Cited by 228Neurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

5-HT1A receptor-regulated signal transduction pathways in brain

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Polter, Abigail M., Li, Xiaohua·2010·Cellular Signalling

Abstract

Serotonin is an influential monoamine neurotransmitter that signals through a number of receptors to modulate brain function. Among different serotonin receptors, the serotonin 1A (5-HT1A) receptors have been tied to a variety of physiological and pathological processes, notably in anxiety, mood, and cognition. 5-HT1A receptors couple not only to the classical inhibitory G protein-regulated signaling pathway, but also to signaling pathways traditionally regulated by growth factors. Despite the importance of 5-HT1A receptors in brain function, little is known about how these signaling mechanisms link 5-HT1A receptors to regulation of brain physiology and behavior. Following a brief summary of the known physiological and behavioral effects of 5-HT1A receptors, this article will review the signaling pathways regulated by 5-HT1A receptors, and discuss the potential implication of these signaling pathways in 5-HT1A receptor-regulated physiological processes and behaviors.

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Crossref · 10.1016/j.cellsig.2010.03.019

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  • Some serotonergic receptors modulate the activity of signaling pathways involved in neuronal plasticity such as ERK or MAPK.

    “Some serotonergic receptors, beyond their traditional association with G proteins, modulate the activity of signaling pathways involved in neuronal plasticity such as extracellular-regulated kinase (ERK) or mitogen-activated protein kinase (MAPK, Cowen, 2007;Polter and Li, 2010).”

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  1. [28]Manahan-Vaughan D Anwyl R Rowan MJ Br J Pharmacol 1994 112 4 1083 1088 7952867 PMC1910231
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Authors
Polter, A. M., & Li, X.
Affiliations
University of Alabama at Birmingham (US)
Corresponding author
Li, Xiaohua
Venue
Cellular Signalling
Publisher
Elsevier BV
Published
2010-10
Volume
22
Issue
10
Pages
1406-1412
ISSN
0898-6568 (ISSN-L)
OpenAlex
W2056800045
Cited by
225
References
181
Citations by year
2026: 10 · 2025: 16 · 2024: 10 · 2023: 21 · 2022: 9 · 2021: 18 · 2020: 9 · 2019: 23 · 2018: 15 · 2017: 9 · 2016: 12 · 2015: 15 · 2014: 20 · 2013: 12 · 2012: 15
FWCI
1.09
Type
journal article
Language
en
Open access
Locations
  • Cellular Signalling (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH (MH073723, MH086622, NS061788)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
5-HT1A receptor, serotonin receptors, signal transduction, G protein-coupled receptor signaling, growth factor signaling, anxiety, mood, cognition, brain physiology, behavior
MeSH terms
Behavior, Brain, Neurons, Signal Transduction, Receptor, Serotonin, 5-HT1A

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