The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
100 years of the Warburg effect: A cancer metabolism endeavor
Open accessAbstract
If you are a scientist and you only know one thing about tumor metabolism, it's likely the Warburg effect. But who was Otto Warburg, and how did his discoveries regarding the metabolism of tumors shape our current thinking about the metabolic needs of cancer cells?
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“Accumulating evidence has demonstrated a close association between glycolytic activity and tumor cell proliferation, survival, and disease progression across multiple cancer types (27).”
From Bioinformatics-based identification of glycolysis-related signatures associated with drug resistance and prognosis in lung adenocarcinoma (2026) · cites this paper as [27]
Citations
Cites
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
Ferroptosis: mechanisms, biology and role in disease
Jiang, X., Stockwell, B. R., & Conrad, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00324-8 · Cited by 7,973
Mutation and cancer: statistical study of retinoblastoma
Knudson, A. G. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.4.820 · Cited by 7,612
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Engelman, J. A., Luo, J., & Cantley, L. C. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1879 · Cited by 3,330
Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
Lunt, S. Y., & Vander Heiden, M. G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154237 · Cited by 3,057
Metabolic reprogramming and cancer progression
Faubert, B., Solmonson, A., & DeBerardinis, R. J. (2020) · Science · doi:10.1126/science.aaw5473 · Cited by 2,740
Kalos, M. D., Levine, B. L., Porter, D. L., Katz, S. I., Grupp, S. A., Bagg, A., & June, C. H. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002842 · Cited by 2,417
Metabolic Pathways in Immune Cell Activation and Quiescence
Pearce, E. L., & Pearce, E. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.005 · Cited by 1,692
Kochenderfer, J. N., Wilson, W. H., Janik, J. E., Dudley, M. E., Stetler-Stevenson, M., Feldman, S. A., Maric, I., Raffeld, M., Nathan, D.-A. N., Lanier, B. J., et al. (2010) · Blood · doi:10.1182/blood-2010-04-281931 · Cited by 1,337
Connecting copper and cancer: from transition metal signalling to metalloplasia
Ge, E. J., Bush, A. I., Casini, A., Cobine, P. A., Cross, J. R., DeNicola, G. M., Dou, Q. P., Franz, K. J., Gohil, V. M., Gupta, S. K., et al. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00417-2 · Cited by 1,332
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1 of the 53 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Krebs, 1972, Otto Heinrich Warburg, 1883-1970, Biogr. Mem. Fellows R. Soc., 18, 629
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Items 201–223 of 223
Liu, L., Zheng, X., Zhao, X., Mao, X., Zhang, F., Jiang, Z., Gao, Z., Wang, Q., Zhu, Y., Huang, Y., et al. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101469
Suleimenov, Y., Samigatova, A., Seksenbayev, B., Altaeva, N., Zhorayeva, A., Bakytzhan, A., & Bekbayev, A. (2026) · Clinical Medicine Insights Oncology · doi:10.1177/11795549261478177
Immune evasion and immunosuppression: Cornerstones of malignant progression
Liu, P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-14064-8.00058-8
Reframing gastric carcinogenesis through a level view of the gastric ecosystem
Dai, X., Wang, S., Luo, Q., Wu, Z., Cui, Z., Ping, Y., Li, J., & Chen, X. (2026) · Discover Oncology · doi:10.1007/s12672-026-05799-z
The multifaceted functions of lactate and its translational potentials in cancer
Wang, P., Yang, X., Yan, Y., Fu, Q., Hu, J., Xu, S., Wang, X., & Jiao, F. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1881938
Yi, Y., Chen, C., He, Y., Yu-zhou, S., Cheng, R., Liu, M., Liu, Z., & Zhang, X. (2026) · Medicinal Research Reviews · doi:10.1002/med.70103
