Slc12a8 is a nicotinamide mononucleotide transporter
Open accessAbstract
Nicotinamide mononucleotide (NMN) is a biosynthetic precursor of NAD+ known to promote cellular NAD+ production and counteract age-associated pathologies associated with a decline in tissue NAD+ levels. How NMN is taken up into cells has not been entirely clear. Here we show that the Slc12a8 gene encodes a specific NMN transporter. We find that Slc12a8 is highly expressed and regulated by NAD+ in the murine small intestine. Slc12a8 knockdown abrogates the uptake of NMN in vitro and in vivo. We further show that Slc12a8 specifically transports NMN, but not nicotinamide riboside, and that NMN transport depends on the presence of sodium ion. Slc12a8 deficiency significantly decreases NAD+ levels in the jejunum and ileum, which is associated with reduced NMN uptake as traced by doubly labeled isotopic NMN. Finally, we observe that Slc12a8 expression is upregulated in the aged murine ileum, which contributes to the maintenance of ileal NAD+ levels. Our work identifies the first NMN transporter and demonstrates that Slc12a8 has a critical role in regulating intestinal NAD+ metabolism.
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Expression of a gut transporter supports the possibility that NMN is bioavailable through oral delivery.
“The expression of a transporter in the gut [76] reinforces that NMN could be made bioavailable through oral delivery.”
From NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health (2023) · cites this paper as [76]
Slc12a8 is an NMN transporter highly expressed and regulated by NAD+ in murine small intestine, and its deficiency abrogates NMN uptake in vitro and in vivo.
“A newly reported NMN transporter, the Slc12a8, is highly expressed and regulated by NAD+, in the murine small intestine, and Slc12a8 deficiency abrogates the uptake of NMN in vitro and in vivo (Grozio et al., 2019).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Grozio et al., 2019
Through slc12a8, 26-month-old mice that took NMN increased their NAD+ levels to close to 3 months old, increasing cell energy in aged mice.
“through a transporter called slc12a8, 26-month-old mice (equivalent to 70 human years) that took NMN increased their NAD+ levels to close to 3 months old (equivalent to 12 human months). The content level in young mice increased the cell energy in aged mice [208].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [208]
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“Stoichiometry 1 K+ : 1 Cl- (out) 1 K+ : 1 Cl- (out) Unknown Inhibitors DIOA DIOA – Comments – – In mouse studies Slc12a8 has been shown to transport the nicotinamide adenine dinucleotide (NAD+) precursor, nicotinamide mononucleotide (NMN) in to cells, and administration of NMN produces anti-ageing effects in vivo [261…”
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“Another study reported that NMN could directly enter cells via Slc12a8 transporter [77].”
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“SLC12A8 has been proposed as an NMN transporter into the cell 70 , but this is still debated 71,72 .”
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“While some studies suggest that NMN is converted to NR before its cellular uptake (Kulikova et al., 2019; Ratajczak et al., 2016), others propose that it gets into the cell through a specific NMN transporter, Slc12a8, at least in the intestine (Grozio et al., 2019).”
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“Adding more complexity, a cell-surface transporter, SLC12A8, was recently reported to mediate the influx of extracellular NMN in the gut [86].”
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“, 2016), while another report argued SLC12A8 was a cellular transporter of NMN whereby the data got challenges (Grozio et al., 2019; Schmidt and Brenner, 2019).”
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Self-citationThe Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
Song, Q., Zhou, X., Xu, K., Liu, S., Zhu, X., & Yang, J. J. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.08.008 · Cited by 122 · see citing works
“One is that the cell can directly absorb NMN through a speci fi c transporter, Slc12a8, a cell membrane transporter in the aged mouse ileum [160].”
BackgroundKlimova, N., Fearnow, A. D., Long, A. N., & Kristián, T. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113144 · Cited by 106 · see citing works
“The fast uptake of NMN and its conversion to NAD+ is supported by a study showing that there is an NMN transporter in the small intestine (Grozio et al., 2019), suggesting the ability to rapidly take up NMN after i.”
