The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations
Open accessAbstract
SUMMARY Many human spinal cord injuries are anatomically incomplete, but exhibit complete paralysis. It is unknown why spared axons fail to mediate functional recovery in these cases. To investigate this, we undertook a small-molecule screen in mice with staggered bilateral hemisections, in which the lumbar spinal cord is deprived of all direct brain-derived innervation but dormant relay circuits remain. We discovered that a KCC2 agonist restored stepping ability, which could be mimicked by selective expression of KCC2, or hyperpolarizing DREADDs, in the inhibitory interneurons between and around the staggered spinal lesions. Mechanistically, these treatments transformed this injury-induced dysfunctional spinal circuit to a functional state, facilitating the relay of brain-derived commands towards the lumbar spinal cord. Thus, our results identify spinal inhibitory interneurons as a roadblock limiting the integration of descending inputs into relay circuits after injury, and suggest KCC2 agonists as promising treatments for promoting functional recovery after spinal cord injury.
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Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
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Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons
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The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
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Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
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PTEN deletion enhances the regenerative ability of adult corticospinal neurons
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LOCOMOTOR CIRCUITS IN THE MAMMALIAN SPINAL CORD
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Cited by
Spinal cord repair: advances in biology and technology
Courtine, G., & Sofroniew, M. V. (2019) · Nature Medicine · doi:10.1038/s41591-019-0475-6 · Cited by 508
Regulation of axonal regeneration after mammalian spinal cord injury
Zheng, B., & Tuszynski, M. H. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00562-y · Cited by 328
Spinal Interneurons as Gatekeepers to Neuroplasticity after Injury or Disease
Zholudeva, L. V., Abraira, V. E., Satkunendrarajah, K., McDevitt, T. C., Goulding, M. D., Magnuson, D. S. K., & Lane, M. A. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.1654-20.2020 · Cited by 74
Metadata
- Authors
- Chen, B., Li, Y., Yu, B., Zhang, Z., Brommer, B., Williams, P. R., Liu, Y., Hegarty, S. V., Zhou, S., Zhu, J., Guo, H., Lu, Y., Zhang, Y., Gu, X., & He, Z.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 174
- Issue
- 3
- Pages
- 521-535.e13
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2883909900
- Cited by
- 253
- References
- 65
- FWCI
- 16.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chen, B., Li, Y., Yu, B., Zhang, Z., Brommer, B., Williams, P. R., Liu, Y., Hegarty, S. V., Zhou, S., Zhu, J., Guo, H., Lu, Y., Zhang, Y., Gu, X., & He, Z. (2018). Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations. Cell. https://doi.org/10.1016/j.cell.2018.06.005
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