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Cited by 212

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Fc Glycan-Mediated Regulation of Placental Antibody Transfer

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Jennewein, Madeleine F., Goldfarb, Ilona, Dolatshahi, Sepideh, Cosgrove, Cormac, Noelette, Francesca J., Krykbaeva, Marina, Das, Jishnu, Sarkar, Aniruddh, Gorman, Matthew J., Fischinger, Stephanie, Boudreau, Carolyn M., Brown, Joelle, Cooperrider, Jennifer H., Aneja, Jasneet, Suscovich, Todd J., Graham, Barney S., Lauer, Georg M., Goetghebuer, Tessa, Marchant, Arnaud, Lauffenburger, Douglas, Kim, Arthur Y., Riley, Laura E., Alter, Galit·2019·Cell
DOI 10.1016/j.cell.2019.05.044
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Abstract

Summary: Despite the worldwide success of vaccination, newborns remain vulnerable to infections. While neonatal vaccination has been hampered by maternal antibody-mediated dampening of immune responses, enhanced regulatory and toleragenic mechanisms, and immune system immaturity, maternal pre-natal immunization aims to boost neonatal immunity via antibody transfer to the fetus. However, emerging data suggest that antibodies are not transferred equally across the placenta. To understand this, we used systems serology to define Fc features associated with antibody transfer. The Fc-profile of neonatal and maternal antibodies differed, skewed towards NK cell-activating antibodies. This selective transfer was linked to di-galactosylated Fc-glycans that selectively bind FcRn and FCGR3A, resulting in transfer of antibodies able to efficiently leverage innate immune cells present at birth. Given emerging data that vaccination may direct antibody glycosylation, our study provides insights for the development of next-generation maternal vaccines designed to elicit antibodies that will most effectively aid neonates.

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Research works printed but not linked: 53