BackgroundThe role of polyamine metabolism in cellular function and physiology
Schibalski, R. S., Shulha, A. S., Tsao, B. P., Palygin, O., & Ilatovskaya, D. V. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00074.2024 · Cited by 107 · see citing works
Regulation of NAD+ metabolism in aging and disease
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Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity
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NRH salvage and conversion to NAD+ requires NRH kinase activity by adenosine kinase
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Reduced nicotinamide mononucleotide is a new and potent NAD + precursor in mammalian cells and mice
Perez, R. Z., Tammaro, A., Schomakers, B. V., Scantlebery, A. M. L., Denis, S. W., Elfrink, H. L., Giroud‐Gerbetant, J., Cantó, C., López‐Leonardo, C., McIntyre, R. L., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202001826r · Cited by 75 · see citing works
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“It has been argued that the hourly kinetics of extracellular NMN to NR conversion cannot explain the minute-order cellular uptake of NMN (Grozio et al., 2019).”
InfluentialNicotinamide Adenine Dinucleotide (NAD) Metabolism as a Relevant Target in Cancer
Navas, L. E., & Carnero, A. (2022) · Cells · doi:10.3390/cells11172627 · Cited by 68 · see citing works
“However, the expression of Slc12a8 is limited to the intestine and others have questioned its ability to transport NMN [46].”
BackgroundCellular Compartmentation and the Redox/Nonredox Functions of NAD +
Kulkarni, C. A., & Brookes, P. S. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7722 · Cited by 64 · see citing works
“The recent discovery of a specific NMN transporter, Slc12a8 (56), will require careful analysis of its cell type expression patterns to resolve this debate.”
BackgroundAbsence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter
Schmidt, M. S., & Brenner, C. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0085-0 · Cited by 64 · see citing works
NAD+ in COVID-19 and viral infections
Zheng, M., Schultz, M. B., & Sinclair, D. A. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.02.001 · Cited by 62 · see citing works
“Canonically, NAD cannot be taken up directly by the cell, but its precursors can [102,115].”
Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases
Hikosaka, K., Yaku, K., Okabe, K., & Nakagawa, T. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1637504 · Cited by 62 · see citing works
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The therapeutic perspective of NAD+ precursors in age-related diseases
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Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation
Hopp, A.-K., Teloni, F., Bisceglie, L., Gondrand, C., Raith, F., Nowak, K., Muskalla, L., Howald, A., Pedrioli, P. G. A., Johnsson, K., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2020.12.034 · Cited by 61 · see citing works
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Li, Z., & Yu, D. (2023) · Industrial Crops and Products · doi:10.1016/j.indcrop.2023.117158 · Cited by 58 · see citing works
NAD+ and NAFLD – caution, causality and careful optimism
Dall, M., Hassing, A. S., & Treebak, J. T. (2021) · The Journal of Physiology · doi:10.1113/jp280908 · Cited by 57 · see citing works
“Another study identified SLC12A8 as a specific NMN transporter (Grozio et al. 2019) (Fig.”
BackgroundImpact of NAD+ metabolism on ovarian aging
Liang, J., Huang, F., Song, Z., Tang, R., Zhang, P., & Chen, R. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00398-w · Cited by 56 · see citing works
“NMN enters cells through specific transporters (the Slc12a8 gene) [268], by conversion into NAM or NR via CD38 or CD73, or through ENTs [159, 188].”
BackgroundWang, X., He, H., Xiong, X., Zhou, S., Wang, W., Feng, L., Han, R., & Xie, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.668491 · Cited by 54 · see citing works
Clinical Evidence for Targeting NAD Therapeutically
Radenković, D., Reason, & Verdin, E. M. (2020) · Pharmaceuticals · doi:10.3390/ph13090247 · Cited by 55 · see citing works
“Notably, in this context, NMN enters cells via the Slc12a8 transporter [69].”
BackgroundSemerena, E., Nencioni, A., & Masternak, K. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1268756 · Cited by 53 · see citing works
“Furthermore, studies show that the extracellular NMN may enter cells and contribute to intracellular NAD biosynthesis (42 – 44).”
BackgroundEnzymology of extracellular NAD metabolism
Gasparrini, M., Sorci, L., & Raffaelli, N. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03742-1 · Cited by 51 · see citing works
Emerging strategies, applications and challenges of targeting NAD+ in the clinic
Zhang, J., Wang, H., Lautrup, S., Nilsen, H. L., Treebak, J. T., Watne, L. O., Selbæk, G., Wu, L. E., Omland, T., Pirinen, E., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00947-6 · Cited by 58 · see citing works
“1) include the extracellular conversion of NMN to NR 208–211 and direct uptake via the transporter SLC12A8, identified in the mouse intestine 212 .”
