare, M. A., Westhead, D. R., & Tooze, R. M. (2019) · npj Systems Biology and Applications · doi:10.1038/s41540-019-0090-7 · Cited by 36
“An extension is provided by pan-cancer classification where cases associated with key molecular features are combined potentially across the boundaries of conventional classification.(2) Gene expression-based classifications have defined both prognostically and pathogenetically distinct cancer subtypes, which have pre…”
Wu, Z., He, Y., Wang, T., Yang, D.-W., Li, D., Deng, C., Cao, L., Zhang, J., Xue, W., & Jia, W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.763875 · Cited by 35
“…of the prognosis associated genes expression with the Frontiers in Cell and Developmental Biology | www.frontiersin.org December 2021 | Volume 9 | Article 7638756 stemness of the same sample, we utilized the stemness score determined by the DNA hypermethylation data and mRNA (Hoadley et al., 2018).”
MethodSelf-citationGene Expression Profiles in Cancers and Their Therapeutic Implications
Creighton, C. J. (2023) · The Cancer Journal · doi:10.1097/ppo.0000000000000638 · Cited by 35
Self-citationCouto, J., Vulin, M., Jehanno, C., Coissieux, M.-M., Hamelin, B., Schmidt, A., Ivanek, R., Sethi, A., Bräutigam, K., Frei, A., et al. (2023) · EMBO Journal · doi:10.15252/embj.2022112559 · Cited by 31
“…but also prostate, colorectal, stomach, pancreatic, uterine, ovarian, and small cell lung cancers (Bell et al , 2011; Curtis et al , 2012; Koboldt et al , 2012; Getz et al , 2013; Abeshouse et al , 2015; George et al , 2015; Pereira et al , 2016; Hoadley et al , 2018; Fig 5C and Dataset EV3).”
The wonders of X-PDT: an advance route to cancer theranostics
Mushtaq, A., Iqbal, M. Z., Tang, J., & Sun, W. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02931-5 · Cited by 35
“…these molecular subtypes can be found in clinical subsets; luminal A and B subtypes express keratins 8/18 and ER-related gene clusters, the BL has overexpression of keratin 5, 17, and EGFR-related genes, and the HER2-Enriched sub-type is characterized by expression of Erb-B2-related genes [71, 72].”
BackgroundHepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice
Liu, Y., Dantas, E., Ferrer, M., Miao, T., Qadiri, M., Liu, Y., Comjean, A., Davidson, E. E., Perrier, T., Ahmed, T., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01265-2 · Cited by 57
“Additionally, transcriptomic data and corresponding survival records were obtained from the Hepato-cellular Carcinoma (LIHC) cohort of 372 participants in the PanCancer Atlas of TCGA Program 75,76 .”
Self-citationInhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia
Lewis, A. C., Gruber, E., Franich, R. L., Armstrong, J. M., Kelly, M. J., Opazo, C., Low, Y. C., Flippe, L., Wijanarko, K. J., Rowe, C. L., et al. (2025) · Cell · doi:10.1016/j.cell.2025.10.028 · Cited by 39
Putative biomarkers for predicting tumor sample purity based on gene expression data
Li, Y., Umbach, D. M., Bingham, A., Li, Q.-J., Zhuang, Y., & Li, L. (2019) · BMC Genomics · doi:10.1186/s12864-019-6412-8 · Cited by 33
“The tumor purity estimates by ABSOLUTE [8] for tumor tissue samples from 33 TCGA tumor types were obtained from [9]; these purity estimates are summarized for each tumor type in Additional file 1: Figure S1.”
BackgroundMethodExploration of Coding and Non-coding Variants in Cancer Using GenomePaint
Zhou, X., Wang, J., Patel, J. N., Valentine, M. B., Shao, Y., Newman, S., Sioson, E., Tian, L., Liu, Y., Brady, S. W., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2020.12.011 · Cited by 34
Self-citationRecent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer
Khella, C. A., Mehta, G. A., Mehta, R. N., & Gatza, M. L. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11020149 · Cited by 35
LRP5 Promotes Gastric Cancer via Activating Canonical Wnt/β-Catenin and Glycolysis Pathways
Nie, X., Wang, H., Wei, X., Li, L., Xue, T., Fan, L., Ma, H., Xia, Y., Wang, Y., & Chen, W. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.11.007 · Cited by 35
Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer
Bonazzi, V., Kondrashova, O., Smith, D. S., Nones, K., Sengal, A. T., Ju, R. J., Packer, L., Koufariotis, L. T., Kazakoff, S. H., Davidson, A. L., et al. (2022) · Genome Medicine · doi:10.1186/s13073-021-00990-z · Cited by 34
“Despite the difference in TP53 mutation status, they all shared low TMB (≤10 Mutations/Mb), high degree of genomic instability (>25% of genome with CNAs and >15 CN segments), and low MSI scores, suggesting microsatellite stability.”
