5-HT1A receptor-regulated signal transduction pathways in brain
Open accessAbstract
Serotonin is an influential monoamine neurotransmitter that signals through a number of receptors to modulate brain function. Among different serotonin receptors, the serotonin 1A (5-HT1A) receptors have been tied to a variety of physiological and pathological processes, notably in anxiety, mood, and cognition. 5-HT1A receptors couple not only to the classical inhibitory G protein-regulated signaling pathway, but also to signaling pathways traditionally regulated by growth factors. Despite the importance of 5-HT1A receptors in brain function, little is known about how these signaling mechanisms link 5-HT1A receptors to regulation of brain physiology and behavior. Following a brief summary of the known physiological and behavioral effects of 5-HT1A receptors, this article will review the signaling pathways regulated by 5-HT1A receptors, and discuss the potential implication of these signaling pathways in 5-HT1A receptor-regulated physiological processes and behaviors.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some serotonergic receptors modulate the activity of signaling pathways involved in neuronal plasticity such as ERK or MAPK.
“Some serotonergic receptors, beyond their traditional association with G proteins, modulate the activity of signaling pathways involved in neuronal plasticity such as extracellular-regulated kinase (ERK) or mitogen-activated protein kinase (MAPK, Cowen, 2007;Polter and Li, 2010).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Polter and Li, 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 6,535 · see citing works
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244 · see citing works
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works
A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,305 · see citing works
Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,887 · see citing works
Pazos, Á., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90856-x · Cited by 1,855 · see citing works
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science · doi:10.1126/science.7839144 · Cited by 1,555 · see citing works
Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor
Yao, R., & Cooper, G. M. (1995) · Science · doi:10.1126/science.7701324 · Cited by 1,390 · see citing works
Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase
Xing, J. W., Ginty, D. D., & Greenberg, M. E. (1996) · Science · doi:10.1126/science.273.5277.959 · Cited by 1,246 · see citing works
Saxe, M. D., Battaglia, F., Wang, J.-W., Malleret, G., David, D. J., Monckton, J. E., Garcia, A. D. R., Sofroniew, M. V., Kandel, E. R., Santarelli, L., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607207103 · Cited by 1,020 · see citing works
Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
Sturgill, T. W., Ray, L. B., ERIKSON, E., & Maller, J. L. (1988) · Nature · doi:10.1038/334715a0 · Cited by 1,017 · see citing works
Regulation of serotonin-2C receptor G-protein coupling by RNA editing
Burns, C. M., Chu, H., Rueter, S. M., Hutchinson, L. K., Canton, H., Sanders-Bush, E., & Emeson, R. B. (1997) · Nature · doi:10.1038/387303a0 · Cited by 1,010 · see citing works
Mitogen-activated protein kinases in synaptic plasticity and memory
Sweatt, J. D. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.04.001 · Cited by 990 · see citing works
Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult
Gross, C. T., Zhuang, X., Stark, K. L., Ramboz, S., Oosting, R. S., Kirby, L. G., Santarelli, L., Beck, S. G., & Hen, R. (2002) · Nature · doi:10.1038/416396a · Cited by 906 · see citing works
Electrophysiological responses of serotoninergic dorsal raphe neurons to 5‐HT1A and 5‐HT1B agonists
Sprouse, J. S., & Aghajanian, G. K. (1987) · Synapse · doi:10.1002/syn.890010103 · Cited by 848 · see citing works
Serotonin receptor 1A knockout: An animal model of anxiety-related disorder
Ramboz, S., Oosting, R. S., Amara, D. A., Kung, H. F., Blier, P., Mendelsohn, M. M., Mann, J. J., Brunner, D., & Hen, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14476 · Cited by 813 · see citing works
Beaulieu, J., Sotnikova, T. D., Yao, W., Kockeritz, L. K., Woodgett, J. R., Gainetdinov, R. R., & Caron, M. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307921101 · Cited by 792 · see citing works
Lüscher, C., Jan, L. Y., Stoffel, M., Malenka, R. C., & Nicoll, R. A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80381-5 · Cited by 762 · see citing works
Elevated anxiety and antidepressant-like responses in serotonin 5-HT 1A receptor mutant mice
Heisler, L. K., Chu, H.-M., Brennan, T. J., Danao, J. A., Bajwa, P., Parsons, L. H., & Tecott, L. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15049 · Cited by 704 · see citing works
Pompeiano, M., Palacios, J., & Mengod, G. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00440.1992 · Cited by 699 · see citing works
Increased anxiety of mice lacking the serotonin 1A receptor
Parks, C. L., Robinson, P. S., Sibille, E. L., Shenk, T. E., & Tóth, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10734 · Cited by 691 · see citing works
Functional significance of adult neurogenesis
Kempermann, G., Wiskott, L., & Gage, F. H. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.03.001 · Cited by 630 · see citing works
Araneda, R. C., & Andrade, R. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90128-b · Cited by 621 · see citing works
The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor
Fargin, A., Raymond, J. R., Lohse, M. J., Kobilka, B. K., Caron, M. G., & Lefkowitz, R. J. (1988) · Nature · doi:10.1038/335358a0 · Cited by 597 · see citing works
5-HT1A receptor function in major depressive disorder
Savitz, J. B., Lucki, I., & Drevets, W. C. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.009 · Cited by 573 · see citing works
Andrade, R., & Nicoll, R. A. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016862 · Cited by 552 · see citing works
Banasr, M., Héry, M., Printemps, R., & Daszuta, A. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300320 · Cited by 539 · see citing works
Akt/GSK3 Signaling in the Action of Psychotropic Drugs
Beaulieu, J., Gainetdinov, R. R., & Caron, M. G. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145634 · Cited by 523 · see citing works
Kobilka, B. K., Frielle, T., Collins, S., Yang-Feng, T. L., Kobilka, T. S., Francke, U., Lefkowitz, R. J., & Caron, M. G. (1987) · Nature · doi:10.1038/329075a0 · Cited by 515 · see citing works
Riad, M., Garcia, S., Watkins, K. C., Jodoin, N., Doucet, �., Langlois, X., Mestikawy, S. E., Hamon, M., & Descarries, L. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000207)417:2 · Cited by 502 · see citing works
Xing, J. W., Kornhauser, J. M., Xia, Z., Thiele, E. A., & Greenberg, M. E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.1946 · Cited by 492 · see citing works
The Role of the Extracellular Signal-Regulated Kinase Signaling Pathway in Mood Modulation
Einat, H., Yuan, P., Gould, T. D., Li, J., Du, J., Zhang, L., Manji, H. K., & Chen, G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07311.2003 · Cited by 475 · see citing works
Multiplicity of mechanisms of serotonin receptor signal transduction
Raymond, J. R., Mukhin, Y. V., Gelasco, A. K., Turner, J. H., Collinsworth, G., Gettys, T. W., Grewal, J. S., & Garnovskaya, M. N. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00169-3 · Cited by 466 · see citing works
Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin
Colino, A., & Halliwell, J. V. (1987) · Nature · doi:10.1038/328073a0 · Cited by 460 · see citing works
The ERK Cascade: A Prototype of MAPK Signaling
Rubinfeld, H., & Seger, R. (2005) · Molecular Biotechnology · doi:10.1385/mb:31:2:151 · Cited by 460 · see citing works
5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants
Richardson-Jones, J. W., Craige, C. P., Guiard, B. P., Stephen, A., Metzger, K. L., Kung, H. F., Gardier, A. M., Dranovsky, A., David, D. J., Beck, S. G., et al. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.003 · Cited by 450 · see citing works
Regulation of Akt and glycogen synthase kinase-3β phosphorylation by sodium valproate and lithium
Sarno, P. D., Li, X., & Jope, R. S. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00215-0 · Cited by 433 · see citing works
Self-citationThe comparative efficacy of buspirone and diazepam in the treatment of anxiety
Goldberg, H. L., & Finnerty, R. J. (1979) · American Journal of Psychiatry · doi:10.1176/ajp.136.9.1184 · Cited by 426 · see citing works
Vivo, M. D., & Maayani, S. (1986) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24854-6 · Cited by 424 · see citing works
5-HT Receptor Classification and Nomenclature: Towards a Harmonization with the Human Genome
Hoyer, D., & Martin, G. B. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00036-1 · Cited by 415 · see citing works
Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.
Goode, N. T., Hughes, K., Woodgett, J. R., & Parker, P. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41866-2 · Cited by 397 · see citing works
Chalmers, D. T., & Watson, S. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90748-k · Cited by 388 · see citing works
Immunocytochemical localization of serotonin1A receptors in the rat central nervous system
Kia, H. K., Miquel, M., Brisorgueil, M., Daval, G., Riad, M., Mestikawy, S. E., Hamon, M., & Verg�, D. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960205)365:2 · Cited by 378 · see citing works
The Role of CREB in Depression and Antidepressant Treatment
Blendy, J. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.003 · Cited by 365 · see citing works
Cyclic AMP Promotes Neuronal Survival by Phosphorylation of Glycogen Synthase Kinase 3β
Li, M., Wang, X., Meintzer, M. K., Laessig, T. A., Birnbaum, M. J., & Heidenreich, K. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.24.9356-9363.2000 · Cited by 363 · see citing works
The Serotonin-1A Receptor in Anxiety Disorders
Akimova, E., Lanzenberger, R. R., & Kasper, S. F. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.012 · Cited by 360 · see citing works
Serotonergic control of the hippocampus via local inhibitory interneurons.
Freund, T. F., Gulyás, A. I., Acsády, L., Görcs, T. J., & Tóth, K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8501 · Cited by 360 · see citing works
Stockmeier, C. A. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(03)00050-5 · Cited by 357 · see citing works
The role of 5-HT1A receptors in learning and memory
Ögren, S. O., Eriksson, T. M., Elvander-Tottie, E., D’Addario, C., Ekstrom, J. C., Svenningsson, P., Meister, B., Kehr, J., & Stiedl, O. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.023 · Cited by 341 · see citing works
Prickaerts, J., Moechars, D., Cryns, K., Lenaerts, I., van Craenendonck, H., Goris, I., Daneels, G., Bouwknecht, J. A., & Steckler, T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5216-05.2006 · Cited by 341 · see citing works
A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment
Duman, C. H., Schlesinger, L., Kodama, M., Russell, D., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.047 · Cited by 338 · see citing works
Sprouse, J. S., & Aghajanian, G. K. (1988) · Neuropharmacology · doi:10.1016/0028-3908(88)90079-2 · Cited by 333 · see citing works
Serotonin and Hippocampal Neurogenesis
Gould, E. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00045-7 · Cited by 328 · see citing works
Long-term potentiation in the amygdala: A cellular mechanism of fear learning and memory
Sigurdsson, T., Doyère, V., Cain, C. K., & LeDoux, J. E. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.06.022 · Cited by 325 · see citing works
Gould, T. D., Einat, H., Bhat, R. V., & Manji, H. K. (2004) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145704004535 · Cited by 314 · see citing works
A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory
King, M. V., Marsden, C. A., & Fone, K. C. F. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.07.001 · Cited by 305 · see citing works
Davidson, J. R. T., DuPont, R. L., Hedges, D., & Haskins, J. T. (1999) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v60n0805 · Cited by 302 · see citing works
In Vivo Regulation of Glycogen Synthase Kinase-3β (GSK3β) by Serotonergic Activity in Mouse Brain
Li, X., Zhu, W., Roh, M.-S., Friedman, A. B., Rosborough, K., & Jope, R. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300439 · Cited by 300 · see citing works
Self-citationBockaert, J., Claeysen, S., Bécamel, C., Dumuis, A., & Marin, P. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0286-1 · Cited by 285 · see citing works
Altered Emotional States in Knockout Mice Lacking 5-HT1A or 5-HT1B Receptors
Zhuang, X. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00047-0 · Cited by 276 · see citing works
Kaidanovich‐Beilin, O., Milman, A., Weizman, A., Pick, C. G., & Eldar-Finkelman, H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.01.008 · Cited by 276 · see citing works
Cassel, J., & Jeltsch‐David, H. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00241-a · Cited by 257 · see citing works
Poul, E. L., Boni, C., Hanoun, N., Laporte, A., Laaris, N., Chauveau, J., Hamon, M., & Lanfumey, L. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00088-x · Cited by 238 · see citing works
5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus
Radley, J. J., & Jacobs, B. L. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03477-7 · Cited by 231 · see citing works
Dunn, R. W., Corbett, R., & Fielding, S. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90811-x · Cited by 225 · see citing works
Polter, A., Beurel, E., Yang, S., Garner, R., Song, L., Miller, C. A., Sweatt, J. D., McMahon, L., Bartolucci, A. A., Li, X., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.43 · Cited by 225 · see citing works
Self-citationSerotonin 5-HT1A Receptors Regulate NMDA Receptor Channels through a Microtubule-Dependent Mechanism
Yuen, E. Y. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1187-05.2005 · Cited by 225 · see citing works
Facilitation of hippocampal long‐lasting potentiation by GABA antagonists
Wigström, H., & Gustafsson, B. (1985) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1985.tb07703.x · Cited by 224 · see citing works
Antidepressant-like activity of 5-HT1A agonists measured with the forced swim test
Wieland, S., & Lucki, I. (1990) · Psychopharmacology · doi:10.1007/bf02244228 · Cited by 222 · see citing works
MAP'ing CNS Development and Cognition: An ERKsome Process
Samuels, I. S., Saitta, S. C., & Landreth, G. E. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.001 · Cited by 200 · see citing works
Cyclic AMP Inhibits Akt Activity by Blocking the Membrane Localization of PDK1*
Kim, S., Jee, K.-Y., Kim, D., Koh, H., & Chung, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m001492200 · Cited by 200 · see citing works
Anxiety as a Developmental Disorder
Leonardo, E. D., & Hen, R. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301569 · Cited by 183 · see citing works
Altered fear circuits in 5-HT1A receptor KO mice
Gross, C. T., Santarelli, L., Brunner, D., Zhuang, X., & Hen, R. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01041-6 · Cited by 181 · see citing works
Increased Fear Response to Contextual Cues in Mice Lacking the 5-HT1A Receptor
Klemenhagen, K. C., Gordon, J. A., David, D. J. P., Hen, R., & Gross, C. T. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300774 · Cited by 167 · see citing works
Maier, S. F., Grahn, R. E., & Watkins, L. R. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.3.404 · Cited by 167 · see citing works
Expansion of signal transduction by G proteins
Birnbaumer, L. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.12.002 · Cited by 162 · see citing works
Rocca, G. J. D., Mukhin, Y. V., Garnovskaya, M. N., Daaka, Y., Clark, G. J., Luttrell, L. M., Lefkowitz, R. J., & Raymond, J. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.4749 · Cited by 160 · see citing works
Hsiung, S., Adlersberg, M., Arango, V., Mann, J. J., Tamir, H., & Liu, K. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01987.x · Cited by 156 · see citing works
Halasy, K., Miettinen, R. A., Szabat, E., & Freund, T. F. (1992) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1992.tb00861.x · Cited by 155 · see citing works
Dumuis, A., Sebben, M., & Bockaert, J. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13142-8 · Cited by 155 · see citing works
Raymond, J. R., Olsen, C. L., & Gettys, T. W. (1993) · Biochemistry · doi:10.1021/bi00092a016 · Cited by 151 · see citing works
Schoeffter, P., & Hoyer, D. (1988) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1988.tb11728.x · Cited by 150 · see citing works
Carli, M., & SAMANIN, R. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09045.x · Cited by 149 · see citing works
Andrews, N., Hogg, S., Gonzalez, L. E., & File, S. E. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)00473-0 · Cited by 148 · see citing works
Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus
Tsetsenis, T., Ma, X.-H., Iacono, L. L., Beck, S. G., & Gross, C. T. (2007) · Nature Neuroscience · doi:10.1038/nn1919 · Cited by 147 · see citing works
Protein kinase B: signalling roles and therapeutic targeting
Sale, E. M., & Sale, G. J. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7274-9 · Cited by 144 · see citing works
la Cour, C. M., Mestikawy, S. E., Hanoun, N., Hamon, M., & Lanfumey, L. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.022756 · Cited by 144 · see citing works
Structure of the Human Serotonin 5‐HT4 Receptor Gene and Cloning of a Novel 5‐HT4 Splice Variant
Bender, E., Pindon, A., Oers, I. V., Zhang, Y., Gommeren, W., Verhasselt, P., Jurzak, M., Leysen, J. E., & Luyten, W. H. M. L. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740478.x · Cited by 141 · see citing works
Serotonin receptor activation leads to neurite outgrowth and neuronal survival
Fricker, A. D., Rios, C., Devi, L. A., & Gomes, I. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.04.016 · Cited by 136 · see citing works
Maier, S. F., Grahn, R. E., & Watkins, L. R. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.3.404 · Cited by 136 · see citing works
Bayliss, D. A., Umemiya, M., & Berger, A. J. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020758 · Cited by 134 · see citing works
Chaput, Y., Blier, P. U., & de Montigny, C. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02796.1986 · Cited by 133 · see citing works
Cai, X., Gu, Z., Zhong, P., Ren, Y., & Yan, Z. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203752200 · Cited by 130 · see citing works
Detke, M. J., Wieland, S., & Lucki, I. (1995) · Psychopharmacology · doi:10.1007/bf02246053 · Cited by 130 · see citing works
Newman‐Tancredi, A., Martel, J.-C., Assié, M. B., Buritova, J., Lauressergues, E., Cosi, C., Heusler, P., Slot, L. A. B., Colpaert, F. C., Vacher, B., et al. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00001.x · Cited by 128 · see citing works
Forkhead Box, Class O Transcription Factors in Brain: Regulation and Behavioral Manifestation
Polter, A. M., Yang, S., Zmijewska, A. A., van Groen, T., Paik, J.-H., DePinho, R. A., Peng, S. L., Jope, R. S., & Li, X. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.005 · Cited by 128 · see citing works
Self-citationSerotonin stimulates mitochondrial transport in hippocampal neurons
Chen, S., Owens, G. C., Crossin, K. L., & Edelman, D. B. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.08.004 · Cited by 128 · see citing works
Serotonin receptor activation reduces calcium current in an acutely dissociated adult central neuron
Penington, N. J., & Kelly, J. S. (1990) · Neuron · doi:10.1016/0896-6273(90)90201-p · Cited by 127 · see citing works
Yuen, E. Y., Jiang, Q., Chen, P., Feng, J., & Yan, Z. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801713200 · Cited by 125 · see citing works
Intra-hippocampal buspirone in animal models of anxiety
Kostowski, W., Płaźnik, A., & Stefański, R. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90803-0 · Cited by 123 · see citing works
Buspirone impairment of performance of passive avoidance and spatial learning tasks in the rat
Rowan, M. J., Cullen, W. K., & Moulton, B. (1990) · Psychopharmacology · doi:10.1007/bf02244613 · Cited by 115 · see citing works
Cheng, L.-L., Wang, S., & Gean, P. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00229.x · Cited by 113 · see citing works
la Cour, C. M., Boni, C., Hanoun, N., Lesch, K., Hamon, M., & Lanfumey, L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-02178.2001 · Cited by 113 · see citing works
Reversal of helpless behavior in rats by putative 5-HT1A agonists
Giral, P., Martin, P., Soubrié, P., & Simon, P. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90034-0 · Cited by 110 · see citing works
MAP Kinase Modules: Many Roads Home
Raman, M., & Cobb, M. H. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.053 · Cited by 107 · see citing works
Martin, P., Beninger, R. J., Hamon, M., & Puech, A. J. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90011-3 · Cited by 105 · see citing works
Madjid, N., Elvander-Tottie, E., Lüttgen, M., Meister, B., Sandin, J., Kuzmin, A., Stiedl, O., & Ögren, S. O. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.092262 · Cited by 103 · see citing works
Involvement of the 5-HT1AReceptors in Classical Fear Conditioning in C57BL/6J Mice
Stiedl, O., Misane, I., Spiess, J., & Ögren, S. O. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08515.2000 · Cited by 102 · see citing works
Cowen, D. S., Sowers, R. S., & Manning, D. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22297 · Cited by 102 · see citing works
Garnovskaya, M. N., van Biesen, T., Hawes, B. E., Casañas, S. J., Lefkowitz, R. J., & Raymond, J. R. (1996) · Biochemistry · doi:10.1021/bi961764n · Cited by 99 · see citing works
Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses
Liang, B., Moussaif, M., Kuan, C.-J., Gargus, J. J., & Sze, J. Y. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.11.004 · Cited by 97 · see citing works
Clarke, W. P., Yocca, F. D., & Maayani, S. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13071-1 · Cited by 95 · see citing works
Qi, H., Mailliet, F., Spedding, M., Rocher, C., Zhang, X., Delagrange, P., McEwen, B. S., Jay, T. M., & Svenningsson, P. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.068 · Cited by 91 · see citing works
Cell-specific signaling of the 5-HT1A receptor. Modulation by protein kinases C and A.
Liu, Y. F., & Albert, P. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54339-8 · Cited by 91 · see citing works
Buspirone produces a dose-related impairment in spatial navigation
McNaughton, N., & Morris, R. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90653-w · Cited by 87 · see citing works
Adayev, T., Ray, I., Sondhi, R., Sobocki, T., & Banerjee, P. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(03)00023-5 · Cited by 82 · see citing works
Chuang, C., & Ng, S. Y. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00480-3 · Cited by 81 · see citing works
Miyata, S., Hirano, S., & Kamei, J. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300354 · Cited by 80 · see citing works
Mauler, F., Fahrig, T., Horváth, E., & Jork, R. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03074-2 · Cited by 80 · see citing works
Carli, M., Tranchina, S., & SAMANIN, R. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90533-a · Cited by 79 · see citing works
Ardenghi, P. G., Barros, D. M., Izquierdo, L. A., Bevilaqua, L. R., der, N. S., Quevedo, J., Rodrigues, C. A., Madruga, M. P., Medina, J. H., & Izquierdo, I. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199712000-00010 · Cited by 77 · see citing works
Adayev, T., El‐Sherif, Y., Barua, M., Penington, N. J., & Banerjee, P. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.721489.x · Cited by 77 · see citing works
Ramos, A. J., Rubio, M. D., Defagot, C., Hischberg, L., Villar, M. J., & Brusco, A. (2004) · Brain Research · doi:10.1016/j.brainres.2004.10.019 · Cited by 77 · see citing works
Serotonin activates MAP kinase and PI3K/Akt signaling pathways in prostate cancer cell lines
Dizeyi, N., Hedlund, P., Bjartell, A. S., Tinzl, M., Austild-Taskén, K., & Abrahamsson, P.-A. (2009) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2009.09.013 · Cited by 74 · see citing works
Huang, G., & Herbert, J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.056 · Cited by 73 · see citing works
Modulation of Neuronal Excitability by Serotonin-NMDA Interactions in Prefrontal Cortex
Zhong, P., Yuen, E. Y., & Yan, Z. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.03.003 · Cited by 71 · see citing works
Raymond, J. R., Albers, F. J., Middleton, J. P., Lefkowitz, R. J., Caron, M. G., Obeid, L. M., & Dennis, V. W. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52444-3 · Cited by 70 · see citing works
Motta, V., Maisonnette, S. S., Morato, S., Castrechini, P., & Brandão, M. L. (1992) · Psychopharmacology · doi:10.1007/bf02244978 · Cited by 70 · see citing works
Bézard, E., Gerlach, I., Moratalla, R., Gross, C. E., & Jork, R. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.02.003 · Cited by 69 · see citing works
Altered inhibition of dentate granule cells during spatial learning in an exploration task
Moser, E. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-03-01247.1996 · Cited by 68 · see citing works
Tada, K., Kasamo, K., Ueda, N., Suzuki, T., Kojima, T., & Ishikawa, K. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38029-2 · Cited by 67 · see citing works
Sakai, N., & Tanaka, C. (1993) · Brain Research · doi:10.1016/0006-8993(93)90921-9 · Cited by 66 · see citing works
Cowen, D. S., Johnson-Farley, N. N., & Travkina, T. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03107.x · Cited by 65 · see citing works
Differential coupling of 5‐HT1 receptors to G proteins of the Gi family
Lin, S. L., Setya, S., Johnson-Farley, N. N., & Cowen, D. S. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704809 · Cited by 63 · see citing works
5-HT1A receptor-mediated inhibition of long-term potentiation in rat visual cortex
Edagawa, Y., Saito, H., & Abe, K. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00286-6 · Cited by 59 · see citing works
Almada, R. C., Borelli, K. G., Albrechet‐Souza, L., & Brandão, M. L. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.05.017 · Cited by 59 · see citing works
Clarke, W. P., Vivo, M. D., Beck, S. G., Maayani, S., & Goldfarb, J. (1987) · Brain Research · doi:10.1016/0006-8993(87)90338-6 · Cited by 58 · see citing works
Kojima, T., Matsumoto, M., Togashi, H., Tachibana, K., Kemmotsu, O., & Yoshioka, M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03756-3 · Cited by 56 · see citing works
Mendez, J. S., Kadia, T. M., Somayazula, R. K., El‐Badawi, K. I., & Cowen, D. S. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730162.x · Cited by 56 · see citing works
Madhavan, L., Freed, W. J., Anantharam, V., & Kanthasamy, A. G. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.044370 · Cited by 56 · see citing works
Critchley, M. A. E., Njung'e, K., & Handley, S. L. (1992) · Psychopharmacology · doi:10.1007/bf02244819 · Cited by 56 · see citing works
5‐Hydroxytryptamine1AReceptor Agonists in Animal Models of Depression and Anxiety
Kostowski, W., Dyr, W., Krząścik, P., Järbe, T. U. C., & Archer, T. (1992) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1992.tb00515.x · Cited by 55 · see citing works
Alessandri, B., Tsuchida, E., & Bullock, R. M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01948-4 · Cited by 54 · see citing works
Analysis of the 5‐HT1Areceptor involvement in passive avoidance in the rat
Misane, I., Johansson, C., & Ögren, S. O. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702098 · Cited by 53 · see citing works
Kushwaha, N., & Albert, P. R. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03904.x · Cited by 53 · see citing works
Hsiung, S., Tamir, H., Franke, T. F., & Liu, K. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03496.x · Cited by 51 · see citing works
Role of extracellular signal-regulated kinase signal transduction pathway in anxiety
Ailing, F., Fan, L., Li, S., & Manji, S. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.01.018 · Cited by 48 · see citing works
Ahlemeyer, B., & Krieglstein, J. (1997) · Brain Research · doi:10.1016/s0006-8993(97)01109-8 · Cited by 48 · see citing works
Schiapparelli, L., Rı́o, J. D., & Frechilla, D. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03193.x · Cited by 47 · see citing works
Zhou, F., Patel, T. D., Swartz, D. R., Xu, Y., & Kelley, M. R. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00101-1 · Cited by 47 · see citing works
Ahlemeyer, B., Glaser, A., Schaper, C., Semkova, I., & Krieglstein, J. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00136-3 · Cited by 46 · see citing works
Role of Hippocampal CaMKII in Serotonin 5-HT1A Receptor-Mediated Learning Deficit in Rats
Moyano, S., Rı́o, J. D., & Frechilla, D. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300504 · Cited by 46 · see citing works
Serotonin 5-HT1A Receptors Modulate Hippocampal Reactivity to Afferent Stimulation
Levkovitz, Y., & Segal, M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-14-05591.1997 · Cited by 45 · see citing works
Harrington, M. A., Shaw, K., Zhong, P., & Ciaranello, R. D. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38604-0 · Cited by 44 · see citing works
5-HT1A receptor-mediated regulation of mitogen-activated protein kinase phosphorylation in rat brain
Chen, J., Shen, C., & Meller, E. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02297-5 · Cited by 44 · see citing works
The 5-HT1A receptor agonist BAY x 3702 prevents staurosporine-induced apoptosis
Suchanek, B., Struppeck, H., & Fahrig, T. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00469-5 · Cited by 43 · see citing works
Buritova, J., Berrichon, G., Cathala, C., Colpaert, F. C., & Cussac, D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.09.004 · Cited by 43 · see citing works
Garnovskaya, M. N., MUKHIN, Y., & RAYMOND, R. J. (1998) · Biochemical Journal · doi:10.1042/bj3300489 · Cited by 42 · see citing works
Edagawa, Y., Saitō, H., & Abe, K. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01300-1 · Cited by 41 · see citing works
5-HT1A receptor agonists induce anterograde amnesia in mice through a postsynaptic mechanism
Mendelson, S. D., Quartermain, D., Francisco, T., & Shemer, A. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90587-8 · Cited by 41 · see citing works
Sullivan, N. R., Crane, J. W., Damjanoska, K. J., Carrasco, G. A., D’Souza, D. N., García, F., & de Kar, L. D. V. (2005) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-004-1005-7 · Cited by 41 · see citing works
Lithium Reduces FoxO3a Transcriptional Activity by Decreasing Its Intracellular Content
Mao, Z., Liu, L., Zhang, R., & Li, X. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.01.006 · Cited by 40 · see citing works
Self-citationDruse, M. J., Tajuddin, N. F., Gillespie, R. A., & Le, P. T. (2005) · Developmental Brain Research · doi:10.1016/j.devbrainres.2005.06.015 · Cited by 39 · see citing works
Koenig, J., Cosquer, B., & Cassel, J. (2007) · Hippocampus · doi:10.1002/hipo.20368 · Cited by 38 · see citing works
Martin, P., TISSIER, M., Adrien, J., & Puech, A. J. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90605-b · Cited by 38 · see citing works
Tachibana, K., Matsumoto, M., Togashi, H., Kojima, T., Morimoto, Y., Kemmotsu, O., & Yoshioka, M. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.11.016 · Cited by 37 · see citing works
Sanberg, C. D., Jones, F. L., Do, V. H., Dieguez, D., & Derrick, B. E. (2006) · Learning & Memory · doi:10.1101/lm.126306 · Cited by 36 · see citing works
Colocho, P. E. S., Rı́o, J. D., & Frechilla, D. (2008) · Brain Research · doi:10.1016/j.brainres.2007.12.032 · Cited by 36 · see citing works
Full and Partial 5-HT1A Receptor Agonists Disrupt Learning and Performance in Rats
Winsauer, P. J., Rodriguez, F., Cha, A. E., & Moerschbaecher, J. M. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37959-5 · Cited by 35 · see citing works
Druse, M. J., Tajuddin, N. F., Gillespie, R. A., Dickson, E., Atieh, M. K., Pietrzak, C. A., & Le, P. T. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2004.02.009 · Cited by 34 · see citing works
Crane, J. W., Shimizu, K., Carrasco, G. A., García, F., Jia, C., Sullivan, N. R., D’Souza, D. N., Zhang, Y., de Kar, L. D. V., Muma, N. A., et al. (2007) · Brain Research · doi:10.1016/j.brainres.2007.07.101 · Cited by 30 · see citing works
Effects of the Serotonin Agonists 8-OH-DPAT, Buspirone, and DOI on Water Maze Performance
Kant, G. J., Wylie, R. M., Chu, K. Y., & Ghosh, S. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00553-4 · Cited by 29 · see citing works
Buspirone attenuates synaptic activation of hippocampal pyramidal cells
Mauk, M., Peroutka, S., & Kocsis, J. D. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-01-00001.1988 · Cited by 27 · see citing works
G alpha o1 decapeptide modulates the hippocampal 5-HT1A potassium current
Oleskevich, S. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.74.5.2189 · Cited by 26 · see citing works
Hsiung, S., Tin, A., Tamir, H., Franke, T. F., & Liu, K. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21676 · Cited by 20 · see citing works
Kovoor, A., & Lester, H. A. (2002) · Neuron · doi:10.1016/s0896-6273(01)00572-4 · Cited by 19 · see citing works
Creson, T. K., Hao, Y., Engel, S. R., Shen, Y., Hamidi, A., Zhuo, M., Manji, H. K., & Chen, G. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00697.x · Cited by 18 · see citing works
GTP-dependent stimulation and inhibition of adenylate cyclase.
Cooper, D. M. F., & Londos, C. (1982) · PubMed · Cited by 18 · see citing works
Lee, H. J., Ban, J. Y., Cho, S. O., & Seong, Y. H. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2004.09.003 · Cited by 16 · see citing works
Agonist properties of pindolol at h5-HT1A receptors coupled to mitogen-activated protein kinase
Millan, M. J., Newman‐Tancredi, A., Duqueyroix, D., & Cussac, D. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01127-x · Cited by 14 · see citing works
Manahan‐Vaughan, D., Anwyl, R., & Rowan, M. J. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb13194.x · Cited by 14 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- [28]Manahan-Vaughan D Anwyl R Rowan MJ Br J Pharmacol 1994 112 4 1083 1088 7952867 PMC1910231
- [111]Cooper DM Londos C Horiz Biochem Biophys 1982 6 309 333 6311719
- [142]Ailing F Fan L Li S Manji S J Psychiatr Res 2008 43 1 55 63 18348889
- [158]Newman-Tancredi A Martel JC Assie MB Buritova J Lauressergues E Cosi C Heusler P Bruins Slot L Colpaert FC Vacher B Cussac D Br J Pharmacol 2009 156 2 338 353 19154445 PMC2697830
- [168]Kaidanovich-Beilin O Milman A Weizman A Pick CG Eldar-Finkelman H Biol Psychiatry 2004 55 8 781 784 15050857
Cited by
Sorted by citations
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works
Kraus, C., Castrén, E., Kasper, S., & Lanzenberger, R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.007 · Cited by 457 · see citing works
The neurobiology of aggression and violence
Rosell, D. R., & Siever, L. J. (2015) · CNS Spectrums · doi:10.1017/s109285291500019x · Cited by 443 · see citing works
GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder
Valvezan, A. J., & Klein, P. S. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00001 · Cited by 384 · see citing works
Stress and the reproductive axis
Toufexis, D., Rivarola, M. A., Lara, H., & Viau, V. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12179 · Cited by 350 · see citing works
Celada, P., Bortolozzi, A., & Artigas, F. (2013) · CNS Drugs · doi:10.1007/s40263-013-0071-0 · Cited by 323 · see citing works
Synaptic plasticity in depression: molecular, cellular and functional correlates.
Marsden, W. N. (2013) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.12.012 · Cited by 321 · see citing works
Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease
Xu, Y., Yan, J., Zhou, P., Li, J., Gao, H., Xia, Y., & Wang, Q. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.02.002 · Cited by 303 · see citing works
Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats
Mørk, A., Montezinho, L. P., Miller, S., Trippodi-Murphy, C., Plath, N., Li, Y., Gulinello, M. E., & Sánchez, C. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.01.019 · Cited by 298 · see citing works
Barnes, N. M., Ahern, G. P., Bécamel, C., Bockaert, J., Camilleri, M., Chaumont‐Dubel, S., Claeysen, S., Cunningham, K. A., Fone, K. C. F., Gershon, M. D., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.118.015552 · Cited by 264 · see citing works
Defeat stress in rodents: from behavior to molecules
Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J.-P., Lesch, K.-P., Daskalakis, N. P., Steinbusch, H. W. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.006 · Cited by 230 · see citing works
Pharmacological Treatment of Anxiety Disorders: The Role of the HPA Axis
Tafet, G. E., & Nemeroff, C. B. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00443 · Cited by 216 · see citing works
Serotonin-1A receptor alterations in depression: a meta-analysis of molecular imaging studies
Wang, L., Zhou, C., Zhu, D., Wang, X., Fang, L., Zhong, J., Mao, Q., Sun, L., Gong, X., Xia, J., et al. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-1025-0 · Cited by 162 · see citing works
Depression and Pain: Use of Antidepressants
Bonilla-Jaime, H., Sánchez-Salcedo, J. A., Estevez-Cabrera, M. M., Molina‐Jiménez, T., Cortes-Altamirano, J. L., & Alfaro-Rodríguez, A. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210609161447 · Cited by 159 · see citing works
Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness
Albert, P. R., François, B. L., & Millar, A. (2011) · Molecular Brain · doi:10.1186/1756-6606-4-21 · Cited by 149 · see citing works
Asan, E., Steinke, M. R., & Lesch, K. (2013) · Histochemistry and Cell Biology · doi:10.1007/s00418-013-1081-1 · Cited by 137 · see citing works
The role of serotonin in memory: interactions with neurotransmitters and downstream signaling
Seyedabadi, M., Fakhfouri, G., Ramezani, V., Mehr, S. E., & Rahimian, R. (2014) · Experimental Brain Research · doi:10.1007/s00221-013-3818-4 · Cited by 137 · see citing works
Regulation of neuronal communication by G protein‐coupled receptors
Huang, Y., & Thathiah, A. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.05.007 · Cited by 131 · see citing works
Molecular aspects of depression: A review from neurobiology to treatment
Boas, G. R. V., de Lacerda, R. B., Paes, M. M., Gubert, P., Almeida, W. L. D. C., Rescia, V. C., Galdino, P. M., de Carvalho, A. A. V., & Oesterreich, S. A. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.02.024 · Cited by 128 · see citing works
Review of Pharmacological Treatment in Mood Disorders and Future Directions for Drug Development
Li, X., Frye, M. A., & Shelton, R. C. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.198 · Cited by 127 · see citing works
Self-citationAltieri, S. C., Garcia‐García, Á. L., Leonardo, E. D., & Andrews, A. M. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn3002174 · Cited by 111 · see citing works
Luo, J., Lushchak, O., Goergen, P., Williams, M. J., & Nässel, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099732 · Cited by 102 · see citing works
Single Serotonergic Neurons that Modulate Aggression in Drosophila
Alekseyenko, O. V., Chan, Y.-B., Fernandez, M. P., Bülow, T. R., Pankratz, M. J., & Kravitz, E. A. (2014) · Current Biology · doi:10.1016/j.cub.2014.09.051 · Cited by 102 · see citing works
Serotonin modulates spike probability in the axon initial segment through HCN channels
Ko, K. W., Rasband, M. N., Meseguer, V., Krämer, R., & Golding, N. L. (2016) · Nature Neuroscience · doi:10.1038/nn.4293 · Cited by 96 · see citing works
Serotonin 1A and Serotonin 4 Receptors
Samuels, B. A., Mendez‐David, I., Faye, C., David, S. A., Pierz, K. A., Gardier, A. M., Hen, R., & David, D. J. P. (2014) · The Neuroscientist · doi:10.1177/1073858414561303 · Cited by 96 · see citing works
What Do We Really Know About 5-HT1A Receptor Signaling in Neuronal Cells?
Rojas, P. S., & Fiedler, J. L. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00272 · Cited by 93 · see citing works
Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands
Chilmończyk, Z., Bojarski, A. J., Pilc, A., & Sylte, I. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160818474 · Cited by 89 · see citing works
Segi‐Nishida, E. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00142 · Cited by 86 · see citing works
Newman‐Tancredi, A., Depoortère, R., Kleven, M. S., Kołaczkowski, M., & Zimmer, L. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107937 · Cited by 83 · see citing works
Modulation of Synaptic Plasticity in the Cortex Needs to Understand All the Players
Meunier, C. N. J., Chameau, P. J. P., & Fossier, P. (2017) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2017.00002 · Cited by 82 · see citing works
Dipasquale, O., Selvaggi, P., Veronese, M., Gabay, A. S., Turkheimer, F., & Mehta, M. A. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.04.007 · Cited by 68 · see citing works
Gene-environment interactions informing therapeutic approaches to cognitive and affective disorders
Rogers, J., Renoir, T., & Hannan, A. J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.038 · Cited by 69 · see citing works
A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors
Nautiyal, K. M., Tritschler, L., Ahmari, S. E., David, D. J. P., Gardier, A. M., & Hen, R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.109 · Cited by 68 · see citing works
Glycogen Synthase Kinase-3 is an Intermediate Modulator of Serotonin Neurotransmission
Polter, A. M., & Li, X. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00031 · Cited by 67 · see citing works
Self-citationZhou, X., Zhang, R., Zhang, S.-H., Wu, J.-H., & Sun, X.-H. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1685-18.2018 · Cited by 53 · see citing works
Functional significance of glycogen synthase kinase-3 regulation by serotonin
Polter, A. M., Yang, S., Jope, R. S., & Li, X. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.09.009 · Cited by 66 · see citing works
Self-citationAlexithymia in Parkinson's disease: A systematic review of the literature
Assogna, F., Cravello, L., Orfei, M. D., Cellupica, N., Caltagirone, C., & Spalletta, G. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.03.021 · Cited by 64 · see citing works
Leiser, S. C., Pehrson, A. L., Robichaud, P. J., & Sánchez, C. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12782 · Cited by 63 · see citing works
Akatsu, S., Ishikawa, C., Takemura, K., Ohtani, A., & Shiga, T. (2015) · Neuroscience Research · doi:10.1016/j.neures.2015.07.002 · Cited by 60 · see citing works
Huang, X., Yang, J., Yang, S., Cao, S., Qin, D., Zhou, Y., Li, X., Ye, Y., & Wu, J. (2017) · Oncotarget · doi:10.18632/oncotarget.22170 · Cited by 60 · see citing works
Self-citationVahid-Ansari, F., Zhang, M., Zahrai, A., & Albert, P. R. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00404 · Cited by 59 · see citing works
Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics
Jaster, A. M., & González‐Maeso, J. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02274-x · Cited by 54 · see citing works
Daniele, S., Pozzo, E. D., Zappelli, E., & Martini, C. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.04.006 · Cited by 55 · see citing works
Varman, D. R., & Rajan, K. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127945 · Cited by 54 · see citing works
From behavioral context to receptors: serotonergic modulatory pathways in the IC
Hurley, L. M., & Sullivan, M. R. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00058 · Cited by 55 · see citing works
Stewart, A., Maity, B., Wunsch, A. M., Meng, F., Wu, Q., Wemmie, J. A., & Fisher, R. A. (2014) · The FASEB Journal · doi:10.1096/fj.13-235648 · Cited by 53 · see citing works
Antidepressant effect of helicid in chronic unpredictable mild stress model in rats
Tong, J., Zhou, Z., Qi, W., Jiang, S., Yang, B., Zhong, Z.-L., Jia, Y., Li, X., Xiong, L., & Nie, L. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.11.052 · Cited by 53 · see citing works
Self-citationJukić, M. M., Opel, N., Ström, J., Carrillo‐Roa, T., Miksys, S. L., Novalen, M., Renblom, A., Sim, S. C., Peñas‐Lledó, E., Courtet, P., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.204 · Cited by 52 · see citing works
Bian, Z., Zhang, W., Tang, J., Fei, Q., Hu, M.-M., Chen, X., Su, L., Fei, C., Ji, D., Mao, C., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.752211 · Cited by 48 · see citing works
Modulating role of serotonergic signaling in sleep and memory
Vaseghi, S., Arjmandi-Rad, S., Eskandari, M., Ebrahimnejad, M., Kholghi, G., & Zarrindast, M. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00339-8 · Cited by 49 · see citing works
Islam, M. R., Moriguchi, S., Tagashira, H., & Fukunaga, K. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.046 · Cited by 49 · see citing works
Settimo, L., & Taylor, D. M. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117742101 · Cited by 45 · see citing works
The therapeutic potential of 5-HT1A receptors: a patent review
Lacivita, E., Pilato, P. D., Giorgio, P. D., Colabufo, N. A., Berardi, F., Perrone, R., & Leopoldo, M. (2012) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2012.703654 · Cited by 43 · see citing works
Brook, E., Mamo, J. C. L., Wong, R. H. X., Al‐Salami, H., Falasca, M., Lam, V., & Takechi, R. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.009 · Cited by 44 · see citing works
Govindula, A., Ranadive, N., Nampoothiri, M., Rao, C. M., Arora, D. S., & Mudgal, J. (2023) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-023-10064-z · Cited by 44 · see citing works
Serotonin-1A Receptor Polymorphism (rs6295) Associated with Thermal Pain Perception
Lindstedt, F., Karshikoff, B., Schalling, M., Höglund, C. O., Ingvar, M., Lekander, M., & Kosek, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043221 · Cited by 43 · see citing works
Shuraiqi, A. A., Al-Habsi, A. A., & Barry, M. J. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.116164 · Cited by 43 · see citing works
Sałaciak, K., & Pytka, K. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107872 · Cited by 42 · see citing works
Alekseyenko, O., Chan, Y., Okaty, B. W., Chang, Y., Dymecki, S., & Kravitz, E. (2019) · Current Biology · doi:10.1016/j.cub.2019.05.070 · Cited by 38 · see citing works
Mori, M., Murata, Y., Matsuo, A., Takemoto, T., & Mine, K. (2014) · Neurological Therapeutics · doi:10.1007/s40120-013-0015-0 · Cited by 34 · see citing works
Vidal, B., Sebti, J., Verdurand, M., Fieux, S., Billard, T., Streichenberger, N., Troakes, C., Newman‐Tancredi, A., & Zimmer, L. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.05.009 · Cited by 37 · see citing works
Daniele, S., Zappelli, E., & Martini, C. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0446-x · Cited by 36 · see citing works
Wu, Z., Ni, G.-L., Shao, A.-M., & Cui, R. C. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.05.051 · Cited by 37 · see citing works
Noguerón-Merino, M. C., Jiménez‐Ferrer, E., Román‐Ramos, R., Zamilpa, A., Tortoriello, J., & Herrera-Ruiz, M. L. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.01.029 · Cited by 36 · see citing works
5-HT1A receptor ligands and their therapeutic applications: review of new patents
Staroń, J., Bugno, R., Hogendorf, A. S., & Bojarski, A. J. (2018) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2018.1514011 · Cited by 33 · see citing works
The role of serotonin neurotransmission in rapid antidepressant actions