Self-citationATP13A3 facilitates polyamine transport in human pancreatic cancer cells
Sekhar, V., Andl, T., & Phanstiel, O. (2022) · Scientific Reports · doi:10.1038/s41598-022-07712-4 · Cited by 50 · see citing works
Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors
She, J., Sheng, R., & Qin, Z. (2021) · Aging and Disease · doi:10.14336/ad.2021.0523 · Cited by 49 · see citing works
“First, NMN is transformed into NAM under the action of membrane-bound CD38, and then, it directly passes through the plasma membrane [21]; second, under the action of membrane-bound CD73, NMN is transformed into NR, which enters cells through ENTs [72]; third, NMN can directly enter cells through an NMN-specific trans…”
BackgroundChen, X., Bahramimehr, F., Shahhamzehei, N., Fu, H., Lin, S., Wang, H., Li, C., Efferth, T., & Hong, C. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155665 · Cited by 50 · see citing works
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Dehhaghi, M., Panahi, H., Kavyani, B., Heng, B., Tan, V., Braidy, N., & Guillemin, G. (2022) · Aging and Disease · doi:10.14336/ad.2021.0824 · Cited by 38 · see citing works
“[132] Grozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K, et al.”
BackgroundCommon Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions
Shen, W., He, J., Hou, T., Si, J., & Chen, S. (2022) · Aging and Disease · doi:10.14336/ad.2021.1208 · Cited by 45 · see citing works
Nutrient transporters: connecting cancer metabolism to therapeutic opportunities
Nwosu, Z. C., Song, M. G., di Magliano, M. P., Lyssiotis, C. A., & Kim, S. E. (2023) · Oncogene · doi:10.1038/s41388-023-02593-x · Cited by 47 · see citing works
“SLC12A8 was recently identified as a transporter specific for NMN and it is highly expressed in the mouse small intestine [77].”
BackgroundRen, Z., Xu, Y., Li, T., Sun, W., Tang, Z., Wang, Y., Zhou, K., Li, J., Ding, Q., Liang, K., et al. (2022) · Animal Nutrition · doi:10.1016/j.aninu.2022.06.009 · Cited by 44 · see citing works
“A recent study showed that NMN can be directly transported into cells by solute carrier family 12 member 8 (Grozio et al., 2019).”
BackgroundNicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns
Bhasin, S., Seals, D. R., Migaud, M. E., Musi, N., & Baur, J. A. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad019 · Cited by 47 · see citing works
Self-citationYamaguchi, T., Higa, K., Yagi-Yaguchi, Y., Ueda, K., Noma, H., Shibata, S., Nagai, T., Tomida, D., Yasu-Mimura, R., Ibrahim, O. M., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz5195 · Cited by 44 · see citing works
Yaku, K., Palikhe, S., Iqbal, T., Hayat, F., Watanabe, Y., Fujisaka, S., Izumi, H., Yoshida, T., Karim, M., Uchida, H., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr1538 · Cited by 40 · see citing works
“A previous study demonstrated that NMN was directly taken up to the small intestine via Slc12a8 ( 32 ).”
Self-citationNAD+ Precursors: A Questionable Redundancy
Cantó, C. (2022) · Metabolites · doi:10.3390/metabo12070630 · Cited by 41 · see citing works
Maric, T., Bazhin, A. A., Khodakivskyi, P. V., Mikhaylov, G., Solodnikova, E. S., Yevtodiyenko, A., Attianese, G. M. P. G., Coukos, G., Irving, M. B., Joffraud, M., et al. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114826 · Cited by 41 · see citing works
Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation
Kim, L., Chalmers, T. J., Madawala, R. J., Smith, G. C., Li, C., Das, A., Poon, E. W. K., Wang, J., Tucker, S. P., Sinclair, D. A., et al. (2023) · FEBS Letters · doi:10.1002/1873-3468.14698 · Cited by 43 · see citing works
Balancing NAD+ deficits with nicotinamide riboside: therapeutic possibilities and limitations
Cercillieux, A., Ciarlo, E., & Cantó, C. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04499-5 · Cited by 41 · see citing works
“This concept has been recently challenged by the identification of a potential NMN transporter, Slc12a8 [238].”
BackgroundFueling genome maintenance: On the versatile roles of NAD+ in preserving DNA integrity
Ruszkiewicz, J. A., Bürkle, A., & Mangerich, A. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102037 · Cited by 39 · see citing works
“Furthermore, exogenous NMN can be taken up by cells, yet the cellular transport of this precursor molecule remains unclear (18, 19), with some studies suggesting that NMN uptake requires the prior conversion to NR by glyco-hydrolase, cluster of differentiation 73 (CD73) (20, 21).”
