100 years of the Warburg effect: A cancer metabolism endeavor

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425

Ferroptosis: mechanisms, biology and role in disease

Jiang, X., Stockwell, B. R., & Conrad, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00324-8 · Cited by 7,973

Mutation and cancer: statistical study of retinoblastoma

Knudson, A. G. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.4.820 · Cited by 7,612

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Engelman, J. A., Luo, J., & Cantley, L. C. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1879 · Cited by 3,330

Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation

Lunt, S. Y., & Vander Heiden, M. G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154237 · Cited by 3,057

Metabolic reprogramming and cancer progression

Faubert, B., Solmonson, A., & DeBerardinis, R. J. (2020) · Science · doi:10.1126/science.aaw5473 · Cited by 2,740

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

Kalos, M. D., Levine, B. L., Porter, D. L., Katz, S. I., Grupp, S. A., Bagg, A., & June, C. H. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002842 · Cited by 2,417

Metabolic Pathways in Immune Cell Activation and Quiescence

Pearce, E. L., & Pearce, E. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.005 · Cited by 1,692

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

Kochenderfer, J. N., Wilson, W. H., Janik, J. E., Dudley, M. E., Stetler-Stevenson, M., Feldman, S. A., Maric, I., Raffeld, M., Nathan, D.-A. N., Lanier, B. J., et al. (2010) · Blood · doi:10.1182/blood-2010-04-281931 · Cited by 1,337

Connecting copper and cancer: from transition metal signalling to metalloplasia

Ge, E. J., Bush, A. I., Casini, A., Cobine, P. A., Cross, J. R., DeNicola, G. M., Dou, Q. P., Franz, K. J., Gohil, V. M., Gupta, S. K., et al. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00417-2 · Cited by 1,332

Site-specific HPV18 integration facilitates cervical carcinogenesis through metabolic reprogramming-induced dysfunction of the SpHK1/S1P/S1PR1 pathway

Wang, L., Li, X., Ren, C., Liu, L., Yao, J., Wu, M., Shen, H., Zhu, D., Wang, X., Yuan, Z., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-025-08195-7 · Cited by 2

Metabolism of tumor infiltrating T cells

Ertl, H. C. J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1711328 · Cited by 3

Lactate metabolism-driven tumor heterogeneity and molecular signatures in intrahepatic cholangiocarcinoma

Wu, A., Li, J.-Y., Zhang, K., Meng, M., Wang, X., Liu, Y., Xie, P., Rong, W., Wu, F., Hong-guang, W. A. N. G., et al. (2026) · World Journal of Gastroenterology · doi:10.3748/wjg.v32.i7.113973 · Cited by 2

In vivo magnetic resonance imaging of glucose via interfacial enzyme-catalyzed signal-amplifying probes

Yang, W., Wu, Z., Ouyang, R., Dai, C., Xu, Y., Wang, H., Yu, G., Zhu, P., Liu, D., Yun, Y., et al. (2026) · Cell Biomaterials · doi:10.1016/j.celbio.2026.100367 · Cited by 2

Brain-targeting nanoplatform repurposing silymarin for enhanced GBM immunotherapy via synergistic mitochondrial suppression

Liu, J., Cheng, W., Tian, H., Wang, Z., Huang, C., & Li, Q. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102951 · Cited by 2

The molecular mechanisms and potential therapeutic implications of the crosstalk between DNA methylation and metabolic reprogramming in thyroid cancer

Zhang, T., Han, H., Zhang, Y., Zhang, T., Ma, L., Yang, Z., & Zhao, Y.-X. (2026) · Cell Death Discovery · doi:10.1038/s41420-026-02981-8 · Cited by 2

Integrative Multi-Omics Analysis Reveals the Characteristic Metabolic Signature of Glioma and Enables Plasma-Based Liquid Biopsy

Jiang, Y., Lan, Y., Wang, Y., Chen, S. R., Shen, Y., Chu, S., Dong, Y., Li, L., Zhang, H., Lu, Z., et al. (2026) · Research · doi:10.34133/research.1199 · Cited by 2

Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets

Ouyang, Q., Hu, Q., Wang, C., He, Y., Zeng, R., Li, Y., Su, C., Lu, G., Zhu, X., Xiao, L., et al. (2026) · MedComm · doi:10.1002/mco2.70675 · Cited by 2

pH-regulating Lipiodol Pickering emulsions enhance transarterial embolization therapy via inducing ferroptosis and activating antitumor immunity

Yang, W., Wang, C., Yu, C., Jiang, N., Yu, B., Ni, Y., Ni, C., Feng, L., & Zhang, L. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102662 · Cited by 2

Interaction networks of macrophage glycolysis and inflammation in sepsis: mechanisms and therapeutic potential

Luo, P., Liu, H., Zhang, T., & He, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1783409 · Cited by 2

Secretory autophagy mediates SLC16A3/MCT4-dependent lactate secretion to drive metastatic progression in triple-negative breast cancer

Wu, S., Lin, H.-J., Lan, K.-Y., Chen, H., Lin, C.-H., Hsu, C.-Y., Lee, Y., Chou, Y.-Y., Chu, Y., Chiang, W.-C., et al. (2026) · Autophagy · doi:10.1080/15548627.2026.2656780 · Cited by 2

ATM promotes PFKP nuclear translocation to balance glycolysis and homologous recombination repair

Liu, H., Zhang, M., Xu, Z., Yang, Z., Pan, Y., Bai, Y., Zhao, X. T., Wang, W.-J., Yang, Y., & Wang, J. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag336 · Cited by 3

A bioenergetic understanding of “aerobic glycolysis”

Wasem, V. L., & Mookerjee, S. A. (2026) · Communications Biology · doi:10.1038/s42003-026-10601-5 · Cited by 3

Compartmental pH regulation in cancer and antitumor immunity: therapeutic opportunities and challenges

Chen, F., Cai, X., Zhou, Q., Huang, Z., Wang, J., Kang, R., Tang, D., & Liu, J. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02408-w · Cited by 2

PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer

Wu, X., Wang, B., Hou, Y., Fang, Y., Jiang, Y., Song, Y., Liu, Y., & Jin, C. (2025) · Biomolecules · doi:10.3390/biom15030356 · Cited by 3

Prospective Clinical Validation of the Serum Metabolomics-based OncoVeryx-F test for the Early Detection of Female-specific Cancers

Mehta, A., Vasudevan, S., Siddiqui, Z., Saquib, N. M., & Gupta, A. (2025) · Journal of Preventive Diagnostic and Treatment Strategies in Medicine · doi:10.4103/jpdtsm.jpdtsm_3_25 · Cited by 2

Role of fructose in renal cell carcinoma progression

Miao, J., Wang, D., Pang, R., Zhang, H., Wu, Y., Sun, X., & Jin, Y. J. (2025) · Discover Oncology · doi:10.1007/s12672-025-02688-9 · Cited by 2

Network pharmacology and experimental study on the inhibition of glycolysis by amentoflavone in pancreatic cancer

He, X., Chen, P., Zhao, Z., Choe, H., Ali, T., Ding, K., Wu, X., Ma, J., & Zhang, L. (2025) · Discover Oncology · doi:10.1007/s12672-025-03697-4 · Cited by 2

Discovery of ATP competitive PDHK1/2 dual inhibitors

Xu, H., Ding, D. Y., Han, X., Miao, K., Liang, C., Yun, H., Zhu, W. Q., Dey, F., Zhao, D., Wu, Y., et al. (2025) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2025.130190 · Cited by 1

Comprehensive weight management as a key factor in improving the effectiveness of endometrial cancer therapy with fertility preservation

Kryukova, A. K., Kosykh, K. Y., Romanchenko, A. P., Belyaeva, Y. V., Budzinskaya, S. A., Alekseeva, V. S., Lozovaya, S. A., Ishberdin, A. I., Ishberdina, A. A., Krysin, N. A., et al. (2025) · V F Snegirev Archives of Obstetrics and Gynecology · doi:10.17816/aog677526 · Cited by 1

