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Identification of ALK in Thinness
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“In Drosophila , knockdown of ALK decreases triglyceride levels and the expression of several insulin-like peptides, while genetic or pharmacological inhibition of ALK extends healthspan and lifespan, mostly in females 135 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [135]
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“and in humans, a loss-of-function mutation of ALK is associated with leanness 135,136 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [135]
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Metadata
- Authors
- Orthofer, M., Valsesia, A., Mägi, R., Wang, Q.-P., Kaczanowska, J., Kozieradzki, I., Leopoldi, A., Cikes, D., Zopf, L. M., Tretiakov, E. O., Demetz, E., Hilbe, R., Boehm, A., Ticevic, M., Nõukas, M., Jais, A., Spirk, K., Clark, T., Amann, S., Lepamets, M., Neumayr, C., Arnold, C., Dou, Z., Kuhn, V., Novatchkova, M., Cronin, S. J. F., Tietge, U. J. F., Müller, S., Pospisilik, J. A., Nagy, V., Hui, C.-C., Lazovic, J., Esterbauer, H., Hagelkruys, A., Tancevski, I., Kiefer, F. W., Harkany, T., Haubensak, W., Neely, G. G., Metspalu, A., Hager, J., Gheldof, N., & Penninger, J. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 181
- Issue
- 6
- Pages
- 1246-1262.e22
- ISSN
- 0092-8674
- Cited by
- 117
- References
- 18
- Language
- en
- Licence
- Funders
- Seventh Framework Programme (FP/2007-2013)
- Horizon 2020 (692145)
- Natural Science Foundation of Guangdong Province (2018B030306002)
- National Natural Science Foundation of China (31800993)
- Austrian Science Fund (DOC 33-B27)
- European Regional Development Fund (2014-2020.4.01.15-0012 GENTRANSMED)
- Vetenskapsrådet (2013-3080, 2018-02838)
- Österreichische Forschungsförderungsgesellschaft
- European Commission
- Österreichischen Akademie der Wissenschaften
- Instituto Mexicano del Petróleo
- Boehringer Ingelheim
- Hjärnfonden (FO2019-0277, FO2017-0293)
- European Research Council (311701)
- Eesti Teadusagentuur (IUT20-60)
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