BackgroundHunt, N. J., Lockwood, G. P., Kang, S. W. S., Westwood, L. J., Limantoro, C., Chrzanowski, W., McCourt, P., Kuncic, Z., Couteur, D. G. L., & Cogger, V. C. (2021) · ACS Nano · doi:10.1021/acsnano.0c09278 · Cited by 38 · see citing works
Ito, N., Takatsu, A., Ito, H., Koike, Y., Yoshioka, K., Kamei, Y., & Imai, S. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111131 · Cited by 38 · see citing works
Self-citationLavoro, A., Falzone, L., Tomasello, B., Conti, G., Libra, M., & Candido, S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1191262 · Cited by 38 · see citing works
“This gene is a sodium-dependent nicotinamide mononucleotide (NMN) symporter that ensures the Nicotinamide Adenine Dinucleotide (NAD) cell reservoir essential for energy metabolism (Grozio et al., 2019).”
BackgroundBrito, S., Baek, J.-M., Cha, B., Heo, H., Lee, S.-H., Lei, L., Jung, S. Y., Lee, S. M., Lee, S. H., Kwak, B.-M., et al. (2022) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2022.05.002 · Cited by 38 · see citing works
Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis
Cao, T., Ni, R., Ding, W., Ji, X., Fan, G., Zhang, Z., & Peng, T. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04767-3 · Cited by 36 · see citing works
“NR requires NRK1/2 for its conversion to NAD + within cells, while NMN can enter the cells through its receptor Slc12a8 [39].”
Degradation of Extracellular NAD+ Intermediates in Cultures of Human HEK293 Cells
Kulikova, V., Shabalin, K. A., Nerinovski, K., Yakimov, A., Svetlova, M., Solovjeva, L., Kropotov, A., Khodorkovskiy, M., Migaud, M. E., Ziegler, M., et al. (2019) · Metabolites · doi:10.3390/metabo9120293 · Cited by 36 · see citing works
“Moreover, recently the solute carrier SLC12A8 has been described as plasma membrane NMN carrier [25].”
BackgroundSelf-citationHe, Z., Yang, X., Tian, X., Li, L., & Liu, M. (2022) · ACS Synthetic Biology · doi:10.1021/acssynbio.2c00350 · Cited by 35 · see citing works
NAD(H) and NADP(H) in plants and mammals
Lu, D., Grant, M., & Lim, B. L. (2025) · Molecular Plant · doi:10.1016/j.molp.2025.05.004 · Cited by 35 · see citing works
Biological synthesis of nicotinamide mononucleotide
Shen, Q., Zhang, S., Xue, Y.-Z., Peng, F., Cheng, D., Xue, Y., & Zheng, Y. (2021) · Biotechnology Letters · doi:10.1007/s10529-021-03191-1 · Cited by 35 · see citing works
Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging
Rahman, S. U., Qadeer, A., & Wu, Z. (2024) · Aging and disease · doi:10.14336/ad.2023.0519-1 · Cited by 34 · see citing works
“However, a recent discovery found a new NMN transporter, solute carrier family 12 member 8 (SLC12A8) in the gut of mice, suggesting that NMN can be directly transported into cells [51] (Fig.”
BackgroundTargeting NAD Metabolism for the Therapy of Age-Related Neurodegenerative Diseases
Li, F., Wu, C., & Wang, G. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01072-3 · Cited by 33 · see citing works
“In 2019, the first NMN transporter Slc12a8 was identified [116], but debate concerning the existence and function of slc12a8 continues [115].”
BackgroundMetabolic Therapy of Heart Failure: Is There a Future for B Vitamins?
Piquereau, J., Boitard, S. E., Ventura‐Clapier, R., & Mericskay, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010030 · Cited by 32 · see citing works
“As mentioned above, NMN may enter some cells through the SLC12A8 transporter [69] or after being dephosphorylated by CD73 to give NR [85,86].”
