The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19
Open accessPublished version of a preprint
Abstract
The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of >100,000 viral antigen-reactive CD4+ T cells from 40 COVID-19 patients. In hospitalized patients compared to non-hospitalized patients, we found increased proportions of cytotoxic follicular helper cells and cytotoxic T helper (TH) cells (CD4-CTLs) responding to SARS-CoV-2 and reduced proportion of SARS-CoV-2-reactive regulatory T cells (TREG). Importantly, in hospitalized COVID-19 patients, a strong cytotoxic TFH response was observed early in the illness, which correlated negatively with antibody levels to SARS-CoV-2 spike protein. Polyfunctional TH1 and TH17 cell subsets were underrepresented in the repertoire of SARS-CoV-2-reactive CD4+ T cells compared to influenza-reactive CD4+ T cells. Together, our analyses provide insights into the gene expression patterns of SARS-CoV-2-reactive CD4+ T cells in distinct disease severities.
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Cites
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Cited by
Adaptive immunity to SARS-CoV-2 and COVID-19
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“…reported here do not assess the role of pre-existing cross-reactive T cells in response to SARS-CoV-2 (Braun et al., 2020; Grifoni et al., 2020a; Meckiff et al., 2020; Weiskopf et al., 2020), as the anti-gen-specific tools used in this study did not distinguish between T cell responses…”
InfluentialSelf-citationSelective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans
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Metadata
- Authors
- Meckiff, B. J., Ramírez-Suástegui, C., Fajardo, V., Chee, S. J., Kusnadi, A., Simon, H., Eschweiler, S., Grifoni, A., Pelosi, E., Weiskopf, D., Sette, A., Ay, F., Seumois, G., Ottensmeier, C. H., & Vijayanand, P.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 183
- Issue
- 5
- Pages
- 1340-1353.e16
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W3090209951
- Cited by
- 561
- References
- 58
- FWCI
- 12.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 389 d)
- Funders
- National Institutes of Health (U19AI118626, R01HL114093, U19AI142742-0S1, S10OD025052, S10RR027366, U19AI14274, R35-GM128938, BD FACSAria-II)
- National Institute for Health Research
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- The paper
- Meckiff, B. J., Ramírez-Suástegui, C., Fajardo, V., Chee, S. J., Kusnadi, A., Simon, H., Eschweiler, S., Grifoni, A., Pelosi, E., Weiskopf, D., Sette, A., Ay, F., Seumois, G., Ottensmeier, C. H., & Vijayanand, P. (2020). Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19. Cell. https://doi.org/10.1016/j.cell.2020.10.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
