Tau biology, tauopathy, traumatic brain injury, and diagnostic challenges

Castellani, Rudy J.; Perry, George

doi:10.3233/jad-180721

Cited by 110Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Tau biology, tauopathy, traumatic brain injury, and diagnostic challenges

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Castellani, Rudy J., Perry, George·2019·Journal of Alzheimer’s Disease

DOI 10.3233/jad-180721PMC PMC6398540

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Abstract

There is considerable interest in the pathobiology of tau protein, given its potential role in neurodegenerative diseases and aging. Tau is an important microtubule associated protein, required for the assembly of tubulin into microtubules and maintaining structural integrity of axons. Tau has other diverse cellular functions involving signal transduction, cellular proliferation, developmental neurobiology, neuroplasticity, and synaptic activity. Alternative splicing results in tau isoforms with differing microtubule binding affinity, differing representation in pathological inclusions in certain disease states, and differing roles in developmental biology and homeostasis. Tau haplotypes confer differing susceptibility to neurodegeneration. Tau phosphorylation is a normal metabolic process, critical in controlling tau’s binding to microtubules, and is ongoing within the brain at all times. Tau may be hyperphosphorylated, and may aggregate as detectable fibrillar deposits in tissues, in both aging and neurodegenerative disease. The hypothesis that p-tau is neurotoxic has prompted constructs related to isomers, low-n assembly intermediates or oligomers, and the “tau prion”. Human postmortem studies have elucidated broad patterns of tauopathy, with tendencies for those patterns to differ as a function of disease phenotype. However, there is extensive overlap, not only between genuine neurodegenerative diseases, but also between aging and disease. Recent studies highlight uniqueness to pathological patterns, including a pattern attributed to repetitive head trauma, although clinical correlations have been elusive. The diagnostic process for tauopathies and neurodegenerative diseases in general is challenging in many respects, and may be particularly problematic for postmortem evaluation of former athletes and military service members.