  1. Abu-Raya, 2016, Transfer of Maternal Antimicrobial Immunity to HIV-Exposed Uninfected Newborns, Front. Immunol., 7, 338, 10.3389/fimmu.2016.00338 · DOI
  2. Ackerman, 2011, A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples, J. Immunol. Methods, 366, 8, 10.1016/j.jim.2010.12.016 · DOI · Paper page
  3. Amenyogbe, 2015, Systems vaccinology: a promise for the young and the poor, Philos. Trans. R. Soc. Lond. B Biol. Sci., 370, 20140340, 10.1098/rstb.2014.0340 · DOI
  4. Arnold, 2007, The impact of glycosylation on the biological function and structure of human immunoglobulins, Annu. Rev. Immunol., 25, 21, 10.1146/annurev.immunol.25.022106.141702 · DOI · Paper page
  5. Arnold, 2016, Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells, Mucosal Immunol., 9, 194, 10.1038/mi.2015.51 · DOI · Paper page
  6. Bakchoul, 2013, Inhibition of HPA-1a alloantibody-mediated platelet destruction by a deglycosylated anti-HPA-1a monoclonal antibody in mice: toward targeted treatment of fetal-alloimmune thrombocytopenia, Blood, 122, 321, 10.1182/blood-2012-11-468561 · DOI · Paper page
  7. Benedetti, 2017, Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway, Nat. Commun., 8, 1483, 10.1038/s41467-017-01525-0 · DOI
  8. Boesch, 2014, Highly parallel characterization of IgG Fc binding interactions, MAbs, 6, 915, 10.4161/mabs.28808 · DOI
  9. Bondt, 2013, Association between galactosylation of immunoglobulin G and improvement of rheumatoid arthritis during pregnancy is independent of sialylation, J. Proteome Res., 12, 4522, 10.1021/pr400589m · DOI · Paper page
  10. Bondt, 2014, Immunoglobulin G (IgG) Fab glycosylation analysis using a new mass spectrometric high-throughput profiling method reveals pregnancy-associated changes, Mol. Cell. Proteomics, 13, 3029, 10.1074/mcp.M114.039537 · DOI · Paper page
  11. Brown, 2012, High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samples, J. Immunol. Methods, 386, 117, 10.1016/j.jim.2012.09.007 · DOI · Paper page
  12. Bruhns, 2009, Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses, Blood, 113, 3716, 10.1182/blood-2008-09-179754 · DOI · Paper page
  13. 1999, Impact of vaccines universally recommended for children--United States, 1990-1998, MMWR Morb. Mortal. Wkly. Rep., 48, 243
  14. Chung, 2017, Systems serology: profiling vaccine induced humoral immunity against HIV, Retrovirology, 14, 57, 10.1186/s12977-017-0380-3 · DOI
  15. Decker, 2016, Abnormal galactosylation of immunoglobulin G in cerebrospinal fluid of multiple sclerosis patients, Mult. Scler., 22, 1794, 10.1177/1352458516631036 · DOI
  16. Edwards, 2014, Immune responses to pertussis vaccines and disease, J. Infect. Dis., 209, S10, 10.1093/infdis/jit560 · DOI
  17. Einarsdottir, 2013, Comparison of the Fc glycosylation of fetal and maternal immunoglobulin G, Glycoconj. J., 30, 147, 10.1007/s10719-012-9381-6 · DOI · Paper page
  18. Einarsdottir, 2014, On the perplexingly low rate of transport of IgG2 across the human placenta, PLoS ONE, 9, e108319, 10.1371/journal.pone.0108319 · DOI · Paper page
  19. Forsyth, 2015, Strategies to decrease pertussis transmission to infants, Pediatrics, 135, e1475, 10.1542/peds.2014-3925 · DOI
  20. Fouda, 2018, The Impact of IgG transplacental transfer on early life immunity, Immunohorizons, 2, 14, 10.4049/immunohorizons.1700057 · DOI · Paper page
  21. Goetghebuer, 2018, Initiation of anti-retroviral therapy before pregnancy reduces the risk of infection-related hospitalization in HIV-exposed uninfected infants born in a high-income country, Clin. Infect. Dis.
  22. Ishikawa, 2015, Fc gamma receptor IIb participates in maternal IgG trafficking of human placental endothelial cells, Int. J. Mol. Med., 35, 1273, 10.3892/ijmm.2015.2141 · DOI
  23. Jansen, 2016, Pregnancy-associated serum N-glycome changes studied by high-throughput MALDI-TOF-MS, Sci. Rep., 6, 23296, 10.1038/srep23296 · DOI
  24. Jansen, 2016, MALDI-TOF-MS reveals differential N-linked plasma- and IgG-glycosylation profiles between mothers and their newborns, Sci. Rep., 6, 34001, 10.1038/srep34001 · DOI · Paper page
  25. Jefferis, 2012, Isotype and glycoform selection for antibody therapeutics, Arch. Biochem. Biophys., 526, 159, 10.1016/j.abb.2012.03.021 · DOI · Paper page
  26. Jennewein, 2017, The Immunoregulatory Roles of Antibody Glycosylation, Trends Immunol., 38, 358, 10.1016/j.it.2017.02.004 · DOI · Paper page
  27. Jennewein, 2017, Transfer of maternal immunity and programming of the newborn immune system, Semin. Immunopathol., 39, 605, 10.1007/s00281-017-0653-x · DOI · Paper page
  28. Jensen, 2017, A two-pronged binding mechanism of IgG to the neonatal Fc receptor controls complex stability and IgG serum half-life, Mol. Cell. Proteomics, 16, 451, 10.1074/mcp.M116.064675 · DOI
  29. Krumsiek, 2011, Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data, BMC Syst. Biol., 5, 21, 10.1186/1752-0509-5-21 · DOI · Paper page
  30. Lau, 2011, In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs, Sci. Signal., 4, ra16, 10.1126/scisignal.2001338 · DOI
  31. Lee, 2013, Neonatal natural killer cell function: relevance to antiviral immune defense, Clin. Dev. Immunol., 2013, 427696, 10.1155/2013/427696 · DOI
  32. Lyden, 2001, The Fc receptor for IgG expressed in the villus endothelium of human placenta is Fc gamma RIIb2, J. Immunol., 166, 3882, 10.4049/jimmunol.166.6.3882 · DOI
  33. Mahan, 2016, Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination, PLoS Pathog., 12, e1005456, 10.1371/journal.ppat.1005456 · DOI
  34. Martinez, 2018, Noncanonical placental Fc receptors: What is their role in modulating transplacental transfer of maternal IgG?, PLoS Pathog., 14, e1007161, 10.1371/journal.ppat.1007161 · DOI
  35. Martinez, 2019, Fc characteristics mediate selective placental transfer of IgG in HIV-infected women, Cell, 178, 190, 10.1016/j.cell.2019.05.046 · DOI
  36. Moore, 2005, Increased levels of galactose-deficient IgG in sera of HIV-1-infected individuals, AIDS, 19, 381, 10.1097/01.aids.0000161767.21405.68 · DOI · Paper page
  37. Nimmerjahn, 2006, Fcgamma receptors: old friends and new family members, Immunity, 24, 19, 10.1016/j.immuni.2005.11.010 · DOI · Paper page
  38. Olin, 2018, Stereotypic Immune System Development in Newborn Children, Cell, 174, 1277, 10.1016/j.cell.2018.06.045 · DOI · Paper page
  39. Palmeira, 2012, IgG placental transfer in healthy and pathological pregnancies, Clin. Dev. Immunol., 2012, 985646, 10.1155/2012/985646 · DOI · Paper page
  40. Pasek, 2006, Galactosylation of IgG from rheumatoid arthritis (RA) patients--changes during therapy, Glycoconj. J., 23, 463, 10.1007/s10719-006-5409-0 · doi:10.1007/s10719-006-5409-0
  41. Piche-Nicholas, 2018, Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics, MAbs, 10, 81, 10.1080/19420862.2017.1389355 · DOI
  42. Pulendran, 2011, Immunological mechanisms of vaccination, Nat. Immunol., 12, 509, 10.1038/ni.2039 · DOI · Paper page
  43. Saso, 2017, Vaccine responses in newborns, Semin. Immunopathol., 39, 627, 10.1007/s00281-017-0654-9 · DOI
  44. Shin, 2014, An atlas of genetic influences on human blood metabolites, Nat. Genet., 46, 543, 10.1038/ng.2982 · DOI · Paper page
  45. Simister, 2003, Placental transport of immunoglobulin G, Vaccine, 21, 3365, 10.1016/S0264-410X(03)00334-7 · DOI · Paper page
  46. Sonneveld, 2016, Glycosylation pattern of anti-platelet IgG is stable during pregnancy and predicts clinical outcome in alloimmune thrombocytopenia, Br. J. Haematol., 174, 310, 10.1111/bjh.14053 · DOI
  47. Takizawa, 2005, A novel Fc gamma R-defined, IgG-containing organelle in placental endothelium, J. Immunol., 175, 2331, 10.4049/jimmunol.175.4.2331 · DOI
  48. Vestrheim, 2014, A pilot study showing differences in glycosylation patterns of IgG subclasses induced by pneumococcal, meningococcal, and two types of influenza vaccines, Immun. Inflamm. Dis., 2, 76, 10.1002/iid3.22 · DOI
  49. Vidarsson, 2014, IgG subclasses and allotypes: from structure to effector functions, Front. Immunol., 5, 520, 10.3389/fimmu.2014.00520 · DOI · Paper page
  50. Westerhuis, 2010, Multivariate paired data analysis: multilevel PLSDA versus OPLSDA, Metabolomics, 6, 119, 10.1007/s11306-009-0185-z · DOI · Paper page
  51. Whittaker, 2018, Neonatal Immunization: Rationale, Current State, and Future Prospects, Front. Immunol., 9, 532, 10.3389/fimmu.2018.00532 · DOI
  52. Winter, 2014, Pertussis epidemic--California, 2014, MMWR Morb. Mortal. Wkly. Rep., 63, 1129
  53. Yu, 2018, Innate Immunity of Neonates and Infants, Front. Immunol., 9, 1759, 10.3389/fimmu.2018.01759 · DOI · Paper page