BackgroundXu, W., Li, L., & Zhang, L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00901 · Cited by 33 · see citing works
Non-canonical roles of NAMPT and PARP in inflammation
Martínez-Morcillo, F. J., Cantón-Sandoval, J., Martínez‐Menchón, T., Corbalán-Vélez, R., Mesa-del-Castillo, P., Pérez‐Oliva, A. B., García‐Moreno, D., & Mulero, V. (2020) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2020.103881 · Cited by 32 · see citing works
Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases
Rotllán, N., Camacho, M., Tondo, M., Diarte‐Añazco, E. M. G., Canyelles, M., Méndez‐Lara, K. A., Benı́tez, S., Alonso, N., Mauricio, D., Escolá‐Gil, J. C., et al. (2021) · Antioxidants · doi:10.3390/antiox10121939 · Cited by 31 · see citing works
“, Slc12a8) exists in murine small intestinal epithelium [58].”
BackgroundNAD + Precursors in Human Health and Disease: Current Status and Future Prospects
Yaku, K., & Nakagawa, T. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0354 · Cited by 31 · see citing works
“Grozio et al. (2019b) reported that NMN was directly taken up through Slc12a8 in a sodium-dependent manner.”
TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity
Ugamraj, H. S., Dang, K. H., Ouisse, L., Buelow, B., Chini, E. N., Castello, G., Allison, J., Clarke, S., Davison, L. M., Buelow, R., et al. (2022) · mAbs · doi:10.1080/19420862.2022.2095949 · Cited by 31 · see citing works
“Recently, a membrane protein, SLC12A8, that may be responsible for the import of NMN into cells was identified.(42) We postulate that the inhibition of extracellular CD38 NADase and NMNase activities by TNB738 prevents the breakdown of extracellular NAD+ and NMN, which subsequently allows uptake into cells, leading to…”
BackgroundImplications of NAD + boosters in translational medicine
Kang, B. E., Choi, J., Stein, S., & Ryu, D. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13334 · Cited by 32 · see citing works
Nakkina, S. P., Gitto, S. B., Pandey, V., Parikh, J. G., Geerts, D., Maurer, H. C., Olive, K. P., Phanstiel, O., & Altomare, D. A. (2021) · Cancers · doi:10.3390/cancers13246391 · Cited by 30 · see citing works
“SLC12A8 has been suggested as an ornithine/polyamine transporter [39–41] and more recently as a nicotinamide mononucleotide transporter [42].”
BackgroundCellular and Mitochondrial NAD Homeostasis in Health and Disease
Waddell, J., Khatoon, R., & Kristián, T. (2023) · Cells · doi:10.3390/cells12091329 · Cited by 30 · see citing works
“Although an NMN-specific transporter SLC12A8 was recently identified, its intracellular or mitochondrial localization has not been reported [16].”
BackgroundImai, S. (2025) · npj Aging · doi:10.1038/s41514-025-00192-6 · Cited by 29 · see citing works
Self-citationCan nicotinamide riboside protect against cognitive impairment?
Braidy, N., & Liu, Y. (2020) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000691 · Cited by 29 · see citing works
NMN: The NAD precursor at the intersection between axon degeneration and anti-ageing therapies
Loreto, A., Antoniou, C., Merlini, E., Gilley, J., & Coleman, M. P. (2023) · Neuroscience Research · doi:10.1016/j.neures.2023.01.004 · Cited by 30 · see citing works
- Authors
- Grozio, A., Mills, K. F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, H. C., Cunningham, R., Sasaki, Y., Migaud, M. E., & Imai, S.-I.
- Affiliations
- Washington University in St. Louis (US)
- University of Genoa (IT)
- USA Mitchell Cancer Institute (US)
- Corresponding author
- Imai, Shin-ichiro
- ORCID
- Venue
- Nature Metabolism
- Published
- 2019-01-07
- Volume
- 1
- Issue
- 1
- Pages
- 47-57
- ISSN
- 2522-5812 (ISSN-L)
- PMC
- PMC6530925
- OpenAlex
- W2903854778
- Cited by
- 287
- References
- 48
- Citations by year
- 2026: 33 · 2025: 37 · 2024: 41 · 2023: 48 · 2022: 39 · 2021: 33 · 2020: 31 · 2019: 22 · 2018: 1
- FWCI
- 12.04
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-07-12)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Funders
- National Institutes of Health (1c06rr015502-01, UL1TR002345)
- Biotechnology and Biological Sciences Research Council (BB/N001842/1)
- National Institute on Aging (R01AG024150, R01AG037457, R01AG047902)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056341, P30DK020579)
- National Center for Research Resources (C06-RR-015502)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- NAD+ metabolism, small intestine, sodium-dependent transport, aging, nicotinamide riboside, NAD biosynthesis
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