Cnidarians and the evolutionary origin of the nervous system

Watanabe, Hiroshi; Fujisawa, Toshitaka; Holstein, Thomas W.

doi:10.1111/j.1440-169x.2009.01103.x

Cited by 208Marine Invertebrate Physiology and EcologyDevelopmental Biology and Gene RegulationNeurobiology and Insect Physiology Research

Cnidarians and the evolutionary origin of the nervous system

Open access

Watanabe, Hiroshi, Fujisawa, Toshitaka, Holstein, Thomas W.·2009·Development, Growth & Differentiation

DOI 10.1111/j.1440-169x.2009.01103.x

Open this paper in CoChat — free account Open PDF

Abstract

Cnidarians are widely regarded as one of the first organisms in animal evolution possessing a nervous system. Conventional histological and electrophysiological studies have revealed a considerable degree of complexity of the cnidarian nervous system. Thanks to expressed sequence tags and genome projects and the availability of functional assay systems in cnidarians, this simple nervous system is now genetically accessible and becomes particularly valuable for understanding the origin and evolution of the genetic control mechanisms underlying its development. In the present review, the anatomical and physiological features of the cnidarian nervous system and the interesting parallels in neurodevelopmental mechanisms between Cnidaria and Bilateria are discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1440-169x.2009.01103.x