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Tau phosphorylation at threonine 231 is one of the earliest events in the cascade of phosphorylation and modulates tubulin assembly.
“Tau phosphorylation at threonine 231 is one of the earliest events in the cascade of phosphorylation,57 that modulates tubulin assembly.58”
From Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease (2022) · cites this paper as [57]
In “Tau protein phosphorylation and hyperphosphorylation” (page unavailable), the paper discusses phosphorylated tau at the Thr231 proline motif, but does not say Thr231 phosphorylation is among the earliest events in a phosphorylation cascade. “Normal tau function” (page unavailable) says tau promotes tubulin polymerization, but does not link that effect specifically to Thr231 phosphorylation; the citing sentence attaches a separate citation to its assembly clause. (LLM, conf=0.78)
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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
The amyloid hypothesis of Alzheimer's disease at 25 years
Selkoe, D. J., & Hardy, J. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606210 · Cited by 6,164 · see citing works
Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium
McKeith, I. G., Boeve, B. F., Dickson, D. W., Halliday, G., Taylor, J.-P., Weintraub, D., Aarsland, D., Galvin, J., Attems, J., Ballard, C. G., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004058 · Cited by 4,476 · see citing works
Protein aggregation and neurodegenerative disease
Ross, C. A., & Poirier, M. A. (2004) · Nature Medicine · doi:10.1038/nm1066 · Cited by 3,454 · see citing works
A protein factor essential for microtubule assembly
Weingarten, M. D., Lockwood, A. H., Hwo, S. Y., & Kirschner, M. W. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.5.1858 · Cited by 3,089 · see citing works
Primary Progressive Aphasia
Weıntraub, S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530120075013 · Cited by 3,012 · see citing works
National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach
Montine, T. J., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0910-3 · Cited by 2,992 · cited 1× · see citing works
“unless the pathology is end-stage [119].”
Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease
Goedert, M., Spillantini, M. G., Jakes, R., Rutherford, D., & Crowther, R. A. (1989) · Neuron · doi:10.1016/0896-6273(89)90210-9 · Cited by 2,492 · see citing works
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.010 · Cited by 2,208 · see citing works
Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years
Braak, H., Thal, D. R., Ghebremedhin, E., & Del Tredici, K. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318232a379 · Cited by 2,194 · see citing works
The spectrum of disease in chronic traumatic encephalopathy
McKee, A. C., Stein, T. D., Nowinski, C. J., Stern, R. A., Daneshvar, D. H., Alvarez, V. E., Lee, H.-S., Hall, G., Wojtowicz, S. M., Baugh, C. M., et al. (2013) · Brain · doi:10.1093/brain/aws307 · Cited by 2,098 · see citing works
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works
Self-citation
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
SantaCruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., Guimaraes, A., DeTure, M., Ramsden, M., McGowan, E., et al. (2005) · Science · doi:10.1126/science.1113694 · Cited by 2,014 · see citing works
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.
Buée, L., Bussière, T., Buée‐Scherrer, V., Delacourte, A., & Hof, P. R. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00019-9 · Cited by 2,007 · see citing works
Transmission and spreading of tauopathy in transgenic mouse brain
Clavaguera, F., Bolmont, T., Crowther, R. A., Abramowski, D., Frank, S., Probst, A., Fraser, G., Stalder, A. K., Beibel, M., Staufenbiel, M., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1901 · Cited by 1,803 · see citing works
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.
Grundke, I., Iqbal, K., Quinlan, M., Tung, Y. C., Zaidi, M. S., & Wisniewski, H. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38495-8 · Cited by 1,780 · see citing works
Primary age-related tauopathy (PART): a common pathology associated with human aging
Crary, J. F., Trojanowski, J. Q., Schneider, J. A., Abisambra, J. F., Abner, E. L., Alafuzoff, I., Arnold, S. E., Attems, J., Beach, T. G., Bigio, E. H., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1349-0 · Cited by 1,467 · see citing works
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
de Calignon, A., Polydoro, M., Suárez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.033 · Cited by 1,427 · see citing works
Propagation of Tau Misfolding from the Outside to the Inside of a Cell
Frost, B., Jacks, R. L., & Diamond, M. I. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808759200 · Cited by 1,252 · see citing works
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration
Cairns, N. J., Bigio, E. H., Mackenzie, I. R. A., Neumann, M., Lee, V. M.-Y., Hatanpaa, K. J., White, C. L., Schneider, J. A., Grinberg, L. T., Halliday, G., et al. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0237-2 · Cited by 1,110 · see citing works
Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football
Mez, J., Daneshvar, D. H., Kiernan, P. T., Abdolmohammadi, B., Alvarez, V. E., Huber, B. R., Alosco, M. L., Solomon, T. M., Nowinski, C. J., McHale, L., et al. (2017) · JAMA · doi:10.1001/jama.2017.8334 · Cited by 1,098 · see citing works
Cloning and sequencing of the cDNA encoding an isoform of microtubule‐associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.
Goedert, M., Spillantini, M. G., Potier, M. C., Ulrich, J., & Crowther, R. A. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03390.x · Cited by 1,037 · see citing works
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
Goedert, M., Jakes, R., Spillantini, M. G., Hasegawa, M., Smith, M. J., & Crowther, R. A. (1996) · Nature · doi:10.1038/383550a0 · Cited by 1,036 · see citing works
Differential Regulation of Dynein and Kinesin Motor Proteins by Tau
Dixit, R., Ross, J. L., Goldman, Y. E., & Holzbaur, E. L. F. (2008) · Science · doi:10.1126/science.1152993 · Cited by 1,012 · see citing works
Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17
Hong, M. (1998) · Science · doi:10.1126/science.282.5395.1914 · Cited by 1,003 · see citing works
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
Augustinack, J. C., Schneider, A., Mandelkow, E.-M., & Hyman, B. T. (2002) · Acta Neuropathologica · doi:10.1007/s004010100423 · Cited by 998 · see citing works
What does it mean to be natively unfolded?
Uversky, V. N. (2002) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2001.02649.x · Cited by 985 · see citing works
Dentritic spines : structure, dynamics and regulation
Hering, H., & Sheng, M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35104061 · Cited by 961 · see citing works
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.
Wischik, C. M., Novak, M., Thøgersen, H. C., Edwards, P. C., Runswick, M. J., Jakes, R., Walker, J. E., Milstein, C., Roth, M., & Klug, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.12.4506 · Cited by 939 · see citing works
Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization.
Goedert, M., & Jakes, R. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07870.x · Cited by 929 · see citing works
Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin
Cleveland, D. W., Hwo, S.-Y., & Kirschner, M. W. (1977) · Journal of Molecular Biology · doi:10.1016/0022-2836(77)90213-3 · Cited by 915 · see citing works
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
Bramblett, G. T., Goedert, M., Jakes, R., Merrick, S. E., Trojanowski, J. Q., & Lee, V. M. Y. (1993) · Neuron · doi:10.1016/0896-6273(93)90057-x · Cited by 903 · see citing works
Phosphorylation affects the ability of tau protein to promote microtubule assembly.
Lindwall, G., & Cole, R. D. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42989-9 · Cited by 901 · see citing works
Documented head injury in early adulthood and risk of Alzheimer’s disease and other dementias
Plassman, B. L., Havlik, R. J., Steffens, D. C., Helms, M. J., Newman, T. N., Drosdick, D., Phillips, C., Gau, B. A., Welsh–Bohmer, K. A., Burke, J. R., et al. (2000) · Neurology · doi:10.1212/wnl.55.8.1158 · Cited by 896 · see citing works
Chronic Traumatic Encephalopathy in a National Football League Player
Omalu, B. I., DeKosky, S. T., Minster, R. L., Kamboh, M. I., Hamilton, R. L., & Wecht, C. H. (2005) · Neurosurgery · doi:10.1227/01.neu.0000163407.92769.ed · Cited by 894 · see citing works
The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy
the TBI/CTE group, McKee, A. C., Cairns, N. J., Dickson, D. W., Folkerth, R. D., Dirk Keene, C., Litvan, I., Perl, D. P., Stein, T. D., Vonsattel, J.-P., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1515-z · Cited by 885 · see citing works
Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease
Mori, H., Kondo, J., & Ihara, Y. (1987) · Science · doi:10.1126/science.3029875 · Cited by 843 · see citing works
Biochemistry and Cell Biology of Tau Protein in Neurofibrillary DegenerationPreprint
Mandelkow, E., & Mandelkow, E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006247 · Cited by 839 · see citing works
The aftermath of boxing
Corsellis, J. A. N., Bruton, C. J., & Freeman-Browne, D. (1973) · Psychological Medicine · doi:10.1017/s0033291700049588 · Cited by 836 · see citing works
A common inversion under selection in Europeans
Stefánsson, H., Helgason, A., Þorleifsson, G., Steinthórsdóttir, V., Másson, G., Barnard, J., Baker, A., Jónasdóttir, Á., Ingason, A., Gudnadottir, V. G., et al. (2005) · Nature Genetics · doi:10.1038/ng1508 · Cited by 830 · see citing works
Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: Implications for Alzheimer’s disease
Ebneth, A., Godemann, R., Stamer, K., Illenberger, S., Trinczek, B., Mandelkow, E.-M., & Mandelkow, E. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.3.777 · Cited by 820 · see citing works
Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease
Bancher, C., Brunner, C., Lassmann, H., Budka, H., Jellinger, K., Wiche, G., Seitelberger, F., Grundke-Iqbal, I., Iqbal, K., & Wisniewski, H. M. (1989) · Brain Research · doi:10.1016/0006-8993(89)91396-6 · Cited by 818 · see citing works
Association of an Extended Haplotype in the Tau Gene with Progressive Supranuclear Palsy
Baker, M., Litvan, I., Houlden, H., Adamson, J., Dickson, D., Perez-Tur, J., Hardy, J., Lynch, T., Bigio, E., & Hutton, M. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.4.711 · Cited by 781 · see citing works
Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.
Köpke, E., Tung, Y. C., Shaikh, S., Alonso, A. C., Iqbal, K., & Grundke-Iqbal, I. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80536-5 · Cited by 779 · see citing works
Punch drunk
MARTLAND, H. S. (1928) · Journal of the American Medical Association · doi:10.1001/jama.1928.02700150029009 · Cited by 774 · see citing works
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
Liu, F., Grundke‐Iqbal, I., Iqbal, K., & Gong, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04391.x · Cited by 759 · see citing works
Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein
Allen, B., Ingram, E., Takao, M., Smith, M. J., Jakes, R., Virdee, K., Yoshida, H., Holzer, M., Craxton, M., Emson, P. C., et al. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09340.2002 · Cited by 746 · see citing works
The acetylation of tau inhibits its function and promotes pathological tau aggregation
Cohen, T. J., Guo, J. L., Hurtado, D. E., Kwong, L. K., Mills, I. P., Trojanowski, J. Q., & Lee, V. M. Y. (2011) · Nature Communications · doi:10.1038/ncomms1255 · Cited by 724 · see citing works
Advanced Maillard reaction end products are associated with Alzheimer disease pathology.
Smith, M. A., Taneda, S., Richey, P. L., Miyata, S., Yan, S. D., Stern, D., Sayre, L. M., Monnier, V. M., & Perry, G. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5710 · Cited by 715 · see citing works
Self-citation
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies
Šimić, G., Leko, M. B., Wray, S., Harrington, C. R., Delalle, I., Milošević, N. J., Bažadona, D., Buée, L., de Silva, R., Giovanni, G. D., et al. (2016) · Biomolecules · doi:10.3390/biom6010006 · Cited by 698 · see citing works
Chronic Traumatic Encephalopathy in a National Football League Player
Kelly, D. F. (2006) · Neurosurgery · doi:10.1097/00006123-200605000-00037 · Cited by 694 · see citing works
CHRONIC TRAUMATIC ENCEPHALOPATHY IN A NATIONAL FOOTBALL LEAGUE PLAYER: PART II
Omalu, B. I., DeKosky, S. T., Hamilton, R. L., Minster, R. L., Kamboh, M. I., Shakir, A. M., & Wecht, C. H. (2006) · Neurosurgery · doi:10.1227/01.neu.0000245601.69451.27 · Cited by 694 · see citing works
Tau protein pathology in neurodegenerative diseases
Spillantini, M. G., & Goedert, M. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01337-x · Cited by 683 · see citing works
Neurodegenerative causes of death among retired National Football League players
Lehman, E. J., Hein, M. J., Baron, S. L., & Gersic, C. M. (2012) · Neurology · doi:10.1212/wnl.0b013e31826daf50 · Cited by 638 · see citing works
Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles
Guo, J. L., & Lee, V. M.-Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.209296 · Cited by 636 · see citing works
Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain.
Brandt, R., Léger, J. G., & Lee, G. S. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.5.1327 · Cited by 624 · see citing works
Neuropathology of Parkinson disease
Dickson, D. W. (2018) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2017.07.033 · Cited by 623 · see citing works
Tau and tauopathies
Arendt, T., Stieler, J. T., & Holzer, M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.08.018 · Cited by 609 · see citing works
Developmentally regulated expression of specific tau sequences
Kosik, K. S., Orecchio, L. D., Bakalis, S., & Neve, R. L. (1989) · Neuron · doi:10.1016/0896-6273(89)90077-9 · Cited by 598 · see citing works
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.
Matsuo, E. S., Shin, R., Billingsley, M., de Voorde, A. V., O'Connor, M., Trojanowski, J., & Lee, V. (1994) · Neuron · doi:10.1016/0896-6273(94)90264-x · Cited by 588 · see citing works
Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2
Neve, R. L., Harris, P. K. W., Kosik, K. S., Kurnit, D. M., & Donlon, T. A. (1986) · Molecular Brain Research · doi:10.1016/0169-328x(86)90033-1 · Cited by 565 · see citing works
In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease
Sayre, L. M., Perry, G. L., Harris, P. L. R., Liu, Y. A., Schubert, K. A., & Smith, M. A. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740270.x · Cited by 538 · see citing works
Self-citation
Aging-related tau astrogliopathy (ARTAG): Harmonized evaluation strategy
Kovacs, G. G., Ferrer, I., Grinberg, L. T., Alafuzoff, I., Attems, J., Budka, H., Cairns, N. J., Crary, J. F., Duyckaerts, C., Ghetti, B., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1509-x · Cited by 532 · see citing works
The occult aftermath of boxing.
Roberts, G. W., Allsop, D., & Bruton, C. (1990) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.5.373 · Cited by 518 · see citing works
Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors.
Drubin, D. G., Feinstein, S. C., Shooter, E. M., & Kirschner, M. W. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.5.1799 · Cited by 510 · see citing works
Invited review: Neuropathology of tauopathies: principles and practice
Kovacs, G. G. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12208 · Cited by 492 · see citing works
Abnormal Alzheimer‐like phosphorylation of tau‐protein by cyclin‐dependent kinases cdk2 and cdk5
Baumann, K., Mandelkow, E., Biernat, J., Piwnica-Worms, H. M., & Mandelkow, E. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80849-p · Cited by 479 · see citing works
The importance of tau phosphorylation for neurodegenerative diseases
Noble, W., Hanger, D. P., Miller, C. C. J., & Lovestone, S. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00083 · Cited by 475 · see citing works
Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.
Strittmatter, W. J., Saunders, A. M., Goedert, M., Weisgraber, K. H., Dong, L. M., Jakes, R., Huang, D. Y., Pericak-Vance, M., Schmechel, D., & Roses, A. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11183 · Cited by 474 · see citing works
Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice
Morris, M., Knudsen, G. M., Maeda, S., Trinidad, J. C., Ioanoviciu, A., Burlingame, A. L., & Mucke, L. (2015) · Nature Neuroscience · doi:10.1038/nn.4067 · Cited by 472 · see citing works
The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System
Tai, H., Serrano‐Pozo, A., Hashimoto, T., Frosch, M. P., Spires‐Jones, T. L., & Hyman, B. T. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.06.033 · Cited by 456 · see citing works
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
Hanger, D. P., Byers, H. L., Wray, S., Leung, K.-Y., Saxton, M. J., Seereeram, A., Reynolds, C. H., Ward, M. A., & Anderton, B. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703269200 · Cited by 455 · see citing works
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
Fulga, T. A., Elson-Schwab, I., Khurana, V., Steinhilb, M. L., Spires, T. L., Hyman, B. T., & Feany, M. B. (2007) · Nature Cell Biology · doi:10.1038/ncb1528 · Cited by 452 · see citing works
Frontotemporal Dementia and Corticobasal Degeneration in a Family with a P301S Mutation in Tau
Bugiani, O., Murrell, J. R., Giaccone, G., Hasegawa, M., Ghigo, G., Tabaton, M., Morbin, M., Primavera, A., Carella, F., Solaro, C., et al. (1999) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199906000-00011 · Cited by 450 · see citing works
Tau prion strains dictate patterns of cell pathology, progression rate, and regional vulnerability in vivo
Kaufman, S. K., Sanders, D. W., Thomas, T. L., Ruchinskas, A. J., Vaquer-Alicea, J., Sharma, A. M., Miller, T. M., & Diamond, M. I. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.055 · Cited by 450 · see citing works
Tau interacts with src-family non-receptor tyrosine kinases
Lee, G. S., Newman, S. T., Gard, D. L., Band, H., & Panchamoorthy, G. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.21.3167 · Cited by 445 · see citing works
Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy
Kondo, A., Shahpasand, K., Mannix, R., Qiu, J., Moncaster, J., Chen, C.-H., Yao, Y., Lin, Y.-M., Driver, J. A., Sun, Y., et al. (2015) · Nature · doi:10.1038/nature14658 · Cited by 445 · see citing works
Invited review: Frontotemporal dementia caused by microtubule‐associated protein tau gene ( MAPT ) mutations: a chameleon for neuropathology and neuroimaging
Ghetti, B. F., Oblak, A. L., Boeve, B. F., Johnson, K. A., Dickerson, B. C., & Goedert, M. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12213 · Cited by 440 · see citing works
Military-related traumatic brain injury and neurodegeneration
McKee, A. C., & Robinson, M. E. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.04.003 · Cited by 423 · see citing works
The neuropathology of sport
McKee, A. C., Daneshvar, D. H., Alvarez, V. E., & Stein, T. D. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1230-6 · Cited by 422 · see citing works
Nuclear Tau, a Key Player in Neuronal DNA Protection
