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MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells
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In the citing paper
“MicroRNAs particularly enriched in the normal brain, such as miR-128-3p, are almost universally suppressed in glioblastoma cells, regardless of their cellular subtype.45,126,130,211”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [130]
Experimental — accuracy not yet measuredIn the citing paper
“Reduced viability and neurosphere formation in vitro, decreased tumor burden and improved survival in the mouse intracranial xenograft model were observed due to this inter-subtype transition.130”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [130]
In the citing paper
“Functional studies demonstrated a shift of GSCs from the most aggressive mesenchymal subclass toward the proneural one upon miR-128-3p replacement.130”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [130]
In the citing paper
“Reduced viability and neurosphere formation in vitro, decreased tumor burden and improved survival in the mouse intracranial xenograft model were observed due to this inter-subtype transition.130”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [130]
In the citing paper
“The direct targeting of both PRCs by miR-128-3p leads to chromatin re-arrangements, followed by the reprogramming of PRC-dependent genes involved in the enforcement of the stemness program and inter-subclasses transition of brain tumor cells.”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [130]
In the citing paper
“Moreover, microRNAs can re-arrange a genetic and molecular landscape in a cell-type-specific manner130 due to the strict tissue and cell-type-specific distribution and functions of microRNAs,210 meaning their targets in cancer and normal cells are different.”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [130]
In the citing paper
“Crucially, many microRNAs coordinately target numerous factors from the same pathway, thus circumventing their physiological redundancy, e.g., miR-128-3p targeting several vital players of the PRC pathway.77,130”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [130]
In the citing paper
“Some functional studies provided several targets of miR-128-3p in cancer and immune cells,126,130 thus supporting the rationale for its application to enhance antitumor and pro-immune activity.”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [130]
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Research works printed but not linked: 31
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- Mao, 2013, Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3, Proc. Natl. Acad. Sci. USA, 110, 8644, 10.1073/pnas.1221478110 · DOI
- Margueron, 2011, The Polycomb complex PRC2 and its mark in life, Nature, 469, 343, 10.1038/nature09784 · DOI · Paper page
- Mineo, 2016, The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches, Cell Rep., 15, 2500, 10.1016/j.celrep.2016.05.018 · DOI
- Mulero, 2013, Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer, Cancer Cell, 24, 151, 10.1016/j.ccr.2013.06.003 · DOI
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- Pasini, 2016, Emerging roles for Polycomb proteins in cancer, Curr. Opin. Genet. Dev., 36, 50, 10.1016/j.gde.2016.03.013 · DOI · Paper page
- Patel, 2014, Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma, Science, 344, 1396, 10.1126/science.1254257 · DOI · Paper page
- Peruzzi, 2013, MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells, Neuro-oncol., 15, 1212, 10.1093/neuonc/not055 · DOI · Paper page
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Cited by
Sorted by citations
MiR-128-3p – a gray eminence of the human central nervous system
Kiel, K., Król, S. K., Bronisz, A., & Godlewski, J. (2024) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2024.102141 · Cited by 15
Self-citation
Metadata
- Authors
- Rooj, A. K., Ricklefs, F., Mineo, M., Nakano, I., Chiocca, E. A., Bronisz, A., & Godlewski, J.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 19
- Issue
- 10
- Pages
- 2026-2032
- ISSN
- 2211-1247
- PMC
- PMC5514838
- Cited by
- 40
- References
- 0
- Language
- en
- Licence
- Funders
- NCI (P01 CA69246, 1R01 CA176203-01A1)
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