Aerobic exercise preconditioning suppresses subcutaneous tumorigenesis via PI3K/AKT-driven metabolic epigenetic reprogramming and immune microenvironment remodeling

Zhang, X., Xia, Y., Zheng, L., Cao, L., Qi, Z., & Ding, S. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112824 · Cited by 1

Comprehensive analysis of metabolic patterns in renal cell carcinoma: implications for prognosis and treatment

Wang, Y., Li, P., Feng, T., Chen, Y., Liu, W., Ge, Q., & Zhang, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1630053 · Cited by 1

Targeting mitochondrial RNA polymerase for triple-negative breast cancer

Lai, X., Wang, D., Gong, H., Jiang, R., Yao, Y., Xue, Q., Liu, Y., Ding, Y., Zhou, W., Yang, S., et al. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103729 · Cited by 1

REEP6 promotes colorectal cancer glycolysis and tumorigenesis through PRMT5-mediated PGAM1 arginine methylation

Wang, T., Zhang, D., Jin, C., Xu, H., Nie, H., Wang, Y., Zhang, C., Feng, Y., Tang, J., & Sun, Y. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.10.025 · Cited by 1

NFATc1-mediated activation of the pentose phosphate pathway and cell cycle dysregulation collectively drive tumor progression

Zhang, S., Xu, G., Cao, T., Yu, F., Okotel, M., Wu, M., Wu, S., Kasim, V., & Huang, C. (2025) · Oncogenesis · doi:10.1038/s41389-025-00581-2 · Cited by 1

Lactate Enhances Non-Homologous End Joining Repair and Chemoresistance Through Facilitating XRCC4–LIG4 Complex Assembly in Ovarian Cancer

Lu, J., Zhu, J., Zhang, H., Zhou, Z., Haoyuan, L., Zheng, C., Huang, X., Chen, S., Pan, C., Li, J., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13122949 · Cited by 1

Research progress in metabolic reprogramming and targeting metabolic pathways for clear cell renal cell carcinoma

Yao, J.-T., Hu, P.-C., Li, X., Xu, J., Wang, K., Ye, S., Meng, X.-Y., Chen, H., Liang, Y., & Ma, Q. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101991 · Cited by 1

Acinetobacter baumannii promotes gastric cancer metastasis via NA-mediated NAD metabolism reprogramming and glycolytic activation

Yang, Y., Yang, R., Chen, Y., He, C., Zhang, Y., Jing, H., Zhang, J., Wang, H., Liang, J., Deng, Z., et al. (2026) · Gut · doi:10.1136/gutjnl-2025-336161 · Cited by 2

Metabolic crosstalk between cancer and stromal cells: Implications for precision oncology

Yang, W., Ding, Y., & Tian, H. (2026) · Surgical Oncology · doi:10.1016/j.suronc.2026.102366 · Cited by 1

Integrative Analysis of Cytotoxic Lymphocytes‐Mediated Tumour Killing Related Genes Reveals LDHA as a Novel Glioblastoma Therapeutic Target

Yu, S., Li, X., Wu, J., Wang, M., Gong, Z., Zhang, B., Shi, H., Wang, X., & Xiang, W. (2026) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.71054 · Cited by 1

Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers

Xiao, X., Lu, C., Chen, H., Zhou, J., Hu, Y., Di, H., Su, G., & Yan, X. (2026) · Advanced Science · doi:10.1002/advs.202513341 · Cited by 1

Involvement of Non-Coding RNAs in the Glucose Metabolic Reprogramming of Oral Squamous Cell Carcinoma: From Mechanisms to Therapeutics

Huang, J., Liu, M., Lin, Y. L., Mai, J., Chen, J., & Yang, Y. (2026) · Biology · doi:10.3390/biology15050373 · Cited by 1

Radiofrequency-responsive liposomal hydrogels loaded 3-bromopyruvate energizes artery embolization on liver cancer

Liu, C., Ren, Y., Hong, C., Li, X., Guo, M., Zhao, L., Liu, Y., Chuansheng, Z., Yang, X., & Zhao, Y. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.174632 · Cited by 1