Sultan, A., Nesslany, F., Violet, M., Bégard, S., Loyens, A., Talahari, S., Mansuroglu, Z., Marzin, D., Sergeant, N., Humez, S., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.199976 · Cited by 421 · cited 1× · see citing works
“Nucleolar organization and protection of genomic DNA is still another potential function [83, 84].”
Background
Phosphorylation determines two distinct species of tau in the central nervous system
Papasozomenos, S. C., & Binder, L. I. (1987) · Cell Motility · doi:10.1002/cm.970080303 · Cited by 420 · see citing works
Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations
Mackenzie, I. R., Neumann, M., Bigio, E. H., Cairns, N. J., Alafuzoff, I. I., Kril, J. J., Kovács, G. G., Ghetti, B. F., Halliday, G. M., Holm, I. E., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0460-5 · Cited by 418 · see citing works
Auguste D and Alzheimer's disease
Maurer, K., Volk, S., & Gerbaldo, H. (1997) · The Lancet · doi:10.1016/s0140-6736(96)10203-8 · Cited by 417 · see citing works
Defects in Axonal Elongation and Neuronal Migration in Mice with Disrupted tau and map1b Genes
Takei, Y., Teng, J., Harada, A., & Hirokawa, N. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.5.989 · Cited by 408 · see citing works
Association of Mild Traumatic Brain Injury With and Without Loss of Consciousness With Dementia in US Military Veterans
Barnes, D. E., Byers, A. L., Gardner, R. C., Seal, K. H., Boscardin, W. J., & Yaffe, K. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.0815 · Cited by 398 · see citing works
Tau proteins: the molecular structure and mode of binding on microtubules.
Hirokawa, N., Shiomura, Y., & Okabe, S. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.4.1449 · Cited by 389 · see citing works
Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes.
LoPresti, P., Szuchet, S., Papasozomenos, S. C., Zinkowski, R. P., & Binder, L. I. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10369 · Cited by 388 · see citing works
Emerging histomorphologic phenotypes of chronic traumatic encephalopathy in American athletes
Omalu, B., Bailes, J., Hamilton, R. L., Kamboh, M. I., Hammers, J., Case, M., & Fitzsimmons, R. (2011) · Neurosurgery · doi:10.1227/neu.0b013e318212bc7b · Cited by 381 · see citing works
Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)
Dickson, D. W., Kouri, N., Murray, M. E., & Josephs, K. A. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9589-0 · Cited by 380 · see citing works
Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.
Schweers, O., Mandelkow, E., Biernat, J., & Mandelkow, E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8463 · Cited by 379 · see citing works
α-Synuclein Binds to Tau and Stimulates the Protein Kinase A-catalyzed Tau Phosphorylation of Serine Residues 262 and 356
Jensen, P. H., Hager, H., Nielsen, M. S., Højrup, P., Gliemann, J., & Jakes, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25481 · Cited by 377 · see citing works
The Microtubule-associated Protein Tau Is Extensively Modified with O-linked N-acetylglucosamine
Arnold, C. S., Johnson, G. W., Cole, R. N., Dong, D. L.-Y., Lee, M., & Hart, G. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.28741 · Cited by 361 · see citing works
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1
Crook, R., Verkkoniemi, A., Pérez‐Tur, J., Mehta, N. D., Baker, M. C., Houlden, H., Farrer, M. J., Hutton, M., Lincoln, S., Hardy, J., et al. (1998) · Nature Medicine · doi:10.1038/nm0498-452 · Cited by 347 · see citing works
Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity
Vanderweyde, T. E., Apicco, D. J., Youmans-Kidder, K., Ash, P. E. A., Cook, C. N., da Rocha, E. L., Jansen‐West, K. R., Frame, A. A., Citro, A., Leszyk, J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.045 · Cited by 346 · see citing works
Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments
Spillantini, M. G., Goedert, M., Crowther, R. A., Murrell, J. R., Farlow, M. R., & Ghetti, B. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4113 · Cited by 334 · see citing works
MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments
Al-Bassam, J., Ozer, R. S., Safer, D., Halpain, S., & Milligan, R. A. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201048 · Cited by 327 · see citing works
Neuronal cytoskeletal changes are an early consequence of repetitive head injury
Geddes, J. F., Vowles, G. H., Nicoll, J. A. R., & Révész, T. (1999) · Acta Neuropathologica · doi:10.1007/s004010051066 · Cited by 323 · see citing works
Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank
Bieniek, K. F., Ross, O. A., Cormier, K. A., Walton, R. L., Soto-Ortolaza, A., Johnston, A. E., DeSaro, P., Boylan, K. B., Graff-Radford, N. R., Wszolek, Z. K., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1502-4 · Cited by 323 · see citing works
Long-term risk of dementia among people with traumatic brain injury in Denmark: a population-based observational cohort study
Fann, J. R., Ribe, A. R., Pedersen, H. S., Fenger-Grøn, M., Christensen, J., Benros, M. E., & Vestergaard, M. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30065-8 · Cited by 322 · see citing works
Molecular Pathological Classification of Neurodegenerative Diseases: Turning towards Precision Medicine
Kovács, G. G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020189 · Cited by 321 · see citing works
Structure of the Bovine Tau Gene: Alternatively Spliced Transcripts Generate a Protein Family
Himmler, A. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.4.1389 · Cited by 319 · see citing works
Early experience of tactile stimulation influences organization of somatic sensory cortex
Simons, D. J., & Land, P. W. (1987) · Nature · doi:10.1038/326694a0 · Cited by 319 · see citing works
Small Ubiquitin-like Modifier (SUMO) Modification of Natively Unfolded Proteins Tau and α-Synuclein
Dorval, V., & Fraser, P. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510127200 · Cited by 319 · see citing works
Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases
Andreadis, A. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.08.010 · Cited by 311 · see citing works
Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation
Cash, A., Aliev, G. M., Siedlak, S. L., Nunomura, A., Fujioka, H., Zhu, X., Raina, A. K., Vinters, H. V., Tabaton, M., Johnson, T., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64296-4 · Cited by 309 · see citing works
Self-citation
Microtubule-associated protein tau is essential for long-term depression in the hippocampus
Kimura, T., Whitcomb, D. J., Jo, J., Regan, P., Piers, T., Heo, S., Brown, C., Hashikawa, T., Murayama, M., Seok, H., et al. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2013.0144 · Cited by 307 · see citing works
The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments
Jeganathan, S., von Bergen, M., Mandelkow, E.-M., & Mandelkow, E. (2008) · Biochemistry · doi:10.1021/bi800783d · Cited by 286 · see citing works
Calcium Signaling in Smooth MusclePreprint
Hill‐Eubanks, D. C., Werner, M. E., Heppner, T. J., & Nelson, M. T. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004549 · Cited by 281 · see citing works
Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration
Pittman, A. M., Myers, A. J., Abou‐Sleiman, P. M., Fung, H., Kaleem, M., Marlowe, L., Duckworth, J., Leung, D. G., Williams, D. R., Kilford, L., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.031377 · Cited by 275 · see citing works
Argyrophilic Grain Disease Is a Sporadic 4-Repeat Tauopathy
Togo, T., Sahara, N., Yen, S.-H., Cookson, N., Ishizawa, T., Hutton, M., de Silva, R., Lees, A., & Dickson, D. W. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.6.547 · Cited by 273 · see citing works
Activity-Dependent Tau Protein Translocation to Excitatory Synapse Is Disrupted by Exposure to Amyloid-Beta Oligomers
Frandemiche, M. L., De Seranno, S., Rush, T., Borel, E., Elie, A., Arnal, I., Lanté, F., & Buisson, A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4261-13.2014 · Cited by 272 · see citing works
Stress Acts Cumulatively To Precipitate Alzheimer's Disease-Like Tau Pathology and Cognitive Deficits
Sotiropoulos, I., Catania, C., Pinto, L., Silva, R., Pollerberg, G. E., Takashima, A., Sousa, N. J., & Almeida, O. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0730-11.2011 · Cited by 265 · see citing works
Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene
Stanford, P. M., Halliday, G. M., Brooks, W. S., Kwok, J. B. J., Storey, C. E., Creasey, H., Morris, J. G. L., Fulham, M. J., & Schofield, P. R. (2000) · Brain · doi:10.1093/brain/123.5.880 · Cited by 262 · see citing works
Alterations in Glucose Metabolism Induce Hypothermia Leading to Tau Hyperphosphorylation through Differential Inhibition of Kinase and Phosphatase Activities: Implications for Alzheimer's Disease
Planel, E., Miyasaka, T., Launey, T., Chui, D.-H., Tanemura, K., Sato, S., Murayama, O., Ishiguro, K., Tatebayashi, Y., & Takashima, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5561-03.2004 · Cited by 261 · see citing works
Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease
Nakamura, K., Greenwood, A., Binder, L. I., Bigio, E. H., Denial, S., Nicholson, L. K., Zhou, X. Z., & Lu, K. P. (2012) · Cell · doi:10.1016/j.cell.2012.02.016 · Cited by 255 · see citing works
Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) players
Ling, H., Morris, H. R., Neal, J. W., Lees, A. J., Hardy, J., Holton, J. L., Revesz, T., & Williams, D. D. R. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1680-3 · Cited by 252 · see citing works
Tau Binds to the Distal Axon Early in Development of Polarity in a Microtubule- and Microfilament-Dependent Manner
Kempf, M., Clement, A. M., Faissner, A., Lee, G. S., & Brandt, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-18-05583.1996 · Cited by 248 · see citing works
