Cited by 72Estrogen and related hormone effectsAdipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

The impact of ERα action on muscle metabolism and insulin sensitivity – Strong enough for a man, made for a woman

Open access
Hevener, Andrea L., Zhou, Zhenqi, Moore, Timothy M., Drew, Brian G., Ribas, Vicent·2018·Molecular Metabolism

Abstract

BACKGROUND: The incidence of chronic disease is elevated in women after menopause. Natural variation in muscle expression of the estrogen receptor (ER)α is inversely associated with plasma insulin and adiposity. Moreover, reduced muscle ERα expression levels are observed in women and animals presenting clinical features of the metabolic syndrome (MetSyn). Considering that metabolic dysfunction impacts nearly a quarter of the U.S. adult population and elevates chronic disease risk including type 2 diabetes, heart disease, and certain cancers, treatment strategies to combat metabolic dysfunction and associated pathologies are desperately needed. SCOPE OF THE REVIEW: This review will provide evidence supporting a critical and protective role for skeletal muscle ERα in the regulation of metabolic homeostasis and insulin sensitivity, and propose novel ERα targets involved in the maintenance of metabolic health. MAJOR CONCLUSIONS: Studies identifying ERα-regulated pathways essential for disease prevention will lay the important foundation for the rational design of novel therapeutics to improve the metabolic health of women while limiting secondary complications that have plagued traditional hormone replacement interventions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.molmet.2018.06.013

Cites

177 of 177 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Estrogen actions in skeletal muscle, liver, adipose tissue, and immune cells are involved in insulin sensitivity and prevention of lipid accumulation and inflammation.

    “Estrogen actions in skeletal muscle, liver, adipose tissue, and immune cells are involved in insulin sensitivity as well as prevention of lipid accumulation and inflammation [20,21,67,68].”

    From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [20]

    The sections on insulin action and skeletal-muscle fatty-acid metabolism link ERα to insulin sensitivity, fatty-acid oxidation, and inflammation in muscle. The paper also says ERα is expressed in liver, adipose tissue, and immune cells, but the retrieved passages do not establish that its actions in each of those tissues prevent lipid accumulation and inflammation. Page numbers were not available in our copy. (LLM, conf=0.84)

    Experimental — accuracy not yet measured
  • Robust evidence demonstrates that estrogen and progesterone have important roles in regulating substrate metabolism.

    “Robust evidence exists that demonstrates the important roles estrogen and progesterone have in regulating substrate metabolism [20,24,66,70,80,82,84,154–159].”

    From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [20]

    The section on ERα and skeletal muscle fatty acid metabolism reports that estrogen affects lipid oxidation, supporting its role in substrate metabolism (page unavailable). The section on insulin action and glucose disposal says progesterone can antagonize GLUT4 expression, but the paper calls for further study of progesterone’s metabolic effects; it does not establish equally robust evidence for progesterone’s broader role. (LLM, conf=0.82)

    Experimental — accuracy not yet measured
  • Estrogen, specifically 17β-estradiol, promotes lipolysis and increases fatty acid availability while decreasing the rate of gluconeogenesis with muscle and liver glycogen sparing.

    “Estrogen, specifically 17β-estradiol, promotes lipolysis and increases fatty acid availability while decreasing the rate of gluconeogenesis with muscle and liver glycogen sparing.”

    From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [20]

    The section “ERα and skeletal muscle fatty acid metabolism and inflammation” reports that estradiol enhances lipid oxidation and fatty-acid transport in muscle. It does not establish that estradiol promotes lipolysis or increases fatty-acid availability, and searches for gluconeogenesis and glycogen found no support for reduced gluconeogenesis or muscle and liver glycogen sparing. No page numbers were provided in our copy. (LLM, conf=0.85)

    Experimental — accuracy not yet measured
  • Significant sex differences and sex hormone influences on carbohydrate and lipid metabolism are apparent.

    “Significant sex differences and sex hormone influences on carbohydrate and lipid metabolism are apparent”
  • Important sex differences exist in mitochondrial function, substrate utilization, insulin sensitivity, immune responses, muscle morphology and body composition, iron metabolism, thermoregulation, hydration, appetite control, and energy availability and endocrine function.

    “important sex differences exist in mitochondrial function [14–16], substrate utilization, and insulin sensitivity [17–24], immune responses [25–28], muscle morphology and body composition [29–32], iron metabolism [33–40], thermoregulation [41–44], hydration [45,46]{Sims, 2008 #55, [47–53], appetite control [54–59], and energy availability and endocrine function [60–65].”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

3 of the 180 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Hevener, A. L., Zhou, Z., Moore, T. M., Drew, B. G., & Ribas, V.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Hevener, Andrea L.
Venue
Molecular Metabolism
Publisher
Elsevier BV
Published
2018-09
Volume
15
Pages
20-34
ISSN
2212-8778 (ISSN-L)
OpenAlex
W2808844109
Cited by
72
References
180
Citations by year
2026: 7 · 2025: 8 · 2024: 5 · 2023: 14 · 2022: 8 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 1
FWCI
1.03
Type
journal article
Language
en
Open access
Locations
  • Molecular Metabolism (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
Funders
  • National Institutes of Health (DK89109, DK063491)
  • Jonsson Comprehensive Cancer Center
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
estrogen receptor alpha, skeletal muscle, muscle metabolism, insulin sensitivity, metabolic syndrome, menopause, sex differences, metabolic health, hormone replacement therapy, type 2 diabetes, adiposity
MeSH terms
Energy Metabolism, Female, Humans, Insulin Resistance, Male, Sex Characteristics, Exercise, Muscle, Skeletal, Estrogen Receptor alpha

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review