CoChat
Sign Up
Cited by 133

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Emerging roles for Polycomb proteins in cancer

Pasini, Diego, Di Croce, Luciano·2016·Current Opinion in Genetics & Development
DOI 10.1016/j.gde.2016.03.013
Open this paper in CoChat — free account

Abstract

The activities of the heterogeneous Polycomb (PcG) group of proteins ensure that the developmental processes of proliferation and cellular identity establishment are carried out correctly. PcG proteins assemble stable multiprotein complexes that, together with additional factors, maintain their target genes in a transcriptionally repressive state. The biochemical and functional features of PcG proteins have been extensively investigated over the years. Here we analyse the biochemical and mechanistic proprieties of PcG proteins with respect to recent advances that link the genetic alterations of PcG activity to cancer development.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.gde.2016.03.013

Cites

10 of 10 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 10 references

Research works printed but not linked: 86

  1. Wang, 2004, Role of histone H2A ubiquitination in Polycomb silencing, Nature, 431, 873, 10.1038/nature02985 · DOI
  2. Margueron, 2008, Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms, Mol Cell, 32, 503, 10.1016/j.molcel.2008.11.004 · DOI
  3. Shen, 2008, EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency, Mol Cell, 32, 491, 10.1016/j.molcel.2008.10.016 · DOI · Paper page
  4. Buchwald, 2006, Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b, EMBO J, 25, 2465, 10.1038/sj.emboj.7601144 · DOI
  5. Cao, 2004, SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex, Mol Cell, 15, 57, 10.1016/j.molcel.2004.06.020 · DOI
  6. Pasini, 2004, Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity, EMBO J, 23, 4061, 10.1038/sj.emboj.7600402 · DOI
  7. Mendenhall, 2010, GC-rich sequence elements recruit PRC2 in mammalian ES cells, PLoS Genet, 6, e1001244, 10.1371/journal.pgen.1001244 · DOI
  8. Pasini, 2010, JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells, Nature, 464, 306, 10.1038/nature08788 · DOI
  9. Tavares, 2012, RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3, Cell, 148, 664, 10.1016/j.cell.2011.12.029 · DOI
  10. Ferrari, 2014, Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity, Mol Cell, 53, 49, 10.1016/j.molcel.2013.10.030 · DOI
  11. Gao, 2012, PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes, Mol Cell, 45, 344, 10.1016/j.molcel.2012.01.002 · DOI
  12. Ballare, 2012, Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity, Nat Struct Mol Biol, 19, 1257, 10.1038/nsmb.2434 · DOI
  13. Gil, 2014, PRC1 complex diversity: where is it taking us?, Trends Cell Biol, 24, 632, 10.1016/j.tcb.2014.06.005 · DOI
  14. Aloia, 2013, Polycomb complexes in stem cells and embryonic development, Development, 140, 2525, 10.1242/dev.091553 · DOI
  15. Luis, 2012, Polycomb in stem cells: PRC1 branches out, Cell Stem Cell, 11, 16, 10.1016/j.stem.2012.06.005 · DOI
  16. Morey, 2012, Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells, Cell Stem Cell, 10, 47, 10.1016/j.stem.2011.12.006 · DOI
  17. O’Loghlen, 2012, MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation, Cell Stem Cell, 10, 33, 10.1016/j.stem.2011.12.004 · DOI
  18. Morey, 2013, RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells, Cell Rep, 3, 60, 10.1016/j.celrep.2012.11.026 · DOI · Paper page
  19. Morey, 2015, Polycomb regulates mesoderm cell fate-specification in embryonic stem cells through activation and repression mechanisms, Cell Stem Cell, 17, 300, 10.1016/j.stem.2015.08.009 · DOI
  20. Xu, 2015, Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions, Mol Cell, 57, 304, 10.1016/j.molcel.2014.12.009 · DOI
  21. Brookes, 2012, Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs, Cell Stem Cell, 10, 157, 10.1016/j.stem.2011.12.017 · DOI
  22. Mousavi, 2012, Polycomb protein Ezh1 promotes RNA polymerase II elongation, Mol Cell, 45, 255, 10.1016/j.molcel.2011.11.019 · DOI
  23. Aranda, 2015, Regulation of gene transcription by Polycomb proteins, Sci Adv, 1, e1500737, 10.1126/sciadv.1500737 · DOI
  24. Bracken, 2009, Polycomb group proteins: navigators of lineage pathways led astray in cancer, Nat Rev Cancer, 9, 773, 10.1038/nrc2736 · DOI · Paper page
  25. Brockdorff, 2013, Noncoding RNA and Polycomb recruitment, RNA, 19, 429, 10.1261/rna.037598.112 · DOI
