Cited by 41Immune cells in cancerCancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment

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Zheng, Xiang, Mansouri, Siavash, Krager, Annika, Grimminger, Friedrich, Seeger, Werner, Pullamsetti, Soni S., Wheelock, Craig E., Savai, Rajkumar·2020·European Respiratory Review

Abstract

Lung cancer is the leading cause of death from cancer worldwide. Recent studies demonstrated that the tumour microenvironment (TME) is pivotal for tumour progression, providing multiple targeting opportunities for therapeutic strategies. As one of the most abundant stromal cell types in the TME, tumour-associated macrophages (TAMs) exhibit high plasticity. Malignant cells alter their metabolic profiles to adapt to the limited availability of oxygen and nutrients in the TME, resulting in functional alteration of TAMs. The metabolic features of TAMs are strongly associated with their functional plasticity, which further impacts metabolic profiling in the TME and contributes to tumourigenesis and progression. Here, we review the functional determination of the TME by TAM metabolic alterations, including glycolysis as well as fatty acid and amino acid metabolism, which in turn are influenced by environmental changes. Additionally, we discuss metabolic reprogramming of TAMs to a tumouricidal phenotype as a potential antitumoural therapeutic strategy.

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Crossref · 10.1183/16000617.0134-2020

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  1. [99]Penny HL, Sieow JL, Adriani G, et al. Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma. Oncoimmunology 2016; 5: e1191731. doi: 10.1080/2162402X.2016.1191731 27622062 PMC5007961 · DOI

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Authors
Zheng, X., Mansouri, S., Krager, A., Grimminger, F., Seeger, W., Pullamsetti, S. S., Wheelock, C. E., & Savai, R.
Affiliations
  • Max Planck Institute for Heart and Lung Research (DE)
  • Justus-Liebig-Universität Gießen (DE)
  • Karolinska Institutet (SE)
  • Goethe University Frankfurt (DE)
Corresponding author
Savai, Rajkumar
Venue
European Respiratory Review
Published
2020-09-30
Volume
29
Issue
157
Pages
200134
ISSN
  • 0905-9180 (ISSN-L)
  • 1600-0617
OpenAlex
W3091096362
Cited by
41
References
120
Citations by year
2026: 4 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 11 · 2021: 7
FWCI
2.36
Type
journal article
Language
en
Open access
Locations
  • European Respiratory Review (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
tumour-associated macrophages, tumor microenvironment, lung cancer, macrophage metabolic reprogramming, glycolysis, fatty acid metabolism, amino acid metabolism, macrophage plasticity, cancer therapy, tumor progression
MeSH terms
Tumor-Associated Macrophages, Humans, Macrophages, Neoplasms, Phenotype, Tumor Microenvironment

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