Impaired mitophagy contributes to osteogenesis and mineralization disorders in fibrous dysplasia

Ling, Z., Hu, L., Jin, S., Ling, F., Jin, C., Yuan, X., Chen, X., Xie, H., Jiang, H., & Fu, Y. (2026) · Autophagy · doi:10.1080/15548627.2026.2643409 · Cited by 1

Harnessing synergy: Innovative combinations to overcome PARP inhibitor resistance in cancer treatment

Huang, Y., Yang, Y., Zhang, Q., & Wang, S. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105278 · Cited by 1

The diagnostic value of SUVmax in predicting lymphovascular space invasion in patients with endometrial cancer: a systematic review and meta-analysis

Meng, X., Jin, H., Xu, H. Y., Lu, J., Wang, Z., Yang, D., & Yang, Z. (2026) · British Journal of Radiology · doi:10.1093/bjr/tqag039 · Cited by 1

Integrative profiling of lactylation reveals prognostic biomarkers and an immunosuppressive niche in acute myeloid leukemia

Guo, Z., Zhang, W., Gao, Z., Li, Q., Guo, D., Yue, L., Liu, Y., Ni, X., Fan, S., & Hai, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1765979 · Cited by 1

PSMD11 stabilizes PGM3 by antagonizing Parkin to promote bladder cancer progression through energy metabolism reprogramming

Cheng, Y., Chen, T., Zheng, G., Song, Z., Zhang, G., Xiao, S., Rao, X., & Zeng, T. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08691-4 · Cited by 1

Metabolic reprogramming and epigenetic regulation: The dual role of lactate and lactylation in pancreatic ductal adenocarcinoma progression and therapeutics

Li, X., Guo, W., Xie, Y., Li, R., Li, W., Wang, H., Du, R., Jiang, H., Liu, Y., & Liu, Z. (2026) · Current Molecular Pharmacology · doi:10.1016/j.cmp.2026.04.002 · Cited by 1

Charting the molecular landscape of cancer: from genomic chaos to epigenetic control and energetic adaptation

Aziz, H. S., Mohammed, N. A. R., Abdulhameed, Y. H., & Ayad, A. (2026) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-026-00852-6 · Cited by 1

Linking metabolism and metastasis: elevated α-hydroxybutyric acid in oral squamous cell carcinoma patients with lymph node metastasis

Gu, X., Coates, P. J., Wang, L., Sgaramella, N., Magan, M., & Nylander, K. (2026) · Metabolomics · doi:10.1007/s11306-026-02431-7 · Cited by 1

Nanomaterial-mediated lactate metabolism regulation for enhanced cancer immunotherapy

Yan, J., Zhao, Z., Sun, F., & Li, B. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.126971 · Cited by 1

Gasdermin C reprograms metabolism through the CAMKK2-AMPK axis to promote lung adenocarcinoma progression and radioresistance

Ren, D., Li, Y., Lu, M., Jiang, W., Xu, H., Wu, L., Yu, K. N., & Han, W. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117427 · Cited by 1

Mitochondrial metabolic reprogramming drives diabetic kidney disease progression: cell-specific mechanisms, metabolic memory, and targeted strategies

Zhang, L., Zhang, Y., 韩流, Wang, J., Hou, L., & Fu, S. (2026) · Molecular Medicine · doi:10.1186/s10020-026-01521-5 · Cited by 2

Lysine lactylation‐mediated post‐translational modification: Molecular mechanisms and therapeutic target exploration in tumour drug resistance

Li, J., Shang, Y., Wu, H., Yang, S. Y., Zuo, M., & Zhao, H. (2026) · Clinical and Translational Medicine · doi:10.1002/ctm2.70714 · Cited by 1

Integrating tongue coating microbiome, tongue coating metabolomics, and exhaled breath metabolomics via machine learning to identify chronic atrophic gastritis

Hou, X., Xu, H., Zhu, L., Ding, S., Shao, Y., Zhang, M., & Lin, X. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1910978 · Cited by 1