  26. Deaton, 2011, CpG islands and the regulation of transcription, Genes Dev, 25, 1010, 10.1101/gad.2037511 · DOI · Paper page
  27. Di Croce, 2013, Transcriptional regulation by Polycomb group proteins, Nat Struct Mol Biol, 20, 1147, 10.1038/nsmb.2669 · DOI · Paper page
  28. Morey, 2010, Polycomb group protein-mediated repression of transcription, Trends Biochem Sci, 35, 323, 10.1016/j.tibs.2010.02.009 · DOI
  29. Schuettengruber, 2009, Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice, Development, 136, 3531, 10.1242/dev.033902 · DOI
  30. Bernstein, 2006, Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin, Mol Cell Biol, 26, 2560, 10.1128/MCB.26.7.2560-2569.2006 · DOI
  31. Hansen, 2008, A model for transmission of the H3K27me3 epigenetic mark, Nat Cell Biol, 10, 1291, 10.1038/ncb1787 · DOI
  32. Margueron, 2009, Role of the polycomb protein EED in the propagation of repressive histone marks, Nature, 461, 762, 10.1038/nature08398 · DOI
  33. Min, 2003, Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27, Genes Dev, 17, 1823, 10.1101/gad.269603 · DOI
  34. Lo, 2012, A bridging model for persistence of a polycomb group protein complex through DNA replication in vitro, Mol Cell, 46, 784, 10.1016/j.molcel.2012.05.038 · DOI
  35. He, 2013, Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes, Nat Cell Biol, 15, 373, 10.1038/ncb2702 · DOI
  36. Wu, 2013, Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation, Mol Cell, 49, 1134, 10.1016/j.molcel.2013.01.016 · DOI
  37. Farcas, 2012, KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands, Elife, 1, e00205, 10.7554/eLife.00205 · DOI
  38. Blackledge, 2014, Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation, Cell, 157, 1445, 10.1016/j.cell.2014.05.004 · DOI
  39. Cooper, 2014, Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment, Cell Rep, 7, 1456, 10.1016/j.celrep.2014.04.012 · DOI
  40. Kalb, 2014, Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression, Nat Struct Mol Biol, 21, 569, 10.1038/nsmb.2833 · DOI
  41. Chiacchiera, 2016, Polycomb complex PRC1 preserves intestinal stem cell identity by sustaining Wnt/beta-catenin transcriptional activity, Cell Stem Cell, 18, 91, 10.1016/j.stem.2015.09.019 · DOI
  42. Bravo, 2015, Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression, J Cell Sci, 128, 3660
  43. Dietrich, 2007, Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus, EMBO J, 26, 1637, 10.1038/sj.emboj.7601632 · DOI · Paper page
  44. Gil, 2004, Polycomb CBX7 has a unifying role in cellular lifespan, Nat Cell Biol, 6, 67, 10.1038/ncb1077 · DOI · Paper page
  45. Piunti, 2014, Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication, Nat Commun, 5, 3649, 10.1038/ncomms4649 · DOI · Paper page
  46. Lee, 2006, Control of developmental regulators by Polycomb in human embryonic stem cells, Cell, 125, 301, 10.1016/j.cell.2006.02.043 · DOI
  47. Boyer, 2006, Polycomb complexes repress developmental regulators in murine embryonic stem cells, Nature, 441, 349, 10.1038/nature04733 · DOI
  48. Bracken, 2006, Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions, Genes Dev, 20, 1123, 10.1101/gad.381706 · DOI
  49. Morey, 2015, Pluripotency and epigenetic factors in mouse embryonic stem cell fate regulation, Mol Cell Biol, 35, 2716, 10.1128/MCB.00266-15 · DOI
  50. Scelfo, 2015, The controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins?, FEBS J, 282, 1703, 10.1111/febs.13112 · DOI
  51. Francis, 2004, Chromatin compaction by a polycomb group protein complex, Science, 306, 1574, 10.1126/science.1100576 · DOI
  52. Breiling, 2001, General transcription factors bind promoters repressed by Polycomb group proteins, Nature, 412, 651, 10.1038/35088090 · DOI
  53. He, 2012, PRC2 directly methylates GATA4 and represses its transcriptional activity, Genes Dev, 26, 37, 10.1101/gad.173930.111 · DOI
  54. Kim, 2013, Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells, Cancer Cell, 23, 839, 10.1016/j.ccr.2013.04.008 · DOI
  55. Pasini, 2010, Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes, Nucleic Acids Res, 38, 4958, 10.1093/nar/gkq244 · DOI
  56. Tie, 2009, CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing, Development, 136, 3131, 10.1242/dev.037127 · DOI
  57. Pengelly, 2013, A histone mutant reproduces the phenotype caused by loss of histone-modifying factor Polycomb, Science, 339, 698, 10.1126/science.1231382 · DOI · Paper page