BackgroundInfluentialHerrgott, G. A., Asmaro, K. P., Wells, M., Sabedot, T. S., Malta, T. M., Mosella, M. S., Nelson, K. K., Scarpace, L. M., Barnholtz‐Sloan, J. S., Sloan, A. E., et al. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac050 · Cited by 35
Self-citationPrecision Combination Therapies Based on Recurrent Oncogenic Coalterations
Li, X., Kong, E., Yan, G., Dereli, Z., Bozorgui, B., Imanirad, P., Elnaggar, J. H., Luna, A., Menter, D. G., Pilie, P. G., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0832 · Cited by 34
Self-citationSong, Q., Ye, Y., Jiang, D., Qin, Z., Xu, C., Wang, H., Huang, J., Chen, L., Luo, R., Zhang, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31719-0 · Cited by 35
Club cells employ regeneration mechanisms during lung tumorigenesis
Chen, Y., Tóth, R., Chocarro, S., Weichenhan, D., Hey, J., Lutsik, P., Sawall, S., Stathopoulos, G. T., Plass, C., & Sotillo, R. (2022) · Nature Communications · doi:10.1038/s41467-022-32052-2 · Cited by 36
Lin, A. L., Rudneva, V. A., Richards, A. L., Zhang, Y., Woo, H. J., Cohen, M. A., Tisnado, J., Majd, N., Wardlaw, S. L., Page‐Wilson, G., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02736-8 · Cited by 35
“It has been shown that tumors arising from the same tissue type and tumors arising from similar tissue types share similar patterns of ane-uploidy [7, 21]; for example, squamous cancers of multiple primary sites cluster together [21, 22].”
BackgroundJiang, X., Ye, J., Dong, Z., Hu, S., & Xiao, M. (2019) · Cancer Management and Research · doi:10.2147/cmar.s187780 · Cited by 34
Cancer Treatment in the Genomic Era
Doherty, G. J., Petruzzelli, M., Beddowes, E. J., Ahmad, S. S., Caldas, C., & Gilbertson, R. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-011840 · Cited by 36
Vlachavas, E., Bohn, J. R., Ückert, F., & Nürnberg, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062822 · Cited by 37
“These results shed light on the molecular underpinnings of cancer, such as cell-of-origin patterns and oncogenic processes, which classify distinct solid tumors and could serve as a valuable resource for precision medicine [17].”
BackgroundLepage, C. C., Palmer, M. C. L., Farrell, A. C., Neudorf, N. M., Lichtensztejn, Z., Nachtigal, M. W., & McManus, K. J. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01317-w · Cited by 40
TIRR inhibits the 53BP1-p53 complex to alter cell-fate programs
Parnandi, N., Rendo, V., Cui, G., Botuyan, M. V., Remišová, M., Nguyen, H. Q., Drané, P., Beroukhim, R., Altmeyer, M., Mer, G., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.03.039 · Cited by 37
Self-citationLindsay, H., Scollon, S., Reuther, J., Voicu, H., Rednam, S. P., Lin, F. Y. H., Fisher, K. E., Chintagumpala, M., Adesina, A. M., Parsons, D. W., et al. (2019) · Molecular Case Studies · doi:10.1101/mcs.a004499 · Cited by 34
An Analysis Regarding the Association Between the ISLR Gene and Gastric Carcinogenesis
Li, S., Zhao, W., & Sun, M. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00620 · Cited by 33
Epithelial cell plasticity: breaking boundaries and changing landscapes
Tata, A., Chow, R. D.-W., & Tata, P. R. (2021) · EMBO Reports · doi:10.15252/embr.202051921 · Cited by 32
“…2007; Jopling et al , 2011; Stange et al , 2013; Tata et al , 2013; Blanpain & Fuchs, 2014; Chua et al , 2014; Friedmann-Morvinski & Verma, 2014; Hogan et al , 2014; S (cid:1) anchez Alvarado & Yamanaka, 2014; Mills & Sansom, 2015; Tata & Rajagopal, 2016a; Tata & Rajagopal, 2016b; Tetteh et al…”
cSurvival: a web resource for biomarker interactions in cancer outcomes and in cell lines
Cheng, X., Liu, Y., Wang, J., Chen, Y., Robertson, A. G., Zhang, X., Jones, S. J. M., & Taubert, S. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac090 · Cited by 36
“The Cancer Genome Atlas We extracted curated clinical outcome endpoints data from the TCGA Pan-Cancer Clinical Data Resource [6] and multiomics molecular data from [43].”
