Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment
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Lung cancer is the leading cause of death from cancer worldwide. Recent studies demonstrated that the tumour microenvironment (TME) is pivotal for tumour progression, providing multiple targeting opportunities for therapeutic strategies. As one of the most abundant stromal cell types in the TME, tumour-associated macrophages (TAMs) exhibit high plasticity. Malignant cells alter their metabolic profiles to adapt to the limited availability of oxygen and nutrients in the TME, resulting in functional alteration of TAMs. The metabolic features of TAMs are strongly associated with their functional plasticity, which further impacts metabolic profiling in the TME and contributes to tumourigenesis and progression. Here, we review the functional determination of the TME by TAM metabolic alterations, including glycolysis as well as fatty acid and amino acid metabolism, which in turn are influenced by environmental changes. Additionally, we discuss metabolic reprogramming of TAMs to a tumouricidal phenotype as a potential antitumoural therapeutic strategy.
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LD accumulation in macrophages is associated with inflammatory conditions, infectious diseases, and cancer.
“LD accumulation in macrophages is associated with several inflammatory conditions (e.g., atherosclerosis) (4, 5), infectious diseases (e.g., mycobacterial infections) (6, 7), and cancer (8, 9).”
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- Authors
- Zheng, X., Mansouri, S., Krager, A., Grimminger, F., Seeger, W., Pullamsetti, S. S., Wheelock, C. E., & Savai, R.
- Affiliations
- Max Planck Institute for Heart and Lung Research (DE)
- Justus-Liebig-Universität Gießen (DE)
- Karolinska Institutet (SE)
- Goethe University Frankfurt (DE)
- Corresponding author
- Savai, Rajkumar
- ORCID
- Venue
- European Respiratory Review
- Publisher
- European Respiratory Society (ERS)
- Published
- 2020-09-30
- Volume
- 29
- Issue
- 157
- Pages
- 200134
- ISSN
- 0905-9180 (ISSN-L)
- 1600-0617
- PMC
- PMC9488699
- OpenAlex
- W3091096362
- Cited by
- 41
- References
- 120
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 11 · 2021: 7
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- European Respiratory Review (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- tumour-associated macrophages, tumor microenvironment, lung cancer, macrophage metabolic reprogramming, glycolysis, fatty acid metabolism, amino acid metabolism, macrophage plasticity, cancer therapy, tumor progression
- MeSH terms
- Tumor-Associated Macrophages, Humans, Macrophages, Neoplasms, Phenotype, Tumor Microenvironment
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