Lactylation at the crossroads: Bridging metabolic rewiring and ferroptotic vulnerability in cancer

Liu, Y., Yang, Q., Wang, X., & Hai, Z. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104341 · Cited by 1

Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting

Ma, S., Liu, C., Ma, S., Wang, S., Xia, Q., & Xu, M. (2026) · MedComm · doi:10.1002/mco2.70966 · Cited by 1

The Expression of SIRT3 in Endometrial Carcinoma and Its Effect on Promoting Apoptosis of Ishikawa Cells

Zhao, X., & Yin, X. (2024) · Biochemical Genetics · doi:10.1007/s10528-024-10995-z · Cited by 1

Bioinformatics-based identification of glycolysis-related signatures associated with drug resistance and prognosis in lung adenocarcinoma

Zheng, Q., Liu, Y., Li, T., Zhang, X., Geng, Y., Chen, Z., Zhou, J., Fan, W., Wang, Y., Zhang, L., et al. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1871582

Development of a Mitochondrial Membrane Permeability Transition Prognosis System in Colon Adenocarcinoma: Risk Stratification and Therapeutic Target Identification

Zhang, B., Xia, M., Zhao, S., Li, Y., Yu, C., Song, L., Wang, S., & Cui, B. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673335900240920070746

Discovery of Atp Competitive Pdhk1/2 Dual InhibitorsPreprint

Zou, G., Xu, H., Ding, D., Han, X., Miao, K., Liang, C., Yun, H., Zhu, W. Q., Dey, F., Zhao, D., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5116949

m6A Demethylase FTO Drives Pancreatic Ductal Adenocarcinoma Metastasis Through Remodeling PFKM Mediated GlycolysisPreprint

Tan, Z., Yang, J., Chen, Y., Zhu, H., Liu, X., He, X., Meng, Q., Xiao, M., Tang, R., Rong, Z., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5158499

Splice-Switching of the Oncogenic BCS1L Isoform Suppresses Ovarian Cancer Progression by Disrupting Mitochondrial Oxidative PhosphorylationPreprint

Xu, M., Wang, Z., Yang, S., Li, G., Zhang, X., Zhao, L., Yang, L. F., Qiu, C., Feng, X., Zhang, K., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5262329

Cancer: Metabolic Risk Factors, Regional Prevalence, and the Warburg Effect - Limelight, July 2025

Nath, K. A. (2025) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2025.05.021

Novel Aza-podophyllotoxin Derivative Inhibits Growth of Triple-Negative Breast Cancer

Dheeraj, A., Garcia-Marques, F. J., Chennai, B., Tailor, D., Bermudez, A., Grau, B. W., Haley, C. B., Pitteri, S. J., & Malhotra, S. V. (2025) · ACS Omega · doi:10.1021/acsomega.5c00052

HRS sustains mitochondrial homeostasis by anchoring destabilized proteins during tumorigenesis

Xiao, B.-L., Li, J., Chen, Z.-K., Zhao, Z.-C., Wang, Y., Liu, H., Xia, H.-F., Fu, Q.-Y., Huang, S.-X., Shang, J., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.148107

Agilent Seahorse XF HS Mini‐Platform: A Comprehensive Guide for Real‐Time Analysis of Cellular Energy Metabolism

Liu, Z., Zhao, F., Li, Q., & Chen, J. (2025) · Food Safety and Health · doi:10.1002/fsh3.70061

ZNF280A and ACRV1 enhance aerobic glycolysis and drive ovarian cancer progression via the PI3K/AKT signaling pathway

Zhu, D., Chen, P., Yu, L., Gao, S., Liu, Y., Pan, S., & Li, L. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110993

Lamin A/C maintains genome topology and regulates transcriptional programs essential for virus-driven B cell activationPreprint

Caruso, L. B., Maestri, D., Kossenkov, A., Goldman, A. R., Cassel, J., Soldan, S. S., Lieberman, P., & Tempera, I. (2026) · bioRxiv · doi:10.64898/2026.01.12.699161

