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Cited by 319

The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.

Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course

Open access
Zhou, Xiaoyuan, Baumann, Ryan, Gao, Xiaohui, Mendoza, Myra, Singh, Sneha, Katz Sand, Ilana, Xia, Zongqi, Cox, Laura M., Chitnis, Tanuja, Yoon, Hongsup, Moles, Laura, Caillier, Stacy J., Santaniello, Adam, Ackermann, Gail, Harroud, Adil, Lincoln, Robin, Gomez, Refujia, González Peña, Antonio, Digga, Elise, Hakim, Daniel Joseph, Vazquez-Baeza, Yoshiki, Soman, Karthik, Warto, Shannon, Humphrey, Greg, Farez, Mauricio, Gerdes, Lisa Ann, Oksenberg, Jorge R., Zamvil, Scott S., Chandran, Siddharthan, Connick, Peter, Otaegui, David, Castillo-Triviño, Tamara, Hauser, Stephen L., Gelfand, Jeffrey M., Weiner, Howard L., Hohlfeld, Reinhard, Wekerle, Hartmut, Graves, Jennifer, Bar-Or, Amit, Cree, Bruce A.C., Correale, Jorge, Knight, Rob, Baranzini, Sergio E.·2022·Cell
DOI 10.1016/j.cell.2022.08.021
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Abstract

Changes in gut microbiota have been associated with several diseases. Here the international Multiple Sclerosis Microbiome Study (iMSMS) studied the gut microbiome of 576 MS patients (36% untreated), and genetically unrelated household healthy controls (1,152 total subjects). We observed a significantly increased proportion of Akkermansia muciniphila, Ruthenibacterium lactatiformans, Hungatella hathewayi and Eisenbergiella tayi and decreased Faecalibacterium prausnitzii and Blautia species. The phytate degradation pathway was over-represented in untreated MS, while pyruvate-producing carbohydrate metabolism pathways were significantly reduced. Microbiome composition, function and derived metabolites also differed in response to disease modifying treatments. The therapeutic activity of interferon-β may in part be associated to upregulation of short chain fatty acid transporters. Distinct microbial networks were observed in untreated MS and healthy controls. These results strongly support specific gut microbiome associations with MS risk, course and progression, and functional changes in response to treatment.

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Metadata

Authors
Zhou, X., Baumann, R., Gao, X., Mendoza, M., Singh, S., Katz Sand, I., Xia, Z., Cox, L. M., Chitnis, T., Yoon, H., Moles, L., Caillier, S. J., Santaniello, A., Ackermann, G., Harroud, A., Lincoln, R., Gomez, R., González Peña, A., Digga, E., Hakim, D. J., Vazquez-Baeza, Y., Soman, K., Warto, S., Humphrey, G., Farez, M., Gerdes, L. A., Oksenberg, J. R., Zamvil, S. S., Chandran, S., Connick, P., Otaegui, D., Castillo-Triviño, T., Hauser, S. L., Gelfand, J. M., Weiner, H. L., Hohlfeld, R., Wekerle, H., Graves, J., Bar-Or, A., Cree, B. A. C., Correale, J., Knight, R., & Baranzini, S. E.
Venue
Cell
Publisher
Elsevier BV
Published
2022-09
Volume
185
Issue
19
Pages
3467-3486.e16
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2022.08.021
OpenAlex
W4295921704
Cited by
319
References
121
FWCI
16.92
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course. https://app.cochat.ai/papers/10.1016/j.cell.2022.08.021
The paper
Zhou, X., Baumann, R., Gao, X., Mendoza, M., Singh, S., Katz Sand, I., Xia, Z., Cox, L. M., Chitnis, T., Yoon, H., Moles, L., Caillier, S. J., Santaniello, A., Ackermann, G., Harroud, A., Lincoln, R., Gomez, R., González Peña, A., Digga, E., . . . Baranzini, S. E. (2022). Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course. Cell. https://doi.org/10.1016/j.cell.2022.08.021

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.