Self-citationMartell, E., Kuzmychova, H., Senthil, H., Kaul, E., Chokshi, C., Venugopal, C., Anderson, C. M., Singh, S. K., & Sharif, T. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01604-y · Cited by 34
“The TCGA GBM patient data used in this study are available from BioPortal for Cancer Genomics [7, 13, 19] https:// www.”
MethodSalo, A. M., Rappu, P., Koski, M. K., Karjalainen, E., Izzi, V., Drushinin, K., Miinalainen, I., Käpylä, J., Heino, J., & Myllyharju, J. (2023) · Matrix Biology · doi:10.1016/j.matbio.2023.12.001 · Cited by 35
Tanaka, A., Ogawa, M., Zhou, Y., Namba, K., Hendrickson, R. C., Miele, M. M., Li, Z., Klimstra, D. S., Buckley, P. G., Gulcher, J. R., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113810 · Cited by 37
Self-citationCommon features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas
Zaccari, P., Cardinale, V., Severi, C., Pedica, F., Carpino, G., Gaudio, E., Doglioni, C., Petrone, M. C., Alvaro, D., Arcidiacono, P. G., et al. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i31.4343 · Cited by 35
Self-citationSiwak, D. R., Li, J., Akbani, R., Liang, H., & Lu, Y. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9755-5_7 · Cited by 33
Self-citationHe, Z., Wang, C., Xue, H., Zhao, R., & Li, G. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01631 · Cited by 33
Gao, Y., Wei, Y., Zhou, X., Huang, S., Zhao, H., & Zeng, P. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.583106 · Cited by 33
The role of the SWI/SNF chromatin remodeling complex in pancreatic ductal adenocarcinoma
Tsuda, M., Fukuda, A., Kawai, M., Araki, O., & Seno, H. (2020) · Cancer Science · doi:10.1111/cas.14768 · Cited by 36
Metadata
- Authors
- Hoadley, K. A., Yau, C., Hinoue, T., Wolf, D. M., Lazar, A. J., Drill, E., Shen, R., Taylor, A. M., Cherniack, A. D., Thorsson, V., Akbani, R., Bowlby, R., Wong, C. K., Wiznerowicz, M., Sanchez-Vega, F., Robertson, A. G., Schneider, B. G., Lawrence, M. S., Noushmehr, H., Malta, T. M., Caesar-Johnson, S. J., Demchok, J. A., Felau, I., Kasapi, M., Ferguson, M. L., Hutter, C. M., Sofia, H. J., Tarnuzzer, R., Wang, Z., Yang, L., Zenklusen, J. C., Zhang, J. (., Chudamani, S., Liu, J., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Wu, Y., Cho, J., DeFreitas, T., Frazer, S., Gehlenborg, N., Getz, G., Heiman, D. I., Kim, J., Lawrence, M. S., Lin, P., Meier, S., Noble, M. S., Saksena, G., Voet, D., Zhang, H., Bernard, B., Chambwe, N., Dhankani, V., Knijnenburg, T., Kramer, R., Leinonen, K., Liu, Y., Miller, M., Reynolds, S., Shmulevich, I., Thorsson, V., Zhang, W., Akbani, R., Broom, B. M., Hegde, A. M., Ju, Z., Kanchi, R. S., Korkut, A., Li, J., Liang, H., Ling, S., Liu, W., Lu, Y., Mills, G. B., Ng, K.