Characterisation of interface astroglial scarring in the human brain after blast exposure: a post-mortem case series
Shively, S. B., Horkayne‐Szakaly, I., Jones, R. V., Kelly, J. P., Armstrong, R. C., & Perl, D. P. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30057-6 · Cited by 244 · see citing works
Alz-50, Ubiquitin and Tau Immunoreactivity of Neurofibrillary Tangles, Pick Bodies and Lewy Bodies
Love, S., Saitoh, T., Quijada, S., Cole, G. M., & Terry, R. D. (1988) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198807000-00001 · Cited by 242 · see citing works
Primary structure of high molecular weight tau present in the peripheral nervous system.
Couchie, D., Mavilia, C., Georgieff, I. S., Liem, R. K. H., Shelanski, M. L., & Nunez, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4378 · Cited by 241 · see citing works
The amino terminus of tau inhibits kinesin‐dependent axonal transport: Implications for filament toxicity
LaPointe, N. E., Morfini, G. A., Pigino, G. F., Gaisina, I. N., Kozikowski, A. P., Binder, L. I., & Brady, S. T. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21850 · Cited by 240 · see citing works
Hyperphosphorylation of tau in PHF.
Morishima-kawashima, M., Hasegawa, M., Takio, K., Suzuki, M., Yoshida, H., Watanabe, A., Titani, K., & Ihara, Y. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00027-c · Cited by 238 · see citing works
Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments.
Księżak-Reding, H., Liu, W.-K., & Shu, H.-Y. C. (1992) · Brain Research · doi:10.1016/0006-8993(92)91476-u · Cited by 237 · see citing works
Chronic traumatic encephalopathy in an Iraqi war veteran with posttraumatic stress disorder who committed suicide
Omalu, B. I., Hammers, J., Bailes, J. E., Hamilton, R. L., Kamboh, M. I., Webster, G., & Fitzsimmons, R. P. (2011) · Neurosurgical FOCUS · doi:10.3171/2011.9.focus11178 · Cited by 235 · see citing works
Tau-Mediated Cytotoxicity in a Pseudohyperphosphorylation Model of Alzheimer's Disease
Fath, T., Eidenmüller, J., & Brandt, R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09733.2002 · Cited by 233 · see citing works
τ in Paired Helical Filaments Is Functionally Distinct from Fetal τ: Assembly Incompetence of Paired Helical Filament‐τ
Yoshida, H., & Ihara, Y. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03642.x · Cited by 232 · see citing works
Soluble forms of tau are toxic in Alzheimer's disease
Kopeikina, K., Hyman, B., & Spires-Jones, T. (2012) · Translational Neuroscience · doi:10.2478/s13380-012-0032-y · Cited by 232 · see citing works
Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease
Schmidt, M., Zhukareva, V., Newell, K., Lee, V., & Trojanowski, J. (2001) · Acta Neuropathologica · doi:10.1007/s004010000330 · Cited by 230 · see citing works
Interaction of Tau with the Neural Membrane Cortex Is Regulated by Phosphorylation at Sites That Are Modified in Paired Helical Filaments
Maas, T., Eidenmüller, J., & Brandt, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000389200 · Cited by 226 · see citing works
Disease-related Modifications in Tau Affect the Interaction between Fyn and Tau
Bhaskar, K., Yen, S.-H. C., & Lee, G. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505895200 · Cited by 223 · see citing works
Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
Lewis, J. M., & Dickson, D. W. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1507-z · Cited by 221 · see citing works
Nitration of Tau Protein Is Linked to Neurodegeneration in Tauopathies
Horiguchi, T., Uryu, K., Giasson, B. I., Ischiropoulos, H., Lightfoot, R. T., Bellmann, C., Richter‐Landsberg, C., Lee, V. M. ‐., & Trojanowski, J. Q. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63462-1 · Cited by 220 · see citing works
Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy
Kouri, N., Ross, O. A., Dombroski, B., Younkin, C. S., Serie, D. J., Soto-Ortolaza, A., Baker, M., Finch, N. C. A., Yoon, H., Kim, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms8247 · Cited by 219 · see citing works
Identification of nuclear tau isoforms in human neuroblastoma cells.
Loomis, P. A., Howard, T. H., Castleberry, R. P., & Binder, L. I. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8422 · Cited by 217 · see citing works
Glial and Neuronal Tau Pathology in Tauopathies: Characterization of Disease-Specific Phenotypes and Tau Pathology Progression
Ferrer, I., López-González, I., Carmona, M., Arregui, L., Dalfó, E., Torrejón-Escribano, B., Diehl, R., & Kovacs, G. G. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000030 · Cited by 217 · see citing works
Tau-dependent microtubule disassembly initiated by prefibrillar β-amyloid
King, M. E., Kan, H.-M., Baas, P. W., Erişir, A., Glabe, C. G., & Bloom, G. S. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200605187 · Cited by 215 · see citing works
Tau Phosphorylation and Sevoflurane Anesthesia: An Association to Postoperative Cognitive Impairment
Le Freche, H., Brouillette, J., Fernandez-Gomez, F.-J., Patin, P., Caillierez, R., Zommer, N., Sergeant, N., Buée-Scherrer, V., Lebuffe, G., Blum, D., et al. (2012) · Anesthesiology · doi:10.1097/aln.0b013e31824be8c7 · Cited by 212 · see citing works
Proapoptotic Effects of Tau Cleavage Product Generated by Caspase-3
Chung, C.-W., Song, Y.-H., Kim, I.-K., Yoon, W. J., Ryu, B. R., Jo, D., Woo, H., Kwon, Y.-K., Kim, H., Gwag, B.-J., et al. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0335 · Cited by 211 · see citing works
Globular glial tauopathies (GGT): consensus recommendations
Ahmed, Z., Bigio, E. H., Budka, H., Dickson, D. W., Ferrer, I., Ghetti, B. F., Giaccone, G., Hatanpaa, K. J., Holton, J. L., Josephs, K. A., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1171-0 · Cited by 205 · see citing works
Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders
Uversky, V. N. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00018 · Cited by 204 · see citing works
Co-Localization of Amyloid Beta and Tau Pathology in Alzheimer's Disease Synaptosomes
Fein, J. A., Sokolow, S., Miller, C. A., Vinters, H. V., Yang, F., Cole, G. M., & Gylys, K. H. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070829 · Cited by 203 · see citing works
Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD
Regan, P., Piers, T., Yi, J.-H., Kim, D.-H., Huh, S., Park, S. J., Ryu, J. H., Whitcomb, D. J., & Cho, K. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2842-14.2015 · Cited by 202 · see citing works
Active glycation in neurofibrillary pathology of Alzheimer disease: Nε-(Carboxymethyl) lysine and hexitol-lysine
Castellani, R. J., Harris, P. L. R., Sayre, L. M., Fujii, J., Taniguchi, N., Vitek, M. P., Founds, H., Atwood, C., Perry, G. L., & Smith, M. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00570-6 · Cited by 198 · see citing works
Self-citation
Re-examination of ex-boxers' brains using immunohistochemistry with antibodies to amyloid ?-protein and tau protein
Tokuda, T., Ikeda, S., Yanagisawa, N., Ihara, Y., & Glenner, G. G. (1991) · Acta Neuropathologica · doi:10.1007/bf00308813 · Cited by 197 · see citing works
Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge City over-75s cohort (CC75C) study
Brayne, C., the Cambridge City over-75s Cohort (CC75C) study neuropathology collaboration, Richardson, K., Matthews, F. E., Fleming, J., Hunter, S., Xuereb, J. H., Paykel, E., Mukaetova-Ladinska, E. B., Huppert, F. A., et al. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1182 · Cited by 191 · see citing works
Tau Oligomers Impair Artificial Membrane Integrity and Cellular Viability
Flach, K., Hilbrich, I., Schiffmann, A., Gärtner, U., Krüger, M., Leonhardt, M., Waschipky, H., Wick, L., Arendt, T., & Holzer, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.396176 · Cited by 188 · see citing works
Body Mass Index, Playing Position, Race, and the Cardiovascular Mortality of Retired Professional Football Players
Baron, S., Hein, M. J., Lehman, E. J., & Gersic, C. M. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.10.050 · Cited by 185 · see citing works
PP2A Regulates Tau Phosphorylation Directly and also Indirectly via Activating GSK-3β
Qian, W., Shi, J., Yin, X., Iqbal, K., Grundke-Iqbal, I., Gong, C., & Liu, F. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1317 · Cited by 185 · see citing works
Alzheimer disease pathology as a host response
Castellani, R. J., Lee, H.-G., Zhu, X., Perry, G., & Smith, M. A. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318177eaf4 · Cited by 171 · see citing works
Self-citation
Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization
Sjöberg, M. K., Shestakova, E., Mansuroglu, Z., Maccioni, R. B., & Bonnefoy, E. (2006) · Journal of Cell Science · doi:10.1242/jcs.02907 · Cited by 166 · see citing works
Axonal Tau mRNA Localization Coincides with Tau Protein in Living Neuronal Cells and Depends on Axonal Targeting Signal
Aronov, S., Aranda, G., Behar, L., & Ginzburg, I. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06577.2001 · Cited by 165 · see citing works
Dementia pugilistica mit anatomischem Befund
Brandenburg, W., & Hallervorden, J. (1954) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00955101 · Cited by 164 · see citing works
“New Old Pathologies”: AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)
Nelson, P. T., Trojanowski, J. Q., Abner, E. L., Al-Janabi, O. M., Jicha, G. A., Schmitt, F. A., Smith, C. D., Fardo, D. W., Wang, W.-X., Kryscio, R. J., et al. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw033 · Cited by 158 · see citing works
Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae
Albayram, Ö., Kondo, A., Mannix, R., Smith, C., Tsai, C.-Y., Li, C., Herbert, M. K., Qiu, J., Monuteaux, M. C., Driver, J. A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01068-4 · Cited by 152 · see citing works
Transgenic Mouse Model of Tauopathies with Glial Pathology and Nervous System Degeneration
Higuchi, M., Ishihara, T., Zhang, B., Hong, M., Andreadis, A., Trojanowski, J. Q., & Lee, V. M. ‐. (2002) · Neuron · doi:10.1016/s0896-6273(02)00789-4 · Cited by 149 · see citing works
Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy
Puvenna, V., Engeler, M., Banjara, M., Brennan, C., Schreiber, P., Dadas, A., Bahrami, A., Solanki, J., Bandyopadhyay, A., Morris, J. K., et al. (2016) · Brain Research · doi:10.1016/j.brainres.2015.11.007 · Cited by 144 · see citing works
Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice
Stancu, I.-C., Vasconcelos, B., Ris, L., Wang, P., Villers, A., Peeraer, E., Buist, A., Terwel, D., Baatsen, P., Oyelami, T., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1413-4 · Cited by 143 · see citing works
Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D2concept
Uversky, V. N. (2010) · Expert Review of Proteomics · doi:10.1586/epr.10.36 · Cited by 141 · see citing works
Activation of the DNA Damage Response by RNA Viruses
Ryan, E. L., Hollingworth, R., & Grand, R. J. A. (2016) · Biomolecules · doi:10.3390/biom6010002 · Cited by 136 · see citing works
Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain
Kovács, G. G., Xie, S. X., Robinson, J. L., Lee, E. B., Smith, D. H., Schuck, T., Lee, V. M. ‐., & Trojanowski, J. Q. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0552-y · Cited by 133 · see citing works
A novel tau transcript in cultured human neuroblastoma cells expressing nuclear tau.
Wang, Y., Loomis, P. A., Zinkowski, R. P., & Binder, L. I. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.2.257 · Cited by 132 · see citing works
Insulin dysfunction and Tau pathology
Khoury, N. B. E., Gratuze, M., Papon, M.-A., Bretteville, A., & Planel, E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00022 · Cited by 131 · see citing works
Tau interaction with microtubules in vivo
Samsonov, A., Yu, J.-Z., Rasenick, M., & Popov, S. V. (2004) · Journal of Cell Science · doi:10.1242/jcs.01531 · Cited by 129 · see citing works
A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau.
Brandt, R., Gergou, A., Wacker, I., Fath, T., & Hutter, H. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.011 · Cited by 126 · see citing works
Pathways of tau fibrillization
Kuret, J., Chirita, C. N., Congdon, E. E., Kannanayakal, T. J., Li, G., Necula, M., Yin, H., & Zhong, Q. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.016 · Cited by 124 · see citing works
Starvation induces tau hyperphosphorylation in mouse brain: implications for Alzheimer's disease
Yanagisawa, M., Planel, E., Ishiguro, K., & Fujita, S. C. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01480-5 · Cited by 123 · see citing works
The Evidence for Chronic Traumatic Encephalopathy in Boxing
McCrory, P. R., Zazryn, T., & Cameron, P. A. (2007) · Sports Medicine · doi:10.2165/00007256-200737060-00001 · Cited by 122 · see citing works
Long-term outcome after severe head injury.
Lewin, W., Marshall, T. F., & Roberts, A. H. N. (1979) · BMJ · doi:10.1136/bmj.2.6204.1533 · Cited by 121 · see citing works
Systematic Review of the Risk of Dementia and Chronic Cognitive Impairment After Mild Traumatic Brain Injury: Results of the International Collaboration on Mild Traumatic Brain Injury Prognosis
Godbolt, A. K., Cancelliere, C., Hincapié, C. A., Marras, C., Boyle, E., Kristman, V. L., Coronado, V. G., & Cassidy, J. D. (2014) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2013.06.036 · Cited by 120 · see citing works
The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome
Gunawardana, C. G., Mehrabian, M., Wang, X., Mueller, I., Lubambo, I., Jonkman, J. E. N., Wang, H., & Schmitt‐Ulms, G. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.050724 · Cited by 119 · see citing works
Neurofibrillary tangles, but not Alzheimer‐type pathology, in a young boxer
Geddes, J. F., Vowles, G. H., Robinson, S. F. D., & Sutcliffe, J. C. (1996) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1996.tb00840.x · Cited by 116 · see citing works
Noradrenergic locus coeruleus neurons: their distant connections and their relationship to neighboring (including cholinergic and GABAergic) neurons of the central gray and reticular formation
Jones, B. E. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63797-8 · Cited by 114 · see citing works
Frontotemporal lobar degeneration: current perspectives
Kurz, A., Riedl, L., Mackenzie, I. R., Förstl, H., & Diehl‐Schmid, J. (2014) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s38706 · Cited by 114 · see citing works
Tau and src family tyrosine kinases
Lee, G. S. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.002 · Cited by 111 · see citing works
Histological evidence of chronic traumatic encephalopathy in a large series of neurodegenerative diseases
Ling, H., Holton, J. L., Shaw, K., Davey, K., Lashley, T., & Revesz, T. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1496-y · Cited by 106 · see citing works
Post-mortem Interval Effects on the Phosphorylation of Signaling Proteins
Li, J., Gould, T. D., Yuan, P., Manji, H. K., & Chen, G. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300112 · Cited by 105 · see citing works
Tau-Mediated Nuclear Depletion and Cytoplasmic Accumulation of SFPQ in Alzheimer's and Pick's Disease
Ke, Y. D., Dramiga, J., Schütz, U., Kril, J. J., Ittner, L. M., Schröder, H., & Götz, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035678 · Cited by 104 · see citing works
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Casson, I. R., Viano, D. C., Haacke, E. M., Kou, Z., & LeStrange, D. G. (2014) · Sports Health A Multidisciplinary Approach · doi:10.1177/1941738114540270 · Cited by 103 · see citing works
Traumatic Brain Injury, Shell Shock, and Posttraumatic Stress Disorder in the Military—Past, Present, and Future
Shively, S. B., & Perl, D. P. (2012) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e318250e9dd · Cited by 100 · see citing works
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MEKK1 interacts with ?-actinin and localizes to stress fibers and focal adhesions
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Self-citation
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Iverson, G. L. (2014) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-092935 · Cited by 90 · see citing works
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Castellani, R. J., & Perry, G. L. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.009 · Cited by 89 · see citing works
Self-citation
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Xia, D., Li, C., & Götz, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.12.017 · Cited by 88 · see citing works
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Cruts, M., Rademakers, R., Gijselinck, I., van der Zee, J., Dermaut, B., Pooter, T. D., Rijk, P. D., Del‐Favero, J., & Broeckhoven, C. V. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi182 · Cited by 88 · see citing works
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Caffrey, T. M., Joachim, C., & Wade-Martins, R. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.002 · Cited by 88 · see citing works
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Platt, T. L., Beckett, T. L., Köhler, K., Niedowicz, D. M., & Murphy, M. P. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.011 · Cited by 86 · see citing works
IMMUNOCYTOCHEMISTRY OF NEUROFIBRILLARY TANGLES IN DEMENTIA PUGILISTICA AND ALZHEIMER'S DISEASE: EVIDENCE FOR COMMON GENESIS
Roberts, G. W. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90934-8 · Cited by 85 · see citing works
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DePalma, R. G., & Hoffman, S. W. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.036 · Cited by 85 · see citing works
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Smet‐Nocca, C., Sambo, A., Wieruszeski, J., Leroy, A., Landrieu, I., Buée, L., & Lippens, G. M. (2004) · Biochemistry · doi:10.1021/bi035479x · Cited by 84 · see citing works
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Seiberlich, V., Bauer, N. G., Schwarz, L., Ffrench‐Constant, C., Goldbaum, O., & Richter‐Landsberg, C. (2015) · Glia · doi:10.1002/glia.22832 · Cited by 84 · see citing works
Sequential phosphorylation of tau protein by cAMP‐dependent protein kinase and SAPK4/p38δ or JNK2 in the presence of heparin generates the AT100 epitope
Yoshida, H., & Goedert, M. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04052.x · Cited by 83 · see citing works
Microtubule-associated proteins (MAPs) in the peripheral nervous system during development and regeneration
Nunez, J., & Fischer, I. (1997) · Journal of Molecular Neuroscience · doi:10.1007/bf02736834 · Cited by 83 · see citing works
Nuclear Magnetic Resonance Spectroscopy Characterization of Interaction of Tau with DNA and Its Regulation by Phosphorylation
Qi, H., Cantrelle, F., Benhelli‐Mokrani, H., Smet‐Nocca, C., Buée, L., Lippens, G. M., Bonnefoy, E., Galas, M., & Landrieu, I. (2015) · Biochemistry · doi:10.1021/bi5014613 · Cited by 83 · see citing works
Neurofibrillary tangles in some cases of dementia pugilistica share antigens with amyloid beta-protein of Alzheimer's disease.
Allsop, D., Haga, S., Bruton, C. J., Ishii, T., & Roberts, G. W. (1990) · Europe PMC (PubMed Central) · Cited by 82 · see citing works
Developmental changes of tau protein and mRNA in cultured rat brain oligodendrocytes
Gorath, M., Stahnke, T., Mronga, T., Goldbaum, O., & Richter‐Landsberg, C. (2001) · Glia · doi:10.1002/glia.1098 · Cited by 81 · see citing works