Cites

191 of 191 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Many aspects of the nervous system are conserved between cnidarians and bilaterians, including neuropeptides and neurotransmitters.
“Though at least 600 million years of evolution separate cnidarians from bilaterians [9–16], many aspects of the nervous system are conserved, including neuropeptides and neurotransmitters [15–20].”
From The Jellyfish Cassiopea Exhibits a Sleep-like State (2017) · cites this paper as [18]
Much of the molecular architecture underlying neurogenesis and neuron functioning is conserved between bilaterians and cnidarians.
“The publication of several cnidarian genomes has shown that much of the molecular architecture underlying neurogenesis and neuron functioning is conserved between bilaterians and cnidarians [17,47–51].”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [51]
Nerve net-like arrangements of neurons cover almost the entire ectoderm in cnidarians and ctenophores.
“Nerve net-like arrangements of neurons cover the almost entire ectoderm in cnidarians and ctenophores [61,129,130–136].”
From Gastric pouches and the mucociliary sole: setting the stage for nervous system evolution (2015) · cites this paper as [136]
The presence of a well-developed nerve net correlates with the presence of basiepithelial muscle fibres directly innervated by nerve net neurons in cnidarians and ctenophores.
“The presence of a well-developed nerve net correlates with the presence of basiepithelial muscle fibres directly innervated by nerve net neurons, in cnidarians and in ctenophores [61,67,128,132,133,135,136,138–142].”
From Gastric pouches and the mucociliary sole: setting the stage for nervous system evolution (2015) · cites this paper as [136]
The purely ectodermal nerve net in cerianthids suggests that the evolution of inner layer neurons occurred independently in ctenophore, cnidarian and bilaterian lineages.
“In the cerianthids, a basal cnidarian lineage, the nerve net appears to be of purely ectodermal nature [128], which suggests that the evolution of inner layer neurons occurred independently in ctenophore, cnidarian and bilaterian lineages [136].”
From Gastric pouches and the mucociliary sole: setting the stage for nervous system evolution (2015) · cites this paper as [136]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Microscopic anatomy of invertebrates
Harrison, F. W. (1991) · Wiley-Liss eBooks · Cited by 2,736 · see citing works
Broad phylogenomic sampling improves resolution of the animal tree of life
Dunn, C. W., Hejnol, A., Matus, D. Q., Pang, K., Browne, W. E., Smith, S. A., Seaver, E., Rouse, G. W., Obst, M., Edgecombe, G. D., et al. (2008) · Nature · doi:10.1038/nature06614 · Cited by 1,921 · cited 2× · see citing works
“Anthozoa is considered to be a representative of the basal group within the Cnidaria (Bridge et al. 1995; Medina et al. 2001; Collins 2002; Dunn et al. 2008).”
Background
Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization
Putnam, N. H., Srivastava, M., Hellsten, U., Dirks, B., Chapman, J., Salamov, A., Terry, A., Shapiro, H., Lindquist, E., Kapitonov, V. V., et al. (2007) · Science · doi:10.1126/science.1139158 · Cited by 1,555 · see citing works
CLIP Identifies Nova-Regulated RNA Networks in the Brain
Ule, J., Jensen, K. B., Ruggiu, M., Mele, A., Ule, A., & Darnell, R. B. (2003) · Science · doi:10.1126/science.1090095 · Cited by 1,120 · see citing works
Structure of a Molluscan Cardioexcitatory Neuropeptide
Price, D. A., & Greenberg, M. J. (1977) · Science · doi:10.1126/science.877582 · Cited by 1,064 · see citing works
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somitePreprint
McMahon, J. A., Takada, S., Zimmerman, L. B., Fan, C., Harland, R. M., & McMahon, A. P. (1998) · Genes & Development · doi:10.1101/gad.12.10.1438 · Cited by 844 · see citing works
DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN XENOPUS EMBRYOS
De Robertis, E. M., & Kuroda, H. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.011403.154124 · Cited by 671 · see citing works
Mash1regulates neurogenesis in the ventral telencephalon
Casarosa, S., Schuurmans, C. J., & Guillemot, F. (1999) · Development · doi:10.1242/dev.126.3.525 · Cited by 639 · see citing works
Settlement and metamorphosis of marine invertebrate larvae
Chia, F., & Rice, M. E. (1978) · Cited by 636 · see citing works
Neural induction, the default model and embryonic stem cells
Muñoz-Sanjuán, I., & Brivanlou, A. H. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn786 · Cited by 635 · see citing works
Dickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the Mouse
Mukhopadhyay, M., Shtrom, S., Rodrı́guez-Esteban, C., Chen, L., Tsukui, T., Gomer, L., Dorward, D. W., Glinka, A., Grinberg, A., Huang, S.-P., et al. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00041-7 · Cited by 634 · see citing works
A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons
Fode, C., Ma, Q., Casarosa, S., Ang, S.-L., Anderson, D. J., & Guillemot, F. (2000) · Genes & Development · doi:10.1101/gad.14.1.67 · Cited by 624 · see citing works
Fibroblast Growth Factor Signaling during Early Vertebrate Development
Böttcher, R. T., & Niehrs, C. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0040 · Cited by 540 · see citing works
The organizer factors Chordin and Noggin are required for mouse forebrain development
Bachiller, D., Klingensmith, J., Kemp, C. R., Belo, J. A., Anderson, R. M., May, S. R., McMahon, J. A., McMahon, A. P., Harland, R. M., Rossant, J., et al. (2000) · Nature · doi:10.1038/35001072 · Cited by 524 · see citing works
Initiation of neural induction by FGF signalling before gastrulation
Streit, A., Berliner, A. J., Papanayotou, C., Sirulnik, A., & Stern, C. D. (2000) · Nature · doi:10.1038/35017617 · Cited by 521 · see citing works
A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
Ang, S., Jin, O., Rhinn, M., Daigle, N., Stevenson, L., & Rossant, J. (1996) · Development · doi:10.1242/dev.122.1.243 · Cited by 501 · see citing works
Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria
Denes, A. S., Jékely, G., Steinmetz, P. R. H., Raible, F., Snyman, H., Prud'homme, B., Ferrier, D. E. K., Balavoine, G., & Arendt, D. (2007) · Cell · doi:10.1016/j.cell.2007.02.040 · Cited by 480 · see citing works
Eukaryotic mRNPs May Represent Posttranscriptional Operons
Keene, J. D., & Tenenbaum, S. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00559-2 · Cited by 457 · see citing works
Neural induction: old problem, new findings, yet more questions
Stern, C. D. (2005) · Development · doi:10.1242/dev.01794 · Cited by 421 · cited 2× · see citing works
“However, recent studies in other vertebrates, ascidians, hemichordates and annelids have questioned the general notion of Bmp inhibition as a universal mechanism in the first phase of neural induction (Streit and Stern 1999; Darras and Nishida 2001; Stern 2005; Lowe et al. 2006; Denes et al. 2007).”
Background
Origins of Bilateral Symmetry: Hox and Dpp Expression in a Sea Anemone
Finnerty, J. R., Pang, K., Burton, P., Paulson, D., & Martindale, M. Q. (2004) · Science · doi:10.1126/science.1091946 · Cited by 407 · see citing works
Evaluating hypotheses of basal animal phylogeny using complete sequences of large and small subunit rRNA
Medina, M., Collins, A. G., Silberman, J. D., & Sogin, M. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171316998 · Cited by 395 · see citing works
Dorsoventral Patterning in Hemichordates: Insights into Early Chordate Evolution
Lowe, C. J., Terasaki, M., Wu, M., Freeman, R. M., Runft, L., Kwan, K., Haigo, S., Aronowicz, J., Lander, E., Gruber, C., et al. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040291 · Cited by 385 · see citing works
Vertebrate Embryonic Cells Will Become Nerve Cells Unless Told Otherwise
Hemmati‐Brivanlou, A., & Melton, D. A. (1997) · Cell · doi:10.1016/s0092-8674(00)81853-x · Cited by 364 · see citing works
RNA-binding protein Musashi family: Roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation
Sakakibara, S., Nakamura, Y., Yoshida, T., Shibata, S., Koike, M., Takano, H., Ueda, S., Uchiyama, Y., Noda, T., & Okano, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232087499 · Cited by 355 · see citing works
Phylogeny of Medusozoa and the evolution of cnidarian life cycles
Collins, A. G. (2002) · Journal of Evolutionary Biology · doi:10.1046/j.1420-9101.2002.00403.x · Cited by 355 · see citing works
EST Analysis of the Cnidarian Acropora millepora Reveals Extensive Gene Loss and Rapid Sequence Divergence in the Model Invertebrates
Kortschak, R. D., Samuel, G., Saint, R., & Miller, D. J. (2003) · Current Biology · doi:10.1016/j.cub.2003.11.030 · Cited by 353 · see citing works
Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo
Streit, A., Lee, K. J., Woo, I., Roberts, C., Jessell, T. M., & Stern, C. D. (1998) · Development · doi:10.1242/dev.125.3.507 · Cited by 352 · see citing works
Musashi: a translational regulator of cell fate
Okano, H., Imai, T., & Okabe, M. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.7.1355 · Cited by 345 · see citing works
A Provisional Regulatory Gene Network for Specification of Endomesoderm in the Sea Urchin Embryo
Davidson, E. H., Rast, J. P., Oliveri, P., Ransick, A., Calestani, C., Yuh, C., Minokawa, T., Amore, G., Hinman, V. F., Arenas‐Mena, C., et al. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0635 · Cited by 338 · see citing works
Maintenance of ancestral complexity and non-metazoan genes in two basal cnidarians
Technau, U., Rudd, S., Maxwell, P., Gordon, P. M. K., Saina, M., Grasso, L. C., Hayward, D. C., Sensen, C. W., Saint, R., Holstein, T. W., et al. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.09.007 · Cited by 337 · see citing works
Self-citation
Mammalian achaete–scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system
Tomita, K., Moriyoshi, K., Nakanishi, S., Guillemot, F., & Kageyama, R. (2000) · EMBO Journal · doi:10.1093/emboj/19.20.5460 · Cited by 331 · see citing works
An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo
Wilson, S. I., Graziano, E., Harland, R. M., Jessell, T. M., & Edlund, H. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00431-0 · Cited by 325 · see citing works
Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors
Jarman, A. P., Sun, Y., Jan, L. Y., & Jan, Y. N. (1995) · Development · doi:10.1242/dev.121.7.2019 · Cited by 317 · see citing works
Neural Tissue in Ascidian Embryos Is Induced by FGF9/16/20, Acting via a Combination of Maternal GATA and Ets Transcription Factors
Bertrand, V., Hudson, C., Caillol, D. H., Popovici, C., & Lemaire, P. (2003) · Cell · doi:10.1016/s0092-8674(03)00928-0 · Cited by 301 · see citing works
Expression and regulation of an FMRFamide‐related neuropeptide gene family in Caenorhabditis elegans
Kim, K., & Li, C. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20189 · Cited by 294 · see citing works
Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition
Delaune, E. A., Lemaire, P., & Kodjabachian, L. (2004) · Development · doi:10.1242/dev.01582 · Cited by 290 · see citing works
Origin and diversification of the basic helix-loop-helix gene family in metazoans: insights from comparative genomics
Simionato, E., Ledent, V., Richards, G. S., Thomas‐Chollier, M., Kerner, P., Coornaert, D., Degnan, B. M., & Vervoort, M. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-33 · Cited by 286 · see citing works
The neuroendocrine system of invertebrates: a developmental and evolutionary perspective
Hartenstein, V. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06964 · Cited by 284 · see citing works
Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate
Broadus, J., Fuerstenberg, S., & Doe, C. Q. (1998) · Nature · doi:10.1038/35861 · Cited by 281 · see citing works
Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification
Rhinn, M., Dierich, A., Shawlot, W., Behringer, R. R., LeMeur, M., & Ang, S. (1998) · Development · doi:10.1242/dev.125.5.845 · Cited by 279 · see citing works
Advanced optics in a jellyfish eye
Nilsson, D., Gislén, L., Coates, M. M., Skogh, C., & Garm, A. L. (2005) · Nature · doi:10.1038/nature03484 · Cited by 271 · see citing works
FGFR-related gene nou-darake restricts brain tissues to the head region of planarians
Cebrià, F., Kobayashi, C., Umesono, Y., Nakazawa, M., Mineta, K., Ikeo, K., Gojobori, T., Itoh, M., Taira, M., Alvarado, A. S., et al. (2002) · Nature · doi:10.1038/nature01042 · Cited by 267 · see citing works
Axial patterning in cephalochordates and the evolution of the organizer
Yu, J., Satou, Y., Holland, N. D., Shin‐I, T., Kohara, Y., Satoh, N., Bronner-Fraser, M. E., & Holland, L. Z. (2007) · Nature · doi:10.1038/nature05472 · Cited by 256 · see citing works
Class-level relationships in the phylum Cnidaria: molecular and morphological evidence.
Bridge, D. M., Cunningham, C., DeSalle, R., & Buss, L. W. (1995) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040246 · Cited by 251 · see citing works
Early central nervous system evolution: an era of skin brains?
Holland, N. D. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1175 · Cited by 250 · see citing works
The cellular function of MASH1 in autonomic neurogenesis
Sommer, L., Shah, N. M., Rao, M. S., & Anderson, D. J. (1995) · Neuron · doi:10.1016/0896-6273(95)90005-5 · Cited by 243 · see citing works
Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome
Keene, J. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111145598 · Cited by 230 · see citing works
FMRFamide-related neuropeptide gene family in Caenorhabditis elegans
Li, C., Kim, K., & Nelson, L. S. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01972-1 · Cited by 228 · see citing works
Neural induction requires BMP inhibition only as a late step, and involves signals other than FGF and Wnt antagonists
Linker, C., & Stern, C. D. (2004) · Development · doi:10.1242/dev.01445 · Cited by 206 · see citing works
The evolution of nervous system centralization
Arendt, D., Denes, A. S., Jékely, G., & Tessmar-Raible, K. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2007.2242 · Cited by 206 · see citing works
A truncated FGF receptor blocks neural induction by endogenous Xenopus inducers
Launay, C., Fromentoux, V., Shi, D., & Boucaut, J. (1996) · Development · doi:10.1242/dev.122.3.869 · Cited by 200 · see citing works
Minimal ProtoHox cluster inferred from bilaterian and cnidarian Hox complements
Chourrout, D., Delsuc, F., Chourrout, P., Edvardsen, R. B., Rentzsch, F., Renfer, E., Jensen, M. F., Zhu, B., de Jong, P., Steele, R. E., et al. (2006) · Nature · doi:10.1038/nature04863 · Cited by 197 · see citing works
Neural Induction in Xenopus: Requirement for Ectodermal and Endomesodermal Signals via Chordin, Noggin, β-Catenin, and Cerberus
Kuroda, H., Wessely, O., & Robertis, E. M. D. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020092 · Cited by 195 · see citing works
c-otx2 is expressed in two different phases of gastrulation and is sensitive to retinoic acid treatment in chick embryo
Bally‐Cuif, L., Gulisano, M., Broccoli, V., & Boncinelli, E. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(94)00301-3 · Cited by 195 · see citing works
Proposal of a model of mammalian neural induction
Levine, A. J., & Brivanlou, A. H. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.05.036 · Cited by 195 · see citing works
CnNK-2,an NK-2 Homeobox Gene, Has a Role in Patterning the Basal End of the Axis in Hydra
Grens, A., Gee, L., Fisher, D. A., & Bode, H. R. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0321 · Cited by 192 · see citing works
Antisera to the sequence Arg-Phe-amide visualize neuronal centralization in hydroid polyps
Grimmelikhuijzen, C. J. P. (1985) · Cell and Tissue Research · doi:10.1007/bf00214639 · Cited by 189 · see citing works
Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs
Mineta, K., Nakazawa, M., Cebrià, F., Ikeo, K., Agata, K., & Gojobori, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332513100 · Cited by 189 · see citing works
Systematic isolation of peptide signal molecules regulating development in hydra: LWamide and PW families
Takahashi, T., Muneoka, Y., Lohmann, J. U., de Haro, M. S. L., Solleder, G., Bosch, T. C. G., David, C. N., Bode, H. R., Koizumi, O., Shimizu, H., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1241 · Cited by 186 · see citing works
Self-citation
The Wnt code: cnidarians signal the way
Guder, C., Philipp, I., Lengfeld, T., Watanabe, H., Hobmayer, B., & Holstein, T. W. (2006) · Oncogene · doi:10.1038/sj.onc.1210052 · Cited by 177 · see citing works
Self-citation
The apical sensory organ of a gastropod veliger is a receptor for settlement cues
Hadfield, M., Meleshkevitch, E., & Boudko, D. (2000) · The Biological Bulletin · doi:10.2307/1542804 · Cited by 176 · see citing works
An ancient Wnt-Dickkopf antagonism inHydra
Guder, C., Pinho, S., Nacak, T. G., Schmidt, H. A., Hobmayer, B., Niehrs, C., & Holstein, T. W. (2006) · Development · doi:10.1242/dev.02265 · Cited by 171 · see citing works
Self-citation
Neural Induction
Weinstein, D. C., & Hemmati‐Brivanlou, A. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.411 · Cited by 170 · see citing works
Asymmetric expression of the BMP antagonists chordin and gremlin in the sea anemone Nematostella vectensis: Implications for the evolution of axial patterning
Rentzsch, F., Anton, R., Saina, M., Hammerschmidt, M., Holstein, T. W., & Technau, U. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.06.003 · Cited by 169 · see citing works
Self-citation
Ultrastructural evidence for a granule-containing sensory-motor-interneuron in Hydra littoralis
Westfall, J. A. (1973) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(73)90055-5 · Cited by 169 · see citing works
FGF signalling controls formation of the apical sensory organ in the cnidarianNematostella vectensis
Rentzsch, F., Fritzenwanker, J. H., Scholz, C. B., & Technau, U. (2008) · Development · doi:10.1242/dev.020784 · Cited by 166 · see citing works
The BMP pathway is essential for re-specification and maintenance of the dorsoventral axis in regenerating and intact planarians
Molina, M. D., Saló, E., & Cebrià, F. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.08.019 · Cited by 163 · see citing works
Early posterior neural tissue is induced by FGF in the chick embryo
Storey, K. G., Goriely, A., Sargent, C. M., Brown, J. M., Burns, H. D., Abud, H. M., & Heath, J. K. (1998) · Development · doi:10.1242/dev.125.3.473 · Cited by 161 · see citing works
A cnidarian neuropeptide of the GLWamide family induces metamorphosis of reef-building corals in the genus Acropora
Iwao, K., Fujisawa, T., & Hatta, M. (2002) · Coral Reefs · doi:10.1007/s00338-002-0219-8 · Cited by 158 · see citing works
Self-citation
GENETIC CONTROL OF CELL FATE SPECIFICATION IN DROSOPHILA PERIPHERAL NERVOUS SYSTEM
Jan, Y. N., & Jan, L. Y. (1994) · Annual Review of Genetics · doi:10.1146/annurev.ge.28.120194.002105 · Cited by 157 · see citing works
RTK and TGF-β signaling pathways genes in the sea urchin genome
Lapraz, F., Röttinger, É., Duboc, V., Range, R., Duloquin, L., Walton, K. D., Wu, S.-Y., Bradham, C. A., Loza‐Coll, M., Hibino, T., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.048 · Cited by 153 · see citing works
Evolution of complex structures: minicollagens shape the cnidarian nematocyst
David, C. N., Özbek, S., Adamczyk, P., Meier, S., Pauly, B. S., Chapman, J., Hwang, J. S., Gojobori, T., & Holstein, T. W. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.07.001 · Cited by 152 · see citing works
Self-citation
Early embryonic expression ofFGF4/6/9gene and its role in the induction of mesenchyme and notochord inCiona savignyiembryos
Imai, K. S., Satoh, N., & Satou, Y. (2002) · Development · doi:10.1242/dev.129.7.1729 · Cited by 151 · see citing works
Doing the MATH: is the mouse a good model for fly development?Preprint
Hassan, B. A., & Bellen, H. J. (2000) · Genes & Development · doi:10.1101/gad.14.15.1852 · Cited by 148 · see citing works
FGF Signaling and the Anterior Neural Induction in Xenopus
Hongo, I., Kengaku, M., & Okamoto, H. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9515 · Cited by 147 · see citing works
Metamorphosin A: A Novel Peptide Controlling Development of the Lower Metazoan Hydractinia echinata (Coelenterata, Hydrozoa)
Leitz, T., Morand, K. L., & Mann, M. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1160 · Cited by 145 · see citing works
Evolutionary conservation of a cell fate specification gene: the Hydra achaete-scute homolog has proneural activity in Drosophila
Grens, A., Mason, E., Marsh, J. L., & Bode, H. R. (1995) · Development · doi:10.1242/dev.121.12.4027 · Cited by 143 · see citing works
A second sensory?motor?interneuron with neurosecretory granules inHydra
Westfall, J. A., & Kinnamon, J. C. (1978) · Journal of Neurocytology · doi:10.1007/bf01176999 · Cited by 140 · see citing works
Axis specification in the spider embryo:dppis required for radial-to-axial symmetry transformation andsogfor ventral patterning
Akiyama‐Oda, Y., & Oda, H. (2006) · Development · doi:10.1242/dev.02400 · Cited by 139 · see citing works
Enzymatic Characterization of the Morphogen Recognized by Agaricia humilis (Scleractinian Coral) Larvae
Morse, D. E., & Morse, A. N. C. (1991) · Biological Bulletin · doi:10.2307/1542493 · Cited by 138 · see citing works
Localized expression of a dpp / BMP2 / 4 ortholog in a coral embryo
Hayward, D. C., Samuel, G., Pontynen, P. C., Catmull, J., Saint, R., Miller, D. J., & Ball, E. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112021499 · Cited by 132 · see citing works
Development of serotonin-like immunoreactivity in the embryos and larvae of nudibranch mollusks with emphasis on the structure and possible function of the apical sensory organ
Kempf, S. C., Page, L. R., & Pires, A. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970929)386:3 · Cited by 130 · see citing works
The marine bacterium Alteromonas espejiana induces metamorphosis of the hydroid Hydractinia echinata
Leitz, T., & Wagner, T. (1993) · Marine Biology · doi:10.1007/bf00346332 · Cited by 130 · see citing works
Dorso/Ventral Genes Are Asymmetrically Expressed and Involved in Germ-Layer Demarcation during Cnidarian Gastrulation
Matus, D. Q., Thomsen, G. H., & Martindale, M. Q. (2006) · Current Biology · doi:10.1016/j.cub.2006.01.052 · Cited by 129 · see citing works
Expression of Cnox-2, a HOM/HOX homeobox gene in hydra, is correlated with axial pattern formation
Shenk, M. A., Bode, H. R., & Steele, R. E. (1993) · Development · doi:10.1242/dev.117.2.657 · Cited by 129 · see citing works
Central Neural Circuitry in the Jellyfish Aglantha
Mackie, G. O. (2004) · Neurosignals · doi:10.1159/000076155 · Cited by 128 · see citing works
FMRFamide immunoreactivity in the nervous system of the medusa Polyorchis penicillatus
Grimmelikhuijzen, C. J. P., & Spencer, A. N. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902300305 · Cited by 128 · see citing works
ULTRASTRUCTURAL EVIDENCE OF POLARIZED SYNAPSES IN THE NERVE NET OF HYDRA
Westfall, J. A., Yamataka, S., & Enos, P. D. (1971) · The Journal of Cell Biology · doi:10.1083/jcb.51.1.318 · Cited by 125 · see citing works
A simple plan-Cnidarians and the origins of developmental mechanisms
Ball, E. E., Hayward, D. C., Saint, R., & Miller, D. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1402 · Cited by 123 · see citing works
The BMP/CHORDIN Antagonism Controls Sensory Pigment Cell Specification and Differentiation in the Ascidian Embryo
Darras, S., & Nishida, H. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0339 · Cited by 121 · see citing works
Discovering neuropeptides in Caenorhabditis elegans by two dimensional liquid chromatography and mass spectrometry