-S., Rao, A., Ryan, M., Wang, J., Weinstein, J. N., Zhang, J., Abeshouse, A., Armenia, J., Chakravarty, D., Chatila, W. K., de Bruijn, I., Gao, J., Gross, B. E., Heins, Z. J., Kundra, R., La, K., Ladanyi, M., Luna, A., Nissan, M. G., Ochoa, A., Phillips, S. M., Reznik, E., Sanchez-Vega, F., Sander, C., Schultz, N., Sheridan, R., Sumer, S. O., Sun, Y., Taylor, B. S., Wang, J., Zhang, H., Anur, P., Peto, M., Spellman, P., Benz, C., Stuart, J. M., Wong, C. K., Yau, C., Hayes, D. N., Parker, J. S., Wilkerson, M. D., Ally, A., Balasundaram, M., Bowlby, R., Brooks, D., Carlsen, R., Chuah, E., Dhalla, N., Holt, R., Jones, S. J. M., Kasaian, K., Lee, D., Ma, Y., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Mungall, K., Robertson, A. G., Sadeghi, S., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Tse, K., Wong, T., Berger, A. C., Beroukhim, R., Cherniack, A. D., Cibulskis, C., Gabriel, S. B., Gao, G. F., Ha, G., Meyerson, M., Schumacher, S. E., Shih, J., Kucherlapati, M. H., Kucherlapati, R. S., Baylin, S., Cope, L., Danilova, L., Bootwalla, M. S., Lai, P. H., Maglinte, D. T., Van Den Berg, D. J., Weisenberger, D. J., Auman, J. T., Balu, S., Bodenheimer, T., Fan, C., Hoadley, K. A., Hoyle, A. P., Jefferys, S. R., Jones, C. D., Meng, S., Mieczkowski, P. A., Mose, L. E., Perou, A. H., Perou, C. M., Roach, J., Shi, Y., Simons, J. V., Skelly, T., Soloway, M. G., Tan, D., Veluvolu, U., Fan, H., Hinoue, T., Laird, P. W., Shen, H., Zhou, W., Bellair, M., Chang, K., Covington, K., Creighton, C. J., Dinh, H., Doddapaneni, H., Donehower, L. A., Drummond, J., Gibbs, R. A., Glenn, R., Hale, W., Han, Y., Hu, J., Korchina, V., Lee, S., Lewis, L., Li, W., Liu, X., Morgan, M., Morton, D., Muzny, D., Santibanez, J., Sheth, M., Shinbrot, E., Wang, L., Wang, M., Wheeler, D. A., Xi, L., Zhao, F., Hess, J., Appelbaum, E. L., Bailey, M., Cordes, M. G., Ding, L., Fronick, C. C., Fulton, L. 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V., Broudy, T., Mirsaidi, C., Nair, P., Drwiega, P., Miller, J., Smith, J., Zaren, H., Park, J.-W., Hung, N. P., Kebebew, E., Linehan, W. M., Metwalli, A. R., Pacak, K., Pinto, P. A., Schiffman, M., Schmidt, L. S., Vocke, C. D., Wentzensen, N., Worrell, R., Yang, H., Moncrieff, M., Goparaju, C., Melamed, J., Pass, H., Botnariuc, N., Caraman, I., Cernat, M., Chemencedji, I., Clipca, A., Doruc, S., Gorincioi, G., Mura, S., Pirtac, M., Stancul, I., Tcaciuc, D., Albert, M., Alexopoulou, I., Arnaout, A., Bartlett, J., Engel, J., Gilbert, S., Parfitt, J., Sekhon, H., Thomas, G., Rassl, D. M., Rintoul, R. C., Bifulco, C., Tamakawa, R., Urba, W., Hayward, N., Timmers, H., Antenucci, A., Facciolo, F., Grazi, G., Marino, M., Merola, R., de Krijger, R., Gimenez-Roqueplo, A.-P., Piché, A., Chevalier, S., McKercher, G., Birsoy, K., Barnett, G., Brewer, C., Farver, C., Naska, T., Pennell, N. A., Raymond, D., Schilero, C., Smolenski, K., Williams, F., Morrison, C., Borgia, J. A., Liptay, M. J., Pool, M., Seder, C. W., Junker, K., Omberg, L., Dinkin, M., Manikhas, G., Alvaro, D., Bragazzi, M. C., Cardinale, V., Carpino, G., Gaudio, E., Chesla, D., Cottingham, S., Dubina, M., Moiseenko, F., Dhanasekaran, R., Becker, K.-F., Janssen, K.-P., Slotta-Huspenina, J., Abdel-Rahman, M. H., Aziz, D., Bell, S., Cebulla, C. M., Davis, A., Duell, R., Elder, J. B., Hilty, J., Kumar, B., Lang, J., Lehman, N. L., Mandt, R., Nguyen, P., Pilarski, R., Rai, K., Schoenfield, L., Senecal, K., Wakely, P., Hansen, P., Lechan, R., Powers, J., Tischler, A., Grizzle, W. E., Sexton, K. C., Kastl, A., Henderson, J., Porten, S., Waldmann, J., Fassnacht, M., Asa, S. L., Schadendorf, D., Couce, M., Graefen, M., Huland, H., Sauter, G., Schlomm, T., Simon, R., Tennstedt, P., Olabode, O., Nelson, M., Bathe, O., Carroll, P. R., Chan, J. M., Disaia, P., Glenn, P., Kelley, R. K., Landen, C. N., Phillips, J., Prados, M., Simko, J., Smith-McCune, K., VandenBerg, S., Roggin, K., Fehrenbach, A., Kendler, A., Sifri, S., Steele, R., Jimeno, A., Carey, F., Forgie, I., Mannelli, M., Carney, M., Hernandez, B., Campos, B., Herold-Mende, C., Jungk, C., Unterberg, A., von Deimling, A., Bossler, A., Galbraith, J., Jacobus, L., Knudson, M., Knutson, T., Ma, D., Milhem, M., Sigmund, R., Godwin, A. K., Madan, R., Rosenthal, H. G., Adebamowo, C., Adebamowo, S. N., Boussioutas, A., Beer, D., Giordano, T., Mes-Masson, A.-M., Saad, F., Bocklage, T., Landrum, L., Mannel, R., Moore, K., Moxley, K., Postier, R., Walker, J., Zuna, R., Feldman, M., Valdivieso, F., Dhir, R., Luketich, J., Pinero, E. M. M., Quintero-Aguilo, M., Carlotti, C. G., Dos Santos, J. S., Kemp, R., Sankarankuty, A., Tirapelli, D., Catto, J., Agnew, K., Swisher, E., Creaney, J., Robinson, B., Shelley, C. S., Godwin, E. M., Kendall, S., Shipman, C., Bradford, C., Carey, T., Haddad, A., Moyer, J., Peterson, L., Prince, M., Rozek, L., Wolf, G., Bowman, R., Fong, K. M., Yang, I., Korst, R., Rathmell, W. K., Fantacone-Campbell, J. L., Hooke, J. A., Kovatich, A. J., Shriver, C. D., DiPersio, J., Drake, B., Govindan, R., Heath, S., Ley, T., Van Tine, B., Westervelt, P., Rubin, M. A., Lee, J. I., Aredes, N. D., Mariamidze, A., Stuart, J. M., Benz, C. C., & Laird, P. W.
- Affiliations
- University of California, San Francisco (US)
- Memorial Sloan Kettering Cancer Center (US)
- Broad Institute (US)
- Vanderbilt University Medical Center (US)
- Henry Ford Health (US)
- Buck Institute for Research on Aging (US)
- Van Andel Institute (US)
- BC Cancer Agency (CA)
- Institute for Systems Biology (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of California, Santa Cruz (US)
- University of North Carolina at Chapel Hill (US)
- Poznan University of Medical Sciences (PL)
- Corresponding author
- Felau, Ina
- Nissan, Moriah G.
- Weisenberger, Daniel J.
- Jones, Corbin D.
- Bellair, Michelle
- Mallery, David
- Oosterhuis, Wolter
- Kefford, Richard
- Vocke, Cathy D.
- Zuna, Rosemary
- Rubin, Mark A.
- Aredes, Natália D.
- ORCID
- Wolf, Denise M.
- Drill, Esther
- Shen, Ronglai
- Taylor, Alison M.
- Schneider, Barbara G.
- Malta, Tathiane M.
- Felau, Ina
- Kasapi, Melpomeni
- Ferguson, Martin L.
- Sofia, Heidi J.
- Tarnuzzer, Roy
- Yang, Liming
- Zenklusen, Jean C.
- Zhang, Jiashan (Julia)
- Liu, Jia
- Pihl, Todd
- Sun, Qiang
- Wu, Ye
- Gehlenborg, Nils
- Getz, Gad
- Heiman, David I.
- Kim, Jaegil
- Lin, Pei
- Noble, Michael S.
- Saksena, Gordon
- Zhang, Hailei
- Bernard, Brady
- Chambwe, Nyasha
- Knijnenburg, Theo
- Liu, Yuexin
- Miller, Michael
- Shmulevich, Ilya
- Zhang, Wei
- Broom, Bradley M.
- Hegde, Apurva M.
- Ju, Zhenlin
- Korkut, Anil
- Li, Jun
- Liang, Han
- Lu, Yiling
- Mills, Gordon B.
- Wang, Jing
- Weinstein, John N.
- Zhang, Jiexin
- Armenia, Joshua
- Chakravarty, Debyani
- Chatila, Walid K.
- Gross, Benjamin E.
- Heins, Zachary J.
- Kundra, Ritika
- Ladanyi, Marc
- Luna, Augustin
- Ochoa, Angelica
- Phillips, Sarah M.
- Reznik, Ed
- Sander, Chris
- Schultz, Nikolaus
- Sun, Yichao
- Taylor, Barry S.
- Zhang, Hongxin
- Spellman, Paul
- Hayes, D. Neil
- Parker, Joel S.
- Wilkerson, Matthew D.
- Holt, Robert
- Jones, Steven J.M.
- Marra, Marco A.
- Moore, Richard A.
- Mungall, Andrew J.
- Sadeghi, Sara
- Tam, Angela
- Wong, Tina
- Berger, Ashton C.
- Beroukhim, Rameen
- Cibulskis, Carrie
- Gabriel, Stacey B.
- Ha, Gavin
- Meyerson, Matthew
- Schumacher, Steven E.
- Shih, Juliann
- Kucherlapati, Melanie H.
- Kucherlapati, Raju S.
- Baylin, Stephen
- Cope, Leslie
- Danilova, Ludmila
- Maglinte, Dennis T.
- Weisenberger, Daniel J.
- Auman, J. Todd
- Hoyle, Alan P.
- Jones, Corbin D.
- Mieczkowski, Piotr A.
- Perou, Charles M.
- Roach, Jeffrey
- Shi, Yan
- Fan, Huihui
- Shen, Hui
- Zhou, Wanding
- Chang, Kyle
- Covington, Kyle
- Creighton, Chad J.
- Dinh, Huyen
- Doddapaneni, HarshaVardhan
- Gibbs, Richard A.
- Han, Yi
- Korchina, Viktoriya
- Liu, Xiuping
- Morgan, Margaret
- Muzny, Donna
- Sheth, Margi
- Shinbrot, Eve
- Wang, Linghua
- Wang, Min
- Wheeler, David A.
- Zhao, Fengmei
- Hess, Julian
- Bailey, Matthew
- Ding, Li
- Fronick, Catrina C.
- Fulton, Robert S.
- Kandoth, Cyriac
- Mardis, Elaine R.
- McLellan, Michael D.
- Miller, Christopher A.
- Wilson, Richard K.
- Sherman, Mark
- Bowen, Jay
- Leraas, Kristen M.
- Lichtenberg, Tara M.
- Ramirez, Nilsa C.
- Zmuda, Erik
- Corcoran, Niall
- Hovens, Christopher
- Fregnani, José H.
- Reis, Rui M.
- Silveira, Henrique C.S.
- Vidal, Daniel O.
- Anderson, Matthew L.
- Ittmann, Michael
- Huntsman, David
- Kohl, Bernard
- Andry, Chris
- Duffy, Elizabeth R.
- Lyadov, Vladimir
- Paklina, Oxana
- Setdikova, Galiya
- Tavobilov, Mikhail
- Warnick, Ronald
- Berkowitz, Ross
- Feltmate, Colleen
- Horowitz, Neil
- Kibel, Adam
- Raut, Chandrajit P.
- Ostrom, Quinn T.
- Sloan, Andrew E.
- Giuliante, Felice
- Goodman, Marc
- Karlan, Beth Y.