Flagged first, then by citations

2 of the 252 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

[27]Di Maria E, Tabaton M, Vigo T, Abbruzzese G, Bellone E, Donati C, Frasson E, Marchese R, Montagna P, Munoz DG, Pramstaller PP, Zanusso G, Ajmar F, Mandich P (2000) Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy. Ann Neurol 47, 374– 337. 10716259
[28]Pastor P, Ezquerra M, Munoz E, Marti MJ, Blesa R, Tolosa E, Oliva R (2000) Significant association between the tau gene A0/A0 genotype and Parkinson's disease. Ann Neurol 47, 242– 245. 10665497
[38]Liu CWA, Lee G, Jay DG (1999) Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons. Cell Motil Cytoskeleton 43, 232– 242. 10401579
[43]Buee L, Bussiere T, Buee-Scherrer V, Delacourte A, Hof PR (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Rev 33, 95– 130. 10967355
[80]Thurston VC, Pena P, Pestell R, Binder LI (1997) Nucleolar localization of the microtubule-associated protein tau in neuroblastomas using sense and anti-sense transfection strategies. Cell Motil Cytoskeleton 38, 100– 110. 9295144
[90]Seiberlich V, Bauer NG, Schwarz L, Ffrench-Constant C, Goldbaum O, Richter-Landsberg C (2015) Downregulation of the microtubule associated protein Tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes. Glia 63, 1621– 1635. 25847153