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Metadata

Authors
Jennewein, M. F., Goldfarb, I., Dolatshahi, S., Cosgrove, C., Noelette, F. J., Krykbaeva, M., Das, J., Sarkar, A., Gorman, M. J., Fischinger, S., Boudreau, C. M., Brown, J., Cooperrider, J. H., Aneja, J., Suscovich, T. J., Graham, B. S., Lauer, G. M., Goetghebuer, T., Marchant, A., Lauffenburger, D., Kim, A. Y., Riley, L. E., & Alter, G.
Venue
Cell
Publisher
Elsevier BV
Published
2019-06
Volume
178
Issue
1
Pages
202-215.e14
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2019.05.044
OpenAlex
W2950802088
Cited by
212
References
11
FWCI
16.35
Type
journal article
Language
en
Open access
bronze
Licence
Funders
  • National Institutes of Health (AI080289, AI102660-01, 1R01A1129797-01, AI129797-01)
  • Ragon Institute of MGH, MIT and Harvard
  • Harvard University Center for AIDS Research

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CoChat. (2026). Citation check: Fc Glycan-Mediated Regulation of Placental Antibody Transfer. https://app.cochat.ai/papers/10.1016/j.cell.2019.05.044
The paper
Jennewein, M. F., Goldfarb, I., Dolatshahi, S., Cosgrove, C., Noelette, F. J., Krykbaeva, M., Das, J., Sarkar, A., Gorman, M. J., Fischinger, S., Boudreau, C. M., Brown, J., Cooperrider, J. H., Aneja, J., Suscovich, T. J., Graham, B. S., Lauer, G. M., Goetghebuer, T., Marchant, A., . . . Alter, G. (2019). Fc Glycan-Mediated Regulation of Placental Antibody Transfer. Cell. https://doi.org/10.1016/j.cell.2019.05.044

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