- Somiari, Stella
- Bennett, Joseph
- Iacocca, Mary
- Lacombe, Louis
- Têtu, Bernard
- Bergeron, Alain
- McGraw, Mary
- Hibshoosh, Hanina
- Sepulveda, Antonia
- Wang, Timothy
- Potapova, Olga
- Voronina, Olga
- Desjardins, Laurence
- Mariani, Odette
- Stern, Marc-Henri
- Cheng, Feixiong
- Signoretti, Sabina
- Berchuck, Andrew
- Bigner, Darell
- Lipp, Eric
- McCall, Shannon
- McLendon, Roger
- Secord, Angeles
- Behera, Madhusmita
- Brat, Daniel J.
- Chen, Amy
- Delman, Keith
- Force, Seth
- Khuri, Fadlo
- Magliocca, Kelly
- Maithel, Shishir
- Olson, Jeffrey J.
- Owonikoko, Taofeek
- Ramalingam, Suresh
- Shin, Dong M.
- Sica, Gabriel
- Zhang, Hongzheng
- Looijenga, Leendert
- Oosterhuis, Wolter
- Zwarthoff, Ellen C.
- Calatozzolo, Chiara
- Cuzzubbo, Stefania
- DiMeco, Francesco
- Finocchiaro, Gaetano
- Mattei, Luca
- Perin, Alessandro
- Pollo, Bianca
- Taubert, Helge
- Wach, Sven
- Wullich, Bernd
- Kycler, Witold
- Murawa, Dawid
- Martin, Julie
- Bubley, Glenn
- Bueno, Raphael
- Richards, William G.
- Kalkanis, Steven
- Mikkelsen, Tom
- Scarpace, Lisa
- Girard, Nicolas
- Aymerich, Marta
- Giné, Eva
- Tang, Yufang
- Colman, Howard
- Evason, Kimberley
- Gabra, Hani
- Juhl, Hartmut
- Hoon, Dave
- Kang, Koo Jeong
- Beuschlein, Felix
- Breggia, Anne
- Birrer, Michael
- Borad, Mitesh
- Bryce, Alan H.
- Chandan, Vishal
- Cheville, John
- Copland, John A.
- Flotte, Thomas
- Ho, Thai
- Kendrick, Michael
- Kocher, Jean-Pierre
- Nagorney, David
- O’Brien, Daniel
- O’Neill, Brian Patrick
- Patel, Tushar
- Rivera, Michael
- Roberts, Lewis
- Smyrk, Thomas
- Torbenson, Michael
- Yang, Ju Dong
- Zhang, Lizhi
- Brimo, Fadi
- Ajani, Jaffer A.
- Behrens, Carmen
- Broaddus, Russell
- Czerniak, Bogdan
- Esmaeli, Bita
- Fujimoto, Junya
- Guo, Charles
- Logothetis, Christopher
- Ramondetta, Lois
- Sood, Anil
- Troncoso, Patricia
- Tsao, Anne
- Wistuba, Ignacio
- Carter, Candace
- Haydu, Lauren
- Jakrot, Valerie
- Kakavand, Hojabr
- Kefford, Richard
- Lee, Kenneth
- Long, Georgina
- Mann, Graham
- Quinn, Michael
- Saw, Robyn
- Scolyer, Richard
- Shannon, Kerwin
- Spillane, Andrew
- Stretch, Jonathan
- Thompson, John
- Wilmott, James
- Chan, Timothy A.
- Ghossein, Ronald
- Gopalan, Anuradha
- Levine, Douglas A.
- Singer, Samuel
- Singh, Bhuvanesh
- Broudy, Thomas
- Nair, Praveen
- Zaren, Howard
- Park, Joong-Won
- Kebebew, Electron
- Linehan, W. Marston
- Metwalli, Adam R.
- Pinto, Peter A.
- Schiffman, Mark
- Schmidt, Laura S.
- Vocke, Cathy D.
- Wentzensen, Nicolas
- Yang, Hannah
- Moncrieff, Marc
- Goparaju, Chandra
- Melamed, Jonathan
- Pass, Harvey
- Cernat, Mircea
- Arnaout, Angel
- Bartlett, John
- Thomas, George
- Rassl, Doris M.
- Rintoul, Robert C.
- Bifulco, Carlo
- Urba, Walter
- Hayward, Nicholas
- Timmers, Henri
- Facciolo, Francesco
- Marino, Mirella
- Piché, Alain
- Chevalier, Simone
- McKercher, Ginette
- Barnett, Gene
- Farver, Carol
- Pennell, Nathan A.
- Borgia, Jeffrey A.
- Seder, Christopher W.