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Neurodegenerative disease treatments by direct TNF reduction, SB623 cells, maraviroc and irisin and MCC950, from an inflammatory perspective – a Commentary
Clark, I. A., & Vissel, B. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1618710 · Cited by 15 · see citing works
Repetitive Traumatic Brain Injury Causes Neuroinflammation before Tau Pathology in Adolescent P301S Mice
Izzy, S., Brown-Whalen, A., Yahya, T., Sarro-Schwartz, A., Jin, G., Chung, J. Y., Lüle, S., Morsett, L. M., Alquraini, A., Wu, L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020907 · Cited by 16 · see citing works
Tau nuclear translocation is a leading step in tau pathology process through P53 stabilization and nucleolar dispersion
Roqanian, S., Ahmadian, S., Nabavi, S. M., Pakdaman, H., Shafiezadeh, M., Goudarzi, G., & Shahpasand, K. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25024 · Cited by 15 · see citing works
Tau as a fluid biomarker of concussion and neurodegeneration
Hossain, I., Blennow, K., Posti, J. P., & Zetterberg, H. (2022) · Concussion · doi:10.2217/cnc-2022-0004 · Cited by 16 · see citing works
Advances in Alzheimer’s disease therapeutics: biochemistry, exploring bioactive compounds and novel approaches
Atoki, A. V., Aja, P. M., Ondari, E. N., & Shinkafi, T. S. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2243050 · Cited by 19 · see citing works
Inhibiting Mitochondrial Cytochrome c Oxidase Downregulates Gene Transcription After Traumatic Brain Injury in Drosophila
Shah, E. J., Hüttemann, M., Sanderson, T. H., Gurdziel, K., & Ruden, D. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.628777 · Cited by 14 · see citing works
Effects of altered tau expression on dentate granule cell excitability in mice
Cloyd, R., Koren, J., Abisambra, J. F., & Smith, B. N. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113766 · Cited by 14 · see citing works
Traumatic Brain Injury and Dementia: Mechanisms, Risk Stratification, and Clinical Management
Al-Rubaie, A. (2025) · Journal of Clinical Neurology · doi:10.3988/jcn.2025.0079 · Cited by 14 · see citing works
Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives
Olesen, M. A., Villavicencio-Tejo, F., Cuevas-Espinoza, V., & Quintanilla, R. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102594 · Cited by 12 · see citing works
Molecular and Diffusion Tensor Imaging Biomarkers of Traumatic Brain Injury: Principles for Investigation and Integration
Turner, S. B., Lazarus, R. C., Marion, D. W., & Main, K. (2021) · Journal of Neurotrauma · doi:10.1089/neu.2020.7259 · Cited by 11 · see citing works
Alternative splicing in aging and Alzheimer's disease: Highlighting the role of tau and estrogen receptor α isoforms in the hypothalamus
Ishunina, T. A. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819973-2.00012-5 · Cited by 11 · see citing works
Diaminocyclopentane-derived O -GlcNAcase inhibitors for combating tau hyperphosphorylation in Alzheimer's disease
Weber, P., Mészáros, Z., Jagečić, D., Hribljan, V., Mitrečić, D., Bojarová, P., Slámová, K., Vrba, J., Kulik, N., Vladimír Křen, A., et al. (2022) · Chemical Communications · doi:10.1039/d2cc02712g · Cited by 11 · see citing works
Spatiotemporal profile of atrophy in the first year following moderate‐severe traumatic brain injury
Brennan, D. J., Duda, J., Ware, J., Whyte, J., Choi, J., Gugger, J. J., Focht, K., Walter, A., Bushnik, T., Gee, J., et al. (2023) · Human Brain Mapping · doi:10.1002/hbm.26410 · Cited by 10 · see citing works
Brain Injury and Later-Life Cognitive Impairment and Neuropathology: The Honolulu-Asia Aging Study
Chosy, E. J., Gross, N., Meyer, M., Liu, C. Y., Edland, S. D., Launer, L. J., & White, L. R. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190053 · Cited by 11 · see citing works
Evidence for Altered White Matter Organization After Mild Traumatic Brain Injury: A Scoping Review on the Use of Diffusion Magnetic Resonance Imaging and Blood-Based Biomarkers to Investigate Acute Pathology and Relationship to Persistent Post-Concussion Symptoms
Papini, M. G., Avila, A. N., Fitzgerald, M., & Hellewell, S. C. (2024) · Journal of Neurotrauma · doi:10.1089/neu.2024.0039 · Cited by 10 · see citing works
Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice
Zamorano, M., Alexander, J. F., Catania, D., Dharmaraj, S., Kavelaars, A., & Heijnen, C. J. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00328-w · Cited by 9 · see citing works
Peripherin: A proposed biomarker of traumatic axonal injury triggered by mechanical force
Fang, T., Yue, L., Zhu, L., Ma, L., Huang, F., Lv, Y., Yang, L., & Yiwu, Z. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16111 · Cited by 9 · see citing works
Stress Granules Modulate SYK to Cause Tau-Associated Neurocognitive Deterioration in 5XFAD Mouse After Anesthesia and Surgery
Shen, Y., Zhang, T., Zhang, Y., Wang, Y., & Yao, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.718701 · Cited by 9 · see citing works
The Adult Neurogenesis Theory of Alzheimer’s Disease
Abbate, C. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221279 · Cited by 8 · see citing works
Potential Correlation Between Molecular Biomarkers and Oxidative Stress in Traumatic Brain Injury
Ionescu, C., Ghidersa, M., Ciobica, A. S., Mavroudis, I. A., Kazis, D. A., Petridis, F., Gorgan, L., & Balmuș, I.-M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083858 · Cited by 8 · see citing works
Diffusion Tensor Imaging Detects Acute Pathology-Specific Changes in the P301L Tauopathy Mouse Model Following Traumatic Brain Injury
Soni, N., Medeiros, R., Alateeq, K., To, X. V., & Nasrallah, F. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.611451 · Cited by 8 · see citing works
Aptamers Targeting Hallmark Proteins of Neurodegeneration
Mollasalehi, N., François‐Moutal, L., Porciani, D., Burke, D. H., & Khanna, M. (2022) · Nucleic Acid Therapeutics · doi:10.1089/nat.2021.0091 · Cited by 8 · see citing works
Increased Risk of Dementia and its Subtypes following Various Forms of Acquired Brain Injury: a Meta-analysis and Systematic Review
Thompson, J., & Vasefi, M. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.06.064 · Cited by 7 · see citing works
A Narrative Review of Existing and Developing Biomarkers in Acute Traumatic Brain Injury for Potential Military Deployed Use
Kocik, V. I., Dengler, B. A., Rizzo, J. A., Moran, M. M., Willis, A. M., April, M. D., & Schauer, S. G. (2023) · Military Medicine · doi:10.1093/milmed/usad433 · Cited by 7 · see citing works
Disclosing tau tangles using PET imaging: a pharmacological review of the radiotracers available in 2021
Wambeke, É. V., Gérard, T., Lhommel, R., & Hanseeuw, B. (2021) · Acta Neurologica Belgica · doi:10.1007/s13760-021-01797-w · Cited by 6 · see citing works
A Model of Traumatic Brain Injury Oligomerizes Tau in Cortical Organoids and Induces Clinically Relevant Pathologies that Synergize with MAPT Mutation
Shiravi, S., Yufa, A., Papavasileiou, P., Lotz, S., Murphy, D., Bertucci, T. B., Temple, S., & Finan, J. D. (2025) · Journal of Neurotrauma · doi:10.1177/08977151251374286 · Cited by 6 · see citing works
TBI and Tau Loss of Function Both Affect Naïve Ethanol Sensitivity in Drosophila
Hoxha, V., Shrestha, G., Baloch, N., Collevechio, S., Laszczyk, R. R., & Roman, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063301 · Cited by 5 · see citing works
Elevated Serum Tau and UCHL-1 Concentrations Within 12 Months of Injury Predict Neurobehavioral Functioning 2 or More Years Following Traumatic Brain Injury: A Longitudinal Study
Lange, R. T., Gill, J., Lippa, S. M., Hungerford, L. D., Walker, T., Kennedy, J. E., Brickell, T. A., & French, L. M. (2023) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000877 · Cited by 6 · see citing works
Exploring the Therapeutic Potential of Phosphorylated Cis-Tau Antibody in a Pig Model of Traumatic Brain Injury
Shin, S. S., Mazandi, V., Schneider, A. L. C., Morton, S. R., Starr, J. P., Weeks, M., Widmann, N. J., Jang, D., Kao, S.-H., Ahlijanian, M., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11071807 · Cited by 4 · see citing works
Neurobiochemical, Peptidomic, and Bioinformatic Approaches to Characterize Tauopathy Peptidome Biomarker Candidates in Experimental Mouse Model of Traumatic Brain Injury
Yadikar, H., Johnson, C., Pafundi, N., Nguyen, L. T., Kurup, M., Torres, I., Al-Enezy, A., Yang, Z., Yost, R. A., Kobeissy, F. H., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-022-03165-y · Cited by 5 · see citing works
Recent Advancements in the Early Diagnosis and Treatment of Alzheimer's Disease
Wu, Y., Fu, L., Li, Q., Gao, X., Zhang, Y., Jin, C., Ding, F., Hong, S. C., Cai, H., & Li, Y. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300181 · Cited by 4 · see citing works
Finite element validation of 3D American football faceguard structural stiffness models
Ferriell, W. D., Batt, G., & DesJardins, J. D. (2020) · Proceedings of the Institution of Mechanical Engineers Part P Journal of Sports Engineering and Technology · doi:10.1177/1754337120978041 · Cited by 5 · see citing works
The structure of the unstructured: mosaic of tau protein linear motifs obtained by high-resolution techniques and molecular simulation
Cehlár, O., Bagarova, O., Hornakova, L., & Škrabana, R. (2021) · General Physiology and Biophysics · doi:10.4149/gpb_2021031 · Cited by 7 · see citing works
Traumatic Encephalopathy Syndrome: Head Impact Exposure and Blood Biomarkers in Professional Combat Athletes.
Kleven, B. D. C., Chien, L., Cross, C., Labus, B., & Bernick, C. (2025) · The journal of head trauma rehabilitation · doi:10.1097/htr.0000000000001048 · Cited by 4 · see citing works
GLP-1 receptor agonist semaglutide ameliorates motor deficits and tau pathology in the rTg4510s mouse model
Zhang, M.-W., Zhou, W.-Y., Li, X., Xu, Z., Lin, H.-M., Tang, Y., Zhao, J., Chen, C., Liu, F., Sun, Y., et al. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110659 · Cited by 4 · see citing works
Blood-Based Biomarkers for Neuroprognostication in Acute Brain Injury
Nguyen, A., Saini, V., & Hinson, H. E. (2023) · Seminars in Neurology · doi:10.1055/s-0043-1775764 · Cited by 4 · see citing works
Adolescent Alcohol and the Spectrum of Cognitive Dysfunction in Aging
Deak, T., Burzynski, H. E., Nunes, P. T., Day, S. M., & Savage, L. M. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-81908-7_12 · Cited by 3 · see citing works
Blood-Based Analysis of Different Tau Variants in Patients With Multiple Traumatic Injuries
Halbgebauer, R., González‐Ortiz, F., Mayer, B., Berger, C., Bergmann, C. B., Rinderknecht, H., Barth, E., Wohlgemuth, L., Mannes, M., Otto, M., et al. (2026) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.58573 · Cited by 3 · see citing works
Advancements in diagnosing Post-concussion Syndrome: insights into epidemiology, pathophysiology, neuropathology, neuroimaging, and salivary biomarkers
Mavroudis, I. A., Petridis, F., Ciobica, A. S., Kamal, F. Z., Pădurariu, M., & Kazis, D. A. (2025) · Acta Neurologica Belgica · doi:10.1007/s13760-024-02695-7 · Cited by 3 · see citing works
Correlation analysis of miRNA-124, miRNA-210 with brain injury and inflammatory response in patients with craniocerebral injury.
Chao, Y., Wang, F., Wang, Y., & Han, B. (2022) · PubMed Central · Cited by 3 · see citing works
Treatment options for post-traumatic epilepsy: an update on clinical and translational aspects
Mula, M. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2469041 · Cited by 3 · see citing works
Patterns of phosphorylated tau accumulation in a spectrum of acquired and developmental brain lesions associated with refractory epilepsy
Mrzyglod, A., Mebrouk, A., Bartkiewicz, J., Hachami, H. E., Ryniejska, M., de Tisi, J., Coras, R., Blümcke, I., Xiao, F., Miserocchi, A., et al. (2025) · Epilepsia · doi:10.1111/epi.18418 · Cited by 3 · see citing works
Tau Protein in Drug-Resistant Epilepsy and Cognitive Decline
Thom, M., & Koepp, M. (2021) · Progress in inflammation research · doi:10.1007/978-3-030-67403-8_7 · Cited by 3 · see citing works
Divergence in the epidemiological estimates of traumatic brain injury in the United States: comparison of two national databases
Stopa, B. M., Harary, M., Jhun, R. S., Job, A., Izzy, S., Smith, T. R., & Gormley, W. B. (2020) · Journal of neurosurgery · doi:10.3171/2020.7.jns201896 · Cited by 3 · see citing works
Biomarkers in Brain Traumatic Injury
Sabet, H. S., Sabet, F. S., Shojaei, K., Yaghoubi, F., & Jafarian, M. (2022) · The Neuroscience Journal of Shefaye Khatam · doi:10.52547/shefa.11.1.133 · Cited by 2 · see citing works
Gα13-Mediated Signaling Cascade Is Related to the Tau Pathology Caused by Anesthesia and Surgery in 5XFAD Transgenic Mice
Zhang, J., Zhang, T., Wang, Y., Yao, L., & Yao, J. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221039 · Cited by 2 · see citing works
Nanowired delivery of antibodies to tau and neuronal nitric oxide synthase together with cerebrolysin attenuates traumatic brain injury induced exacerbation of brain pathology in Parkinson’s disease
Ozkızılcık, A., Sharma, A., Feng, L., Muresanu, D. F., Tian, Z. R., Lafuente, J. V., Buzoianu, A. D., Nozari, A., Wiklund, L., & Sharma, H. S. (2023) · International review of neurobiology · doi:10.1016/bs.irn.2023.07.001 · Cited by 2 · see citing works
Serum tau protein and myelin basic protein in pediatric patients with congenital heart defects undergoing cardiac surgery: preliminary assessment as novel neuromarkers of brain injury
Chiperi, L. E., Tecar, C., & Huţanu, A. (2023) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-023-03582-5 · Cited by 2 · see citing works
Efficacy of Stem Cell-derived Extracellular Vesicles in the Treatment of Alzheimer's Disease Model Mice: A Systematic Review and Meta-analysis
Zheng, Q., Wang, S., Wang, T., & Zhang, G. (2025) · Current Stem Cell Research & Therapy · doi:10.2174/011574888x352270250407170235 · Cited by 2 · see citing works
Brain Biomarkers in Patients with COVID-19 and Neurological Manifestations: A Narrative Review
Tyagi, M., Kapoor, I., Mahajan, C., Gupta, N., & Prabhakar, H. (2022) · Journal of Neuroanaesthesiology and Critical Care · doi:10.1055/s-0042-1744395 · Cited by 3 · see citing works
Research progress on biomarkers of traumatic brain injury
Shen, X., Cheng, S., Chen, S., Wang, M., Li, T., Xu, W., Zhang, Y., Yuan, P., & Shi, L. (2026) · Animal Models and Experimental Medicine · doi:10.1002/ame2.70173 · Cited by 1 · see citing works
Correlation of brain injury biomarkers with brain dysfunction, brain injury, and outcomes in critically ill patients: a post hoc exploratory analysis
Ruhlmann, M., Xu, L., Bauer, M., Lehmann, T., Panagiotou, G., Neugebauer, S., Kiehntopf, M., Klawitter, F., & Ehler, J. (2026) · Infection · doi:10.1007/s15010-026-02790-2 · Cited by 1 · see citing works
Blood biomarker outliers and clinical events during intensive care in patients with traumatic brain injury
Koivikko, P., Posti, J. P., Hossain, I., Mohammadian, M., Tenovuo, O. S., Hutchinson, P., Katila, A. J., Maanpää, H.-R., Menon, D. K., Newcombe, V., et al. (2026) · Brain and Spine · doi:10.1016/j.bas.2026.106078 · Cited by 1 · see citing works
Mutual Sliding Motion of Wrapped Filaments for Biomedical and Engineering Applications
Li, G., Pourdeyhimi, B., & Yarin, A. L. (2020) · Langmuir · doi:10.1021/acs.langmuir.0c00446 · Cited by 1 · see citing works
Phosphorylated tau 181 (p-tau181) as an innovative, fast and robust biomarker for cerebrospinal fluid leaks
Bosse, M., Bélik, F., Pesch, V. V., & Bayart, J. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12624-6 · Cited by 1 · see citing works
Pathological Tau as a Cause, and Consequence, of Cellular Dysfunction
Meier, S. E. (2019) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2019.368
Investigação da associação de variantes polimórficas, sítios de metilação e tamanho de telômeros com resposta a longo prazo de lítio em transtorno bipolar
Michelon, L. (2019) · doi:10.11606/t.5.2019.tde-25102019-131555
THE ROLE OF MICROTUBULE-ASSOCIATED PROTEIN TAU IN NEURONAL EXCITABILITY AND EPILEPTOGENESIS
Cloyd, R. (2021) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2021.271
Tau Biomarkers for Long-Term Effects of Neurotrauma: Technology Versus the Null Hypothesis
Castellani, R. J. (2021) · Neuromethods · doi:10.1007/978-1-0716-1712-0_13
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Shvetz, C. (2023) · doi:10.22215/etd/2023-15799
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Castellani, R. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-99651-8.00002-8
Self-citation
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Castellani, R. J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-99651-8.00008-9
Self-citation
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Pektaş, F., Dursun, N., Tan, B., Yaylalı, O., Babür, E., & Süer, C. (2025) · Neurochemical Journal · doi:10.1134/s1819712425700102
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Orsini, F., Pollice, G., Carpano, F., Cipolloni, L., Cioffi, A., Cecannecchia, C., Bibbò, R., & Simone, S. D. (2025) · Forensic Sciences · doi:10.3390/forensicsci5030033
Tau-Cytoskeleton and their interaction with other neurodegenerative proteins
Sahu, S., Rangappa, N., Chinnathambi, S., & Mishra, M. (2025) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2025.10.032
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To, X. V., & Nasrallah, F. A. (2021) · Figshare · doi:10.6084/m9.figshare.13532993

Authors: Castellani, R. J., & Perry, G.
Affiliations: West Virginia University (US)
The University of Texas at San Antonio (US)
Corresponding author: Castellani, Rudy J.
ORCID: Castellani, Rudy J.
Perry, George
Venue: Journal of Alzheimer’s Disease
Publisher: SAGE Publications
Published: 2018-12-18
Volume: 67
Issue: 2
Pages: 447-467
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-180721
PMC: PMC6398540
OpenAlex: W2906559084
Cited by: 110
References: 252
Citations by year: 2026: 10 · 2025: 16 · 2024: 9 · 2023: 18 · 2022: 13 · 2021: 23 · 2020: 17 · 2019: 4
FWCI: 1.44
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/4.0/ (unspecified)
Locations: Journal of Alzheimer s Disease (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: tau protein, tauopathy
MeSH terms: Brain Injuries, Traumatic, Animals, Humans, tau Proteins, Neurodegenerative Diseases, Tauopathies, Post-Concussion Syndrome

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Tau biology, tauopathy, traumatic brain injury, and diagnostic challenges

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