Targeting store-operated Ca2+ entry as a novel strategy to overcome treatment resistance in melanoma

Gutiérrez, D. M. V., Niemeyer, B. A., Kreis, S., & Bréchard, S. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189548

Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells

Wu, Q., Li, Z., Gong, T., Zheng, X., Zhou, X., & Peng, X. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1706727 · Cited by 1

Machine learning derived proliferating T cell-related signature: a novel biomarker for prognosis and treatment efficacy in clear cell renal cell carcinoma

Liu, D., Wang, L., Pan, X., Zhao, J., Tang, Y., Liang, J., & Zeng, H. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116361

Phosphoenolpyruvate carboxykinase 2 as a prognostic biomarker: expression and clinical significance in Group 3 and Group 4 medulloblastoma

Zheng, S., Lin, L., Ren, G., Lan, H., Pan, Y., Zhang, M., Guan, W., Wang, R., & Wang, L. (2026) · Journal of Neuro-Oncology · doi:10.1007/s11060-025-05416-z

Global Quantitative Dynamics and Early Warning Signals of Hepatocellular Carcinoma: Integrating Theoretical Modeling with Experimental Validation

Yu, C., Neumann, S., Pattison, S. T., & Wang, J. (2026) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.6c00322

Persistent lactic acidosis in ALK-positive anaplastic large cell lymphoma: a case report and literature review

Jin, H., Xu, Z., Qing, A., Huang, Q., Chen, X., Luo, Y., Hong, P., & Qiu, Y. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1744202

Splice-switching of the oncogenic BCS1L isoform suppresses ovarian cancer progression by disrupting mitochondrial function

Xu, M., Wang, Z., Yang, S., Li, G., Zhang, X., Zhao, L., Yang, L., Qiu, C., Feng, X., Zhang, K., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08495-6

Crosstalk between protein lipidation and ubiquitination in tumor biology

Liao, J., Huang, Q., Yang, Z., Zou, M., Ren, J., Fang, R., Wen, J., Gao, Y., Peng, J., & Hao, L. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02277-3

CSDE1 Drives Glycolysis and the Progression of Prostate Cancer Through RAC1 ‐Dependent RAS / MAPK Activation

Yin, Z., Wang, Z., Gong, W., Wang, Z., Li, Z., Xu, L., Ning, J., Gao, L., Pan, T., Yu, W., et al. (2026) · The FASEB Journal · doi:10.1096/fj.202504006r

Enzyme‐Activated MRI for In Vivo Glucose Imaging via a Biodegradable Chromium Nanoprobe

Xu, Y., Yang, W., Yun, Y., Wang, H., Wu, Z., Yu, Y., & Zhang, B. (2026) · Advanced Science · doi:10.1002/advs.74861

Reprogramming of amino acid metabolism in cholangiocarcinoma: A potential target for metabolic-targeted therapy

Khawkhiaw, K., Lert-itthiporn, W., Seyedasli, N., Chiu, C., & Saengboonmee, C. (2026) · World Journal of Gastroenterology · doi:10.3748/wjg.v32.i13.115536

Beta-sitosterol-baicalein-guanosine synergistically alleviates Warburg effect in colorectal cancer via EGFR/ERK pathway

Zhou, P., Zeng, Q., Zhang, Q., Zhou, X., & Cheng, S. (2026) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgag006

The role of the GATOR1 complex in mitochondrial function and quality control

Zhang, H. (2025) · theses.fr (ABES) · doi:10.70675/1dad907cz4477z4068z81c2z087317cd244e

New insights into the ambivalent role and clinical implications of tripartite motif family proteins in colorectal cancer

Zou, H., Guo, Y., Pan, Q., Chen, Y., Huang, J., 周一军, Yang, X., Zhu, Y., Mo, L., Cai, J., et al. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218514

The Combination of Iron Chelator Deferoxamine and Glycolytic Inhibitors, 2-Deoxy-D-Glucose and Dichloroacetate, Synergistically Suppress the Proliferation of Human Breast Carcinoma Cell Lines

江贤朋, & Baucom, C. C. (2026) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2026.144020

