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Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity
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“The strongest evidence for a direct role of tau in RNA regulation is that physiological tau regulates TIA1-associated RNA granule trafficking as well as the TIA1 interactome in primary cultures of mouse hippocampal neurons 4 .”
From Tau is an m 6 A-associated RNA binding protein that causes RNA dysregulation in disease (2026) · cites this paper as [4]
In the citing paper
“A growing body of evidence implicates interactions between pathogenic tau, RNA, and RNA-binding proteins (RBPs) in disease pathogenesis 3-13 .”
From Tau is an m 6 A-associated RNA binding protein that causes RNA dysregulation in disease (2026) · cites this paper as [4]
In the citing paper
“RBPs constitute a large fraction of the tau interactome 11 , and pathogenic tau can have aberrant interactions with RBPs, leading to downstream consequences in cellular and RNA-related phenotypes 3,4,9,10,14-16 .”
From Tau is an m 6 A-associated RNA binding protein that causes RNA dysregulation in disease (2026) · cites this paper as [4]
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“Physiological tau is known to regulate TIA1associated RNA granule trafficking as well as the TIA1 interactome in primary cultures of mouse hippocampal neurons 4 .”
From Tau is an m 6 A-associated RNA binding protein that causes RNA dysregulation in disease (2026) · cites this paper as [4]
In the citing paper
“Previous studies suggest that tau pathology is associated with strong changes in the biology of RNA binding proteins (RBPs) as well as the nuclear membrane”
From Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy (2021) · cites this paper as Vanderweyde et al., 2016
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Cites
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“Under basal conditions, tau is present in dendrites only at low levels but localizes to the somatodendritic compartment during stress (Frandemiche et al., 2014; Hoover et al., 2010; Zempel et al., 2013; Zempel and Mandelkow, 2014).”
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Metadata
- Authors
- Vanderweyde, T., Apicco, D. J., Youmans-Kidder, K., Ash, P. E. A., Cook, C., Lummertz da Rocha, E., Jansen-West, K., Frame, A. A., Citro, A., Leszyk, J. D., Ivanov, P., Abisambra, J. F., Steffen, M., Li, H., Petrucelli, L., & Wolozin, B.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 15
- Issue
- 7
- Pages
- 1455-1466
- ISSN
- 2211-1247
- PMC
- PMC5325702
- Cited by
- 342
- References
- 5
- Language
- en
- Licence
- Funders
- CurePSP
- U.S. Department of Defense (AG042213, 11811993)
- BrightFocus Foundation
- National Institutes of Health (ES020395, NS089544, AG050471)
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