- Junker, Kerstin
- Omberg, Larsson
- Manikhas, George
- Alvaro, Domenico
- Bragazzi, Maria Consiglia
- Cardinale, Vincenzo
- Carpino, Guido
- Gaudio, Eugenio
- Dubina, Michael
- Moiseenko, Fedor
- Dhanasekaran, Renumathy
- Becker, Karl-Friedrich
- Janssen, Klaus-Peter
- Cebulla, Colleen M.
- Elder, J. Bradley
- Lehman, Norman L.
- Nguyen, Phuong
- Pilarski, Robert
- Rai, Karan
- Schoenfield, Lynn
- Wakely, Paul
- Lechan, Ronald
- Tischler, Arthur
- Grizzle, William E.
- Henderson, Joel
- Porten, Sima
- Fassnacht, Martin
- Asa, Sylvia L.
- Schadendorf, Dirk
- Couce, Marta
- Graefen, Markus
- Huland, Hartwig
- Sauter, Guido
- Schlomm, Thorsten
- Simon, Ronald
- Tennstedt, Pierre
- Nelson, Mark
- Bathe, Oliver
- Carroll, Peter R.
- Chan, June M.
- Kelley, Robin K.
- Landen, Charles N.
- Prados, Michael
- VandenBerg, Scott
- Roggin, Kevin
- Kendler, Ady
- Steele, Ruth
- Jimeno, Antonio
- Forgie, Ian
- Mannelli, Massimo
- Carney, Michael
- Campos, Benito
- Unterberg, Andreas
- Bossler, Aaron
- Ma, Deqin
- Milhem, Mohammed
- Godwin, Andrew K.
- Madan, Rashna
- Adebamowo, Clement
- Adebamowo, Sally N.
- Boussioutas, Alex
- Beer, David
- Giordano, Thomas
- Bocklage, Therese
- Landrum, Lisa
- Moore, Kathleen
- Moxley, Katherine
- Zuna, Rosemary
- Feldman, Michael
- Luketich, James
- Carlotti, Carlos Gilberto
- Kemp, Rafael
- Tirapelli, Daniela
- Catto, James
- Swisher, Elizabeth
- Creaney, Jenette
- Robinson, Bruce
- Shelley, Carl Simon
- Bradford, Carol
- Carey, Thomas
- Prince, Mark
- Rozek, Laura
- Wolf, Gregory
- Fong, Kwun M.
- Yang, Ian
- Rathmell, W. Kimryn
- Kovatich, Albert J.
- Shriver, Craig D.
- DiPersio, John
- Drake, Bettina
- Govindan, Ramaswamy
- Heath, Sharon
- Ley, Timothy
- Rubin, Mark A.
- Lee, Jung Il
- Aredes, Natália D.
- Mariamidze, Armaz
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 173
- Issue
- 2
- Pages
- 291-304.e6
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC5957518
- OpenAlex
- W2796153844
- Cited by
- 2,546
- References
- 58
- Citations by year
- 2026: 284 · 2025: 294 · 2024: 296 · 2023: 355 · 2022: 375 · 2021: 374 · 2020: 330 · 2019: 178 · 2018: 56
- FWCI
- 71.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (acceptedVersion, cc-by-nc-nd)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-nd)
- UWA Profiles and Research Repository (UWA) (submittedVersion, cc-by)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, cc-by-nc-nd)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by-nc-nd)
- mediaTUM (Technical University of Munich) (submittedVersion, other-oa)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by-nc-nd)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Funders
- National Human Genome Research Institute
- National Cancer Institute
- National Institutes of Health (U24 CA143866, U24 CA143843, P30 CA016672, U24 CA143867, U24 CA143840, U24 CA143882, U24 CA143858, U24 CA143835, U54 HG003273, U24 CA143883, U24 CA143848, U24 CA144025, U24 CA143845, U54 HG003079, U24 CA143799, U54 HG003067)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- cell of origin, molecular classification of cancer, pan-cancer analysis, TCGA, aneuploidy, DNA methylation, mRNA expression, microRNA expression, reverse phase protein array, histological subtypes, tissue type, stemness, molecular clustering
- MeSH terms
- Aneuploidy, Chromosomes, Humans, Mutation, Neoplasm Proteins, Neoplasms, RNA, Messenger, Cluster Analysis, Databases, Factual, CpG Islands, DNA Methylation, MicroRNAs
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