Husson, S. J., Clynen, E., Baggerman, G., LOOF, A. D., & Schoofs, L. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.044 · Cited by 119 · see citing works
Threshold-Dependent BMP-Mediated Repression: A Model for a Conserved Mechanism That Patterns the Neuroectoderm
Mizutani, C. M., Meyer, N. P., Roelink, H., & Bier, E. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040313 · Cited by 119 · see citing works
Hemichordates and the origin of chordates
Gerhart, J. C., Lowe, C. J., & Kirschner, M. W. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.06.004 · Cited by 113 · see citing works
Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains
Kudoh, T., Concha, M. L., Houart, C., Dawid, I. B., & Wilson, S. W. (2004) · Development · doi:10.1242/dev.01227 · Cited by 112 · see citing works
Differential Functions of the C. elegans FGF Receptor in Axon Outgrowth and Maintenance of Axon Position
Bülow, H. E., Boulin, T., & Hobert, O. (2004) · Neuron · doi:10.1016/s0896-6273(04)00246-6 · Cited by 109 · see citing works
Signalling pathways in Drosophila and vertebrate retinal development
Kumar, J. P. (2001) · Nature Reviews Genetics · doi:10.1038/35098564 · Cited by 107 · see citing works
Fine structural studies of the nervous system and the apical organ in the planula larva of the sea anemone Anthopleura elegantissima
Chia, F., & Koss, R. (1979) · Journal of Morphology · doi:10.1002/jmor.1051600303 · Cited by 102 · see citing works
LWamides from Cnidaria constitute a novel family of neuropeptides with morphogenetic activity
Gajewski, M., Leitz, T., Schlo�herr, J., & Plickert, G. (1996) · Development Genes and Evolution · doi:10.1007/bf00365801 · Cited by 100 · see citing works
Neural induction: a bird's eye view
Streit, A., & Stern, C. D. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(98)01620-5 · Cited by 99 · see citing works
The radial‐symmetric hydra and the evolution of the bilateral body plan: an old body became a young brain
Meinhardt, H. (2002) · BioEssays · doi:10.1002/bies.10045 · Cited by 97 · see citing works
CnOtx, a Member of the Otx Gene Family, Has a Role in Cell Movement in Hydra
Smith, K. M., Gee, L., Blitz, I. L., & Bode, H. R. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9337 · Cited by 96 · see citing works
The role of GLWamides in metamorphosis of Hydractinia echinata
Schmich, J. X. F. R., Trepel, S., & Leitz, T. (1998) · Development Genes and Evolution · doi:10.1007/s004270050181 · Cited by 92 · see citing works
FGF signaling in gastrulation and neural development in Nematostella vectensis, an anthozoan cnidarian
Matus, D. Q., Thomsen, G. H., & Martindale, M. Q. (2007) · Development Genes and Evolution · doi:10.1007/s00427-006-0122-3 · Cited by 92 · see citing works
EXCITATORY ACTIONS OF Antho-RFamide, AN ANTHOZOAN NEUROPEPTIDE, ON MUSCLES AND CONDUCTING SYSTEMS IN THE SEA ANEMONE CALLIACTIS PARASITICA
McFARLANE, I. D., Graff, D., & Grimmelikhuijzen, C. J. P. (1987) · Journal of Experimental Biology · doi:10.1242/jeb.133.1.157 · Cited by 91 · see citing works
Structure and development of the apical organ in trochophores of Spirobranchus polycerus, Phyllodoce maculata and Phyllodoce mucosa (Polychaeta)
Lacalli, T. C. (1981) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1981.0045 · Cited by 88 · see citing works
Nerve ring of the hypostome in Hydra. I. Its structure, development, and maintenance
Koizumi, O., Itazawa, M., Mizumoto, H., Minobe, S., Javois, L. C., Grimmelikhuijzen, C. J. P., & Bode, H. R. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903260103 · Cited by 88 · see citing works
Swimming, feeding, circulation and vision in the Australian box jellyfish, Chironex fleckeri (Cnidaria:Cubozoa)
Hamner, W., Jones, M. R. L., & Hamner, P. (1995) · Marine and Freshwater Research · doi:10.1071/mf9950985 · Cited by 86 · see citing works
Ocelli of hydromedusae
Singla, C. L. (1974) · Cell and Tissue Research · doi:10.1007/bf00226774 · Cited by 85 · see citing works
Molecular genetic insights into deuterostome evolution from the direct-developing hemichordate Saccoglossus kowalevskii
Lowe, C. J. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2007.2247 · Cited by 85 · see citing works
Ultrastructural evidence for two‐cell and three‐cell neural pathways in the tentacle epidermis of the sea anemone Aiptasia pallida
Westfall, J. A., Elliott, C. F., & Carlin, R. W. (2002) · Journal of Morphology · doi:10.1002/jmor.1075 · Cited by 83 · see citing works
A Novel Neuropeptide, Hym-176, Induces Contraction of the Ectodermal Muscle in Hydra
Yum, S., Takahashi, T., Koizumi, O., Ariura, Y., Kobayakawa, Y., Mohri, S., & Fujisawa, T. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8831 · Cited by 82 · see citing works
Self-citation
Neural Induction in Whole Chick Embryo Cultures by FGF
Álvarez, I. S., de Araújo, M. C. P. M., & Nieto, M. A. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8903 · Cited by 82 · see citing works
A Bird's Eye View
Michelotti, N., de Silva, C., Johnson-Buck, A. E., Manzo, A. J., & Walter, N. G. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(10)75006-0 · Cited by 81 · see citing works
Developmental expression of the hemichordate otx ortholog
Harada, Y., Okai, N., Taguchi, S., Tagawa, K., Humphreys, T., & Satoh, N. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00279-8 · Cited by 81 · see citing works
The EGF and FGF Receptors Mediate Neuroglian Function to Control Growth Cone Decisions during Sensory Axon Guidance in Drosophila
García-Alonso, L., Romani, S., & Jiménez, F. (2000) · Neuron · doi:10.1016/s0896-6273(00)00150-1 · Cited by 79 · see citing works
Evolution and development of the vertebrate ear
Fritzsch, B., & Beisel, K. W. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00558-5 · Cited by 79 · see citing works
Rhopalia are integrated parts of the central nervous system in box jellyfish
Garm, A., Ekström, P., Boudes, M., & Nilsson, D.-E. (2006) · Cell and Tissue Research · doi:10.1007/s00441-005-0134-8 · Cited by 79 · see citing works
Bone morphogenetic protein is required for dorso‐ventral patterning in the planarian Dugesia japonica
Orii, H., & Watanabe, K. (2007) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2007.00931.x · Cited by 77 · see citing works
Retinal development in Drosophila: specifying the first neuron
Hsiung, F. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.10.1207 · Cited by 76 · see citing works
Three different prohormones yield a variety of Hydra-RFamide (Arg-Phe-NH2) neuropeptides in Hydra magnipapillata
Darmer, D., Hauser, F., Nothacker, H., Bosch, T. C. G., Williamson, M. P., & Grimmelikhuijzen, C. J. P. (1998) · Biochemical Journal · doi:10.1042/bj3320403 · Cited by 76 · see citing works
Planarian fibroblast growth factor receptor homologs expressed in stem cells and cephalic ganglions
Ogawa, K., Kobayashi, C., Hayashi, T., Orii, H., Watanabe, K., & Agata, K. (2002) · Development Growth & Differentiation · doi:10.1046/j.1440-169x.2002.00634.x · Cited by 75 · see citing works
Control of planula migration by LWamide and RFamide neuropeptides inHydractinia echinata
Katsukura, Y., Andō, H., David, C. N., Grimmelikhuijzen, C. J. P., & Sugiyama, T. (2004) · Journal of Experimental Biology · doi:10.1242/jeb.00974 · Cited by 75 · see citing works
Expression of the Head GeneLox22-Otxin the LeechHelobdellaand the Origin of the Bilaterian Body Plan
Bruce, A. E. E., & Shankland, M. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8968 · Cited by 73 · see citing works
Induction of metamorphosis with potassium ions requires development of competence and an anterior signalling centre in the ascidian Herdmania momus
Degnan, B. M., Souter, D., Degnan, B. M., & Long, S. (1997) · Development Genes and Evolution · doi:10.1007/s004270050066 · Cited by 73 · see citing works
Components of both major axial patterning systems of the Bilateria are differentially expressed along the primary axis of a ‘radiate’ animal, the anthozoan cnidarian Acropora millepora
de Jong, D. M., Hislop, N. R., Hayward, D. C., Reece-Hoyes, J. S., Pontynen, P. C., Ball, E. E., & Miller, D. J. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.07.034 · Cited by 71 · see citing works
Early development, pattern, and reorganization of the planula nervous system in Aurelia (Cnidaria, Scyphozoa)
Nakanishi, N., Yuan, D., Jacobs, D. K., & Hartenstein, V. (2008) · Development Genes and Evolution · doi:10.1007/s00427-008-0239-7 · Cited by 71 · see citing works
Observations on the anatomy, behaviour, reproduction and life cycle of the cubozoan Carybdea sivickisi
Hartwick, R. F. (1991) · Hydrobiologia · doi:10.1007/bf00026459 · Cited by 71 · see citing works
Math6, a bHLH gene expressed in the developing nervous system, regulates neuronal versus glial differentiation
Inoue, C., Bae, S., Takatsuka, K., Inoue, T., Bessho, Y., & Kageyama, R. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00476.x · Cited by 70 · see citing works
Evolutionary aspects of developmentally regulated helix-loop-helix transcription factors in striated muscle of jellyfish
Müller, P., Seipel, K., Yanze, N., Reber-Müller, S., Streitwolf-Engel, R., Stierwald, M., Spring, J. Ü., & Schmid, V. (2003) · Developmental Biology · doi:10.1016/s0012-1606(02)00091-x · Cited by 69 · see citing works
EFFECTS OF THREE ANTHOZOAN NEUROPEPTIDES, ANTHO-RWamide I, ANTHO-RWamide II and ANTHO-RFamide, ON SLOW MUSCLES FROM SEA ANEMONES
McFARLANE, I. D., Anderson, P. A. V., & Grimmelikhuijzen, C. J. P. (1991) · Journal of Experimental Biology · doi:10.1242/jeb.156.1.419 · Cited by 69 · see citing works
Larval development in Cnidaria: A connection to bilateria?
Gröger, H., & Schmid, V. J. (2001) · genesis · doi:10.1002/gene.1013 · Cited by 69 · see citing works
Anti-Neural-Inhibition: A Conserved Mechanism for Neural Induction
Bier, E. (1997) · Cell · doi:10.1016/s0092-8674(00)80250-0 · Cited by 68 · see citing works
The ring nerve of the box jellyfish Tripedalia cystophora
Garm, A. L., Poussart, Y., Parkefelt, L., Ekström, P., & Nilsson, D.-E. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0393-7 · Cited by 67 · see citing works
Ultrastructural localization of RFamide‐like peptides in neuronal dense‐cored vesicles in the peduncle of Hydra
Koizumi, O., Wilson, J. D., Grimmelikhuijzen, C. J. P., & Westfall, J. A. (1989) · Journal of Experimental Zoology · doi:10.1002/jez.1402490105 · Cited by 67 · see citing works
Hyzic, theHydrahomolog of thezic/odd-pairedgene, is involved in the early specification of the sensory nematocytes
Lindgens, D., Holstein, T. W., & Technau, U. (2003) · Development · doi:10.1242/dev.00903 · Cited by 66 · see citing works
Self-citation
Expression and function of a starfish Otx ortholog, AmOtx: a conserved role for Otx proteins in endoderm development that predates divergence of the eleutherozoa
Hinman, V. F., Nguyen, A. T., & Davidson, E. H. (2003) · Mechanisms of Development · doi:10.1016/j.mod.2003.08.002 · Cited by 65 · see citing works
Distribution of Nerve Elements Showing FMRFamide‐like Immunoreactivity in Hydromedusae
Mackie, G. O., Singla, C. L., & Stell, W. K. (1985) · Acta Zoologica · doi:10.1111/j.1463-6395.1985.tb00840.x · Cited by 64 · see citing works
Inhibition of metamorphosis by RFamide neuropeptides in planula larvae of Hydractinia echinata
Katsukura, Y., David, C. N., Grimmelikhuijzen, C. J. P., & Sugiyama, T. (2003) · Development Genes and Evolution · doi:10.1007/s00427-003-0361-5 · Cited by 64 · see citing works
Observations on the anatomy, behaviour, reproduction and life cycle of the cubozoan Carybdea sivickisi
Hartwick, R. F. (1991) · Springer eBooks · doi:10.1007/978-94-011-3240-4_24 · Cited by 64 · see citing works
Metamorphosin A is a neuropeptide
Leitz, T., & Lay, M. (1995) · Development Genes and Evolution · doi:10.1007/bf00208495 · Cited by 63 · see citing works