CDC6/THBS1 accelerates pancreatic cancer progression via AKT-mediated glycolytic reprogramming

Yin, M., Chen, X., Liu, Z., Wang, C., Chen, T., & Zhu, J. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08758-2

The MIF-CD74 axis drives colorectal cancer via glycolytic reprogramming and is targeted by a novel small-molecule inhibitor

Lou, J., Chen, Y., Li, Y., Liu, Z. H., Hu, S., Ding, M., Qin, J., Sun, H., & Pan, Y. (2026) · Cellular Oncology · doi:10.1007/s13402-026-01202-9

Lactate-associated transcriptomic alterations and malignant phenotypes in colorectal cancer

Li, S., Feng, S., Li, X., Su, R., Deng, J., Cheng, S., & Hou, Y. Y. (2026) · Discover Oncology · doi:10.1007/s12672-026-05147-1

Targeting lipid metabolism to overcome therapeutic resistance in renal cell carcinoma: Mechanisms and emerging strategies

Feng, Y., Zhang, S., Li, J., Yue, D., & Wang, Y. (2026) · Current Urology · doi:10.1097/cu9.0000000000000355

Biomimetic nanozyme reverse the Warburg effect to empower intrahepatic cholangiocarcinoma immunotherapy

Zhu, Y., Duan, Y., Dai, L., Liu, B., Lv, M., Lin, J., Li, Y., Qiu, Y., Cheng, R., Lu, S., et al. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124318

Active ingredients of medicine food homology plants for tumor chemoresistance reversal: a systematic review

Bai, S., Tang, Z., Mahemuti, D., Ma, L., Huang, Q., Kong, Y., Chen, Y., Su, Z., Shataera, D., & Maimaitijiang, A. (2026) · Cogent Food & Agriculture · doi:10.1080/23311932.2026.2630417

ZIP7 Drives Glycolytic Reprogramming and Lactate-Mediated Immune Remodeling in Lung Adenocarcinoma Through GSK3β-NRF2 Signaling

Tang, Z., Shi, Y., Jiang, X., Jiang, S., Maihemuti, N., Zhang, J., Tang, B., & Xu, Z. S. (2026) · Biomedicines · doi:10.3390/biomedicines14061262 · Cited by 1

Dual inhibition of glycolysis and epigenetics via a nanodelivery system for colorectal cancer treatment

Li, T., Zhao, J., Liu, J., Chen, Y., & Li, S. (2026) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2026.102977

ALKBH2 promotes the Warburg effect and bladder cancer progression under hypoxic conditions via the PI3K/AKT pathway

Yang, Z., Ma, J., Qiang, Z., Xie, W., Jiao, L., Hu, Z., Zhang, T., Zhang, L., Lv, J., Yue, F., et al. (2026) · Clinical and Experimental Medicine · doi:10.1007/s10238-026-02212-5

Methyltransferase-like protein 7B promotes glycolysis and malignant progression in papillary thyroid carcinoma cells via the USP28/HIF-1α axis

Fengyu, X. U., & Qiuping, X. I. E. (2026) · Journal of Zhejiang University (Medical Sciences) · doi:10.3724/zdxbyxb-2025-0822

Oxidative Stress Induced Senescent Macrophage‐Driven Squamous Cell Carcinoma Invasion via Glutamine Metabolic Reprogramming

Wang, S. Z., Mu, J., Zhao, W., Hu, C., Shi, X., Zhou, H., Liu, J., & Wu, F. (2026) · Aging Cell · doi:10.1111/acel.70592

Lactate in ruminant health: metabolic roles and the emerging significance of lactylation

Li, X., Jiang, M., Huang, Y., Wang, D., & Cheng, J. (2026) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-026-01442-7 · Cited by 1

HsClpP-Engaging Selective Mitochondrial Pan-PDK Degraders for Cancer Therapy

Yang, Y., Zhang, H., Yang, M., Ou, J., Dai, Z., Xu, M., 闫海波, Liu, X., He, Y., Yang, A., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c00879