  58. Pengelly, 2015, Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation, Genes Dev, 29, 1487, 10.1101/gad.265439.115 · DOI
  59. Illingworth, 2015, The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development, Genes Dev, 29, 1897, 10.1101/gad.268151.115 · DOI
  60. Piunti, 2011, Epigenetic factors in cancer development: polycomb group proteins, Futur Oncol, 7, 57, 10.2217/fon.10.157 · DOI
  61. Vizan, 2015, Role of PRC2-associated factors in stem cells and disease, FEBS J, 282, 1723, 10.1111/febs.13083 · DOI
  62. van Lohuizen, 1991, Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging, Cell, 65, 737, 10.1016/0092-8674(91)90382-9 · DOI
  63. Kondo, 2008, Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation, Nat Genet, 40, 741, 10.1038/ng.159 · DOI
  64. Wassef, 2015, Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis, Genes Dev, 29, 2547, 10.1101/gad.269522.115 · DOI
  65. Alabert, 2015, Two distinct modes for propagation of histone PTMs across the cell cycle, Genes Dev, 29, 585, 10.1101/gad.256354.114 · DOI
  66. Morin, 2010, Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin, Nat Genet, 42, 181, 10.1038/ng.518 · DOI
  67. Yap, 2011, Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation, Blood, 117, 2451, 10.1182/blood-2010-11-321208 · DOI
  68. Sneeringer, 2010, Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas, Proc Natl Acad Sci U S A, 107, 20980, 10.1073/pnas.1012525107 · DOI
  69. Caganova, 2013, Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis, J Clin Investig, 123, 5009, 10.1172/JCI70626 · DOI
  70. Beguelin, 2013, EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation, Cancer Cell, 23, 677, 10.1016/j.ccr.2013.04.011 · DOI
  71. Barsotti, 2015, Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth, Oncotarget, 6, 2928, 10.18632/oncotarget.2758 · DOI
  72. Bradley, 2014, EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation, Chem Biol, 21, 1463, 10.1016/j.chembiol.2014.09.017 · DOI
  73. Radulovic, 2013, Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms, Leukemia, 27, 523, 10.1038/leu.2012.368 · DOI
  74. Simon, 2012, A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia, Genes Dev, 26, 651, 10.1101/gad.186411.111 · DOI · Paper page
  75. Ntziachristos, 2012, Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia, Nat Med, 18, 298, 10.1038/nm.2651 · DOI
  76. Herrera-Merchan, 2012, Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease, Nat Commun, 3, 623, 10.1038/ncomms1623 · DOI
  77. De Raedt, 2014, PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies, Nature, 514, 247, 10.1038/nature13561 · DOI
  78. Rathert, 2015, Transcriptional plasticity promotes primary and acquired resistance to BET inhibition, Nature, 525, 543, 10.1038/nature14898 · DOI
  79. Wu, 2012, Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas, Nat Genet, 44, 251, 10.1038/ng.1102 · DOI · Paper page
  80. Funato, 2014, Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation, Science, 346, 1529, 10.1126/science.1253799 · DOI · Paper page
  81. Hashizume, 2014, Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma, Nat Med, 20, 1394, 10.1038/nm.3716 · DOI · Paper page
  82. Kim, 2014, Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth, Cancer Genet, 207, 365, 10.1016/j.cancergen.2014.04.004 · DOI
  83. Wilson, 2011, SWI/SNF nucleosome remodellers and cancer, Nat Rev Cancer, 11, 481, 10.1038/nrc3068 · DOI
  84. Wilson, 2010, Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation, Cancer Cell, 18, 316, 10.1016/j.ccr.2010.09.006 · DOI
  85. Kim, 2015, SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2, Nat Med, 21, 1491, 10.1038/nm.3968 · DOI
  86. Kim, 2013, Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer, Nat Chem Biol, 9, 643, 10.1038/nchembio.1331 · DOI

Cited by

Sorted by citations

See all 133

Metadata

Authors
Pasini, D., & Di Croce, L.
Venue
Current Opinion in Genetics & Development
Publisher
Elsevier BV
Published
2016-02
Volume
36
Pages
50-58
ISSN
0959-437X
DOI
10.1016/j.gde.2016.03.013
Cited by
133
References
10
Language
en
Licence
Funders
  • Ministerio de Educación y Ciencia (SAF2013-48926-P)
  • AGAUR
  • La Marato TV3
  • Fundación Vencer El Cáncer (VEC)
  • Spanish Ministry of Economy and Competitiveness
  • Italian Association for Cancer Research
  • Italian Ministry of Health (GR-2011-02348313)
  • Umberto Veronesi Foundation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review