Hydra Peptide Project 1993–2007
Fujisawa, T. (2008) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2008.00997.x · Cited by 63 · see citing works
Self-citation
Developmental and evolutionary aspects of the basic helix–loop–helix transcription factors Atonal-like 1 and Achaete-scute homolog 2 in the jellyfish
Seipel, K., Yanze, N., & Schmid, V. J. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.01.035 · Cited by 62 · see citing works
Isolation of Four Novel Neuropeptides, the Hydra-RFamides I–IV, fromHydra magnipapillata
Moosler, A., Rinehart, K. L., & Grimmelikhuijzen, C. J. P. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1849 · Cited by 61 · see citing works
Types of neurons and synaptic connections at hypostome‐tentacle junctions in Hydra
Kinnamon, J. C., & Westfall, J. A. (1982) · Journal of Morphology · doi:10.1002/jmor.1051730110 · Cited by 60 · see citing works
Isolation of <Glu-Leu-Leu-Gly-Gly-Arg-Phe-NH2 (Pol-RFamide), a novel neuropeptide from hydromedusae
Grimmelikhuijzen, C. J. P., Hahn, M., Rinehart, K. L., & Spencer, A. N. (1988) · Brain Research · doi:10.1016/0006-8993(88)90219-3 · Cited by 60 · see citing works
Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition
Rentzsch, F., Bakkers, J., Kramer, C., & Hammerschmidt, M. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20244 · Cited by 60 · see citing works
Signalling by the FGFR-like tyrosine kinase, Kringelchen, is essential for bud detachment inHydra vulgaris
Sudhop, S., Coulier, F., Bieller, A., Vogt, A., Hotz, T., & Hassel, M. (2004) · Development · doi:10.1242/dev.01267 · Cited by 59 · see citing works
Nerve Ring of the Hypostome in Hydra: Is It an Origin of the Central Nervous System of Bilaterian Animals?
Koizumi, O. (2007) · Brain Behavior and Evolution · doi:10.1159/000095204 · Cited by 58 · see citing works
Genomic organization, gene structure, and developmental expression of three Clustered otx genes in the sea anemone Nematostella vectensis
Mazza, M. E., Pang, K., Martindale, M. Q., & Finnerty, J. R. (2007) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21158 · Cited by 57 · see citing works
Identification of a new member of the GLWamide peptide family: physiological activity and cellular localization in cnidarian polyps
Takahashi, T., Kobayakawa, Y., Muneoka, Y., Fujisawa, Y., Mohri, S., Hatta, M., Shimizu, H., Fujisawa, T., Sugiyama, T., Takahara, M., et al. (2003) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(03)00088-5 · Cited by 56 · see citing works
Self-citation
The structure and expression of a preprohormone of a neuropeptide, Hym‐176 in Hydra magnipapillata
Yum, S., Takahashi, T., Hatta, M., & Fujisawa, T. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01314-3 · Cited by 54 · see citing works
Self-citation
Evolutionary Convergence in Nervous Systems: Insights from Comparative Phylogenetic Studies
Nishikawa, K. C. (2002) · Brain Behavior and Evolution · doi:10.1159/000063561 · Cited by 54 · see citing works
Expression and Developmental Regulation of the Hydra-RFamide and Hydra-LWamide Preprohormone Genes inHydra:Evidence for Transient Phases of Head Formation
Mitgutsch, C., Hauser, F., & Grimmelikhuijzen, C. J. P. (1999) · Developmental Biology · doi:10.1006/dbio.1998.9150 · Cited by 53 · see citing works
Involvement of Hydra achaete–scute gene CnASH in the differentiation pathway of sensory neurons in the tentacles
Hayakawa, E., Fujisawa, C., & Fujisawa, T. (2004) · Development Genes and Evolution · doi:10.1007/s00427-004-0430-4 · Cited by 53 · see citing works
Self-citation
Observations on the anatomy and behaviour of the cubozoanCarybdea rastoniihaacke
Matsumoto, G. I. (1995) · Marine and Freshwater Behaviour and Physiology · doi:10.1080/10236249509378935 · Cited by 52 · see citing works
Chapter 18 Transdifferentiation Occurs Continuously in Adult Hydra
Bode, H. R., Dunne, J. F., Heimfeld, S., Huang, L. W., Javois, L. C., Koizumi, O., Westerfield, J., & Yaross, M. S. (1986) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)60668-7 · Cited by 51 · see citing works
Proportion-altering factor (PAF) stimulates nerve cell formation in Hydractinia echinata
Plickert, G. (1989) · Cell Differentiation and Development · doi:10.1016/0922-3371(89)90780-6 · Cited by 49 · see citing works
Requirement of SpOtx in Cell Fate Decisions in the Sea Urchin Embryo and Possible Role as a Mediator of β-Catenin Signaling
Li, X., Wikramanayake, A. H., & Klein, W. H. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9360 · Cited by 48 · see citing works
Peduncle of Hydra and the heart of higher organisms share a common ancestral origin
Shimizu, H., & Fujisawa, T. (2003) · genesis · doi:10.1002/gene.10213 · Cited by 47 · see citing works
Self-citation
Central Circuitry in the Jellyfish Aglantha Digitale: I. The Relay System
Mackie, G. O., & Meech, R. W. (1995) · Journal of Experimental Biology · doi:10.1242/jeb.198.11.2261 · Cited by 46 · see citing works
Evidence for a Common Pattern of Peptidergic Innervation of Cnidocytes
Anderson, P. A. V., Thompson, L. F., & Moneypenny, C. G. (2004) · Biological Bulletin · doi:10.2307/1543588 · Cited by 45 · see citing works
Neuroglian and FasciclinII can promote neurite outgrowth via the FGF receptor Heartless
Forni, J. J., Romani, S., Doherty, P., & Tear, G. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.02.003 · Cited by 44 · see citing works
Perioral synaptic connections and their possible role in the feeding behavior of Hydra
Westfall, J. A., & Kinnamon, J. C. (1984) · Tissue and Cell · doi:10.1016/0040-8166(84)90055-7 · Cited by 44 · see citing works
Antho-RFamide Immunoreactivity in Neuronal Synaptic and Nonsynaptic Vesicles of Sea Anemones
Westfall, J. A., & Grimmelikhuijzen, C. J. P. (1993) · Biological Bulletin · doi:10.2307/1542134 · Cited by 43 · see citing works
Central Circuitry in the Jellyfish Aglantha Digitale: II. The Ring Giant and Carrier Systems
Mackie, G. O., & Meech, R. W. (1995) · Journal of Experimental Biology · doi:10.1242/jeb.198.11.2271 · Cited by 43 · see citing works
Central Circuitry in the Jellyfish Aglantha Digitale: III. the Rootlet and Pacemaker Systems
Mackie, G. O., & Meech, R. W. (2000) · Journal of Experimental Biology · doi:10.1242/jeb.203.12.1797 · Cited by 42 · see citing works
Maintenance and Regeneration of the Nerve Net in Hydra
Bode, H. R., Heimfeld, S., Koizumi, O., LlTTLEFIELD, C. L., & Yaross, M. S. (1988) · American Zoologist · doi:10.1093/icb/28.4.1053 · Cited by 40 · see citing works
Ultrastructure of Invertebrate Synapses
Westfall, J. A. (1987) · Springer eBooks · doi:10.1007/978-1-4613-1955-9_2 · Cited by 39 · see citing works
The anatomy of the nervous system of the hydrozoan jellyfish, Polyorchis penicillatus, as revealed by a monoclonal antibody
Lin, Y.-C., Gallin, W. J., & Spencer, A. N. (2001) · Invertebrate Neuroscience · doi:10.1007/s101580100008 · Cited by 39 · see citing works
Neuropeptides in coelenterates: a review
Grimmelikhuijzen, C. J. P., Graff, D., Koizumi, O., Westfall, J. A., & McFarlane, I. D. (1991) · Hydrobiologia · doi:10.1007/bf00026513 · Cited by 38 · see citing works
Chemical anatomy of hydra nervous system using antibodies against hydra neuropeptides: a review
Koizumi, O., Sato, N., & Goto, C. (2007) · Springer eBooks · doi:10.1007/978-1-4020-2762-8_5 · Cited by 37 · see citing works
Characterization of a RFamide-positive subset of ganglionic cells in the hydrozoan planular nerve net
Martin, V. J. (1992) · Cell and Tissue Research · doi:10.1007/bf00353898 · Cited by 35 · see citing works
BEHAVIORAL AND ELECTROPHYSIOLOGICAL STUDIES OF HYDRA. III. COMPONENTS OF FEEDING BEHAVIOR
Rushforth, N. B., & HOFMAN, F. (1972) · Biological Bulletin · doi:10.2307/1540250 · Cited by 34 · see citing works
Ultrastructural Localization of Antho-RWamides I and II at Neuromuscular Synapses in the Gastrodermis and Oral Sphincter Muscle of the Sea Anemone Calliactis parasitica
Westfall, J. A., Sayyar, K. L., Elliott, C. F., & Grimmelikhuijzen, C. J. P. (1995) · Biological Bulletin · doi:10.2307/1542145 · Cited by 33 · see citing works
Chemical anatomy of hydra nervous system using antibodies against hydra neuropeptides: a review
Koizumi, O., Sato, N., & Goto, C. (2004) · Hydrobiologia · doi:10.1007/s10750-004-2636-x · Cited by 32 · see citing works
Immunohistochemical studies of GLWamides in Cnidaria
Schmich, J., Rudolf, R., Trepel, S., & Leitz, T. (1998) · Cell and Tissue Research · doi:10.1007/s004410051167 · Cited by 31 · cited 5× · see citing works
“LWamide-positive cell bodies are also located at the base of tentacles and in Hydractinia polyps LWamide-positive processes can form dense longitudinal bundles (Schmich et al. 1998a).”
BackgroundInfluential
Neuropeptides and photic behavior in Cnidaria
Plickert, G., & Schneider, B. (2004) · Hydrobiologia · doi:10.1007/s10750-004-2689-x · Cited by 30 · see citing works
Neuropeptides and photic behavior in Cnidaria
Plickert, G., & Schneider, B. (2007) · Springer eBooks · doi:10.1007/978-1-4020-2762-8_6 · Cited by 29 · see citing works
Fine structure studies of the ocelli of Polyorchis penicillatus (Hydrozoa, Anthomedusae) and their connection with the nerve ring
Singla, C. L., & Weber, C. (1982) · Zoomorphology · doi:10.1007/bf00310304 · Cited by 28 · see citing works
A change in response to Bmp signalling precedes ectodermal fate choice
Dee, C. T., Gibson, A., Rengifo, A., Sun, S.-K., Patient, R. K., & Scotting, P. J. (2006) · The International Journal of Developmental Biology · doi:10.1387/ijdb.062204cd · Cited by 24 · see citing works
Neuropeptides in coelenterates: a review
Grimmelikhuijzen, C. J. P., Graff, D., Koizumi, O., Westfall, J. A., & McFarlane, I. D. (1991) · Springer eBooks · doi:10.1007/978-94-011-3240-4_78 · Cited by 23 · see citing works
Function of the Apical Sensory Organ in the Development of Invertebrates
Voronezhskaya, E. E., & Khabarova, M. Y. (2003) · Doklady Biological Sciences · doi:10.1023/a:1024453416281 · Cited by 21 · see citing works
Development of Nerve Cells in Hydrozoan Planulae: II. Examination of Sensory Cell Differentiation Using Electron Microscopy and Immunocytochemistry
Martin, V. J. (1988) · Biological Bulletin · doi:10.2307/1541894 · Cited by 21 · see citing works
Posttranscriptional Generation of Macromolecular Complexes
Keene, J. D. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00496-9 · Cited by 20 · see citing works
Fine structure of ocelli of an anthomedusan, Nemopsis dofleini, with special reference to synaptic organization
Yamamoto, M., & Yoshida, M. (1980) · Zoomorphology · doi:10.1007/bf00310283 · Cited by 18 · see citing works
The nervous system in the hypostome of Pelmatohydra robusta: The presence of a circumhypostomal nerve ring in the epidermis
Matsuno, T., & Kageyama, T. (1984) · Journal of Morphology · doi:10.1002/jmor.1051820204 · Cited by 18 · see citing works
Implications of cnidarian gene expression patterns for the origins of bilaterality is the glass half full or half empty?
Ball, E. E., de Jong, D. M., Schierwater, B., Shinzato, C., Hayward, D. C., & Miller, D. J. (2007) · Integrative and Comparative Biology · doi:10.1093/icb/icm028 · Cited by 18 · see citing works
Feeding and wounding responses in Hydra suggest functional and structural polarization of the tentacle nervous system
Shimizu, H. (2002) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(01)00516-5 · Cited by 12 · see citing works
The Relay system
Abramson, B. N., Littenberg, W., Skinner, M. R., & Thomas, C. M. (1965) · NASA Technical Reports Server (NASA) · Cited by 9 · see citing works
Immunocytochemically Defined Populations of Neurons Progressively Increase in Size Through Embryogenesis ofHydra vulgaris
Brumwell, G. B., & Martin, V. J. (2002) · Biological Bulletin · doi:10.2307/1543459 · Cited by 5 · see citing works
EGF（epidermal growth factor）
剛, 渡. (2002) · 外科 · Cited by 5 · see citing works