Skeletal muscle biomass as an underappreciated fate of glucose

Wackerhage, H., Eggelbusch, M., Hulmi, J. J., & Mäntyselkä, S. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00295.2026

The Metabolic States of Cancer-Associated Fibroblasts: Targeting Stromal Reprogramming to Impede Tumor Progression and Immune Evasion

Yu, Z., Lu, X. L., Pi, R., Zhang, X., Jian, H., Lin, X., Wang, W., & Bai, X. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl49071

USP20-mediated PGAM1 stabilization promotes glycolysis and confers osimertinib resistance in non-small cell lung carcinoma

Meng, Y., Wang, X., Wu, S., Lin, W., Wang, M., Li, K., Mei, P., Huang, Q., Yongde, L., & Wang, N. (2026) · Oncogene · doi:10.1038/s41388-026-03889-4

PRRC2A-mediated m6A modification on NCOA4 promotes thymic epithelial tumor progression through PKM2-induced glycolysis

Wang, T., Xia, L., zhang, L., Feng, Y., Haoran, E., Yu, J., Huang, H., Wu, J., Chen, C., Zhao, Y., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08883-y

Malnutrition in MASLD-related hepatocellular carcinoma: assessment limitations, multidimensional mechanisms, and microbiome-based interventions

Huang, B., Tian, C., & Sui, Y. (2026) · Hepatoma Research · doi:10.20517/2394-5079.2026.42

GUDCA drives colorectal cancer progression via ALKBH5-mediated m6A modification of ENO1 and glycolytic reprogramming

Lin, R., Jin, S., Yang, W., Zhang, J., Jiang, J., Xiao, W., Xie, Y., Zhuo, C., & Wang, X. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1791014

PPP2R2C promotes aerobic glycolysis and mediates pemetrexed resistance in lung adenocarcinomas by upregulating TCP1-dependent protein folding of glycolytic enzymes

Chen, J., Wang, X., Wang, Z., Li, G., & Han, F. (2026) · Respiratory Research · doi:10.1186/s12931-026-03681-8

The pyruvate dehydrogenase complex at the crossroads of cancer metabolism and cell death

Cai, X., Chen, F., Liang, R., Tang, H., Zhou, Q., Lin, J., Kang, R., Tang, D., & Liu, J. (2026) · Cell chemical biology · doi:10.1016/j.chembiol.2026.06.009 · Cited by 1

Decoding osteosarcoma pathogenesis: the pivotal influence of m 6 A modification

Huang, C., Han, Z., Su, J., Zhang, M. X., Lin, Y., He, H., Tang, Y., Guo, P., Wang, Y., & Chen, H. T. (2026) · Epigenetics · doi:10.1080/15592294.2026.2705608 · Cited by 1

Feeding the epigenome: EZH2 as a metabolic integrator of cell fate in development and cancer

Ansari, S. A., & Emerald, B. S. (2026) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2026.101499 · Cited by 1

Microbial growth control: integrating protein abundance and activity

Wang, Y., Dai, X., & Zhu, M. (2026) · Current Opinion in Microbiology · doi:10.1016/j.mib.2026.102803

Fatty acid metabolism in glioma: a review of novel targets and therapeutic strategies

Zhou, X., Wang, D., Zhang, W., & Li, G. (2026) · Chinese Neurosurgical Journal · doi:10.1186/s41016-026-00442-w

We need to talk about the Warburg effect

DeBerardinis, R. J., & Chandel, N. S. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0172-2 · Cited by 887

Warburg effect(s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism

Otto, A. M. (2016) · Cancer & Metabolism · doi:10.1186/s40170-016-0145-9 · Cited by 192

Targeting the Warburg Effect for Cancer Therapy: A Long and Winding Road

Abreu, P. L., & Urbano, A. M. (2016) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781681082899116030006 · Cited by 6

Microreviews in Cell and Molecular Biology 2012 Current Findings in Cancer Cell Metabolism

(2016)

Current Findings in Cancer Cell Metabolism

Brunsteter, T. (2012) · Microreviews in Cell and Molecular Biology