Hippocampal-amygdala memory circuits govern experience-dependent observational fear
Open accessAbstract
The empathic ability to vicariously experience the other's fearful situation, a process called observational fear (OF), is critical to survive in nature and function in society. OF can be facilitated by both prior similar fear experience in the observer and social familiarity with the demonstrator. However, the neural circuit mechanisms of experience-dependent OF (Exp OF) remain unknown. Here, we demonstrate that hippocampal-basolateral amygdala (HPC-BLA) circuits in mice without involving the anterior cingulate cortex, considered a center of OF, mediate Exp OF. Dorsal HPC neurons generate fear memory engram cells in BLA encoding prior similar fear experiences, which are essential for Exp OF. On the other hand, ventral HPC neurons respond to the familiar demonstrator's aversive situation during Exp OF, which reactivates the fear memory engram cells in BLA to elicit Exp OF. Our study provides new insights into the memory engram-dependent perception-action coupling that underlies empathic behaviors like Exp OF.
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Hippocampal-to-basolateral amygdala circuits are necessary for enhanced social fear learning in mice that previously experienced a footshock.
“Recently hippocampal-to-BLA circuits were found to be necessary for enhanced social fear learning in mice that previously experienced a footshock [108].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [108]
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Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
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Cited by
Sorted by citations
Neural circuits regulating prosocial behaviors
Walsh, J. J., Christoffel, D. J., & Malenka, R. C. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01348-8 · Cited by 72 · see citing works
- Authors
- Terranova, J. I., Yokose, J., Osanai, H., Marks, W. D., Yamamoto, J., Ogawa, S. K., & Kitamura, T.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 110
- Issue
- 8
- Pages
- 1416-1431.e13
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC9035063
- OpenAlex
- W4210843030
- Cited by
- 117
- References
- 115
- Citations by year
- 2026: 27 · 2025: 35 · 2024: 21 · 2023: 23 · 2022: 11
- FWCI
- 11.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Uehara Memorial Foundation
- National Institute of Mental Health (F32MH119721, F32MH122082, R01MH120134, R01MH125916, T32MH076690)
- Japan Society for the Promotion of Science (201860198)
- National Institute on Drug Abuse (T32DA007290)
- Daiichi Sankyo Foundation of Life Science
- Brain and Behavior Research Foundation (26391, 28801)
- Brain Research Foundation (BRFSG-2018-04)
- Whitehall Foundation (2019-05-38)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- hippocampus, basolateral amygdala, empathy, social familiarity, perception-action coupling, anterior cingulate cortex
- MeSH terms
- Amygdala, Animals, Fear, Gyrus Cinguli, Hippocampus, Mice, Basolateral Nuclear Complex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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