Flagged first, then by citations

Research works printed but not linked: 4

1440169x, 2009, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/j.1440-169X.2009.01103.x, Wiley Online Library on [19/02/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License 2009 The Authors Journal compilation © 2009 Japanese Society of Developmental Biologists
1440169x, 2009, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/j.1440-169X.2009.01103.x, Wiley Online Library on [19/02/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License 2009 The Authors Journal compilation © 2009 Japanese Society of Developmental Biologists
1440169x, 2009, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/j.1440-169X.2009.01103.x, Wiley Online Library on [19/02/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License 2009 The Authors Journal compilation © 2009 Japanese Society of Developmental Biologists
1440169x, 2009, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/j.1440-169X.2009.01103.x, Wiley Online Library on [19/02/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

Sorted by citations

Invertebrate neurophylogeny: suggested terms and definitions for a neuroanatomical glossary
Richter, S., Loesel, R., Purschke, G., Schmidt‐Rhaesa, A., Scholtz, G., Stach, T., Vogt, L., Wanninger, A., Brenneis, G., Döring, C., et al. (2010) · Frontiers in Zoology · doi:10.1186/1742-9994-7-29 · Cited by 334 · see citing works
“The nervous system of Cnidaria and Ctenophora is typically organized as a plexus which functions as a nerve net [18,190,220,276,277].”
Background
From nerve net to nerve ring, nerve cord and brain — evolution of the nervous system
Arendt, D., Tosches, M. A., & Marlow, H. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.15 · Cited by 279 · see citing works
The Jellyfish Cassiopea Exhibits a Sleep-like State
Nath, R. D., Bedbrook, C. N., Abrams, M. J., Basinger, T., Bois, J. S., Prober, D. A., Sternberg, P. W., Gradinaru, V., & Goentoro, L. (2017) · Current Biology · doi:10.1016/j.cub.2017.08.014 · Cited by 260 · see citing works
Unraveling the evolutionary determinants of sleep
Joiner, W. J. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.068 · Cited by 232 · see citing works
RETRACTED: Chemically mediated behavior of recruiting corals and fishes: A tipping point that may limit reef recovery
Dixson, D. L., Abrego, D., & Hay, M. E. (2014) · Science · doi:10.1126/science.1255057 · Cited by 216 · see citing works
Retracted
Tryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor
Wei, G. Z., Martin, K. A., Xing, P. Y., Agrawal, R., Whiley, L., Wood, T. K., Hejndorf, S., Ng, Y. Z., Low, J. Z. Y., Rossant, J., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021091118 · Cited by 214 · see citing works
“That is, nerve cells appeared before the mesoderm layer, which, among many different cell types, control blood cells and adaptive immunity (1).”
Background
Nervous systems of the sea anemone Nematostella vectensis are generated by ectoderm and endoderm and shaped by distinct mechanisms
Nakanishi, N., Renfer, E., Technau, U., & Rentzsch, F. (2012) · Development · doi:10.1242/dev.071902 · Cited by 188 · see citing works
“Interstitial cells can give rise to neurons, cnidocytes (stinging cells), gland cells and, in some species, also epithelial cells (Bosch et al., 2010; Bosch and David, 1987; David and Murphy, 1977; Muller et al., 2004; Watanabe et al., 2009).”
Background
What nervous systems do: early evolution, input–output, and the skin brain thesis
Keijzer, F., van Duijn, M., & Lyon, P. (2013) · Adaptive Behavior · doi:10.1177/1059712312465330 · Cited by 173 · see citing works
The Bilaterian Head Patterning Gene six3/6 Controls Aboral Domain Development in a Cnidarian
Sinigaglia, C., Busengdal, H., Leclère, L., Technau, U., & Rentzsch, F. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001488 · Cited by 169 · see citing works
“In contrast, despite regional differences in neuron density, neither Nematostella nor other cnidarian planulae or polyps display a comparable brain-like centralization of the nervous system at the oral or aboral end [83,85,101,102].”
Background
The neuropeptide complement of the marine annelid Platynereis dumerilii
Conzelmann, M., Williams, E. A., Krug, K., Franz-Wachtel, M., Macek, B., & Jékely, G. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-906 · Cited by 165 · see citing works
“Neuropeptides represent by far the largest group of neurotransmitters and neuromodulators [1] and are considered the oldest neuronal signaling molecules in metazoans [2].”
Background
The rise of the starlet sea anemone Nematostella vectensis as a model system to investigate development and regeneration
Layden, M. J., Rentzsch, F., & Röttinger, É. (2016) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.222 · Cited by 148 · see citing works
“Most agree that the nervous systems of bilaterians (the central and peripheral nervous systems) are derived from a nerve net-like ancestral nervous system.(98,99) Thus, better understanding development of nerve nets in Nematostella and other cnidarians will inform us about the structure and molecular make up of the an…”
Background
Evolution of sodium channels predates the origin of nervous systems in animals
Liebeskind, B. J., Hillis, D. M., & Zakon, H. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106363108 · Cited by 149 · see citing works
“Some medusozoans have concentrated nerve clusters and complex sense organs, which likely emerged convergently with the bilaterian central nervous system, as such nerve concentration is absent in anthozoans (34).”
Background
Chemical transmission in the sea anemone Nematostella vectensis: a genomic perspective
Anctil, M. (2009) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2009.07.001 · Cited by 139 · see citing works
“A blast search apparently yielded Hydra genes for muscarinic receptors (Watanabe et al., 2009), but none is identified and there is no evidence that the gene sequences were subjected to scrutiny for functional domains.”
Background
Neuropeptides regulate swimming depth of Platynereis larvae
Conzelmann, M., Offenburger, S.-L., Asadulina, A., Keller, T., Münch, T. A., & Jékely, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109085108 · Cited by 136 · see citing works
“Neuropeptides are considered the oldest neuronal signaling molecules in animals (26).”
Background
Interoception and the origin of feelings: A new synthesis
Carvalho, G. B., & Damasio, A. (2021) · BioEssays · doi:10.1002/bies.202000261 · Cited by 132 · see citing works
Transgenic analysis of a SoxB gene reveals neural progenitor cells in the cnidarian Nematostella vectensis
Richards, G. S., & Rentzsch, F. (2014) · Development · doi:10.1242/dev.112029 · Cited by 110 · see citing works
“At the molecular level, Nematostella possesses many genes related to conserved bilaterian neural genes (Putnam et al., 2007; Watanabe et al., 2009), and subsets of its nervous system have been examined using antibodies against conserved neuropeptide precursor molecules [e.”
Background
The first brain: Species comparisons and evolutionary implications for the enteric and central nervous systems
Furness, J. B., & Stebbing, M. J. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13234 · Cited by 128 · see citing works
Neuropeptidergic integration of behavior in Trichoplax adhaerens, an animal without synapses
Senatore, A., Reese, T. S., & Smith, C. L. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.162396 · Cited by 113 · see citing works
“Many sensory neurosecretory cells in cnidarians and bilaterians are peptidergic (Spencer, 1989; Scharrer, 1990; Cazzamali and Grimmelikhuijzen, 2002; Grimmelikhuijzen et al., 2002; Plickert and Schneider, 2004; Kass-Simon and Pierobon, 2007; Watanabe et al., 2009; Conzelmann et al., 2011; Grimmelikhuijzen and Hauser,…”
Background
Gastric pouches and the mucociliary sole: setting the stage for nervous system evolution
Arendt, D., Benito-Gutierrez, E., Brunet, T., & Marlow, H. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0286 · Cited by 112 · see citing works
New insights on ctenophore neural anatomy: Immunofluorescence study in Pleurobrachia pileus (Müller, 1776)
Jager, M., Chiori, R., Alié, A., Dayraud, C., Quéinnec, E., & Manuel, M. (2011) · Journal of Experimental Zoology Part B: Molecular and Developmental Evolution · doi:10.1002/jez.b.21386 · Cited by 107 · see citing works
“& 2010 WILEY-LISS, INC. several homologues of bilaterian neural genes in cnidarian neuro-sensory cells (reviews in Galliot et al., 2009; Watanabe et al., 2009).”
Background
Do jellyfish have central nervous systems?
Satterlie, R. A. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.043687 · Cited by 113 · see citing works
“In comparison to neurons of bilateral animals, they contain close to a complete set of signaling molecules that are involved in nervous system development, maintenance and communication (see Watanabe et al., 2009).”
Background
The chemical brain hypothesis for the origin of nervous systems
Jékely, G. (2021) · Philosophical Transactions of the Royal Society B · doi:10.1098/rstb.2019.0761 · Cited by 108 · see citing works
Nematostella vectensis achaete-scutehomologNvashAregulates embryonic ectodermal neurogenesis and represents an ancient component of the metazoan neural specification pathway
Layden, M. J., Boekhout, M., & Martindale, M. Q. (2012) · Development · doi:10.1242/dev.073221 · Cited by 98 · see citing works
“Additionally, FGF signaling and the closely related epidermal growth factor (EGF) signaling provide crucial instructive cues during bilaterian central nervous system development (Stern, 2005; Watanabe et al., 2009).”
Background
Ancestral state reconstruction of ontogeny supports a bilaterian affinity for Dickinsonia
Gold, D. A., Runnegar, B., Gehling, J. G., & Jacobs, D. K. (2015) · Evolution & Development · doi:10.1111/ede.12168 · Cited by 99 · see citing works
The cellular and molecular basis of cnidarian neurogenesis
Rentzsch, F., Layden, M. J., & Manuel, M. (2016) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.257 · Cited by 95 · see citing works
“Molecularly, genes encoding for several of the major receptor-ligand pairs involved in bilaterian neurite guidance (Semaphorin and Plexin, Ephrin and Eph, Wnt and Ryk, Netrin and Neogenin/DCC, Unc5, RGM) are present in the Nematostella genome.(48) Interestingly, Netrin and RGM are expressed in different subdomains in…”
Background
Immortality and the base of multicellular life: Lessons from cnidarian stem cells
Watanabe, H., Hoang, V. T., Mättner, R. A., & Holstein, T. W. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.09.008 · Cited by 95 · see citing works
“The importance of cnidarians as a model for understanding the evolutionary origin of the nervous system in metazoan evolution has been recently revised elsewhere [9,68,69]).”
BackgroundSelf-citation
Evolution of eumetazoan nervous systems: insights from cnidarians
Kelava, I., Rentzsch, F., & Technau, U. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0065 · Cited by 84 · see citing works
Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis
Watanabe, H., Kuhn, A., Fushiki, M., Agata, K., Özbek, S., Fujisawa, T., & Holstein, T. W. (2014) · Nature Communications · doi:10.1038/ncomms6536 · Cited by 79 · see citing works
Self-citation
The role of G protein-coupled receptors in the early evolution of neurotransmission and the nervous system
Krishnan, A., & Schiöth, H. B. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.110312 · Cited by 81 · see citing works
“…glutamate, γaminobutyric acid (GABA), glycine, epinephrine, norepinephrine, Th e Jo ur na l o f E xp er im en ta l B io lo gy dopamine and serotonin transmitters, as well as neuropeptides, are involved in cnidarian neurotransmission (Kass-Simon and Pierobon, 2007; Watanabe et al., 2009) (Fig.”
BackgroundInfluential
Regulation of Nematostella neural progenitors by SoxB, Notch and bHLH genes
Richards, G. S., & Rentzsch, F. (2015) · Development · doi:10.1242/dev.123745 · Cited by 80 · see citing works
“Indeed, genomic comparisons have shown that cnidarians possess many orthologues to key bilaterian neural-related genes (Chapman et al., 2010; Galliot et al., 2009; Putnam et al., 2007; Watanabe et al., 2009), but a functional characterisation of the majority of these candidates is lacking.”
Origin and Evolution of the Neuroendocrine Control of Reproduction in Vertebrates, With Special Focus on Genome and Gene Duplications
Dufour, S., Quérat, B., Tostivint, H., Pasqualini, C., Vaudry, H., & Rousseau, K. (2019) · Physiological Reviews · doi:10.1152/physrev.00009.2019 · Cited by 85 · see citing works
Moving and sensing without input and output: early nervous systems and the origins of the animal sensorimotor organization
Keijzer, F. (2015) · Biology & Philosophy · doi:10.1007/s10539-015-9483-1 · Cited by 78 · see citing works
“Keywords Early nervous systems Skin brain thesis Sensorimotor organization Embodiment Input–output view Coordination view F. Keijzer (&) Department of Theoretical Philosophy, University of Groningen, Oude Boteringestraat 52, 9712 GL Groningen, The Netherlands e-mail: f.a.keijzer@rug.nl”
Background
NvPOU4/Brain3 Functions as a Terminal Selector Gene in the Nervous System of the Cnidarian Nematostella vectensis
Tournière, O., Dolan, D., Richards, G. S., Sunagar, K., Columbus-Shenkar, Y. Y., Moran, Y., & Rentzsch, F. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.031 · Cited by 74 · see citing works
Evolution of the bilaterian mouth and anus
Nielsen, C., Brunet, T., & Arendt, D. (2018) · Nature Ecology & Evolution · doi:10.1038/s41559-018-0641-0 · Cited by 70 · see citing works
Convergent Evolution of Sodium Ion Selectivity in Metazoan Neuronal Signaling
Gur Barzilai, M., Reitzel, A. M., Kraus, J. E. M., Gordon, D., Technau, U., Gurevitz, M., & Moran, Y. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.06.016 · Cited by 76 · see citing works
Convergence of ion channel genome content in early animal evolution
Liebeskind, B. J., Hillis, D. M., & Zakon, H. H. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501195112 · Cited by 76 · see citing works
BMP and Delta/Notch signaling control the development of amphioxus epidermal sensory neurons: insights into the evolution of the peripheral sensory system
Lu, T.-M., Luo, Y., & Yu, J. (2012) · Development · doi:10.1242/dev.073833 · Cited by 75 · see citing works
“Although cnidarians typically have a diffuse nerve net, some regionalization patterns of neurons and their neurites have been identified in several types of cnidarians (Galliot et al., 2009; Watanabe et al., 2009).”
Background
Elementary nervous systems
Arendt, D. (2021) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2020.0347 · Cited by 72 · see citing works
The genome of the giant Nomura’s jellyfish sheds light on the early evolution of active predation
Kim, H., Weber, J. A., Lee, N., Park, S. G., Cho, Y. S., Bhak, Y., Lee, N., Jeon, Y., Jeon, S., Luria, V. A., et al. (2019) · BMC Biology · doi:10.1186/s12915-019-0643-7 · Cited by 63 · see citing works
“3b; Additional file 5: Tables S34–S37); consistent with the anatomy of jellyfish tentacles, which contain the sensory cells and a loose plexus of the neuronal subpopulation at the base of the ectoderm [21].”
Background
Differential sensitivity of coral larvae to natural levels of ultraviolet radiation during the onset of larval competence
Aranda, M., Banaszak, A. T., Bayer, T., Luyten, J. R., Medina, M., & Voolstra, C. R. (2011) · Molecular Ecology · doi:10.1111/j.1365-294x.2011.05153.x · Cited by 62 · see citing works
“Compromised neurogenesis could consequently impair larval behaviour such as locomotion and settlement (Katsukura et al. 2004; Plickert & Schneider 2004; Watanabe et al. 2009), resulting in reduced motility and decreased settlement rates at later stages.”
Background
Molecular characterization of larval development from fertilization to metamorphosis in a reef-building coral
Strader, M. E., Aglyamova, G. V., & Matz, M. V. (2018) · BMC Genomics · doi:10.1186/s12864-017-4392-0 · Cited by 61 · see citing works
“Although a role of FGF signaling in sensory cell development has not been fully substantiated in cnidarians [103], it is possible that the role of FGF signaling in anthozoans without an apical organ is the development of other sensory cells that are critical in detection of environmental stimulus prior to settlement.”
Complex neural architecture in the diploblastic larva of Clava multicornis (Hydrozoa, Cnidaria)
Piraino, S., Zega, G., Di Benedetto, C., Leone, A., Dell'Anna, A., Pennati, R., Candia Carnevali, D., Schmid, V., & Reichert, H. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22614 · Cited by 56 · see citing works
“…are thought to represent important internal signals for the coordination of the metamorphic process in cnidarians (Schwoerer-Böhning et al., 1990; Leitz, 1993; Schmich et al., 1998a,b; Plickert et al., 2003) as well as for the synaptic transmission of neuronal activity (Watanabe et al., 2009).”
BackgroundMethodInfluential
Predation and the Origin of Neurones
Monk, T., & Paulin, M. G. (2014) · Brain Behavior and Evolution · doi:10.1159/000368177 · Cited by 54 · see citing works
“Molecular evidence indicates that all nervous systems share a degree of genetic conservation [Ghysen, 2003; Gomez-Skarmeta et al., 2003; Ball et al., 2004; Matus et al., 2006; Denes et al., 2007; Jacobs et al., 2007; Arendt et al., 2008; Watanabe et al., 2009; Hirth, 2010], but some nervous systems are more closely re…”
BackgroundInfluential
Steps towards a centralized nervous system in basal bilaterians: Insights from neurogenesis of the acoelSymsagittifera roscoffensis
Semmler, H., Chiodin, M., Bailly, X., Martı́nez, P., & Wanninger, A. (2010) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2010.01207.x · Cited by 55 · see citing works
“Some medusoid adults have unequally distributed ring-shaped or longitudinal neurites and regions with condensed neuronal cell bodies along the body axis, but until now it remains unclear whether these have been carried over from the larval stage or form de novo in adults (Watanabe et al. 2009).”
Background
The GPCR repertoire in the demosponge Amphimedon queenslandica: insights into the GPCR system at the early divergence of animals
