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The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages

Open access
Martin, Darren P., Weaver, Steven, Tegally, Houriiyah, San, James Emmanuel, Shank, Stephen D., Wilkinson, Eduan, Lucaci, Alexander G., Giandhari, Jennifer, Naidoo, Sureshnee, Pillay, Yeshnee, Singh, Lavanya, Lessells, Richard J., Gupta, Ravindra K., Wertheim, Joel O., Nekturenko, Anton, Murrell, Ben, Harkins, Gordon W., Lemey, Philippe, MacLean, Oscar A., Robertson, David L., de Oliveira, Tulio, Kosakovsky Pond, Sergei L.·2021·Cell
DOI 10.1016/j.cell.2021.09.003

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Abstract

The independent emergence late in 2020 of the B.1.1.7, B.1.351, and P.1 lineages of SARS-CoV-2 prompted renewed concerns about the evolutionary capacity of this virus to overcome public health interventions and rising population immunity. Here, by examining patterns of synonymous and non-synonymous mutations that have accumulated in SARS-CoV-2 genomes since the pandemic began, we find that the emergence of these three “501Y lineages” coincided with a major global shift in the selective forces acting on various SARS-CoV-2 genes. Following their emergence, the adaptive evolution of 501Y lineage viruses has involved repeated selectively favored convergent mutations at 35 genome sites, mutations we refer to as the 501Y meta-signature. The ongoing convergence of viruses in many other lineages on this meta-signature suggests that it includes multiple mutation combinations capable of promoting the persistence of diverse SARS-CoV-2 lineages in the face of mounting host immune recognition.

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Cites

Show all 37 references

Research works printed but not linked: 30

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Metadata

Authors
Martin, D. P., Weaver, S., Tegally, H., San, J. E., Shank, S. D., Wilkinson, E., Lucaci, A. G., Giandhari, J., Naidoo, S., Pillay, Y., Singh, L., Lessells, R. J., Gupta, R. K., Wertheim, J. O., Nekturenko, A., Murrell, B., Harkins, G. W., Lemey, P., MacLean, O. A., Robertson, D. L., de Oliveira, T., & Kosakovsky Pond, S. L.
Venue
Cell
Publisher
Elsevier BV
Published
2021-09
Volume
184
Issue
20
Pages
5189-5200.e7
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2021.09.003
OpenAlex
W3198909684
Cited by
291
References
37
FWCI
18.80
Type
journal article
Language
en
Open access
bronze
Licence

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CoChat. (2026). Citation check: The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages. https://app.cochat.ai/papers/10.1016/j.cell.2021.09.003
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Martin, D. P., Weaver, S., Tegally, H., San, J. E., Shank, S. D., Wilkinson, E., Lucaci, A. G., Giandhari, J., Naidoo, S., Pillay, Y., Singh, L., Lessells, R. J., Gupta, R. K., Wertheim, J. O., Nekturenko, A., Murrell, B., Harkins, G. W., Lemey, P., MacLean, O. A., . . . Kosakovsky Pond, S. L. (2021). The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages. Cell. https://doi.org/10.1016/j.cell.2021.09.003

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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