Zhang, S., Li, M., Liu, M., Patten, N. D., Labaf, M., Jeong, J., Sun, H., Lourie, J., Zou, K., Patalano, S. C., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2534152123
Ren, Y., Wang, Q., Qu, X., & 车晓芳 (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1917412
宗小亚, Zu, W.-B., & Tang, D. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105600
Glutamine metabolism and its roles in tumor radiotherapy by regulating DNA damage repair
Huang, Y., Wang, H., Zhang, S., Jiang, Z., Shen, R., Chang, W., & Jiang, X. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1915673
Liu, J., Li, J., Zhou, H., Ha, W., Wu, X., Liu, X., Jiang, Y., Gong, C., Cheng, Y., Liu, Q., et al. (2026) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.71373
Heterogeneity in cancer: molecular mechanisms and therapeutic strategies
He, Y., Niu, L., Ren, Y.-M., Yuan, G.-Q., Pan, Y.-W., & Jin, W. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-03064-x
Recent advances in tumor-activated prodrug nanoparticles for cancer immunotherapy
Wang, G., Du, K., Sun, D., Tong, S., Ren, Y., & Zhou, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1968703
Early metabolic rewiring precedes arsenic-induced carcinogenesis in human lung epithelial cells
Cassidy, R. N., Seburn, E., Pyman, A., Saintilnord, W. N., Mittendorf, S., Hegazy, Y. A., Sheldon, R. D., Chandler, D. P., & Fondufe‐Mittendorf, Y. N. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04555-0
Metabolites and cancer metastasis
Yang, S., Shi, S., Hou, J., Zhang, J., & Su, Z. (2026) · Oncogene · doi:10.1038/s41388-026-03930-6
Chen, Q., Wu, J., Chen, Q., Man, Y., Tan, Y., Liu, Y., & Liu, Z. (2026) · Chinese Chemical Letters · doi:10.1016/j.cclet.2026.113491
Ferrocenyl-carbohydrate conjugates: Synthesis and advances in drug discovery
Rhaz, A. E., Erb, W., Messaoudi, S., & Bideau, F. L. (2026) · Tetrahedron · doi:10.1016/j.tet.2026.135478
Liu, R., Chen, X., Li, H.-M., Zhao, W., Zhong, J., & Ya-jie Tang, A. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118524
Yang, J., Cai, X., He, F., 张君红, Zhang, Z., Yi, Z., Xie, C., & Xu, B. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02903-1
Zhang, Y., Dong, Y., Chen, S., Li, M., Liu, X., Hou, J., & Zhou, S. (2026) · 中国科学通报：英文版 · doi:10.1016/j.scib.2026.10.019
Li, X., Wang, H., Xie, Y., Li, W., Guo, W., Du, R., Hong, J., & Liu, Z. (2026) · Protein and Peptide Letters · doi:10.1016/j.ppl.2026.10.003
BindingDB Entry 50023793: Discovery of ATP competitive PDHK1/2 dual inhibitors.
BindingDB (2026) · UC San Diego · doi:10.7270/q2bk1jb2
Opportunities and Challenges of Overflow Metabolism in Industrial Microorganisms
Xu, M., Liu, S., Sun, D., & Ren, H. (2026) · ACS Synthetic Biology · doi:10.1021/acssynbio.6c00508
Metadata
- Authors
- Fendt, S.-M.
- Affiliations
- VIB-KU Leuven Center for Cancer Biology (BE)
- Corresponding author
- Fendt, Sarah-Maria
- ORCID
- Fendt, Sarah-Maria
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2024-07
- Volume
- 187
- Issue
- 15
- Pages
- 3824-3828
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W4400978492
- Cited by
- 223
- References
- 53
- Citations by year
- 2026: 116 · 2025: 98 · 2024: 9
- FWCI
- 44.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 389 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Funders
- Stichting Tegen Kanker
- World Cancer Research Fund International (IIG_FULL_2023_001)
- Fonds Baillet Latour
- Fonds Wetenschappelijk Onderzoek
- Gilead Sciences
- Wereld Kanker Onderzoek Fonds
- Australian Research Council
- KU Leuven
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- Warburg effect, Otto Warburg, cancer metabolism, glycolysis, history of cancer research, metabolic reprogramming
- MeSH terms
- Warburg Effect, Oncologic, Animals, Glycolysis, Humans, Neoplasms, History, 20th Century, History, 21st Century
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