Krishnan, A., Dnyansagar, R., Almén, M. S., Williams, M. J., Fredriksson, R., Manoj, N., & Schiöth, H. B. (2014) · BMC Evolutionary Biology · doi:10.1186/s12862-014-0270-4 · Cited by 54 · see citing works
“In Nematostella, an ectodermal and endodermal nerve net constituting of a simple and diffuse nervous system runs throughout the animal’s body [23,24].”
Background
The role of cnidarian developmental biology in unraveling axis formation and Wnt signaling
Holstein, T. W. (2022) · Developmental Biology · doi:10.1016/j.ydbio.2022.04.005 · Cited by 51 · see citing works
Self-citation
How do environmental factors influence life cycles and development? An experimental framework for early‐diverging metazoans
Bosch, T. C. G., Adamska, M., Augustin, R., Domazet‐Lošo, T., Forêt, S., Fraune, S., Funayama, N., Grasis, J. A., Hamada, M., Hatta, M., et al. (2014) · BioEssays · doi:10.1002/bies.201400065 · Cited by 52 · see citing works
The brain: a concept in flux
Pagán, O. R. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0383 · Cited by 54 · see citing works
Comparative genomics of mortal and immortal cnidarians unveils novel keys behind rejuvenation
Pascual-Torner, M., Carrero, D., Pérez-Silva, J. G., Álvarez-Puente, D., Roiz‐Valle, D., Bretones, G., Rodríguez, D., Maeso, D., Mateo-González, E., Español, Y., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118763119 · Cited by 49 · see citing works
A combined strategy of neuropeptide prediction and tandem mass spectrometry identifies evolutionarily conserved ancient neuropeptides in the sea anemone Nematostella vectensis
Hayakawa, E., Watanabe, H., Menschaert, G., Holstein, T. W., Baggerman, G., & Schoofs, L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215185 · Cited by 47 · see citing works
“A previous study showed a highly conserved set of genes in the Nematostella vectensis genome, including molecules involved in neurotransmission [28,89].”
BackgroundInfluentialSelf-citation
The Xenopus doublesex-related gene Dmrt5 is required for olfactory placode neurogenesis
Parlier, D., Moers, V., Campenhout, C. V., Preillon, J., Leclère, L., Saulnier, A., Sirakov, M., Busengdal, H., Kricha, S., Marine, J., et al. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.10.003 · Cited by 47 · see citing works
GABAergic Synaptic Plasticity during a Developmentally Regulated Sleep-Like State inC. elegans
Dabbish, N., & Raizen, D. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0742-11.2011 · Cited by 42 · see citing works
“Nervous system remodeling is an ancient, widespread phenomenon seen in animals ranging from cnidarians to vertebrates (Nakanishi et al., 2008; Watanabe et al., 2009).”
Vertebrate Cranial Placodes as Evolutionary Innovations—The Ancestor's Tale
Schlosser, G. (2015) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2014.11.008 · Cited by 43 · see citing works
A Non-sulfated Chondroitin Stabilizes Membrane Tubulation in Cnidarian Organelles
Adamczyk, P., Zenkert, C., Balasubramanian, P. G., Yamada, S., Murakoshi, S., Sugahara, K., Hwang, J. S., Gojobori, T., Holstein, T. W., & Özbek, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107904 · Cited by 40 · see citing works
Self-citation
Characterization of NvLWamide-like neurons reveals stereotypy in Nematostella nerve net development
Havrilak, J. A., Faltine-Gonzalez, D. Z., Wen, Y., Fodera, D. M., Simpson, A. C., Magie, C. R., & Layden, M. J. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.08.028 · Cited by 37 · see citing works
Microfluidics for electrophysiology, imaging, and behavioral analysis of Hydra
Badhiwala, K. N., Gonzales, D. L., Vercosa, D. G., Avants, B. W., & Robinson, J. T. (2018) · Lab on a Chip · doi:10.1039/c8lc00475g · Cited by 36 · see citing works
The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34
Vidal, B., Gülez, B., Cao, W. X., Leyva‐Díaz, E., Reilly, M. B., Tekieli, T., & Hobert, O. (2022) · eLife · doi:10.7554/elife.76003 · Cited by 37 · see citing works
“Pharyngeal neurons combine sensory, inter- and motor neuron features and are also not localized to ganglia but rather diffusely localized, resembling the architecture of more ancient nerve nets (Albertson and Thomson, 1976; Watanabe et al., 2009).”
Background
Neuronal cell death during metamorphosis of Hydractina echinata (Cnidaria, Hydrozoa)
Seipp, S., Schmich, J., Will, B., Schetter, E., Plickert, G., & Leitz, T. (2010) · Invertebrate Neuroscience · doi:10.1007/s10158-010-0109-7 · Cited by 36 · see citing works
“…1300 Morris Park Ave., Chanin Building, Room 606, New York, NY 10461, USA E. Schetter G. Plickert Biozentrum der Universität, Institut für Zoologie, Universität zu Köln, Zülpicher Str. 47b, 50674 Köln, Germany Westfall 1995; Koizumi and Bode 1991; Watanabe et al. 2009 for a recent review).”
Modern genomic tools reveal the structural and cellular diversity of cnidarian nervous systems
Rentzsch, F., Juliano, C. E., & Galliot, B. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.12.004 · Cited by 36 · see citing works
Evo-devo of non-bilaterian animals
Lanna, E. (2015) · Genetics and Molecular Biology · doi:10.1590/s1415-475738320150005 · Cited by 35 · see citing works
“It has already been shown that some neural bHLH transcription factors are expressed in developing neurons in hydrozoans (Grens et al., 1995; Seipel et al., 2004; reviewed in Watanabe et al., 2009).”
BackgroundInfluential
Genomics and development of Nematostella vectensis and other anthozoans
Rentzsch, F., & Technau, U. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.05.024 · Cited by 32 · see citing works
Effect of neurotoxic compounds on ephyrae of Aurelia aurita jellyfish
Costa, E., Gambardella, C., Piazza, V., Greco, G., Lavorano, S., Beltrandi, M., Bongiovanni, E., Gnone, G., Faimali, M., & Garaventa, F. (2015) · Hydrobiologia · doi:10.1007/s10750-015-2284-3 · Cited by 34 · see citing works
“Moreover, a role of neuronal control has been proved to regulate the periodic contractions of A. aurita body, in order to generate ring-vortices of the surrounding medium (Satterlie, 2002; Watanabe et al., 2009).”
BackgroundResult
A myxozoan genome reveals mosaic evolution in a parasitic cnidarian
Guo, Q., Atkinson, S. D., Xiao, B., Zhai, Y., Bartholomew, J. L., & Gu, Z. (2022) · BMC Biology · doi:10.1186/s12915-022-01249-8 · Cited by 33 · see citing works
“Primitive nervous system? While free-living cnidarians have simple nerve nets [85], there is no evidence that similar nerves are present in myxozoans even though they can sense proximity of hosts and can have motile, multi-cellular stages [56].”
Background
Unipotent progenitors contribute to the generation of sensory cell types in the nervous system of the cnidarian Nematostella vectensis
Busengdal, H., & Rentzsch, F. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.08.021 · Cited by 35 · see citing works
A new look at the architecture and dynamics of the Hydra nerve net
Keramidioti, A., Schneid, S., Busse, C., von Laue, C. C., Bertulat, B., Salvenmoser, W., Heß, M., Alexandrova, O., Glauber, K. M., Steele, R. E., et al. (2023) · eLife · doi:10.7554/elife.87330.3 · Cited by 32 · see citing works
Self-citation
Evolution of the Pax-Six-Eya-Dach network: the calcisponge case study
Fortunato, S., Leininger, S., & Adamska, M. (2014) · EvoDevo · doi:10.1186/2041-9139-5-23 · Cited by 32 · see citing works
“ciliatum express SoxB [24], a transcription factor involved in bilaterian neurogenesis [34,35] and expressed in cnidarian neurosensory cells [36].”
Background
Phylostratigraphic Profiles in Zebrafish Uncover Chordate Origins of the Vertebrate Brain
Šestak, M. S., & Domazet‐Lošo, T. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu319 · Cited by 29 · see citing works
“These increases might be expected, given that the first nervous system emerged in this evolutionary range (Koizumi 2007; SchmidtRhaesa 2007; Galliot et al. 2009; Watanabe et al. 2009).”
Background
Comparative analyses of developmental transcription factor repertoires in sponges reveal unexpected complexity of the earliest animals
Fortunato, S. A. V., Adamski, M., & Adamska, M. (2015) · Marine Genomics · doi:10.1016/j.margen.2015.07.008 · Cited by 31 · see citing works
New Insights Into the Roles of Retinoic Acid Signaling in Nervous System Development and the Establishment of Neurotransmitter Systems
Zieger, E., & Schubert, M. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.09.001 · Cited by 31 · see citing works
Insights into the evolution of digestive systems from studies of Trichoplax adhaerens
Smith, C. L., & Mayorova, T. D. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-03057-z · Cited by 28 · see citing works
Organization of the ectodermal nervous structures in jellyfish: scyphomedusae
Satterlie, R. A., & Eichinger, J. M. (2014) · The Biological Bulletin · doi:10.1086/bblv226n1p29 · Cited by 30 · see citing works
“In a more general sense, various forms of tubulin antibodies have been used to stain neurons in cnidarians (Groger and Schmid, 2001; Galliot et al., 2009; Watanabe et al., 2009; Nakanishi et al., 2009, 2010), as have RFamide antibodies (Grimmelikhuijzen et al., 1996, 2002).”
Background
Nervous system immunohistochemistry of the parasitic cnidarian Polypodium hydriforme at its free-living stage
Ev, R., & Raikova, O. I. (2015) · Zoology · doi:10.1016/j.zool.2015.11.004 · Cited by 30 · see citing works
Neural anatomy of echinoid early juveniles and comparison of nervous system organization in echinoderms
Formery, L., Orange, F., Formery, A., Yaguchi, S., Lowe, C. J., Schubert, M., & Croce, J. C. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.25012 · Cited by 30 · see citing works
Cephalopods: Ambassadors for rethinking cognition
Schnell, A. K., & Clayton, N. S. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.12.062 · Cited by 30 · see citing works
Do epidermal keratinocytes have sensory and information processing systems?
Denda, M., & Nakanishi, S. (2021) · Experimental Dermatology · doi:10.1111/exd.14494 · Cited by 30 · see citing works
Insm1 -expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis
Tournière, O., Gahan, J. M., Busengdal, H., Bartsch, N., & Rentzsch, F. (2022) · Science Advances · doi:10.1126/sciadv.abi7109 · Cited by 25 · see citing works
Hydraulic and electric control of cell spheroids
Duclut, C., Prost, J., & Jülicher, F. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021972118 · Cited by 26 · see citing works
The synapsin gene family in basal chordates: evolutionary perspectives in metazoans
Candiani, S., Moronti, L., Pennati, R., de Bernardi, F. L., Benfenati, F., & Pestarino, M. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-32 · Cited by 26 · see citing works
“Thus, the emergence of E domain appears to be correlated with the beginning of the genesis of nervous organization, since the simplest metazoans known to possess a nervous system are those of the phylum Cnidaria [39].”
Identification of the neuropeptide precursor genes potentially involved in the larval settlement in the Echiuran worm Urechis unicinctus
Hou, X., Qin, Z., Wei, M., Fu, Z., Liu, R., Lu, L., Bai, S., Ma, Y., & Zhang, Z. (2020) · BMC Genomics · doi:10.1186/s12864-020-07312-4 · Cited by 25 · see citing works
Structure and evolution of neuronal wiring receptors and ligands
Cortés, E. C., Pak, J. S., & Özkan, E. (2022) · Developmental Dynamics · doi:10.1002/dvdy.512 · Cited by 23 · see citing works
“DCC homologs have been identified in bilaterians as common receptors that guide commissural projections but are also present in cnidarians(15): For example, the anthozoan model organism Nematostella vectensis (starlet sea anemone) is known to have a complete set of Netrin, DCC, and Unc5-like proteins.(15) In vertebrat…”
Background
Medusa: A Review of an Ancient Cnidarian Body Form
Ames, C. L. (2018) · Results and problems in cell differentiation · doi:10.1007/978-3-319-92486-1_7 · Cited by 26 · see citing works
Fast Neurotransmission Related Genes Are Expressed in Non Nervous Endoderm in the Sea Anemone Nematostella vectensis
Oren, M., Brickner, I., Appelbaum, L., & Levy, O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093832 · Cited by 24 · see citing works
“The first appearance of functional nervous systems in animal evolution is attributed to the coelenterates, including the ctenophores (comb jellies) and the cnidarians [5].”
Background
Are G-protein-Coupled Receptors Involved in Mediating Larval Settlement and Metamorphosis of Coral Planulae?
Tran, C., & Hadfield, M. G. ‏. (2012) · Biological Bulletin · doi:10.1086/bblv222n2p128 · Cited by 24 · see citing works
Cnidarian Nerve Nets and Neuromuscular Efficiency
Satterlie, R. A. (2015) · Integrative and Comparative Biology · doi:10.1093/icb/icv067 · Cited by 23 · see citing works
The function of the ophiuroid nerve ring: how a decentralized nervous system controls coordinated locomotion
Clark, E., Kanauchi, D., Kano, T., Aonuma, H., Briggs, D. E. G., & Ishiguro, A. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.192104 · Cited by 22 · see citing works
“Other examples of decentralized nervous control in the animal kingdom include the diffused nerve nets of cnidarians (Watanabe et al., 2009) and other bilaterians such as xenacoelomorphs and hemichordates (Martín-Durán et al.”
Background
Intracellular pH regulation: characterization and functional investigation of H+ transporters in Stylophora pistillata
Capasso, L., Ganot, P., Planas-Bielsa, V., Tambutté, S., & Zoccola, D. (2021) · BMC Molecular and Cell Biology · doi:10.1186/s12860-021-00353-x · Cited by 20 · see citing works
Co-expression of synaptic genes in the sponge Amphimedon queenslandica uncovers ancient neural submodules
Wong, E., Mölter, J., Anggono, V., Degnan, B. M., & Degnan, B. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-51282-x · Cited by 19 · see citing works
PHYRN: A Robust Method for Phylogenetic Analysis of Highly Divergent Sequences
Bhardwaj, G., Ko, K. D., Hong, Y., Zhang, Z., Ho, N. L., Chintapalli, S. V., Kline, L. A., Gotlin, M. J., Hartranft, D. N., Patterson, M. E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034261 · Cited by 17 · see citing works
“580 million years ago), which are some of the first organisms known to have a developed neural net, radial axis of symmetry, muscle cells, and stem cells [49,50].”
Background
Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila
Sizemore, T. R., Jonaitis, J., & Dacks, A. M. (2023) · Nature Communications · doi:10.1038/s41467-023-41012-3 · Cited by 21 · see citing works
“isons test was used to determine if: (1) MIPergic LNs preferentially innervate based on the functional group found along the odorant that activates the given glomerulus’ odorant receptor; (2) SPR-GAL4::VP16 expression in antennae and maxillary palps significantly differs between males, mated females, and virgin female…”
Nervous System Development and Neuropeptides Characterization in Embryo and Larva: Insights from a Non-Chordate Deuterostome, the Sea Cucumber Apostichopus japonicus
Zheng, Y., Cong, X., Liu, H., Wang, Y., Storey, K. B., & Chen, M. (2022) · Biology · doi:10.3390/biology11101538 · Cited by 16 · see citing works
Extracellular matrix and morphogenesis in cnidarians: a tightly knit relationship
Bergheim, B. G., & Özbek, S. (2019) · Essays in Biochemistry · doi:10.1042/ebc20190021 · Cited by 16 · see citing works
Melatonin Distribution Reveals Clues to Its Biological Significance in Basal Metazoans
Roopin, M., & Levy, O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052266 · Cited by 16 · see citing works
“Although a complete understanding of the cnidarian nervous system has not been obtained, potentially centralized elements, such as circular nerve ring structures, are believed to represent complex features of these presumably simple systems (reviewed in [50]) and have been demonstrated to functionally coordinate a wid…”
Background
Transcriptional characterisation of the Exaiptasia pallida pedal disc
Davey, P. A., Rodrigues, M., Clarke, J., & Aldred, N. (2019) · BMC Genomics · doi:10.1186/s12864-019-5917-5 · Cited by 18 · see citing works
Neuropeptide expression in the box jellyfish Tripedalia cystophora —New insights into the complexity of a “simple” nervous system
Nielsen, S. K. D., Koch, T. L., Wiisbye, S. H., Grimmelikhuijzen, C. J. P., & Garm, A. L. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25133 · Cited by 14 · see citing works
“…nature of the neuronal inducers among cnidarians is still unclear, and increased knowledge here would provide important insights not only into the evolutionary origin of neural induction but also into the molecular evolution of the centralized nervous system in bilaterians (Watanabe et al., 2009).”
Background
NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis
B., L. Q. I., Bartsch, N., Kouzel, I. U., Busengdal, H., Richards, G. S., Steinmetz, P. R. H., & Rentzsch, F. (2023) · Nature Communications · doi:10.1038/s41467-023-39789-4 · Cited by 13 · see citing works
Reconciling Ontic and Epistemic Constraints on Mechanistic Explanation, Epistemically
van Eck, D. (2014) · Axiomathes · doi:10.1007/s10516-014-9243-x · Cited by 14 · see citing works
The Sialic Acid-Dependent Nematocyst Discharge Process in Relation to Its Physical-Chemical Properties Is a Role Model for Nanomedical Diagnostic and Therapeutic Tools
Zhang, R., Jin, L., Zhang, N., Petridis, A. K., Eckert, T., Scheiner‐Bobis, G., Bergmann, M., Scheidig, A. J., Schauer, R., Yan, M., et al. (2019) · Marine Drugs · doi:10.3390/md17080469 · Cited by 13 · see citing works
“Sialic acid molecules which play also a crucial role in developmental processes [90,91] were invented during the evolution in Echinodermata (e.”
Background
A single neuron subset governs a single coactive neuron circuit in Hydra vulgaris, representing a possible ancestral feature of neural evolution
Noro, Y., Shimizu, H., Mineta, K., & Gojobori, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-89325-x · Cited by 14 · see citing works
Human transcriptome nexuses: Basic-eukaryotic and metazoan
Vinogradov, A. E. (2010) · Genomics · doi:10.1016/j.ygeno.2010.03.004 · Cited by 14 · see citing works
“The nervous system originated very early in the evolution of metazoans, just after the divergence of sponge and eumetazoan lineages [38,39].”
Background
The histology of Nanomia bijuga (Hydrozoa: Siphonophora)
Church, S. H., Siebert, S., Bhattacharyya, P., & Dunn, C. W. (2015) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.22629 · Cited by 14 · see citing works

