Convergent Evolution of Sodium Ion Selectivity in Metazoan Neuronal Signaling
Open accessAbstract
Ion selectivity of metazoan voltage-gated Na(+) channels is critical for neuronal signaling and has long been attributed to a ring of four conserved amino acids that constitute the ion selectivity filter (SF) at the channel pore. Yet, in addition to channels with a preference for Ca(2+) ions, the expression and characterization of Na(+) channel homologs from the sea anemone Nematostella vectensis, a member of the early-branching metazoan phylum Cnidaria, revealed a sodium-selective channel bearing a noncanonical SF. Mutagenesis and physiological assays suggest that pore elements additional to the SF determine the preference for Na(+) in this channel. Phylogenetic analysis assigns the Nematostella Na(+)-selective channel to a channel group unique to Cnidaria, which diverged >540 million years ago from Ca(2+)-conducting Na(+) channel homologs. The identification of Cnidarian Na(+)-selective ion channels distinct from the channels of bilaterian animals indicates that selectivity for Na(+) in neuronal signaling emerged independently in these two animal lineages.
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A key component of neuronal physiology has evolved independently in cnidarians and bilaterians.
“suggesting that a key component of neuronal physiology has evolved independently in these two lineages [82,83].”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [83]
The selectivity filter of Nav channels differs significantly in cnidarians and bilaterians.
“However, the selectivity filter differs significantly in cnidarians and bilaterians”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [83]
Both cnidarian and bilaterian Nav channels have evolved from an ancestral voltage-gated Ca2+ (Cav) channel.
“Both cnidarian and bilaterian Nav channels have evolved from an ancestral voltage-gated Ca2+ (Cav) channel.”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [83]
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- Authors
- Gur Barzilai, M., Reitzel, A. M., Kraus, J. E. M., Gordon, D., Technau, U., Gurevitz, M., & Moran, Y.
- Affiliations
- Woods Hole Oceanographic Institution (US)
- University of Vienna (AT)
- Tel Aviv University (IL)
- Corresponding author
- Moran, Yehu
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 2
- Issue
- 2
- Pages
- 242-248
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC3809514
- OpenAlex
- W2154102976
- Cited by
- 76
- References
- 35
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 11 · 2015: 10 · 2014: 8 · 2013: 5
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Phaidra (Universität Wien) (submittedVersion, cc-by-nc-nd)
- Open Access Server of the Woods Hole Scientific Community (Woods Hole Scientific Community) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Science Foundation
- University of Pennsylvania
- Pennsylvania State University
- Austrian Science Fund (P 21108)
- Universität Wien
- Tel Aviv University
- University of California, San Diego
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (F32HD062178)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- sodium selectivity, voltage-gated sodium channels, selectivity filter, convergent evolution, Nematostella vectensis, Cnidaria, neuronal signaling, channel pore structure, phylogenetic analysis, sea anemone
- MeSH terms
- Amino Acid Sequence, Animals, Calcium, Molecular Sequence Data, Synaptic Transmission, Neurons, Sea Anemones, Sodium, Ion Transport, Evolution, Molecular, Voltage-Gated Sodium Channels
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