Pehrson, A. L., Roberts, D., Khawaja, A., & McNair, R. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06098-5 · Cited by 33 · see citing works
Shimizu, S., Ishino, Y., Takeda, T., Tohyama, M., & Miyata, S. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/9475384 · Cited by 32 · see citing works
Marin, P., Bécamel, C., Chaumont‐Dubel, S., Vandermoere, F., Bockaert, J., & Claeysen, S. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00005-0 · Cited by 32 · see citing works
Kawakami, M., Umeda, M., Nakagata, N., Takeo, T., & Yamamura, K. (2011) · BMC Developmental Biology · doi:10.1186/1471-213x-11-68 · Cited by 31 · see citing works
Chilmończyk, Z., Bojarski, A. J., Pilc, A., & Sylte, I. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.01.011 · Cited by 31 · see citing works
Kraus, C., Hahn, A., Savli, M., Kranz, G. S., Baldinger, P., Höflich, A. S., Spindelegger, C., Ungersboeck, J., Haeusler, D., Mitterhauser, M., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.07.035 · Cited by 31 · see citing works
In vivo biased agonism at 5-HT1A receptors: characterisation by simultaneous PET/MR imaging
Vidal, B., Fieux, S., Redouté, J., Villien, M., Bonnefoi, F., Bars, D. L., Newman‐Tancredi, A., Costes, N., & Zimmer, L. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0145-2 · Cited by 30 · see citing works
Effects of environmental manipulations in genetically targeted animal models of affective disorders
Renoir, T., Pang, T. Y., & Hannan, A. J. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.04.003 · Cited by 31 · see citing works
Murata, Y., Yanagihara, Y. T., Mori, M., Mine, K., & Enjoji, M. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.03.054 · Cited by 29 · see citing works
The 5-HT1A receptor as a serotonergic target for neuroprotection in cerebral ischemia
Aguiar, R. P., Newman‐Tancredi, A., Prickaerts, J., & de Oliveira, R. M. W. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110210 · Cited by 29 · see citing works
Kalvala, A. K., Bagde, A., Arthur, P., Kulkarni, T., Bhattacharya, S., Surapaneni, S. K., Patel, N. K., Nimma, R., Gebeyehu, A., Kommineni, N., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020554 · Cited by 29 · see citing works
Oyamada, Y., Horiguchi, M., Rajagopal, L., Miyauchi, M., & Meltzer, H. Y. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.040 · Cited by 29 · see citing works
Ma, J., Wu, C. F., Wang, F., Yang, J., Dong, Y. X., Su, G. Y., Zhang, K., Wang, Z. Q., Xu, L. W., Pan, X., et al. (2016) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12616 · Cited by 29 · see citing works
CBD and the 5-HT1A receptor: A medicinal and pharmacological review
Alexander, C., Jeon, J., Nickerson, K., Hassler, S. N., & Vasefi, M. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116742 · Cited by 28 · see citing works
Medeiros, L. R., Cartolano, M. C., & McDonald, M. D. (2013) · Journal of Comparative Physiology B · doi:10.1007/s00360-013-0793-9 · Cited by 28 · see citing works
Mendiguren, A., Aostri, E., Rodilla, I., Pujana, I., Noskova, E., & Pineda, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1183019 · Cited by 27 · see citing works
Estradiol accelerates the effects of fluoxetine on serotonin 1A receptor signaling
Li, Q., Sullivan, N. R., McAllister, C. E., de Kar, L. D. V., & Muma, N. A. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.005 · Cited by 26 · see citing works
Li, W., Xi, Y., Wang, J., Zhang, Y., Li, H., & Liu, X. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250097 · Cited by 25 · see citing works
Becker, G., Streichenberger, N., Billard, T., Newman‐Tancredi, A., & Zimmer, L. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12306 · Cited by 25 · see citing works
Hassan, M., Abbas, Q., Seo, S., Shahzadi, S., Alashwal, H., Zaki, N., Iqbal, Z., & Moustafa, A. A. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9044 · Cited by 24 · see citing works
Jiménez‐Ferrer, E., Herrera-Ruiz, M. L., Ramírez-García, R., Herrera-Arellano, A., & Tortoriello, J. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.06.029 · Cited by 25 · see citing works
Brys, I., Halje, P., Scheffer-Teixeira, R., Varney, M. A., Newman‐Tancredi, A., & Petersson, P. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.01.010 · Cited by 24 · see citing works
Wang, F., & Liu, Y. (2019) · Gynecological Endocrinology · doi:10.1080/09513590.2019.1680622 · Cited by 23 · see citing works
Escitalopram Ameliorates Forskolin-Induced Tau Hyperphosphorylation in HEK239/tau441 Cells
Ren, Q., Wang, Y., Gong, W.-G., Zhou, Q.-D., Xu, L., & Zhang, Z. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0519-4 · Cited by 23 · see citing works
Moreno-Ramos, O. A., Lattig, M. C., & González Barrios, A. F. (2013) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-10-59 · Cited by 22 · see citing works
Xiang, C., Liu, S., Fan, Y., Wang, X., Jia, Y., Li, L., Cong, S., & Han, F. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.03.008 · Cited by 22 · see citing works
Serotonergic modulation of visual neurons in Drosophila melanogaster
Sampson, M. M., Gschweng, K. M. M., Hardcastle, B., Bonanno, S. L., Sizemore, T. R., Arnold, R. C., Gao, F., Dacks, A. M., Frye, M. A., & Krantz, D. E. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009003 · Cited by 22 · see citing works
Heydari, A., & Davoudi, S. (2016) · Seizure · doi:10.1016/j.seizure.2016.12.005 · Cited by 22 · see citing works
Ishikawa, C., & Shiga, T. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.014 · Cited by 22 · see citing works
Hsieh, T. Y., Chang, Y., & Wang, S. (2019) · Food & Function · doi:10.1039/c8fo02189a · Cited by 22 · see citing works
Levigoureux, E., Vidal, B., Fieux, S., Bouillot, C., Emery, S., Newman‐Tancredi, A., & Zimmer, L. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00584 · Cited by 21 · see citing works
Pharmacological MRI to investigate the functional selectivity of 5-HT1A receptor biased agonists
Vidal, B., Bolbos, R. I., Redouté, J., Langlois, J., Costes, N., Newman‐Tancredi, A., & Zimmer, L. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107867 · Cited by 21 · see citing works
Charytoniuk, T., Sztolsztener, K., Harasim‐Symbor, E., Berk, K., Chabowski, A., & Konstantynowicz-Nowicka, K. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112057 · Cited by 22 · see citing works
Serotonin and the search for the anatomical substrate of aggression
Alekseyenko, O. V., & Kravitz, E. A. (2014) · Fly · doi:10.1080/19336934.2015.1045171 · Cited by 21 · see citing works
Dose related effects of buspirone on pain, learning / memory and food intake
Haleem, D. J., Nawaz, S., & Salman, T. (2018) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2018.09.017 · Cited by 21 · see citing works
- Authors
- Polter, A. M., & Li, X.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Li, Xiaohua
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 22
- Issue
- 10
- Pages
- 1406-1412
- ISSN
- 0898-6568 (ISSN-L)
- PMC
- PMC2903656
- OpenAlex
- W2056800045
- Cited by
- 225
- References
- 181
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 10 · 2023: 21 · 2022: 9 · 2021: 18 · 2020: 9 · 2019: 23 · 2018: 15 · 2017: 9 · 2016: 12 · 2015: 15 · 2014: 20 · 2013: 12 · 2012: 15
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (MH073723, MH086622, NS061788)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- 5-HT1A receptor, serotonin receptors, signal transduction, G protein-coupled receptor signaling, growth factor signaling, anxiety, mood, cognition, brain physiology, behavior
- MeSH terms
- Behavior, Brain, Neurons, Signal Transduction, Receptor, Serotonin, 5-HT1A
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review