Evolution of eumetazoan nervous systems: insights from cnidarians
Kelava, I., Rentzsch, F., & Technau, U. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0065 · Cited by 84 · see citing works
Origin and Evolution of the Nervous System Considered from the Diffuse Nervous System of Cnidarians
Koizumi, O. (2016) · Springer eBooks · doi:10.1007/978-3-319-31305-4_6 · Cited by 13 · see citing works
Modern genomic tools reveal the structural and cellular diversity of cnidarian nervous systems
Rentzsch, F., Juliano, C. E., & Galliot, B. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.12.004 · Cited by 36 · see citing works
Back Through Time: How Cnidarians and Basal Metazoans Shed Light on Ancient Nervous Systems
Watanabe, H. (2017) · Diversity and commonality in animals · doi:10.1007/978-4-431-56469-0_3 · Cited by 7 · see citing works
Self-citation
Origin and Evolution of the First Nervous System
Lichtneckert, R., & Reichert, H. (2007) · Elsevier eBooks · doi:10.1016/b0-12-370878-8/00157-9 · Cited by 23 · see citing works

Authors: Watanabe, H., Fujisawa, T., & Holstein, T. W.
Affiliations: Heidelberg University (DE)
Corresponding author: Watanabe, Hiroshi
Holstein, Thomas W.
ORCID: Watanabe, Hiroshi
Holstein, Thomas W.
Venue: Development, Growth & Differentiation
Publisher: Wiley
Published: 2009-03-30
Volume: 51
Issue: 3
Pages: 167-183
ISSN: 0012-1592 (ISSN-L)
1440-169X
DOI: 10.1111/j.1440-169x.2009.01103.x
OpenAlex: W1636647670
Cited by: 206
References: 191
Citations by year: 2026: 6 · 2025: 11 · 2024: 16 · 2023: 9 · 2022: 16 · 2021: 26 · 2020: 13 · 2019: 17 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 19 · 2014: 15 · 2013: 5 · 2012: 8
FWCI: 0.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Development Growth & Differentiation (publishedVersion)
PubMed (publishedVersion)
Funders: Alexander von Humboldt-Stiftung
Toyobo Biotechnology Foundation
Deutsche Forschungsgemeinschaft (SFB 488)
Topics: Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: Cnidaria, nervous system evolution, brain development, Bilateria, comparative neuroanatomy
MeSH terms: Animals, Cnidaria, Biological Evolution, Nervous System, Phylogeny

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cnidarians and the evolutionary origin of the nervous system

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks